Tle1 tumor suppressor negatively regulates inflammation in vivo and modulates NF-κB inflammatory pathway

scientific article published on February 2016

Tle1 tumor suppressor negatively regulates inflammation in vivo and modulates NF-κB inflammatory pathway is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2016PNAS..113.1871R
P356DOI10.1073/PNAS.1511380113
P932PMC publication ID4763742
P698PubMed publication ID26831087

P50authorMikael PittetQ45776556
David A. SweetserQ55283656
Subhankar MukhopadhyayQ59487610
Borja SaezQ61159850
David T ScaddenQ88652265
P2093author name stringXi Chen
Jianfeng Wang
Rae'e Yamin
Ferdinando Pucci
Cassandra M Kelleher
Alwiya M Ahmed
Selvi Ramasamy
Daching Ding
P2860cites workInhibition of nuclear factor-kappaB-mediated transcription by association with the amino-terminal enhancer of split, a Groucho-related protein lacking WD40 repeatsQ22011204
Pf1, a novel PHD zinc finger protein that links the TLE corepressor to the mSin3A-histone deacetylase complexQ24291300
TLE1 modifies the effects of NOD2 in the pathogenesis of Crohn's diseaseQ24307593
Molecular interaction between TLE1 and the carboxyl-terminal domain of HES-1 containing the WRPW motifQ24308186
Sirt1 interacts with transducin-like enhancer of split-1 to inhibit nuclear factor kappaB-mediated transcriptionQ24336407
Molecular functions of the TLE tetramerization domain in Wnt target gene repressionQ24338688
Inflammation and cancerQ24649640
Hes6 promotes cortical neurogenesis and inhibits Hes1 transcription repression activity by multiple mechanismsQ24682396
Demand-adapted regulation of early hematopoiesis in infection and inflammationQ27011458
Angiotensin signalling in pulmonary fibrosisQ27025157
NF-kappaB and the immune responseQ28271031
Transducin-like Enhancer of split 2, a mammalian homologue of Drosophila Groucho, acts as a transcriptional repressor, interacts with Hairy/Enhancer of split proteins, and is expressed during neuronal developmentQ28292810
JNK1 inhibits GluR1 expression and GluR1-mediated calcium influx through phosphorylation and stabilization of Hes-1Q28565815
Activating the PARP-1 sensor component of the groucho/ TLE1 corepressor complex mediates a CaMKinase IIdelta-dependent neurogenic gene activation pathwayQ28579105
Groucho/TLE family proteins and transcriptional repressionQ28609075
A role for Groucho tetramerization in transcriptional repressionQ28609165
Proteomics. Tissue-based map of the human proteomeQ29617248
NF-kappaB at the crossroads of life and deathQ29619302
Loss of TLE1 and TLE4 from the del(9q) commonly deleted region in AML cooperates with AML1-ETO to affect myeloid cell proliferation and survivalQ33318747
Transcriptional corepressor TLE1 functions with Runx2 in epigenetic repression of ribosomal RNA genesQ33732988
Control of apoptosis by Rel/NF-kappaB transcription factorsQ33797163
The corepressor Tle4 is a novel regulator of murine hematopoiesis and bone developmentQ34083894
Delineation of the minimal commonly deleted segment and identification of candidate tumor-suppressor genes in del(9q) acute myeloid leukemiaQ34433808
A cytokine-mediated link between innate immunity, inflammation, and cancerQ34625152
Conversion of dorsal from an activator to a repressor by the global corepressor GrouchoQ35196355
Notch signal suppresses Toll-like receptor-triggered inflammatory responses in macrophages by inhibiting extracellular signal-regulated kinase 1/2-mediated nuclear factor κB activationQ35838949
IL-1beta disrupts postnatal lung morphogenesis in the mouseQ35855262
Transducin-like enhancer of Split-1 (TLE1) combines with Forkhead box protein G1 (FoxG1) to promote neuronal survival.Q35922513
Transient expression of IL-1beta induces acute lung injury and chronic repair leading to pulmonary fibrosisQ36028616
Site-specific phosphorylation of the p65 protein subunit mediates selective gene expression by differential NF-κB and RNA polymerase II promoter recruitmentQ36508608
Essential role of Notch signaling in effector memory CD8+ T cell-mediated airway hyperresponsiveness and inflammation.Q36639992
NF-κB functions in tumor initiation by suppressing the surveillance of both innate and adaptive immune cellsQ36940385
Integrated regulation of Toll-like receptor responses by Notch and interferon-gamma pathwaysQ36977850
Increased cAMP in monocytes augments Notch signaling mechanisms by elevating RBP-J and transducin-like enhancer of Split (TLE)Q37048321
The role of toll-like receptors in chronic inflammationQ37616733
Grg3/TLE3 and Grg1/TLE1 induce monohormonal pancreatic β-cells while repressing α-cell functionsQ37715581
Constitutive NF-kappa B activation, enhanced granulopoiesis, and neonatal lethality in I kappa B alpha-deficient miceQ38289217
IL-6 cooperates with G-CSF to induce protumor function of neutrophils in bone marrow by enhancing STAT3 activationQ39158374
MicroRNA-657 promotes tumorigenesis in hepatocellular carcinoma by targeting transducin-like enhancer protein 1 through nuclear factor kappa B pathwaysQ39240312
The role of TLE1 in synovial sarcomaQ39592700
Epigenetic inactivation of the Groucho homologue gene TLE1 in hematologic malignanciesQ39976300
Notch- and transducin-like enhancer of split (TLE)-dependent histone deacetylation explain interleukin 12 (IL-12) p70 inhibition by zymosanQ41820830
Grg1 acts as a lung-specific oncogene in a transgenic mouse modelQ42805585
Disrupted development of the cerebral hemispheres in transgenic mice expressing the mammalian Groucho homologue transducin-like-enhancer of split 1 in postmitotic neurons.Q52538980
Upregulation of the IFN-gamma-stimulated genes in the development of delayed pigmented spots on the dorsal skin of F1 mice of HR-1 x HR/De.Q54667963
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectNF-κBQ411114
P1104number of pages6
P304page(s)1871-1876
P577publication date2016-02-01
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleTle1 tumor suppressor negatively regulates inflammation in vivo and modulates NF-κB inflammatory pathway
P478volume113

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cites work (P2860)
Q91031402A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing
Q90573584Bring along your friends: Homotypic and heterotypic circulating tumor cell clustering to accelerate metastasis
Q37735959Clinicopathologic and Prognostic Significance of Transducin-Like Enhancer of Split 1 Protein Expression in Invasive Breast Cancer
Q50099690Genome-Wide Identification and Characterization of WD40 Protein Genes in the Silkworm, Bombyx mori
Q37519403Genome-wide Analysis of WD40 Protein Family in Human.
Q104439980Global BioID-based SARS-CoV-2 proteins proximal interactome unveils novel ties between viral polypeptides and host factors involved in multiple COVID19-associated mechanisms
Q64125300Hes1 attenuates type I IFN responses via VEGF-C and WDFY1
Q91910243Identification of Differentially Expressed miRNAs and mRNAs in Vestibular Schwannoma by Integrated Analysis
Q37716622Liver X receptors agonist GW3965 re-sensitizes gefitinib-resistant human non-small cell lung cancer cell to gefitinib treatment by inhibiting NF-κB in vitro
Q64983114Lnc-GIHCG promotes cell proliferation and migration in gastric cancer through miR- 1281 adsorption.
Q30854149Ly6Chi Monocytes and Their Macrophage Descendants Regulate Neutrophil Function and Clearance in Acetaminophen-Induced Liver Injury
Q91387375Neutrophils escort circulating tumour cells to enable cell cycle progression
Q107343984SARS-CoV-2 viral proteins NSP1 and NSP13 inhibit interferon activation through distinct mechanisms
Q28073815TLE1 function and therapeutic potential in cancer
Q60595370TLE4 acts as a corepressor of Hes1 to inhibit inflammatory responses in macrophages
Q41781737TLE4 regulation of wnt-mediated inflammation underlies its role as a tumor suppressor in myeloid leukemia
Q64994154Tle corepressors are differentially partitioned to instruct CD8+ T cell lineage choice and identity.
Q59340031Unique, Intersecting, and Overlapping Roles of C/EBP β and CREB in Cells of the Innate Immune System

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