Telomere uncapping by the G-quadruplex ligand RHPS4 inhibits clonogenic tumour cell growth in vitro and in vivo consistent with a cancer stem cell targeting mechanism

scientific article published on 3 April 2007

Telomere uncapping by the G-quadruplex ligand RHPS4 inhibits clonogenic tumour cell growth in vitro and in vivo consistent with a cancer stem cell targeting mechanism is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/SJ.BJC.6603691
P932PMC publication ID2360152
P698PubMed publication ID17406367
P5875ResearchGate publication ID6416321

P2093author name stringA M Burger
M F G Stevens
V Smith
F Dai
P Phatak
R B Gartenhaus
J C Cookson
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Biological activity of the G-quadruplex ligand RHPS4 (3,11-difluoro-6,8,13-trimethyl-8H-quino[4,3,2-kl]acridinium methosulfate) is associated with telomere capping alterationQ45013871
G-Quadruplex stabilization by telomestatin induces TRF2 protein dissociation from telomeres and anaphase bridge formation accompanied by loss of the 3' telomeric overhang in cancer cellsQ46815329
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P433issue8
P407language of work or nameEnglishQ1860
P921main subjectcell growthQ189159
neoplastic stem cellsQ1638475
P304page(s)1223-1233
P577publication date2007-04-03
P1433published inBritish Journal of CancerQ326309
P1476titleTelomere uncapping by the G-quadruplex ligand RHPS4 inhibits clonogenic tumour cell growth in vitro and in vivo consistent with a cancer stem cell targeting mechanism
P478volume96