A phase I and pharmacokinetic study of NK105, a paclitaxel-incorporating micellar nanoparticle formulation

scientific article published on 26 June 2007

A phase I and pharmacokinetic study of NK105, a paclitaxel-incorporating micellar nanoparticle formulation is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/SJ.BJC.6603855
P932PMC publication ID2360299
P698PubMed publication ID17595665
P5875ResearchGate publication ID232771793

P2093author name stringKato K
Yamada Y
Ikeda M
Shimada Y
Matsumura Y
Muro K
Hamaguchi T
Ueno H
Shirao K
Nakahama H
Okusaka T
Yasui H
Morizane C
P2860cites workNew guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of CanadaQ27860904
A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancsQ28285226
Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a reviewQ29617388
Poly-(L)-glutamic acid-paclitaxel (CT-2103) [XYOTAX], a biodegradable polymeric drug conjugate: characterization, preclinical pharmacology, and preliminary clinical dataQ30783388
The taxanes: an updateQ33903877
Paclitaxel (taxol)Q34723890
The dawning era of polymer therapeuticsQ35128900
Fatal outcome of a hypersensitivity reaction to paclitaxel: a critical review of premedication regimensQ35671440
NK105, a paclitaxel-incorporating micellar nanoparticle, is a more potent radiosensitising agent compared to free paclitaxelQ36612282
Cisplatin-incorporating polymeric micelles (NC-6004) can reduce nephrotoxicity and neurotoxicity of cisplatin in ratsQ36615327
NK105, a paclitaxel-incorporating micellar nanoparticle formulation, can extend in vivo antitumour activity and reduce the neurotoxicity of paclitaxelQ36616645
Phase I clinical trial and pharmacokinetic evaluation of NK911, a micelle-encapsulated doxorubicinQ36696233
Taxol: a novel investigational antimicrotubule agentQ37593661
Chemotherapy in the management of patients with inoperable non-small cell lung cancerQ40918601
Phase I study of paclitaxel by three-hour infusion: hypotension just after infusion is one of the major dose-limiting toxicitiesQ42556376
Phase I and pharmacokinetic study of ABI-007, a Cremophor-free, protein-stabilized, nanoparticle formulation of paclitaxelQ43990070
Hypersensitivity reactions from taxolQ44119231
Phase I and pharmacokinetic study of Genexol-PM, a cremophor-free, polymeric micelle-formulated paclitaxel, in patients with advanced malignanciesQ44918003
Phase I and pharmacokinetics trial of ABI-007, a novel nanoparticle formulation of paclitaxel in patients with advanced nonhematologic malignanciesQ46781761
A phase I and pharmacokinetic study of paclitaxel poliglumex (XYOTAX), investigating both 3-weekly and 2-weekly schedulesQ46797233
Novel SN-38-incorporating polymeric micelles, NK012, eradicate vascular endothelial growth factor-secreting bulky tumors.Q53593123
Phase III Trial of Nanoparticle Albumin-Bound Paclitaxel Compared With Polyethylated Castor Oil–Based Paclitaxel in Women With Breast CancerQ56626150
Accelerated titration designs for phase I clinical trials in oncologyQ73598986
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectnanoparticleQ61231
pharmacokineticsQ323936
P304page(s)170-176
P577publication date2007-06-26
P1433published inBritish Journal of CancerQ326309
P1476titleA phase I and pharmacokinetic study of NK105, a paclitaxel-incorporating micellar nanoparticle formulation
P478volume97

Reverse relations

cites work (P2860)
Q39675117A high capacity polymeric micelle of paclitaxel: Implication of high dose drug therapy to safety and in vivo anti-cancer activity
Q37408420A simple method to improve the stability of docetaxel micelles
Q37234202Advances of cancer therapy by nanotechnology
Q37652883An in vivo mechanism for the reduced peripheral neurotoxicity of NK105: a paclitaxel-incorporating polymeric micellar nanoparticle formulation
Q39377073Antitumor effect and pharmacokinetics of intraperitoneal NK105, a nanomicellar paclitaxel formulation for peritoneal dissemination
Q35091789Application of magnetic nanoparticles to gene delivery
Q38356347Applications of polymer micelles for imaging and drug delivery
Q88175987Biodegradable Polymeric Nanoparticles for Therapeutic Cancer Treatments
Q59264434Bioinspired nanoarchitectonics as emerging drug delivery systems
Q37129736Clinically relevant anticancer polymer Paclitaxel therapeutics
Q35438759Core-Crosslinked Polymeric Micelles: Principles, Preparation, Biomedical Applications and Clinical Translation
Q38792197Current Update of a Carboxymethylcellulose-PEG Conjugate Platform for Delivery of Insoluble Cytotoxic Agents to Tumors
Q47442172Design and development of multifunctional polyphosphoester-based nanoparticles for ultrahigh paclitaxel dual loading
Q64108949Development and Biological Analysis of a Novel Orthotopic Peritoneal Dissemination Mouse Model Generated Using a Pancreatic Ductal Adenocarcinoma Cell Line
Q26749611Development of polymeric micelles for targeting intractable cancers
Q37265495Disposition of drugs in block copolymer micelle delivery systems: from discovery to recovery
Q88965445Dual Acting Polymeric Nano-Aggregates for Liver Cancer Therapy
Q58094600Effects of stability of PEGylated micelles on the accelerated blood clearance phenomenon
Q55071436Emerging Therapeutic Potential of Nanoparticles in Pancreatic Cancer: A Systematic Review of Clinical Trials.
Q60957206Enhanced Anticancer Activity of 5'-DFUR-PCL-MPEG Polymeric Prodrug Micelles Encapsulating Chemotherapeutic Drugs
Q35674222Enhanced antitumor effect of anti-tissue factor antibody-conjugated epirubicin-incorporating micelles in xenograft models.
Q50254425Evaluation of a combination tumor treatment using thermo-triggered liposomal drug delivery and carbon ion irradiation
Q38161447Extracellular stability of nanoparticulate drug carriers
Q37351089Fluorescence imaging enabled biodegradable photostable polymeric micelles.
Q48257489General overview of lipid-polymer hybrid nanoparticles, dendrimers, micelles, liposomes, spongosomes and cubosomes.
Q42379631Glycaemic control boosts glucosylated nanocarrier crossing the BBB into the brain
Q34590348Highly stable, ligand-clustered “patchy” micelle nanocarriers for systemic tumor targeting
Q42158141Hydrophobic pharmaceuticals mediated self-assembly of beta-cyclodextrin containing hydrophilic copolymers: novel chemical responsive nano-vehicles for drug delivery.
Q39611679Improving drug potency and efficacy by nanocarrier-mediated subcellular targeting.
Q58910105In VitroCharacterization of Pluronic F127 and D--Tocopheryl Polyethylene Glycol 1000 Succinate Mixed Micelles as Nanocarriers for Targeted Anticancer-Drug Delivery
Q26744830Interventional Nanotheranostics of Pancreatic Ductal Adenocarcinoma
Q41880684Mechanistic understanding of in vivo protein corona formation on polymeric nanoparticles and impact on pharmacokinetics
Q30438973Multifunctional polymeric micelles for delivery of drugs and siRNA.
Q36058744NC-6301, a polymeric micelle rationally optimized for effective release of docetaxel, is potent but is less toxic than native docetaxel in vivo
Q37693046Nanoparticles containing insoluble drug for cancer therapy
Q28387499Nanotechnologies for noninvasive measurement of drug release
Q36097175Nanovector-based therapies in advanced pancreatic cancer
Q37879444New short interfering RNA-based therapies for glomerulonephritis
Q38180666Novozym 435-catalyzed syntheses of polyesters and polyamides of medicinal and industrial relevance
Q37657516Overcoming the barriers in micellar drug delivery: loading efficiency, in vivo stability, and micelle-cell interaction
Q37250009Paclitaxel Nano-Delivery Systems: A Comprehensive Review
Q38071668Paclitaxel drug delivery systems
Q36028787Perspectives on clinical translation of smart nanotherapeutics
Q37399257Phase I study of NK105, a nanomicellar paclitaxel formulation, administered on a weekly schedule in patients with solid tumors.
Q84504572Phase II study of NK105, a paclitaxel-incorporating micellar nanoparticle, for previously treated advanced or recurrent gastric cancer
Q65000705Photo-controlled release of paclitaxel and model drugs from RNA pyramids.
Q35775850Poly(2-oxazoline) based micelles with high capacity for 3rd generation taxoids: preparation, in vitro and in vivo evaluation
Q57351284Poly(2-oxazoline) block copolymer based formulations of taxanes: effect of copolymer and drug structure, concentration, and environmental factors
Q36716915Poly(2-oxazoline)s as polymer therapeutics
Q38588547Polymeric Micelles: Recent Advancements in the Delivery of Anticancer Drugs.
Q90694715Polymeric Nanocarriers of Drug Delivery Systems in Cancer Therapy
Q37319114Polymeric micellar delivery systems in oncology
Q37141404Polymeric micelles and alternative nanonized delivery vehicles for poorly soluble drugs
Q37679942Polymeric micelles as a new drug carrier system and their required considerations for clinical trials
Q38228138Polymeric micelles as drug carriers: their lights and shadows
Q37211504Polymeric micelles from poly(ethylene glycol)-poly(amino acid) block copolymer for drug and gene delivery
Q30478123Polymeric micelles in anticancer therapy: targeting, imaging and triggered release
Q38202058Polymeric micelles: nanocarriers for cancer-targeted drug delivery
Q38575282Polymeric nanoparticles: the future of nanomedicine
Q37975554Polypeptides and polyaminoacids in drug delivery
Q34702599Preparation, pharmacokinetics, biodistribution, antitumor efficacy and safety of Lx2-32c-containing liposome
Q49904261RNA-based micelles: A novel platform for chemotherapeutic drug loading and delivery
Q38161791Recent advances in amino acid N-carboxyanhydrides and synthetic polypeptides: chemistry, self-assembly and biological applications
Q38795892Sialoganglioside Micelles for Enhanced Paclitaxel Solubility: In Vitro Characterization.
Q38697200Structural modifications in polymeric micelles to impart multifunctionality for improved drug delivery
Q41621174Synthesis and self-assembly of RGD-functionalized PEO-PB amphiphiles
Q30940472Systemic delivery of nanoparticle formulation of novel tubulin inhibitor for treating metastatic melanoma
Q35086678Targeted albumin-based nanoparticles for delivery of amphipathic drugs
Q59101713The Chemistry of Bioconjugation in Nanoparticles-Based Drug Delivery System
Q38206349The drug discovery by nanomedicine and its clinical experience
Q27693205The potential of polymeric micelles in the context of glioblastoma therapy
Q37815479The rise and rise of stealth nanocarriers for cancer therapy: passive versus active targeting
Q35025984The significance of microscopic mass spectrometry with high resolution in the visualisation of drug distribution
Q39945883Therapeutic efficacy of a polymeric micellar doxorubicin infused by convection-enhanced delivery against intracranial 9L brain tumor models.
Q45214606Translating materials design to the clinic
Q38177770What nanomedicine in the clinic right now really forms nanoparticles?