Molecular consequences of SOD2 expression in epigenetically silenced pancreatic carcinoma cell lines

scientific article published on 25 September 2007

Molecular consequences of SOD2 expression in epigenetically silenced pancreatic carcinoma cell lines is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/SJ.BJC.6604000
P932PMC publication ID2360443
P698PubMed publication ID17895890
P5875ResearchGate publication ID5948545

P2093author name stringS B Thomas
W L Farrar
B Peng
E M Hurt
P2860cites workOverexpression of manganese superoxide dismutase selectively modulates the activity of Jun-associated transcription factors in fibrosarcoma cellsQ24311827
Zebularine: A Novel DNA Methylation Inhibitor that Forms a Covalent Complex with DNA MethyltransferasesQ27639568
Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate agingQ28191739
GSTP1 CpG island hypermethylation is responsible for the absence of GSTP1 expression in human prostate cancer cellsQ28363395
Reverse phase protein microarrays which capture disease progression show activation of pro-survival pathways at the cancer invasion frontQ30989699
Mutations in the promoter reveal a cause for the reduced expression of the human manganese superoxide dismutase gene in cancer cells.Q31917763
Molecular alterations in primary prostate cancer after androgen ablation therapyQ33224548
Mitochondrial oxidative stress. Physiologic consequences and potential for a role in agingQ33981614
Biochemistry of oxygen toxicityQ34507383
The role of manganese superoxide dismutase in the growth of pancreatic adenocarcinoma.Q34532264
Radical causes of cancer.Q35097371
Cross-talk between calcium and reactive oxygen species signalingQ36513350
Enforced expression of superoxide dismutase 2/manganese superoxide dismutase disrupts autocrine interleukin-6 stimulation in human multiple myeloma cells and enhances dexamethasone-induced apoptosisQ40396810
Epigenetic silencing of manganese superoxide dismutase (SOD-2) in KAS 6/1 human multiple myeloma cells increases cell proliferationQ40418971
Alteration of cellular phenotype and responses to oxidative stress by manganese superoxide dismutase and a superoxide dismutase mimic in RWPE-2 human prostate adenocarcinoma cellsQ40558546
Redox regulation of pancreatic cancer cell growth: role of glutathione peroxidase in the suppression of the malignant phenotype.Q40578955
Suppression of the malignant phenotype in human pancreatic cancer cells by the overexpression of manganese superoxide dismutaseQ40654651
Superoxide dismutase is induced during rat pancreatic acinar cell injuryQ40749649
Maspin gene expression in tumor suppression induced by overexpressing manganese-containing superoxide dismutase cDNA in human breast cancer cellsQ41027107
Overexpression of manganese superoxide dismutase in DU145 human prostate carcinoma cells has multiple effects on cell phenotypeQ42454974
The molecular pathogenesis of prostate cancer: Implications for prostate cancer prevention.Q43570305
Overexpression of manganese superoxide dismutase suppresses tumor formation by modulation of activator protein-1 signaling in a multistage skin carcinogenesis model.Q43708545
2-Methoxyestradiol induces mitochondria dependent apoptotic signaling in pancreatic cancer cellsQ44010945
Superoxide-dependent and -independent mitochondrial signaling during apoptosis in multiple myeloma cellsQ44588843
Stable suppression of tumorigenicity by virus-mediated RNA interferenceQ45730805
Transfection and expression of MnSOD cDNA decreases tumor malignancy of human oral squamous carcinoma SCC-25 cellsQ45881258
Potent antitumor activity of 2-methoxyestradiol in human pancreatic cancer cell lines.Q52979705
Inhibition of cell growth by overexpression of manganese superoxide dismutase (MnSOD) in human pancreatic carcinoma.Q53875777
Antitumor properties of 2(1H)-pyrimidinone riboside (zebularine) and its fluorinated analogues.Q54284800
Suppression of the malignant phenotype of human glioma cells by overexpression of manganese superoxide dismutase.Q55478798
MnSOD expression is less frequent in tumour cells of invasive breast carcinomas than in in situ carcinomas or non-neoplastic breast epithelial cellsQ74602361
Mechanisms of endothelial response to oxidative aggression: protective role of autologous VEGF and induction of VEGFR2 by H2O2Q80088244
Manganese superoxide dismutase overexpression inhibits the growth of androgen-independent prostate cancer cellsQ81004798
P4510describes a project that usesImageJQ1659584
ImageQuantQ112270642
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectpancreatic carcinomaQ18556536
P304page(s)1116-1123
P577publication date2007-09-25
P1433published inBritish Journal of CancerQ326309
P1476titleMolecular consequences of SOD2 expression in epigenetically silenced pancreatic carcinoma cell lines
P478volume97

Reverse relations

cites work (P2860)
Q609073045-aza-2'-deoxycytidine in the regulation of antioxidant enzymes in retinal endothelial cells and rat diabetic retina
Q50437524A defined metabolic state in pre B cells governs B-cell development and is counterbalanced by Swiprosin-2/EFhd1.
Q28291048A review of pterostilbene antioxidant activity and disease modification
Q38876540Acquired Mitochondrial Abnormalities, Including Epigenetic Inhibition of Superoxide Dismutase 2, in Pulmonary Hypertension and Cancer: Therapeutic Implications
Q39356058Acquisition of resistance of pancreatic cancer cells to 2-methoxyestradiol is associated with the upregulation of manganese superoxide dismutase
Q37709819Biochemical and molecular modulation of CCl4-induced peripheral and central damage by Tilia americana var. mexicanaextracts
Q41942561Epigenetic attenuation of mitochondrial superoxide dismutase 2 in pulmonary arterial hypertension: a basis for excessive cell proliferation and a new therapeutic target.
Q35573935Epigenetic mechanisms of pulmonary hypertension.
Q28084220Epigenetic regulation of Keap1-Nrf2 signaling
Q39052777Epigenetic regulation of redox signaling in diabetic retinopathy: Role of Nrf2.
Q24642670Epigenetic silencing of SOD2 by histone modifications in human breast cancer cells
Q34564550Fraternal twins: Swiprosin-1/EFhd2 and Swiprosin-2/EFhd1, two homologous EF-hand containing calcium binding adaptor proteins with distinct functions
Q30459047Genetic oxidative stress variants and glioma risk in a Chinese population: a hospital-based case-control study
Q34541180Genomic analysis of pterostilbene predicts its antiproliferative effects against pancreatic cancer in vitro and in vivo
Q37139542Histone deacetylation contributes to low extracellular superoxide dismutase expression in human idiopathic pulmonary arterial hypertension
Q47144151Insights into the Dichotomous Regulation of SOD2 in Cancer.
Q34284548Manganese superoxide dismutase: beyond life and death
Q90260807Mitochondria in the Pulmonary Vasculature in Health and Disease: Oxygen-Sensing, Metabolism, and Dynamics
Q39021506Mitochondrial oxidative stress-induced epigenetic modifications in pancreatic epithelial cells
Q37617682MnSOD in oxidative stress response-potential regulation via mitochondrial protein influx
Q26998478Oxygen in human health from life to death--An approach to teaching redox biology and signaling to graduate and medical students
Q33791981Proteomics in pancreatic cancer research
Q90639050Regulation of Energy Metabolism during Early B Lymphocyte Development
Q27001050Regulation of SOD2 in cancer by histone modifications and CpG methylation: closing the loop between redox biology and epigenetics
Q37317586Regulation of superoxide dismutase genes: implications in disease
Q42911793Simultaneous determination of 8-hydroxy-2′-deoxyguanosine and 5-methyl-2′-deoxycytidine in DNA sample by high performance liquid chromatography/positive electrospray ionization tandem mass spectrometry
Q41662731Superoxide Dismutases in Pancreatic Cancer
Q37211903Superoxide dismutase downregulation in osteoarthritis progression and end-stage disease
Q64992307Superoxide dismutases: Dual roles in controlling ROS damage and regulating ROS signaling.
Q28069443The emerging role of epigenetics in pulmonary arterial hypertension: an important avenue for clinical trials (2015 Grover Conference Series)
Q37555457Transcription factors, transcriptional coregulators, and epigenetic modulation in the control of pulmonary vascular cell phenotype: therapeutic implications for pulmonary hypertension (2015 Grover Conference series).
Q33884481Up-regulation of mitochondrial antioxidation signals in ovarian cancer cells with aggressive biologic behavior

Search more.