Mitochondria-targeted peptide antioxidants: novel neuroprotective agents

scientific article published on 18 August 2006

Mitochondria-targeted peptide antioxidants: novel neuroprotective agents is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P6179Dimensions Publication ID1035078161
P356DOI10.1208/AAPSJ080362
P932PMC publication ID2761060
P698PubMed publication ID17025271
P5875ResearchGate publication ID6770327

P2093author name stringHazel H Szeto
P2860cites workDifferential effects of superoxide dismutase isoform expression on hydroperoxide-induced apoptosis in PC-12 cellsQ24293297
Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascadeQ24311006
Interactions of mitochondria-targeted and untargeted ubiquinones with the mitochondrial respiratory chain and reactive oxygen species. Implications for the use of exogenous ubiquinones as therapies and experimental toolsQ28241521
Oxidative stress in neurodegeneration: cause or consequence?Q28275946
Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosisQ28283313
Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortalityQ28292632
Complex III releases superoxide to both sides of the inner mitochondrial membraneQ28509539
A novel neurological phenotype in mice lacking mitochondrial manganese superoxide dismutaseQ28510284
Cytochrome c release from mitochondria proceeds by a two-step processQ28571562
Mitochondrial dysfunction and oxidative damage in parkin-deficient miceQ28593859
Axonal degeneration in paraplegin-deficient mice is associated with abnormal mitochondria and impairment of axonal transportQ28594710
Mitochondria and apoptosisQ29547905
The mitochondrial permeability transition pore and its role in cell deathQ29614183
Mitochondrial free radical generation, oxidative stress, and agingQ29614202
Extension of murine life span by overexpression of catalase targeted to mitochondriaQ29614546
Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutantsQ29615627
Selective targeting of an antioxidant to mitochondriaQ30581066
Protein nitration in a mouse model of familial amyotrophic lateral sclerosis: possible multifunctional role in the pathogenesisQ30777447
Fluorescent dyes alter intracellular targeting and function of cell-penetrating tetrapeptidesQ31121431
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Selective targeting of a redox-active ubiquinone to mitochondria within cells: antioxidant and antiapoptotic propertiesQ31621261
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Mitochondria, oxidative damage, and inflammation in Parkinson's diseaseQ34212155
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The mitochondrial death/life regulator in apoptosis and necrosisQ34465435
Superoxide dismutase and the death of motoneurons in ALS.Q34553806
Oxidatively modified proteins in aging and diseaseQ34615830
The relationship between oxidative/nitrative stress and pathological inclusions in Alzheimer's and Parkinson's diseasesQ34679230
Delivery of bioactive molecules to mitochondria in vivo.Q34983135
Protective effects of M40403, a selective superoxide dismutase mimetic, in myocardial ischaemia and reperfusion injury in vivoQ35044475
Cell-permeable, mitochondrial-targeted, peptide antioxidantsQ35594854
Mitochondrial enzyme activities as biochemical markers of agingQ35722427
Catalytic antioxidants: a radical approach to new therapeuticsQ35808784
Mitochondrial metabolism of reactive oxygen species.Q36088215
Pathophysiologic role of oxidative stress-induced poly(ADP-ribose) polymerase-1 activation: focus on cell death and transcriptional regulationQ36114650
Mitochondria take center stage in aging and neurodegenerationQ36264218
Targeting antioxidants to mitochondria: a new therapeutic directionQ36341069
Alzheimer's brains harbor somatic mtDNA control-region mutations that suppress mitochondrial transcription and replicationQ36986848
Mitochondria-targeted peptide prevents mitochondrial depolarization and apoptosis induced by tert-butyl hydroperoxide in neuronal cell linesQ40363556
Superoxide dismutase/catalase mimetics are neuroprotective against selective paraquat-mediated dopaminergic neuron death in the substantial nigra: implications for Parkinson diseaseQ40411589
Mitochondria permeability transition-dependent tert-butyl hydroperoxide-induced apoptosis in hepatoma HepG2 cellsQ40593167
Caspase‐3 dependent proteolytic activation of protein kinase Cδ mediates and regulates 1‐methyl‐4‐phenylpyridinium (MPP+)‐induced apoptotic cell death in dopaminergic cells: relevance to oxidative stress in dopaminergic degenerationQ40631358
Superoxide production by the mitochondrial respiratory chainQ41488866
Cell internalization of the third helix of the Antennapedia homeodomain is receptor-independent.Q42632235
Requirements for superoxide-dependent tyrosine hydroperoxide formation in peptidesQ42806258
In vivo pharmacokinetics of selective mu-opioid peptide agonistsQ43641850
Neuroprotection from delayed postischemic administration of a metalloporphyrin catalytic antioxidant.Q43653393
The adenine nucleotide translocator: a target of nitric oxide, peroxynitrite, and 4-hydroxynonenalQ43683788
Green tea polyphenol (-)-epigallocatechin-3-gallate prevents N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced dopaminergic neurodegenerationQ43735211
Profound spinal tolerance after repeated exposure to a highly selective mu-opioid peptide agonist: role of delta-opioid receptorsQ44028888
A highly potent peptide analgesic that protects against ischemia-reperfusion-induced myocardial stunningQ44068518
Transcellular transport of a highly polar 3+ net charge opioid tetrapeptideQ44255029
Studies on the internalization mechanism of cationic cell-penetrating peptides.Q44463875
Mitochondria-targeted antioxidants protect Friedreich Ataxia fibroblasts from endogenous oxidative stress more effectively than untargeted antioxidants.Q44552037
Role of reactive oxygen species and cardiolipin in the release of cytochrome c from mitochondriaQ44680963
Cell-permeable peptide antioxidants targeted to inner mitochondrial membrane inhibit mitochondrial swelling, oxidative cell death, and reperfusion injuryQ44922430
Supplementation of endothelial cells with mitochondria-targeted antioxidants inhibit peroxide-induced mitochondrial iron uptake, oxidative damage, and apoptosisQ44954085
Mechanism of tert-butylhydroperoxide induced apoptosis in rat hepatocytes: involvement of mitochondria and endoplasmic reticulumQ45712649
Prevention of 1-methyl-4-phenylpyridinium- and 6-hydroxydopamine-induced nitration of tyrosine hydroxylase and neurotoxicity by EUK-134, a superoxide dismutase and catalase mimetic, in cultured dopaminergic neuronsQ46217083
Mitochondrial and nuclear DNA-repair capacity of various brain regions in mouse is altered in an age-dependent manner.Q46590824
A potent opiate agonist protects against myocardial stunning during myocardial ischemia and reperfusion in ratsQ46666228
Additive neuroprotective effects of a histone deacetylase inhibitor and a catalytic antioxidant in a transgenic mouse model of amyotrophic lateral sclerosisQ46805732
ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's diseaseQ47754186
Mutant superoxide dismutase 1 forms aggregates in the brain mitochondrial matrix of amyotrophic lateral sclerosis mice.Q48975079
Copper-dependent inhibition of human cytochrome c oxidase by a dimeric conformer of amyloid-beta1-42.Q49134222
Mutated human SOD1 causes dysfunction of oxidative phosphorylation in mitochondria of transgenic mice.Q51714635
Modulation of membrane phospholipid fatty acid composition by age and food restrictionQ70578417
Alterations in mitochondrial membrane fluidity by lipid peroxidation productsQ72461830
Loss of molecular interaction between cytochrome c and cardiolipin due to lipid peroxidationQ73101546
Mitochondrial permeability transition in hepatocytes induced by t-BuOOH: NAD(P)H and reactive oxygen speciesQ73322667
Coenzyme Q10 in the central nervous system and its potential usefulness in the treatment of neurodegenerative diseasesQ73614293
Synthetic superoxide dismutase/catalase mimetics reduce oxidative stress and prolong survival in a mouse amyotrophic lateral sclerosis modelQ73852676
Peroxynitrite-mediated inactivation of manganese superoxide dismutase involves nitration and oxidation of critical tyrosine residuesQ74248716
Contribution of increased mitochondrial free Ca2+ to the mitochondrial permeability transition induced by tert-butylhydroperoxide in rat hepatocytesQ77363690
Cell-permeable peptide antioxidants as a novel therapeutic approach in a mouse model of amyotrophic lateral sclerosisQ80076165
Potent mitochondria-targeted peptides reduce myocardial infarction in ratsQ80147610
Are mitochondria critical in the pathogenesis of Alzheimer's disease?Q81440649
Targeting an antioxidant to mitochondria decreases cardiac ischemia-reperfusion injuryQ81901994
P433issue3
P407language of work or nameEnglishQ1860
P304page(s)E521-31
P577publication date2006-08-18
P1433published inThe AAPS JournalQ10695361
P1476titleMitochondria-targeted peptide antioxidants: novel neuroprotective agents
P478volume8

Reverse relations

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