Subcutaneous trastuzumab: development of a new formulation for treatment of HER2-positive early breast cancer

scientific article published on 14 February 2013

Subcutaneous trastuzumab: development of a new formulation for treatment of HER2-positive early breast cancer is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.2147/OTT.S27733
P932PMC publication ID3575209
P698PubMed publication ID23430730

P50authorEmilie HeninQ43094730
Gilles FreyerQ79780278
P2093author name stringOlivia Le Saux
Amina Mohtaram
Naoual Bakrin
Claire Falandry
Salima Hamizi
P2860cites workStructure of the extracellular region of HER2 alone and in complex with the Herceptin FabQ27640593
Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2.Q27824766
Randomized phase II trial of the efficacy and safety of trastuzumab combined with docetaxel in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer administered as first-line treatment: the M77001 study groupQ27824835
Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancerQ27824847
Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogeneQ27860693
Inhibitory Fc receptors modulate in vivo cytotoxicity against tumor targetsQ28140238
Trastuzumab (herceptin), a humanized anti-Her2 receptor monoclonal antibody, inhibits basal and activated Her2 ectodomain cleavage in breast cancer cellsQ28201813
Efficacy and safety of neoadjuvant pertuzumab and trastuzumab in women with locally advanced, inflammatory, or early HER2-positive breast cancer (NeoSphere): a randomised multicentre, open-label, phase 2 trialQ28254919
Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancerQ29547699
Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancerQ29616112
Nonclinical studies addressing the mechanism of action of trastuzumab (Herceptin).Q33730975
Four-year follow-up of trastuzumab plus adjuvant chemotherapy for operable human epidermal growth factor receptor 2-positive breast cancer: joint analysis of data from NCCTG N9831 and NSABP B-31.Q33964848
The six hyaluronidase-like genes in the human and mouse genomesQ34103842
Adjuvant trastuzumab in HER2-positive breast cancerQ35710898
Home-based subcutaneous immunoglobulin G replacement therapy under real-life conditions in children and adults with antibody deficiency.Q35959163
HyaluronanQ36001372
Recombinant human hyaluronidase (rHuPH20): an enabling platform for subcutaneous drug and fluid administrationQ36903813
Subcutaneous immunoglobulin: opportunities and outlookQ37626132
Review of the mechanism of action and clinical efficacy of recombinant human hyaluronidase coadministration with current prandial insulin formulationsQ37716042
Hyaluronidase: a review of approved formulations, indications and off-label use in chronic pain managementQ37737317
Adjuvants to local anaesthesia in ophthalmic surgeryQ37858272
Safety and pharmacokinetics of subcutaneous ceftriaxone administered with or without recombinant human hyaluronidase (rHuPH20) versus intravenous ceftriaxone administration in adult volunteersQ43233644
The INFUSE-Morphine IIB study: use of recombinant human hyaluronidase (rHuPH20) to enhance the absorption of subcutaneous morphine in healthy volunteersQ43263909
The INFUSE-Morphine study: use of recombinant human hyaluronidase (rHuPH20) to enhance the absorption of subcutaneously administered morphine in patients with advanced illnessQ43263911
Angioedema related to the use of hyaluronidase in cataract surgeryQ44963914
Hyaluronidase and its substrate hyaluronan: biochemistry, biological activities and therapeutic usesQ45345655
Comparison of subcutaneous and intravenous administration of trastuzumab: a phase I/Ib trial in healthy male volunteers and patients with HER2-positive breast cancerQ46087752
Factors influencing route of administration for epoetin treatment among hemodialysis patients in the United States.Q51939149
Prognostic factors for health-related quality of life in adults and children with primary antibody deficiencies receiving SCIG home therapy.Q53171720
Subcutaneous versus intravenous administration of (neo)adjuvant trastuzumab in patients with HER2-positive, clinical stage I–III breast cancer (HannaH study): a phase 3, open-label, multicentre, randomised trialQ57579927
Flow-assisted diagnosis of anaphylaxis to hyaluronidaseQ58617680
A recombinant human enzyme for enhanced interstitial transport of therapeuticsQ64377594
The serum kinetics of bovine testicular hyaluronidase in dogs, rats and humansQ70406091
Cost effectiveness of adjuvant trastuzumab in human epidermal growth factor receptor 2-positive breast cancerQ79794472
Effect of hyaluronidase on the subcutaneous absorption of electrolytes in humansQ80645601
Assessment and implication of the allergic sensitivity to a single dose of recombinant human hyaluronidase injection: a double-blind, placebo-controlled clinical trialQ81353003
Recombinant human hyaluronidase-enabled subcutaneous pediatric rehydrationQ84634340
P275copyright licenseCreative Commons Attribution-NonCommercial 3.0 UnportedQ18810331
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjecttrastuzumabQ412616
P304page(s)89-94
P577publication date2013-02-14
P1433published inOncoTargets and TherapyQ7092081
P1476titleSubcutaneous trastuzumab: development of a new formulation for treatment of HER2-positive early breast cancer
P478volume6

Reverse relations

cites work (P2860)
Q89547608Cost-minimization analysis of subcutaneous versus intravenous trastuzumab administration in Chilean patients with HER2-positive early breast cancer
Q58583000Development of New Formulations of Biologics: Expectations, Immunogenicity, and Safety for Subcutaneous Trastuzumab
Q38654371Fixed Dosing of Monoclonal Antibodies in Oncology
Q53354258Measuring tissue back-pressure--in vivo injection forces during subcutaneous injection.
Q92255092Overcoming Drug Resistance by Taking Advantage of Physical Principles: Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC)
Q38198973Subcutaneous trastuzumab: a review of its use in HER2-positive breast cancer
Q91910615The comparative efficacy and risk of harms of the intravenous and subcutaneous formulations of trastuzumab in patients with HER2-positive breast cancer: a rapid review

Search more.