Genetic variation throughout the folate metabolic pathway influences negative symptom severity in schizophrenia

scientific article published on 20 October 2011

Genetic variation throughout the folate metabolic pathway influences negative symptom severity in schizophrenia is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1093/SCHBUL/SBR150
P932PMC publication ID3576161
P698PubMed publication ID22021659

P50authorEric A MacklinQ45310572
Joshua L RoffmanQ47502175
Jordan W SmollerQ57394220
Donald C GoffQ90481276
P2093author name stringDavid G Brohawn
Adam Z Nitenson
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The positive and negative syndrome scale (PANSS) for schizophreniaQ28301751
Cloning, expression, genomic localization, and enzymatic activities of the mouse homolog of prostate-specific membrane antigen/NAALADase/folate hydrolaseQ28512009
Personal genomes: The case of the missing heritabilityQ29614582
Neuroimaging-genetic paradigms: a new approach to investigate the pathophysiology and treatment of cognitive deficits in schizophreniaQ31036338
In vivo NMR measures of NAA and the neurobiology of schizophreniaQ31046915
Epistasis between COMT and MTHFR in maternal-fetal dyads increases risk for preeclampsiaQ33815618
Glutamate and schizophrenia: beyond the dopamine hypothesisQ33996803
Contribution of methylenetetrahydrofolate reductase (MTHFR) polymorphisms to negative symptoms in schizophreniaQ34004490
A common mutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status.Q34025724
Catechol-o-methyltransferase, cognition, and psychosis: Val158Met and beyondQ34494146
Folate, homocysteine, and negative symptoms in schizophreniaQ34550533
From trans-methylation to cytosine methylation: evolution of the methylation hypothesis of schizophreniaQ34977902
Polymorphisms in genes involved in folate metabolism and colorectal neoplasia: a HuGE reviewQ35672899
The role of one-carbon metabolism in schizophrenia and depressionQ36905614
MTHFR 677C --> T genotype disrupts prefrontal function in schizophrenia through an interaction with COMT 158Val --> Met.Q36970899
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Polymorphisms in one-carbon metabolism pathway genes and risk for bladder cancer in a Tunisian populationQ39411356
No Association Between Functional Polymorphisms in COMT and MTHFR and Schizophrenia Risk in Korean PopulationQ41568991
Homocysteine-reducing strategies improve symptoms in chronic schizophrenic patients with hyperhomocysteinemiaQ42166996
Molecular pathways involved in neuronal cell adhesion and membrane scaffolding contribute to schizophrenia and bipolar disorder susceptibilityQ42649179
A second common variant in the methylenetetrahydrofolate reductase (MTHFR) gene and its relationship to MTHFR enzyme activity, homocysteine, and cardiovascular disease riskQ43787664
Homocysteine metabolism and B-vitamins in schizophrenic patients: low plasma folate as a possible independent risk factor for schizophreniaQ44627940
Relations of glutamate carboxypeptidase II (GCPII) polymorphisms to folate and homocysteine concentrations and to scores of cognition, anxiety, and depression in a homogeneous Norwegian population: the Hordaland Homocysteine StudyQ45204706
Relationship of cognition and psychopathology to functional impairment in schizophreniaQ46616400
Polymorphisms in the catechol-O-methyltransferase (COMT) gene influence plasma total homocysteine levelsQ46812598
Interactive effects of COMT Val108/158Met and MTHFR C677T on executive function in schizophreniaQ46815103
Regionally specific pattern of neurochemical pathology in schizophrenia as assessed by multislice proton magnetic resonance spectroscopic imagingQ48854560
Polymorphisms in catechol-O-methyltransferase and methylenetetrahydrofolate reductase in relation to the risk of schizophrenia.Q51900183
Rates of adult schizophrenia following prenatal exposure to the Chinese famine of 1959-1961.Q51927352
Enhancement of recovery from psychiatric illness by methylfolate.Q52056334
Polymorphisms of methylenetetrahydrofolate reductase and methionine synthase genes and bladder cancer risk: a case-control study with meta-analysis.Q53317307
Folate supplementation in schizophrenia: A possible role for MTHFR genotypeQ57845812
Folate levels in psychiatric outpatientsQ73022530
SchizophreniaQ73874580
MTHFD 1958G>A and MTR 2756A>G polymorphisms are associated with bipolar disorder and schizophreniaQ80118342
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectschizophreniaQ41112
metabolic pathwayQ68685
folic acidQ127060
genetic variationQ349856
P304page(s)330-338
P577publication date2011-10-20
P1433published inSchizophrenia BulletinQ4049133
P1476titleGenetic variation throughout the folate metabolic pathway influences negative symptom severity in schizophrenia
P478volume39