Inhibition of cell proliferation and induction of apoptosis by oleanane triterpenoid (CDDO-Me) in pancreatic cancer cells is associated with the suppression of hTERT gene expression and its telomerase activity

scientific article published on 16 May 2012

Inhibition of cell proliferation and induction of apoptosis by oleanane triterpenoid (CDDO-Me) in pancreatic cancer cells is associated with the suppression of hTERT gene expression and its telomerase activity is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.BBRC.2012.05.024
P932PMC publication ID3576813
P698PubMed publication ID22609405
P5875ResearchGate publication ID225048843

P50authorKirit PindoliaQ42766691
P2093author name stringSahn-Ho Kim
Yongbo Liu
Subhash C Gautam
Xiaohua Gao
Ali S Arbab
Dorrah Deeb
P2860cites workhEST2, the Putative Human Telomerase Catalytic Subunit Gene, Is Up-Regulated in Tumor Cells and during ImmortalizationQ24310670
Telomere shortening and apoptosis in telomerase-inhibited human tumor cellsQ24598974
Specific Association of Human Telomerase Activity with Immortal Cells and CancerQ27860801
On the road to immortality: hTERT upregulation in cancer cellsQ28257238
The RNA component of human telomeraseQ28288330
A survey of telomerase activity in human cancerQ29614858
Beginning to understand the end of the chromosomeQ30312045
Sulforaphane causes epigenetic repression of hTERT expression in human breast cancer cell linesQ33631239
Synthetic triterpenoids prolong survival in a transgenic mouse model of pancreatic cancer.Q34332428
Genistein depletes telomerase activity through cross-talk between genetic and epigenetic mechanismsQ34369723
Triterpenoid CDDO-Me blocks the NF-kappaB pathway by direct inhibition of IKKbeta on Cys-179.Q34568528
Synthetic triterpenoid CDDO prevents the progression and metastasis of prostate cancer in TRAMP mice by inhibiting survival signalingQ34913859
The significance of telomerase activation and cellular immortalization in human cancerQ34999777
Evolving views of telomerase and cancerQ35147354
Prevention of Prostate Cancer with Oleanane Synthetic Triterpenoid CDDO-Me in the TRAMP Mouse Model of Prostate CancerQ35234294
Oleanane triterpenoid CDDO-Me inhibits Akt activity without affecting PDK1 kinase or PP2A phosphatase activity in cancer cellsQ35688777
Regulation of telomerase activity in immortal cell linesQ36560197
Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell deathQ36742412
Triterpenoids and rexinoids as multifunctional agents for the prevention and treatment of cancer.Q36796876
Isolation of a candidate human telomerase catalytic subunit gene, which reveals complex splicing patterns in different cell types.Q36885740
Telomere-associated proteins: cross-talk between telomere maintenance and telomere-lengthening mechanismsQ37368068
Chromosome first aid.Q37430022
Sp1 cooperates with c-Myc to activate transcription of the human telomerase reverse transcriptase gene (hTERT).Q38316509
Novel semisynthetic triterpenoid AMR-Me inhibits telomerase activity in human leukemic CEM cells and exhibits in vivo antitumor activity against Dalton's lymphoma ascites tumorQ39376059
The synthetic triterpenoids CDDO-methyl ester and CDDO-ethyl amide prevent lung cancer induced by vinyl carbamate in A/J miceQ40158424
Synthetic triterpenoids inhibit growth and induce apoptosis in human glioblastoma and neuroblastoma cells through inhibition of prosurvival Akt, NF-kappaB and Notch1 signalingQ40158789
Genistein represses telomerase activity via both transcriptional and posttranslational mechanisms in human prostate cancer cellsQ40314340
Signal transducer and activator of transcription 3 (STAT3) regulates human telomerase reverse transcriptase (hTERT) expression in human cancer and primary cells.Q40390493
The synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid induces caspase-dependent and -independent apoptosis in acute myelogenous leukemiaQ40497248
The novel triterpenoid CDDO induces apoptosis and differentiation of human osteosarcoma cells by a caspase-8 dependent mechanismQ43578278
Synthetic triterpenoids enhance transforming growth factor beta/Smad signalingQ44370211
Induction of hTERT expression and phosphorylation by estrogen via Akt cascade in human ovarian cancer cell linesQ44817156
The novel triterpenoid CDDO-Me suppresses MAPK pathways and promotes p38 activation in acute myeloid leukemia cellsQ46523672
Telomerase activity in human germline and embryonic tissues and cellsQ49024139
The novel triterpenoid C-28 methyl ester of 2-cyano-3, 12-dioxoolen-1, 9-dien-28-oic acid inhibits metastatic murine breast tumor growth through inactivation of STAT3 signalingQ53555135
Telomerase modulates expression of growth-controlling genes and enhances cell proliferationQ73322990
Akt protein kinase enhances human telomerase activity through phosphorylation of telomerase reverse transcriptase subunitQ77388144
Differential telomerase activity, expression of the telomerase catalytic sub-unit and telomerase-RNA in ovarian tumorsQ77995579
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectpancreatic cancerQ212961
P304page(s)561-567
P577publication date2012-05-16
P1433published inBiochemical and Biophysical Research CommunicationsQ864228
P1476titleInhibition of cell proliferation and induction of apoptosis by oleanane triterpenoid (CDDO-Me) in pancreatic cancer cells is associated with the suppression of hTERT gene expression and its telomerase activity
P478volume422

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cites work (P2860)
Q92237902Anti-Cancer Effects of Pristimerin and the Mechanisms: A Critical Review
Q38736995Aphanin, a triterpenoid from Amoora rohituka inhibits K-Ras mutant activity and STAT3 in pancreatic carcinoma cells
Q34415403Bardoxolone methyl (CDDO-Me) as a therapeutic agent: an update on its pharmacokinetic and pharmacodynamic properties
Q27002903Broad targeting of angiogenesis for cancer prevention and therapy
Q38807055CDDO and Its Role in Chronic Diseases.
Q53596121Dose-dependent cytotoxic effects of boldine in HepG-2 cells-telomerase inhibition and apoptosis induction.
Q38903062Downregulation of telomerase activity by diclofenac and curcumin is associated with cell cycle arrest and induction of apoptosis in colon cancer
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Q36144711Genomic instability in human cancer: Molecular insights and opportunities for therapeutic attack and prevention through diet and nutrition.
Q35680729Hsp90 Is a Novel Target Molecule of CDDO-Me in Inhibiting Proliferation of Ovarian Cancer Cells
Q34069749Induction of Apoptosis in Pancreatic Cancer Cells by CDDO-Me Involves Repression of Telomerase through Epigenetic Pathways
Q36783439Inhibition of Telomerase Activity by Oleanane Triterpenoid CDDO-Me in Pancreatic Cancer Cells is ROS-Dependent
Q37731917Oleanolic acid and its synthetic derivatives for the prevention and therapy of cancer: preclinical and clinical evidence.
Q38817363Oleanolic acid derivatives for pharmaceutical use: a patent review
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Q21245749Preclinical evidences toward the use of triterpenoid CDDO-Me for solid cancer prevention and treatment
Q47265475Telomerase Inhibitors from Natural Products and Their Anticancer Potential
Q36715258Telomerase Reverse Transcriptase (TERT) is a Therapeutic Target of Oleanane Triterpenoid CDDO-Me in Prostate Cancer
Q42114458Time Course Expression Analysis of 1[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole Induction of Cytoprotection in Human Endothelial Cells
Q38129642Triterpenoids as reversal agents for anticancer drug resistance treatment

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