NK4, a four-kringle antagonist of HGF, inhibits spreading and invasion of human pancreatic cancer cells

scientific article published on March 2001

NK4, a four-kringle antagonist of HGF, inhibits spreading and invasion of human pancreatic cancer cells is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1021212817
P356DOI10.1054/BJOC.2000.1682
P932PMC publication ID2363826
P698PubMed publication ID11259105
P5875ResearchGate publication ID12073749

P2093author name stringTanaka M
Matsumoto K
Nakamura T
Kuba K
Mizumoto K
Maehara N
P2860cites workMolecular cloning and expression of human hepatocyte growth factorQ24305558
Hepatocyte growth factor/scatter factor induces not only scattering but also cohort migration of human colorectal-adenocarcinoma cellsQ31963959
Hepatocyte growth factor/scatter factor, its molecular, cellular and clinical implications in cancerQ33607176
Purification of the migration stimulating factor produced by fetal and breast cancer patient fibroblastsQ33848365
Isolation and expression of cDNA for different forms of hepatocyte growth factor from human leukocyteQ33860778
Purification of scatter factor, a fibroblast-derived basic protein that modulates epithelial interactions and movementQ34294357
Biology of pancreatic cancerQ34394264
Molecular cloning and sequence analysis of cDNA for human hepatocyte growth factorQ35307866
Activation of the urokinase plasminogen activator/urokinase plasminogen activator receptor system and redistribution of E-cadherin are associated with hepatocyte growth factor-induced motility of pancreas tumor cells overexpressing Met.Q35753150
Hepatocyte growth factor and Met receptor expression in human pancreatic carcinogenesisQ35798481
Hepatocyte growth factor/scatter factor is present in most pleural effusion fluids from cancer patientsQ36134982
Scatter factor: molecular characteristics and effect on the invasiveness of epithelial cellsQ36223889
The many faces of hepatocyte growth factor: from hepatopoiesis to hematopoiesisQ36235637
Proliferative response of human and animal tumours to surgical wounding of normal tissues: onset, duration and inhibitionQ36420063
Enhanced tumorigenicity and invasion-metastasis by hepatocyte growth factor/scatter factor-met signalling in human cells concomitant with induction of the urokinase proteolysis networkQ36557528
Hepatocyte growth factor and invasion-stimulatory activity are induced in pleural fluid by surgery in lung cancer patientsQ36619723
The National Cancer Data Base report on pancreatic cancerQ36799546
Fibroblast-mediated acceleration of human epithelial tumor growth in vivoQ37657276
Nk4, a new HGF/SF variant, is an antagonist to the influence of HGF/SF on the motility and invasion of colon cancer cellsQ40896268
Role of the plasminogen activator and matrix metalloproteinase systems in epidermal growth factor- and scatter factor-stimulated invasion of carcinoma cellsQ40993570
Does surgical stress cause tumor metastasis?Q41101710
Transforming growth factor-beta and hepatocyte growth factor produced by gastric fibroblasts stimulate the invasiveness of scirrhous gastric cancer cellsQ41129457
Scatter factor expression and regulation in human glial tumorsQ41184022
Regulation of scatter factor production via a soluble inducing factorQ41438276
Effect of hepatocyte growth factor on cadherin-mediated cell-cell adhesion.Q41563875
Regulation of fibroblast hepatocyte growth factor/scatter factor expression by human breast carcinoma cell lines and peptide growth factorsQ41565880
Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growthQ41596252
Hepatocyte growth factor (HGF) as a tissue organizer for organogenesis and regenerationQ41641693
Coexpression of the c-met proto-oncogene and hepatocyte growth factor in human pancreatic cancerQ46602989
Hepatocyte growth factor/scatter factor induces tyrosine phosphorylation of focal adhesion kinase (p125FAK) and promotes migration and invasion by oral squamous cell carcinoma cellsQ46722158
Acquisition of invasive phenotype in gallbladder cancer cells via mutual interaction of stromal fibroblasts and cancer cells as mediated by hepatocyte growth factor.Q55314245
Partial purification and characterization of hepatocyte growth factor from serum of hepatectomized ratsQ60034429
Regulation of spreading and growth of colon cancer cells by hepatocyte growth factorQ61857463
Treatment and survival in 13560 patients with pancreatic cancer, and incidence of the disease, in the West Midlands: An epidemiological studyQ62065473
Pancreatic carcinomaQ67734499
Hepatocyte growth factor increases urokinase-type plasminogen activator (u-PA) and u-PA receptor expression in Madin-Darby canine kidney epithelial cellsQ67862186
Increased levels of human hepatocyte growth factor in serum and peritoneal fluid after partial hepatectomyQ70899153
Hepatocyte growth factor is a potent mitogen for normal human pancreas cells in vitroQ71755093
Recurrence after resection for ductal adenocarcinoma of the pancreasQ71973040
Tyrosine phosphorylation of beta-catenin and plakoglobin enhanced by hepatocyte growth factor and epidermal growth factor in human carcinoma cellsQ72178134
Expression of the Met/hepatocyte growth factor receptor in human pancreatic cancerQ72571222
Effect of hepatocyte growth factor on the expression of E- and P-cadherin in gastric carcinoma cell linesQ72785129
HGF/NK4, a four-kringle antagonist of hepatocyte growth factor, is an angiogenesis inhibitor that suppresses tumor growth and metastasis in miceQ73299590
Induction of hepatocyte growth factor in fibroblasts by tumor-derived factors affects invasive growth of tumor cells: in vitro analysis of tumor-stromal interactionsQ73555198
HGF/NK4 is a specific antagonist for pleiotrophic actions of hepatocyte growth factorQ74121111
Potentiated angiogenic effect of scatter factor/hepatocyte growth factor via induction of vascular endothelial growth factor: the case for paracrine amplification of angiogenesisQ74191318
Membrane type 1-matrix metalloproteinase is involved in the formation of hepatocyte growth factor/scatter factor-induced branching tubules in madin-darby canine kidney epithelial cellsQ77472189
Inhibition of tumor growth and invasion by a four-kringle antagonist (HGF/NK4) for hepatocyte growth factorQ77768538
Therapeutic angiogenesis induced by human recombinant hepatocyte growth factor in rabbit hind limb ischemia model as cytokine supplement therapyQ77894883
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectpancreatic cancerQ212961
P304page(s)864-873
P577publication date2001-03-01
P1433published inBritish Journal of CancerQ326309
P1476titleNK4, a four-kringle antagonist of HGF, inhibits spreading and invasion of human pancreatic cancer cells
P478volume84

Reverse relations

cites work (P2860)
Q38956369A DNA aptamer to c-Met inhibits cancer cell migration.
Q41205527Analogs of the hepatocyte growth factor and macrophage-stimulating protein hinge regions act as Met and Ron dual inhibitors in pancreatic cancer cells
Q37970379Biochemical role of the collagen-rich tumour microenvironment in pancreatic cancer progression
Q33899938Biological approaches to therapy of pancreatic cancer
Q64889128Cancer-Associated Fibroblasts Enhance Survival and Progression of the Aggressive Pancreatic Tumor Via FGF-2 and CXCL8.
Q78819166Co-cultivation of pancreatic cancer cells with orthotopic tumor-derived fibroblasts: fibroblasts stimulate tumor cell invasion via HGF secretion whereas cancer cells exert a minor regulative effect on fibroblasts HGF production
Q41137386Differential expression of miRNAs in pancreatobiliary type of periampullary adenocarcinoma and its associated stroma
Q33867389Effects of adenoviral-mediated gene transduction of NK4 on proliferation, movement, and invasion of human colonic LS174T cancer cells in vitro
Q36318551Exploring the tumour environment: cancer-associated fibroblasts as targets in cancer therapy
Q40561060Gallbladder cancer treatment using adenovirus expressing the HGF/NK4 gene in a peritoneal implantation model.
Q40708249Gene transduction of NK4, HGF antagonist, inhibits in vitro invasion and in vivo growth of human pancreatic cancer.
Q43521896High c-Met expression in stage I-II pancreatic adenocarcinoma: proposal for an immunostaining scoring method and correlation with poor prognosis.
Q40203442Inhibition of c-Met as a therapeutic strategy for esophageal adenocarcinoma
Q40704803Intraperitoneal injection of adenovirus-mediated NK4 gene suppresses peritoneal dissemination of pancreatic cancer cell line AsPC-1 in nude mice.
Q80487795Lymphatic spread is related to VEGF-C expression and D2-40-positive myofibroblasts in intrahepatic cholangiocarcinoma
Q28235183Met, metastasis, motility and more
Q30838867PAK4 interacts with p85 alpha: implications for pancreatic cancer cell migration
Q46845221Peritumoral injection of adenovirus vector expressing NK4 combined with gemcitabine treatment suppresses growth and metastasis of human pancreatic cancer cells implanted orthotopically in nude mice and prolongs survival
Q35739397Process of hepatic metastasis from pancreatic cancer: biology with clinical significance
Q40568729Reduced HGF expression in subcutaneous CT26 tumor genetically modified to secrete NK4 and its possible relation with antitumor effects.
Q40669797Requirement of different signaling pathways mediated by insulin-like growth factor-I receptor for proliferation, invasion, and VPF/VEGF expression in a pancreatic carcinoma cell line
Q40749632SF/HGF-c-Met autocrine and paracrine promote metastasis of hepatocellular carcinoma.
Q73767192SPARC/osteonectin is a frequent target for aberrant methylation in pancreatic adenocarcinoma and a mediator of tumor-stromal interactions
Q34099443Suppression of human colon tumor growth by adenoviral vector-mediated NK4 expression in an athymic mouse model
Q40715924Tumor suppression effect using NK4, a molecule acting as an antagonist of HGF, on human gastric carcinomas.

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