Dlg-1 Interacts With and Regulates the Activities of Fibroblast Growth Factor Receptors and EphA2 in the Mouse Lens

scientific article published on February 2016

Dlg-1 Interacts With and Regulates the Activities of Fibroblast Growth Factor Receptors and EphA2 in the Mouse Lens is …
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scholarly articleQ13442814

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P356DOI10.1167/IOVS.15-17727
P932PMC publication ID4771194
P698PubMed publication ID26906157

P2093author name stringAnne E Griep
SungKyoung Lee
Shalini Shatadal
P2860cites workPDZ proteins bind, cluster, and synaptically colocalize with Eph receptors and their ephrin ligandsQ22008644
Human discs large and scrib are localized at the same regions in colon mucosa and changes in their expression patterns are correlated with loss of tissue architecture during malignant progression.Q51224744
Ephrin-Eph signalling drives the asymmetric division of notochord/neural precursors in Ciona embryos.Q51992543
Signaling through FGF receptor-2 is required for lens cell survival and for withdrawal from the cell cycle during lens fiber cell differentiation.Q52054624
Differential expression of fibroblast growth factor receptors during rat lens morphogenesis and growth.Q52193202
Fibroblast growth factor 2 uses distinct signaling pathways for cell proliferation and cell shape changes in corneal endothelial cellsQ71620733
IGF-1 enhancement of FGF-induced lens fiber differentiation in rats of different agesQ72569240
IGF enhancement of FGF-induced fibre differentiation and DNA synthesis in lens explantsQ73151143
Generation of Fgfr1 conditional knockout miceQ77668152
Evaluation of fibroblast growth factor signaling during lens fiber cell differentiationQ78853020
Inducible prostate intraepithelial neoplasia with reversible hyperplasia in conditional FGFR1-expressing miceQ79370200
Planar cell polarity in the mammalian eye lensQ26849727
Signal transfer by eph receptorsQ28145221
Mechanism and role of PDZ domains in signaling complex assemblyQ28190934
EPHA2 is associated with age-related cortical cataract in mice and humansQ28475827
Requirement of PDZ-containing proteins for cell cycle regulation and differentiation in the mouse lens epitheliumQ28505156
Fibroblast growth factor receptor signaling is essential for lens fiber cell differentiationQ28507340
Conditional inactivation of FGF receptor 2 reveals an essential role for FGF signaling in the regulation of osteoblast function and bone growthQ28508542
Loss of ephrin-A5 function disrupts lens fiber cell packing and leads to cataractQ28508868
Loss of Dlg-1 in the mouse lens impairs fibroblast growth factor receptor signalingQ28513415
Frs2α enhances fibroblast growth factor-mediated survival and differentiation in lens developmentQ28591710
Mutagenesis of the epithelial polarity gene, discs large 1, perturbs nephrogenesis in the developing mouse kidneyQ28594022
Lens developmentQ33812596
Fibroblast growth factor receptor-mediated rescue of x-ephrin B1-induced cell dissociation in Xenopus embryosQ33961672
Growth factor signaling in vitreous humor-induced lens fiber differentiation.Q33994186
Diverse roles of Eph/ephrin signaling in the mouse lensQ34091291
A role for epha2 in cell migration and refractive organization of the ocular lens.Q34100250
Trans-activation of EphA4 and FGF receptors mediated by direct interactions between their cytoplasmic domainsQ34245285
Human cataract mutations in EPHA2 SAM domain alter receptor stability and functionQ34263351
Cell-autonomous requirements for Dlg-1 for lens epithelial cell structure and fiber cell morphogenesisQ34467050
Requirement for Dlgh-1 in planar cell polarity and skeletogenesis during vertebrate developmentQ34563058
Understanding the role of growth factors in embryonic development: insights from the lensQ34699933
Fibroblast growth factor receptor 1 (Fgfr1) is not essential for lens fiber differentiation in miceQ34790680
An essential role for FGF receptor signaling in lens developmentQ35911050
Regulation of the DLG tumor suppressor by β-cateninQ36129684
Fibroblast growth factor 2 (Fgf2) inhibits differentiation of mesenchymal stem cells by inducing Twist2 and Spry4, blocking extracellular regulated kinase activation, and altering Fgf receptor expression levelsQ36135708
EphA2 and Src regulate equatorial cell morphogenesis during lens developmentQ37209165
Emerging role of the scaffolding protein Dlg1 in vesicle traffickingQ38119533
Comparative transcriptome analysis of epithelial and fiber cells in newborn mouse lenses with RNA sequencingQ38302313
EphA4 promotes cell proliferation and migration through a novel EphA4-FGFR1 signaling pathway in the human glioma U251 cell lineQ39940130
Lens differentiation in vertebrates. A review of cellular and molecular featuresQ40320035
Conditional activation of fibroblast growth factor receptor (FGFR) 1, but not FGFR2, in prostate cancer cells leads to increased osteopontin induction, extracellular signal-regulated kinase activation, and in vivo proliferationQ40626116
The function of FGF signaling in the lens placodeQ42085785
A cell polarity protein aPKClambda is required for eye lens formation and growthQ42461436
Localization of PDZ domain containing proteins Discs Large-1 and Scribble in the mouse eye.Q46886375
Differential expression of the human homologue of drosophila discs large oncosuppressor in histologic samples from human papillomavirus-associated lesions as a marker for progression to malignancyQ47278604
Insertion of a Pax6 consensus binding site into the alphaA-crystallin promoter acts as a lens epithelial cell enhancer in transgenic miceQ47432719
To differentiate or not to differentiate: regulation of cell fate decisions by being in the right place at the right timeQ47703917
P275copyright licenseCreative Commons Attribution-NonCommercial-NoDerivs 4.0 InternationalQ24082749
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P433issue2
P407language of work or nameEnglishQ1860
P304page(s)707-718
P577publication date2016-02-01
P1433published inInvestigative Ophthalmology Visual ScienceQ6060707
P1476titleDlg-1 Interacts With and Regulates the Activities of Fibroblast Growth Factor Receptors and EphA2 in the Mouse Lens
P478volume57