A new look at Crohn's disease: breakdown of the mucosal antibacterial defense

scientific article published on August 2006

A new look at Crohn's disease: breakdown of the mucosal antibacterial defense is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1196/ANNALS.1326.030
P698PubMed publication ID17057212

P50authorJan WehkampQ42715392
P2093author name stringEduard F Stange
P2860cites workInflammatory Bowel DiseaseQ22248115
High prevalence of adherent-invasive Escherichia coli associated with ileal mucosa in Crohn’s diseaseQ22250942
A frameshift mutation in NOD2 associated with susceptibility to Crohn's diseaseQ22251291
Isolation and characterization of human beta -defensin-3, a novel human inducible peptide antibioticQ24290539
Synbiotic therapy (Bifidobacterium longum/Synergy 1) initiates resolution of inflammation in patients with active ulcerative colitis: a randomised controlled pilot trialQ24685494
Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's diseaseQ27860821
Antimicrobial peptides of multicellular organismsQ28131811
Regulation of intestinal alpha-defensin activation by the metalloproteinase matrilysin in innate host defenseQ28145389
Defensins: antimicrobial peptides of innate immunityQ28204453
Secretion of microbicidal alpha-defensins by intestinal Paneth cells in response to bacteriaQ28204776
A peptide antibiotic from human skinQ28242199
Nod2-dependent regulation of innate and adaptive immunity in the intestinal tractQ28587612
Genotypes and phenotypes in Crohn's disease: do they help in clinical management?Q30478821
Crohn's disease and the NOD2 gene: a role for paneth cellsQ33187690
Antibiotic peptides as mediators of innate immunityQ33987884
Paneth cell trypsin is the processing enzyme for human defensin-5.Q34129474
Protection against enteric salmonellosis in transgenic mice expressing a human intestinal defensinQ34186394
Widespread expression of beta-defensin hBD-1 in human secretory glands and epithelial cellsQ34407161
Changes in the bacterial flora of the neoterminal ileum after ileocolonic resection for Crohn's diseaseQ34523071
Enteric salmonella infection inhibits Paneth cell antimicrobial peptide expressionQ34716119
"For whom the bell tolls!" -- innate defense mechanisms and survival strategies of the intestinal epithelium against lumenal pathogensQ35041259
Crohn's disease: a defensin deficiency syndrome?Q35168862
Antimicrobial peptides in innate immunity of the human intestineQ35541235
Defensin deficiency, intestinal microbes, and the clinical phenotypes of Crohn's diseaseQ35993236
The Paneth cell and the innate immune responseQ36036656
Inducible expression of an antibiotic peptide gene in lipopolysaccharide-challenged tracheal epithelial cellsQ37617129
NF-kappaB- and AP-1-mediated induction of human beta defensin-2 in intestinal epithelial cells by Escherichia coli Nissle 1917: a novel effect of a probiotic bacterium.Q40017434
Enhanced Escherichia coli adherence and invasion in Crohn's disease and colon cancerQ40538834
Toll-like receptor 4-dependent activation of dendritic cells by beta-defensin 2.Q40692879
NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal alpha-defensin expressionQ41917631
Defensin pattern in chronic gastritis: HBD-2 is differentially expressed with respect to Helicobacter pylori status.Q42161372
Mucosal flora in inflammatory bowel diseaseQ43503928
Inducible and constitutive beta-defensins are differentially expressed in Crohn's disease and ulcerative colitis.Q54762013
P407language of work or nameEnglishQ1860
P921main subjectCrohn's diseaseQ1472
P304page(s)321-331
P577publication date2006-08-01
P1433published inAnnals of the New York Academy of SciencesQ2431664
P1476titleA new look at Crohn's disease: breakdown of the mucosal antibacterial defense
P478volume1072