Epidermal growth factor stimulates RSK2 activation through activation of the MEK/ERK pathway and src-dependent tyrosine phosphorylation of RSK2 at Tyr-529.

scientific article published on 21 December 2007

Epidermal growth factor stimulates RSK2 activation through activation of the MEK/ERK pathway and src-dependent tyrosine phosphorylation of RSK2 at Tyr-529. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M709673200
P932PMC publication ID2367159
P698PubMed publication ID18156174

P50authorSagar LonialQ66431075
P2093author name stringJing Chen
Sumin Kang
Ting-Lei Gu
Ailan Guo
Shaozhong Dong
Hong Ruan
Hanna Jean Khoury
P2860cites workRequirement of Rsk-2 for epidermal growth factor-activated phosphorylation of histone H3Q22010472
Phosphorylation of p90 ribosomal S6 kinase (RSK) regulates extracellular signal-regulated kinase docking and RSK activityQ24679767
90-kDa ribosomal S6 kinase is phosphorylated and activated by 3-phosphoinositide-dependent protein kinase-1.Q27863657
Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinaseQ28283499
Identification of an extracellular signal-regulated kinase (ERK) docking site in ribosomal S6 kinase, a sequence critical for activation by ERK in vivoQ28294928
Regulation of transcription by MAP kinase cascadesQ29618477
Role and regulation of 90 kDa ribosomal S6 kinase (RSK) in signal transduction.Q33690319
Signal transduction via the MAP kinases: proceed at your own RSK.Q36381460
The search for physiological substrates of MAP and SAP kinases in mammalian cellsQ36914508
FGFR3 activates RSK2 to mediate hematopoietic transformation through tyrosine phosphorylation of RSK2 and activation of the MEK/ERK pathwayQ39042319
A phosphoserine-regulated docking site in the protein kinase RSK2 that recruits and activates PDK1.Q39922852
Evidence for two catalytically active kinase domains in pp90rskQ40018405
Structural bioinformatics-based design of selective, irreversible kinase inhibitorsQ40307105
Ser-10 phosphorylation of histone H3 and immediate early gene expression in oncogene-transformed mouse fibroblastsQ42820135
A MAP kinase docking site is required for phosphorylation and activation of p90(rsk)/MAPKAP kinase-1.Q48922580
Thermally Switchable Periodicities and Diffraction from Mesoscopically Ordered MaterialsQ57370347
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectphosphorylationQ242736
P304page(s)4652-4657
P577publication date2007-12-21
P1433published inJournal of Biological ChemistryQ867727
P1476titleEpidermal growth factor stimulates RSK2 activation through activation of the MEK/ERK pathway and src-dependent tyrosine phosphorylation of RSK2 at Tyr-529.
P478volume283

Reverse relations

cites work (P2860)
Q24632768Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases
Q33584146Coordinating cellular events during spermatogenesis: a biochemical model
Q41910374Fibroblast growth factor receptor 3 associates with and tyrosine phosphorylates p90 RSK2, leading to RSK2 activation that mediates hematopoietic transformation
Q35108153Functional cyclic AMP response element in the breast cancer resistance protein (BCRP/ABCG2) promoter modulates epidermal growth factor receptor pathway- or androgen withdrawal-mediated BCRP/ABCG2 transcription in human cancer cells.
Q37315384Hydrostatic pressure-dependent changes in cyclic AMP signaling in optic nerve head astrocytes from Caucasian and African American donors
Q52655388Kaempferol targeting on the fibroblast growth factor receptor 3-ribosomal S6 kinase 2 signaling axis prevents the development of rheumatoid arthritis.
Q30433106RSK in tumorigenesis: connections to steroid signaling
Q37694863RSK2 activity mediates glioblastoma invasiveness and is a potential target for new therapeutics
Q48347255RSK2 drives cell motility by serine phosphorylation of LARG and activation of Rho GTPases
Q30423242RSK2 protein suppresses integrin activation and fibronectin matrix assembly and promotes cell migration
Q36212896Resistance to EGF receptor inhibitors in glioblastoma mediated by phosphorylation of the PTEN tumor suppressor at tyrosine 240.
Q38895271Ribosomal S6 kinase (RSK) modulators: a patent review
Q37104693Ribosomal S6 kinase 2 directly phosphorylates the 5-hydroxytryptamine 2A (5-HT2A) serotonin receptor, thereby modulating 5-HT2A signaling
Q39441370Selective Targeting of RSK Isoforms in Cancer
Q37802388Targeting RSK2 in human malignancies
Q28115584Tyrosines 868, 966, and 972 in the kinase domain of JAK2 are autophosphorylated and required for maximal JAK2 kinase activity
Q39162303p90 RSK2 mediates antianoikis signals by both transcription-dependent and -independent mechanisms
Q35083267p90RSK2 is essential for FLT3-ITD- but dispensable for BCR-ABL-induced myeloid leukemia.

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