Normal T-cell activation in elite controllers with preserved CD4+ T-cell counts

scientific article published on November 2015

Normal T-cell activation in elite controllers with preserved CD4+ T-cell counts is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1097/QAD.0000000000000860
P932PMC publication ID4773905
P698PubMed publication ID26544698

P50authorJodie Dionne-OdomQ86426293
Andrew O WestfallQ44237002
P2093author name stringAnju Bansal
Paul A Goepfert
Edgar T Overton
Sarah Sterrett
Nathan Erdmann
P2860cites workInterleukin-21-producing HIV-1-specific CD8 T cells are preferentially seen in elite controllersQ24629567
HLA B*5701 is highly associated with restriction of virus replication in a subgroup of HIV-infected long term nonprogressorsQ24676982
CD4+ T cells from elite controllers resist HIV-1 infection by selective upregulation of p21Q28307312
The major genetic determinants of HIV-1 control affect HLA class I peptide presentationQ29417018
HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cellsQ29616205
Increased Levels of Macrophage Inflammatory Proteins Result in Resistance to R5-Tropic HIV-1 in a Subset of Elite Controllers.Q30372415
Clinical, immunological and treatment-related factors associated with normalised CD4+/CD8+ T-cell ratio: effect of naïve and memory T-cell subsetsQ33591190
Perforin expression directly ex vivo by HIV-specific CD8 T-cells is a correlate of HIV elite controlQ33594461
HIV-infected individuals with low CD4/CD8 ratio despite effective antiretroviral therapy exhibit altered T cell subsets, heightened CD8+ T cell activation, and increased risk of non-AIDS morbidity and mortalityQ33618542
Low proportions of CD28- CD8+ T cells expressing CD57 can be reversed by early ART initiation and predict mortality in treated HIV infectionQ33947817
Genetic and immunologic heterogeneity among persons who control HIV infection in the absence of therapy.Q34009945
HIV+ elite controllers have low HIV-specific T-cell activation yet maintain strong, polyfunctional T-cell responsesQ34275430
HIV controllers: a homogeneous group of HIV-1-infected patients with spontaneous control of viral replicationQ34448446
Heterogeneity in HIV suppression by CD8 T cells from HIV controllers: association with Gag-specific CD8 T cell responsesQ34984762
Replication-competent HIV strains infect HIV controllers despite undetectable viremia (ANRS EP36 study)Q61365620
Elevated CD38 antigen expression on CD8+ T cells is a stronger marker for the risk of chronic HIV disease progression to AIDS and death in the Multicenter AIDS Cohort Study than CD4+ cell count, soluble immune activation markers, or combinations ofQ73848661
Survival and proliferation of CD28- T cells during HIV-1 infection relate to the amplitude of viral replicationQ84142062
Immune activation and antibody responses in non-progressing elite controller individuals infected with HIV-1Q84444040
Predicting AIDS-related events using CD4 percentage or CD4 absolute countsQ35040103
B cell follicle sanctuary permits persistent productive simian immunodeficiency virus infection in elite controllersQ35058635
HIV controllers with different viral load cutoff levels have distinct virologic and immunologic profilesQ35102172
Differential levels of soluble inflammatory markers by human immunodeficiency virus controller status and demographicsQ35408098
Immunologic failure despite suppressive antiretroviral therapy is related to activation and turnover of memory CD4 cellsQ35557198
Hospitalization Rates and Reasons Among HIV Elite Controllers and Persons With Medically Controlled HIV InfectionQ35661912
HIV controllers exhibit potent CD8 T cell capacity to suppress HIV infection ex vivo and peculiar cytotoxic T lymphocyte activation phenotypeQ35749755
Relationship between T cell activation and CD4+ T cell count in HIV-seropositive individuals with undetectable plasma HIV RNA levels in the absence of therapyQ36304297
HIV-specific CD8+ T cells from elite controllers are primed for survival.Q36760035
Increased coronary atherosclerosis and immune activation in HIV-1 elite controllersQ36862952
Human immunodeficiency virus controllers: mechanisms of durable virus control in the absence of antiretroviral therapyQ36950611
Evidence for persistent low-level viremia in individuals who control human immunodeficiency virus in the absence of antiretroviral therapyQ37033224
Lytic granule loading of CD8+ T cells is required for HIV-infected cell elimination associated with immune controlQ37054526
Mucosal immune responses to HIV-1 in elite controllers: a potential correlate of immune controlQ37169129
Effect of antiretroviral therapy on HIV reservoirs in elite controllersQ37212990
Role of viral replication, antiretroviral therapy, and immunodeficiency in HIV-associated atherosclerosisQ37215251
Evidence for translocation of microbial products in patients with idiopathic CD4 lymphocytopenia.Q37435942
T cell dynamics and the response to HAART in a cohort of HIV-1-infected elite suppressorsQ37439446
Association of HIV-specific and total CD8+ T memory phenotypes in subtype C HIV-1 infection with viral set pointQ37473934
An evaluation of HIV elite controller definitions within a large seroconverter cohort collaborationQ37525462
Evidence for innate immune system activation in HIV type 1-infected elite controllers.Q37604465
A systematic review of definitions of extreme phenotypes of HIV control and progressionQ38154750
Coinhibitory receptors and CD8 T cell exhaustion in chronic infectionsQ38228016
Selective increase of activation antigens HLA-DR and CD38 on CD4+ CD45RO+ T lymphocytes during HIV-1 infectionQ39130048
Heterogeneous neutralizing antibody and antibody-dependent cell cytotoxicity responses in HIV-1 elite controllersQ40659603
Glucose transporter 1-expressing proinflammatory monocytes are elevated in combination antiretroviral therapy-treated and untreated HIV+ subjectsQ41678934
Isolation and characterization of replication-competent human immunodeficiency virus type 1 from a subset of elite suppressors.Q41827503
Antiretroviral treatment of adult HIV infection: 2014 recommendations of the International Antiviral Society-USA Panel.Q42205327
HIV "elite controllers" are characterized by a high frequency of memory CD8+ CD73+ T cells involved in the antigen-specific CD8+ T-cell response.Q42247922
Persistent low-level viremia in HIV-1 elite controllers and relationship to immunologic parametersQ43070781
Clinical outcomes of elite controllers, viremic controllers, and long-term nonprogressors in the US Department of Defense HIV natural history studyQ44429168
CD4 percentage, CD4 number, and CD4:CD8 ratio in HIV infection: which to choose and how to use.Q46405812
Premature age-related comorbidities among HIV-infected persons compared with the general populationQ51000618
Low CD4+ T-cell counts in HIV patients receiving effective antiretroviral therapy are associated with CD4+ T-cell activation and senescence but not with lower effector memory T-cell function.Q51981873
Differential upregulation of CD38 on different T-cell subsets may influence the ability to reconstitute CD4+ T cells under successful highly active antiretroviral therapy.Q51993594
CDC staging based on absolute CD4 count and CD4 percentage in an HIV-1-infected Indian population: treatment implicationsQ57951557
Immune activation set point during early HIV infection predicts subsequent CD4+ T-cell changes independent of viral loadQ58034113
CD4% is the best predictor of development of AIDS in a cohort of HIV-infected homosexual menQ58436713
P433issue17
P407language of work or nameEnglishQ1860
P304page(s)2245-2254
P577publication date2015-11-01
P1433published inAIDSQ4651863
P1476titleNormal T-cell activation in elite controllers with preserved CD4+ T-cell counts
P478volume29

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cites work (P2860)
Q33745355A Subset of Extreme Human Immunodeficiency Virus (HIV) Controllers Is Characterized by a Small HIV Blood Reservoir and a Weak T-Cell Activation Level
Q40045238A summary of the second annual HIV Microbiome workshop.
Q52680990Class-modeling analysis reveals T-cell homeostasis disturbances involved in loss of immune control in elite controllers.
Q90779635HIV controllers: to treat or not to treat? Is that the right question?
Q58701373HIV-1 intron-containing RNA expression induces innate immune activation and T cell dysfunction
Q64100454Harnessing CD8 T Cells Under HIV Antiretroviral Therapy
Q59349690Mechanisms of abrupt loss of virus control in a cohort of previous HIV controllers
Q40625213Mucosal Regulatory T Cells and T Helper 17 Cells in HIV-Associated Immune Activation
Q90534685Plasmatic Levels of IL-18, IP-10, and Activated CD8+ T Cells Are Potential Biomarkers to Identify HIV-1 Elite Controllers With a True Functional Cure Profile
Q90165772Rapid development of HIV elite control in a patient with acute infection
Q57177414Understanding the CD8 T-cell response in natural HIV control

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