Targeting the EGF receptor in ovarian cancer with the tyrosine kinase inhibitor ZD 1839 ("Iressa").

scientific article published on February 2002

Targeting the EGF receptor in ovarian cancer with the tyrosine kinase inhibitor ZD 1839 ("Iressa"). is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/SJ.BJC.6600058
P932PMC publication ID2375224
P698PubMed publication ID11875715
P5875ResearchGate publication ID11486414

P2093author name stringJ F Smyth
S P Langdon
A Ritchie
K G Macleod
J M Sewell
P2860cites workCharacterization and properties of nine human ovarian adenocarcinoma cell lines.Q52833986
Antitumor effect and potentiation of cytotoxic drugs activity in human cancer cells by ZD-1839 (Iressa), an epidermal growth factor receptor-selective tyrosine kinase inhibitorQ57424632
Requirement for intrinsic protein tyrosine kinase in the immediate and late actions of the EGF receptorQ59054268
The pathway to signal achievementQ59067952
Efficacy of cytotoxic agents against human tumor xenografts is markedly enhanced by coadministration of ZD1839 (Iressa), an inhibitor of EGFR tyrosine kinaseQ59566187
Evidence for the involvement of transforming growth factor alpha and epidermal growth factor receptor autocrine growth mechanism in primary human ovarian cancers in vitroQ67700822
Inhibition of the epidermal growth factor receptor tyrosine kinase by PD153035 in human A431 tumors in athymic nude miceQ71574182
United Kingdom Co-ordinating Committee on Cancer Research (UKCCCR) Guidelines for the Welfare of Animals in Experimental Neoplasia (Second Edition)Q74155605
The ErbB signaling network: receptor heterodimerization in development and cancerQ29617919
Receptors for epidermal growth factor and other polypeptide mitogensQ34163558
The prognostic value of epidermal growth factor receptor mRNA expression in primary ovarian cancerQ36135007
Epidermal growth factor receptor-mediated cell motility: phospholipase C activity is required, but mitogen-activated protein kinase activity is not sufficient for induced cell movementQ36234800
Inhibition of transforming growth factor alpha (TGF-alpha)-mediated growth effects in ovarian cancer cell lines by a tyrosine kinase inhibitor ZM 252868.Q36617561
Specific inhibition of epidermal growth factor receptor tyrosine kinase by 4-anilinoquinazolinesQ36821859
Tyrosine kinase inhibition: an approach to drug developmentQ40613606
Transforming growth factor-alpha acts as an autocrine growth factor in ovarian carcinoma cell linesQ41643277
Mitogenic effects of epidermal growth factor and transforming growth factor-alpha on EGF-receptor positive human ovarian carcinoma cell linesQ41645823
Overexpression of EGFR and c-erbB2 causes enhanced cell migration in human breast cancer cells and NIH3T3 fibroblastsQ42831208
A specific inhibitor of the epidermal growth factor receptor tyrosine kinaseQ42834515
Epidermal growth factor receptor expression in normal ovarian epithelium and ovarian cancer. I. Correlation of receptor expression with prognostic factors in patients with ovarian cancer.Q43779560
Estrogen regulation of transforming growth factor-alpha in ovarian cancerQ48031429
P275copyright licenseCreative Commons Attribution-NonCommercial-ShareAlike 3.0 UnportedQ15643954
P6216copyright statuscopyrightedQ50423863
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectovarian cancerQ172341
P304page(s)456-462
P577publication date2002-02-01
P1433published inBritish Journal of CancerQ326309
P1476titleTargeting the EGF receptor in ovarian cancer with the tyrosine kinase inhibitor ZD 1839 ("Iressa").
P478volume86

Reverse relations

cites work (P2860)
Q38603140A novel approach in the treatment of neuroendocrine gastrointestinal tumours. Targeting the epidermal growth factor receptor by gefitinib (ZD1839)
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Q42963970A phase II study of erlotinib (OSI-774) given in combination with carboplatin in patients with recurrent epithelial ovarian cancer (NCIC CTG IND.149).
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Q35548334Biologic directed therapies in gynecologic oncology
Q40234950Characterization of CSOC 882, a novel immortalized ovarian cancer cell line expressing EGFR, HER2, and activated AKT.
Q44541800Characterization of sequence-dependent synergy between ZD1839 ("Iressa") and oxaliplatin.
Q35053674Clinical proteomics: present and future prospects.
Q24626049Data-independent proteomic screen identifies novel tamoxifen agonist that mediates drug resistance
Q34525925Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors
Q26863231EGFR/HER-targeted therapeutics in ovarian cancer
Q28482093Efficacy of a non-hypercalcemic vitamin-D2 derived anti-cancer agent (MT19c) and inhibition of fatty acid synthesis in an ovarian cancer xenograft model
Q33642087Epidermal growth factor-induced GnRH-II synthesis contributes to ovarian cancer cell invasion
Q39884252F84, a quinazoline derivative, exhibits high potent antitumor activity against human gynecologic malignancies
Q35213252Future directions in the management of ovarian cancer
Q38798293Gefitinib ('Iressa', ZD1839) inhibits the growth response of bladder tumour cell lines to epidermal growth factor and induces TIMP2.
Q36790475Gonadotropins activate oncogenic pathways to enhance proliferation in normal mouse ovarian surface epithelium.
Q36695270Id-I stimulates cell proliferation through activation of EGFR in ovarian cancer cells
Q39990587Implications of EGFR inhibition in ovarian cancer cell proliferation
Q40619039Inhibition of proliferation and induction of apoptosis in breast cancer cells by the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor ZD1839 ('Iressa') is independent of EGFR expression level
Q36736349Investigational agents against platinum-resistant ovarian cancer
Q35968752Novel agents in epithelial ovarian cancer
Q36904860Novel agents in ovarian cancer.
Q35213223Oncogenic pathways implicated in ovarian epithelial cancer
Q36524232Photodynamic therapy activated signaling from epidermal growth factor receptor and STAT3: Targeting survival pathways to increase PDT efficacy in ovarian and lung cancer
Q30402667Proteomics and biomarkers in clinical trials for drug development
Q39998587Pyk2/ERK 1/2 mediate Sp1- and c-Myc-dependent induction of telomerase activity by epidermal growth factor
Q43005223Regulation of epidermal growth factor receptor in human colon cancer cell lines by interferon alpha
Q37034341Significant increase in hEGF uptake is correlated with formation of EGFR dimers induced by the EGFR tyrosine kinase inhibitor gefitinib
Q37485865Targeting the epidermal growth factor receptor in epithelial ovarian cancer: current knowledge and future challenges.
Q36974713Thyrostimulin-TSHR signaling promotes the proliferation of NIH:OVCAR-3 ovarian cancer cells via trans-regulation of the EGFR pathway

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