An ets-related gene, ERG, is rearranged in human myeloid leukemia with t(16;21) chromosomal translocation

scientific article published on November 1993

An ets-related gene, ERG, is rearranged in human myeloid leukemia with t(16;21) chromosomal translocation is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode1993PNAS...9010280S
P356DOI10.1073/PNAS.90.21.10280
P932PMC publication ID47758
P698PubMed publication ID8234289
P5875ResearchGate publication ID14965579

P2093author name stringHayashi Y
Ohki M
Shimizu K
Kaneko Y
Asano S
Ichikawa H
Ohira M
Tojo A
Maseki N
P2860cites workGene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumoursQ24298221
The erg gene: a human gene related to the ets oncogeneQ24299030
The ets sequence from the transforming gene of avian erythroblastosis virus, E26, has unique domains on human chromosomes 11 and 21: both loci are transcriptionally activeQ24609161
Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform ExtractionQ25938986
erg, a human ets-related gene on chromosome 21: alternative splicing, polyadenylation, and translationQ28295357
Structure and expression of human Fli-1 geneQ34253097
A putative second cell-derived oncogene of the avian leukaemia retrovirus E26.Q34255162
The ERGB/Fli-1 gene: isolation and characterization of a new member of the family of human ETS transcription factorsQ34262934
Isolation and regional mapping of DNA sequences unique to human chromosome 21.Q35199586
Regional localization of DNA sequences on chromosome 21 using somatic cell hybridsQ35200986
Assignment of anonymous DNA probes to specific intervals of human chromosomes 16 and X.Q35564622
Chromosome aberrations and cancerQ37538405
t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1Q37627380
Molecular and functional characterization of the promoter of ETS2, the human c-ets-2 geneQ37685279
Establishment of a human acute myeloid leukemia cell line (Kasumi-1) with 8;21 chromosome translocation.Q41685189
Molecular assignment of a translocation breakpoint in acute myeloid leukemia with t(8;21).Q41685840
The ets gene family.Q42111288
Adenine phosphoribosyltransferase deficiency in cultured mouse mammary tumor FM3A cells resistant to 4-carbamoylimidazolium 5-olateQ42801151
A primary map of 24 loci on human chromosome 16.Q43438436
Consistent disruption of the AML1 gene occurs within a single intron in the t(8;21) chromosomal translocationQ43833895
Sequence-tagged sites (STSs) for a set of mapped markers on chromosome 21Q67577183
Translocation (8;21) and its variants in acute nonlymphocytic leukemia. The relative importance of chromosomes 8 and 21 to the genesis of the diseaseQ67921951
Translocation t(16;21) in acute nonlymphocytic leukemia with abnormal eosinophilsQ67989095
t(16;21) in a Ph positive CMLQ68157720
The ETS-domain: a new DNA-binding motif that recognizes a purine-rich core DNA sequenceQ68624466
t(16;21)(p11.2;q22): a recurrent primary rearrangement in ANLLQ70162122
A NotI restriction map of the entire long arm of human chromosome 21Q70485045
The 8;21 chromosome translocation in acute myeloid leukemia is always detectable by molecular analysis using AML1Q70609736
P433issue21
P407language of work or nameEnglishQ1860
P921main subjectleukemiaQ29496
myeloid leukemiaQ11688946
P1104number of pages5
P304page(s)10280-10284
P577publication date1993-11-01
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleAn ets-related gene, ERG, is rearranged in human myeloid leukemia with t(16;21) chromosomal translocation
P478volume90

Reverse relations

cites work (P2860)
Q42684235A DNA Contact Map for the Mouse Runx1 Gene Identifies Novel Haematopoietic Enhancers
Q38504257A Recurrent Translocation, t(16;21)(q24;q22), Associated with Acute Myelogenous Leukemia: Identification by Fluorescence In Situ Hybridization
Q33885920A domain of TEL conserved in a subset of ETS proteins defines a specific oligomerization interface essential to the mitogenic properties of the TEL-PDGFR beta oncoprotein
Q77344066A novel EWS-ERG rearrangement generating two hybrid mRNAs in a peripheral primitive neuroectodermal tumour (pPNET) with a t(15;22) translocation
Q34640225A rapid RT-PCR based method to isolate complementary DNA fragments flanking retrovirus integration sites
Q36691805Adult human sarcomas. I. Basic science
Q43922213An intragenic ERG deletion is a marker of an oncogenic subtype of B-cell precursor acute lymphoblastic leukemia with a favorable outcome despite frequent IKZF1 deletions.
Q38050656B-lineage transcription factors and cooperating gene lesions required for leukemia development
Q41838202BAALC and ERG Expression in Egyptian Patients with Acute Myeloid Leukemia, Relation to Survival and Response to Treatment
Q39454928BCR-ABL prevents c-jun-mediated and proteasome-dependent FUS (TLS) proteolysis through a protein kinase CbetaII-dependent pathway
Q36532514Cellular and molecular mechanisms of synovial joint and articular cartilage formation
Q28140198Characterization of the human and mouse ETV1/ER81 transcription factor genes: role of the two alternatively spliced isoforms in the human
Q52512616Chromosomal translocations in human cancer.
Q57051122Comparative structure analysis of the ETSi domain of ERG3 and its complex with the E74 promoter DNA sequence
Q36564203Constitutive c-ets2 expression in M1D+ myeloblast leukemic cells induces their differentiation to macrophages
Q37341273Cryptic FUS-ERG fusion identified by RNA-sequencing in childhood acute myeloid leukemia
Q33385721Dual requirement for the ETS transcription factors Fli-1 and Erg in hematopoietic stem cells and the megakaryocyte lineage
Q33960227Dual transforming activities of the FUS (TLS)-ERG leukemia fusion protein conferred by two N-terminal domains of FUS (TLS).
Q21710685ELF4 is fused to ERG in a case of acute myeloid leukemia with a t(X;21)(q25–26;q22)
Q34091302ERG deregulation induces PIM1 over-expression and aneuploidy in prostate epithelial cells
Q38681610ERG expression in prostate cancer: biological relevance and clinical implication
Q36652758ERP, a new member of the ets transcription factor/oncoprotein family: cloning, characterization, and differential expression during B-lymphocyte development
Q24634316EWS-erg and EWS-Fli1 fusion transcripts in Ewing's sarcoma and primitive neuroectodermal tumors with variant translocations
Q34298092EWS‐FLI‐1 and EWS‐ERG chimeric mRNAs in Ewing's sarcoma and primitive neuroectodermal tumor
Q30493247Ebp1 sumoylation, regulated by TLS/FUS E3 ligase, is required for its anti-proliferative activity
Q44991765Ectopic expression of the ets transcription factor ER81 in transgenic mouse mammary gland enhances both urokinase plasminogen activator and stromelysin-1 transcription
Q41337243Establishment and characterization of IRTA17 and IRTA21, two novel acute non-lymphocytic leukaemia cell lines with t(16;21) translocation
Q40726018Expression of Ets-related transcription factors and matrix metalloproteinase genes in human breast cancer cells
Q77769562Expression of the FUS domain restores liposarcoma development in CHOP transgenic mice
Q35592105Function of PEA3 Ets transcription factors in mammary gland development and oncogenesis
Q71678482Fusion of the FUS gene with ERG in acute myeloid leukemia with t(16;21)(p11;q22)
Q40968149Gene rearrangements in Ewing's sarcoma
Q42278719Genetic mutations in RNA-binding proteins and their roles in ALS.
Q33880683Genomic organization of the human e1af gene,a member of Ets transcription factors.
Q22010700Human chromosomal localization, tissue/tumor expression, and regulatory function of the ets family gene EHF
Q37281690Increased PEA3/E1AF and decreased Net/Elk-3, both ETS proteins, characterize human NSCLC progression and regulate caveolin-1 transcription in Calu-1 and NCI-H23 NSCLC cell lines.
Q45730515Large-scale identification of novel potential disease loci in mouse leukemia applying an improved strategy for cloning common virus integration sites
Q73367499Liposarcoma initiated by FUS/TLS-CHOP: the FUS/TLS domain plays a critical role in the pathogenesis of liposarcoma
Q33988757Modulation of androgen receptor signaling in hormonal therapy-resistant prostate cancer cell lines
Q34051653Molecular genetics of chromosome translocations involving EWS and related family members
Q34135434Molecular pathways: targeting ETS gene fusions in cancer
Q74450239Molecular phylogeny of the ETS gene family
Q44830496Multiple functional domains of the oncoproteins Spi-1/PU.1 and TLS are involved in their opposite splicing effects in erythroleukemic cells
Q44645793Mutual repression of transcriptional activation between the ETS-related factor ERG and estrogen receptor
Q34772060Myxochondroid metaplasia of the plantar foot: a distinctive pseudoneoplastic lesion resembling nuchal fibrocartilaginous pseudotumor and the equine digital cushion
Q38354873Oligomerization of the ABL tyrosine kinase by the Ets protein TEL in human leukemia
Q92410968Oncogenic ETS Factors in Prostate Cancer
Q38508281Partial chromosome 21 amplification in a child with acute lymphoblastic leukemia.
Q47863498Pediatric Acute Megakaryoblastic Leukemia: Multitasking Fusion Proteins and Oncogenic Cooperations.
Q37083967Perturbation of fetal hematopoiesis in a mouse model of Down syndrome's transient myeloproliferative disorder
Q35022522Post-transcriptional mechanisms in BCR/ABL leukemogenesis: role of shuttling RNA-binding proteins
Q38320097Purification, crystallization and preliminary X-ray crystallographic analysis of the ETS domain of human Ergp55 in complex with the cfos promoter DNA sequence.
Q34750188Reciprocal products of chromosomal translocations in human cancer pathogenesis: key players or innocent bystanders?
Q38823486Reduced Erg Dosage Impairs Survival of Hematopoietic Stem and Progenitor Cells
Q26747155Regulation of endothelial homeostasis, vascular development and angiogenesis by the transcription factor ERG
Q24669651Retroviral transduction of TLS-ERG initiates a leukemogenic program in normal human hematopoietic cells
Q34316135Role of Ets transcription factors in mammary gland development and oncogenesis
Q27730257Solution structure of the ets domain of Fli-1 when bound to DNA
Q34326572Structural modeling and DNA binding autoinhibition analysis of Ergp55, a critical transcription factor in prostate cancer.
Q24533281TLS/FUS, a pro-oncogene involved in multiple chromosomal translocations, is a novel regulator of BCR/ABL-mediated leukemogenesis
Q46786388TLS/FUS-ERG fusion gene in acute lymphoblastic leukemia with t(16;21)(p11;q22) and monitoring of minimal residual disease
Q89157968Targeting Transcription Factors for Cancer Treatment
Q34555986The ETS family of oncogenic transcription factors in solid tumours.
Q52170371The Ets family member Erg gene is expressed in mesodermal tissues and neural crests at fundamental steps during mouse embryogenesis.
Q24811898The Ews-ERG fusion protein can initiate neoplasia from lineage-committed haematopoietic cells
Q26799478The biology of pediatric acute megakaryoblastic leukemia
Q52168068The chimeric FUS/TLS-CHOP fusion protein specifically induces liposarcomas in transgenic mice.
Q38444138The oncogene ERG: a key factor in prostate cancer
Q28281239The transcription factor Erg is essential for definitive hematopoiesis and the function of adult hematopoietic stem cells
Q36183609Transcription factor ERG and joint and articular cartilage formation during mouse limb and spine skeletogenesis.
Q41589633Transcriptional regulation during myelopoiesis
Q42521353Utility of immunohistochemical detection of prostate-specific Ets for the diagnosis of benign and malignant prostatic epithelial lesions
Q35088118Whole genome analyses of a well-differentiated liposarcoma reveals novel SYT1 and DDR2 rearrangements
Q36545848YK-4-279 effectively antagonizes EWS-FLI1 induced leukemia in a transgenic mouse model

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