Site-3 toxins and cardiac sodium channels

scientific article published on 27 September 2006

Site-3 toxins and cardiac sodium channels is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.TOXICON.2006.09.017
P932PMC publication ID1852437
P698PubMed publication ID17092528
P5875ResearchGate publication ID6703825

P2093author name stringDorothy A Hanck
Michael F Sheets
P2860cites workStructure of the KvAP voltage-dependent K+ channel and its dependence on the lipid membraneQ24534875
Crystal structure of toxin II from the scorpion Androctonus australis Hector refined at 1.3 A resolutionQ27731270
The structure of versutoxin (delta-atracotoxin-Hv1) provides insights into the binding of site 3 neurotoxins to the voltage-gated sodium channelQ27748197
Site of covalent attachment of alpha-scorpion toxin derivatives in domain I of the sodium channel alpha subunitQ33673173
The Na channel voltage sensor associated with inactivation is localized to the external charged residues of domain IV, S4.Q33869265
The voltage sensor in voltage-dependent ion channelsQ33881262
Spiders of medical importance in the Asia-Pacific: atracotoxin, latrotoxin and related spider neurotoxinsQ33960668
Comparison of heterologously expressed human cardiac and skeletal muscle sodium channelsQ34016936
The interaction of sea anemone and scorpion neurotoxins with tetrodotoxin-resistant Na+ channels in rat myoblasts. A comparison with Na+ channels in other excitable and non-excitable cellsQ34248275
Neurotoxins that Act on Voltage-Sensitive Sodium Channels in Excitable MembranesQ34251672
Sodium channel inactivation in the crayfish giant axon. Must channels open before inactivating?Q34252481
Binding specificity of sea anemone toxins to Nav 1.1-1.6 sodium channels: unexpected contributions from differences in the IV/S3-S4 outer loop.Q34323654
Localization of the receptor site for alpha-scorpion toxins by antibody mapping: implications for sodium channel topologyQ34327263
Molecular determinants of high affinity binding of alpha-scorpion toxin and sea anemone toxin in the S3-S4 extracellular loop in domain IV of the Na+ channel alpha subunitQ34384573
SCORPION, a molecular database of scorpion toxinsQ34402027
Actions of three structurally distinct sea anemone toxins on crustacean and insect sodium channelsQ44548362
Role of Asn-16 and Ser-19 in anthopleurin B binding. Implications for the electrostatic nature of Na(V) site 3.Q44915864
Mechanisms of closure of cardiac sodium channels in rabbit ventricular myocytes: single-channel analysisQ45551261
Jingzhaotoxin-I, a novel spider neurotoxin preferentially inhibiting cardiac sodium channel inactivationQ46232249
Sodium channel inactivation from resting states in guinea-pig ventricular myocytesQ46474350
Voltage sensor of Kv1.2: structural basis of electromechanical couplingQ46588794
Molecular modeling of local anesthetic drug binding by voltage-gated sodium channelsQ46713419
Delta-atracotoxins from Australian funnel-web spiders compete with scorpion alpha-toxin binding on both rat brain and insect sodium channelsQ48333215
delta-Atracotoxins from australian funnel-web spiders compete with scorpion alpha-toxin binding but differentially modulate alkaloid toxin activation of voltage-gated sodium channelsQ48379571
The interaction between the activator agents batrachotoxin and veratridine and the gating processes of neuronal sodium channelsQ51810529
Tetrodotoxin-insensitive sodium channels. Binding of polypeptide neurotoxins in primary cultures of rat muscle cellsQ51867172
Comparison of the effects of Anemonia toxin II on sodium and gating currents in frog myelinated nerveQ52673734
Decreased rate of sodium conductance inactivation in the node of Ranvier induced by a polypeptide toxin from sea anemoneQ52838902
The role of exposed tryptophan residues in the activity of the cardiotonic polypeptide anthopleurin B.Q53981963
Mechanism of inactivation of single sodium channels after modification by chloramine-T, sea anemone toxin and scorpion toxinQ54120454
A reinterpretation of mammalian sodium channel gating based on single channel recordingQ59062717
Strategy for analysing the co-operativity of intramolecular interactions in peptides and proteinsQ68891112
A mechanistic interpretation of the action of toxin II from Anemonia sulcata on the cardiac sodium channelQ68998615
Polypeptide neurotoxins modify gating and apparent single-channel conductance of veratridine-activated sodium channels in planar lipid bilayersQ69358873
Proton nmr relaxation study of the dynamics of anthopleurin-A in solutionQ69585523
Evidence for voltage-dependent S4 movement in sodium channelsQ71909065
Rate of action of Anemonia sulcata toxin II on sodium channels in myelinated nerve fibresQ72540378
Differences in the binding sites of two site-3 sodium channel toxinsQ73718150
Differential phospholipid binding by site 3 and site 4 toxins. Implications for structural variability between voltage-sensitive sodium channel domainsQ81229955
Peptide toxins in sea anemones: structural and functional aspectsQ34478906
Structure and structure-function relationships of sea anemone proteins that interact with the sodium channelQ34550953
Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reactionQ34684384
Purification of three polypeptides with neuroand cardiotoxic activity from the sea anemone Anemonia sulcataQ34818026
Voltage-gated sodium channel toxins: poisons, probes, and future promiseQ35141466
Potassium channelsQ35589981
Binding of sea anemone toxin to receptor sites associated with gating system of sodium channel in synaptic nerve endings in vitroQ36361171
The role of the putative inactivation lid in sodium channel gating current immobilizationQ36412221
Molecular action of lidocaine on the voltage sensors of sodium channelsQ36412378
Augmentation of recovery from inactivation by site-3 Na channel toxins. A single-channel and whole-cell study of persistent currentsQ36421295
Kinetic analysis of the action of Leiurus scorpion alpha-toxin on ionic currents in myelinated nerveQ36433793
Cardiac Na currents and the inactivating, reopening, and waiting properties of single cardiac Na channelsQ36433797
Rapid voltage-dependent dissociation of scorpion alpha-toxins coupled to Na channel inactivation in amphibian myelinated nervesQ36433865
Voltage-dependent open-state inactivation of cardiac sodium channels: gating current studies with Anthopleurin-A toxinQ36435536
Modification of inactivation in cardiac sodium channels: ionic current studies with Anthopleurin-A toxinQ36435540
Transfer of twelve charges is needed to open skeletal muscle Na+ channelsQ36435658
A unique role for the S4 segment of domain 4 in the inactivation of sodium channelsQ36435804
Sodium channel activation gating is affected by substitutions of voltage sensor positive charges in all four domainsQ36435921
Movement of voltage sensor S4 in domain 4 is tightly coupled to sodium channel fast inactivation and gating charge immobilizationQ36438978
Importance of the unique cationic residues arginine 12 and lysine 49 in the activity of the cardiotonic polypeptide anthopleurin B.Q38312254
Leucine 18, a hydrophobic residue essential for high affinity binding of anthopleurin B to the voltage-sensitive sodium channel.Q38358890
Purification and characterisation of four polypeptides with neurotoxic activity from Condylactis aurantiacaQ39108042
Isolation and Characterization of the Cardiotonic Polypeptide Anthopleurin-A from the Sea Anemone Anthopleura xanthogrammicaQ39113884
A polypeptide (AP-A) from sea anemone (Anthopleura xanthogrammica) with potent positive inotropic actionQ39118414
Time- and voltage-dependent interactions of antiarrhythmic drugs with cardiac sodium channelsQ39707961
Interactions between quaternary lidocaine, the sodium channel gates, and tetrodotoxinQ40300883
Arg-14 loop of site 3 anemone toxins: effects of glycine replacement on toxin affinityQ40609534
Lidocaine alters activation gating of cardiac Na channelsQ40883510
Gating of skeletal and cardiac muscle sodium channels in mammalian cellsQ40988455
A Specific Interaction between the Cardiac Sodium Channel and Site-3 Toxin Anthopleurin BQ41067774
Dose-dependent modulation of the cardiac sodium channel by sea anemone toxin ATXIIQ41089124
Electrophysiological characteristics of cloned skeletal and cardiac muscle sodium channelsQ41180157
Cardiac sodium channels expressed in a peripheral neurotumor-derived cell line, RT4-B8.Q41200225
Molecular basis of charge movement in voltage-gated sodium channelsQ41254973
Sodium channel mutations in paramyotonia congenita uncouple inactivation from activationQ41491359
Voltage sensors in domains III and IV, but not I and II, are immobilized by Na+ channel fast inactivationQ41608443
Cloning and expression of wild-type and mutant forms of the cardiotonic polypeptide anthopleurin B.Q41613526
Inactivation of the sodium channel. I. Sodium current experimentsQ41897655
Inactivation of the sodium channel. II. Gating current experimentsQ41933393
Distinct primary structures of the major peptide toxins from the venom of the spider Macrothele gigas that bind to sites 3 and 4 in the sodium channel.Q42047248
Multiple conformations of the sea anemone polypeptide anthopleurin-A in solutionQ42199395
Molecular determinants of state-dependent block of Na+ channels by local anestheticsQ42284240
The open pore conformation of potassium channelsQ42677283
Multiple cationic residues of anthopleurin B that determine high affinity and channel isoform discriminationQ42679379
Potential-dependent action of Anemonia sulcata toxins III and IV on sodium channels in crayfish giant axonsQ44289077
P433issue2
P1104number of pages13
P304page(s)181-193
P577publication date2006-09-27
P13046publication type of scholarly workreview articleQ7318358
P1433published inToxiconQ7830412
P1476titleSite-3 toxins and cardiac sodium channels
P478volume49