SIRT1 alleviates senescence of degenerative human intervertebral disc cartilage endo-plate cells via the p53/p21 pathway

scientific article published on 4 March 2016

SIRT1 alleviates senescence of degenerative human intervertebral disc cartilage endo-plate cells via the p53/p21 pathway is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/SREP22628
P932PMC publication ID4778056
P698PubMed publication ID26940203
P5875ResearchGate publication ID297604991

P2093author name stringXin Lin
Wei Huang
Wei Jiang
Wen Dong
Xiaojun Zhang
Zhenming Hu
Quanhe Qiu
Jie Hao
Xi Liang
Jieliang Shen
Dawu Wang
Liangbo Lin
Nian Zhou
Zhaojun Song
P2860cites workLow back pain: a twentieth century health care enigmaQ47812078
Magnetic resonance classification of lumbar intervertebral disc degeneration.Q48737575
Oxidative stress induces senescence in chondrocytes.Q53270994
Catabolic stress induces features of chondrocyte senescence through overexpression of caveolin 1: possible involvement of caveolin 1-induced down-regulation of articular chondrocytes in the pathogenesis of osteoarthritis.Q54615793
Vertebral end-plate changes with aging of human vertebraeQ70384344
Evidence for the accumulation of oxidative stress during cellular ageing of human diploid fibroblastsQ72207028
Chondrocyte senescence, joint loading and osteoarthritisQ80851787
Senescence mechanisms of nucleus pulposus chondrocytes in human intervertebral discsQ84092699
Covalent and noncovalent modifiers of the p53 proteinQ22009048
Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescenceQ24297146
Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylaseQ24297207
Human Sir2 and the 'silencing' of p53 activityQ30309900
Apoptotic cell death is not a widespread phenomenon in normal aging and osteoarthritis human articular knee cartilage: a study of proliferation, programmed cell death (apoptosis), and viability of chondrocytes in normal and osteoarthritic human kneeQ30992895
Glucocorticoids induce senescence in primary human tenocytes by inhibition of sirtuin 1 and activation of the p53/p21 pathway: in vivo and in vitro evidenceQ33834757
The vertebral end-plate: what do we know?Q33925728
Oxidative DNA damage and senescence of human diploid fibroblast cells.Q34323707
Antagonistic crosstalk between NF-κB and SIRT1 in the regulation of inflammation and metabolic disordersQ34351149
Calorie restriction--the SIR2 connectionQ34398200
p300/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by MDM2.Q34585107
SIRT1 protects against apoptosis by promoting autophagy in degenerative human disc nucleus pulposus cellsQ34684132
Pathomechanisms of cartilage destruction by mechanical injuryQ36327997
Sirtuin regulation in aging and injuryQ36379286
Accelerated cellular senescence in degenerate intervertebral discs: a possible role in the pathogenesis of intervertebral disc degenerationQ36392322
Senescence in cells of the aging and degenerating intervertebral disc: immunolocalization of senescence-associated beta-galactosidase in human and sand rat discsQ36724604
Reactive nitrogen and oxygen species in interleukin-1-mediated DNA damage associated with osteoarthritis.Q36725162
The cell biology of intervertebral disc aging and degenerationQ36942950
SIRT1 inhibits apoptosis of degenerative human disc nucleus pulposus cells through activation of Akt pathwayQ37179916
Aging and osteoarthritis: the role of chondrocyte senescence and aging changes in the cartilage matrixQ37268683
Cellular senescence: molecular mechanisms, in vivo significance, and redox considerationsQ37314233
Crosstalk between Oxidative Stress and SIRT1: Impact on the Aging ProcessQ38084036
The lumbar intervertebral disc: from embryonic development to degeneration.Q38128053
H2O2 accelerates cellular senescence by accumulation of acetylated p53 via decrease in the function of SIRT1 by NAD+ depletionQ40114764
Aging and Degeneration of the Human Intervertebral DiscQ40474143
Recovery of function in osteoarthritic chondrocytes induced by p16INK4a-specific siRNA in vitroQ40524357
The biology of replicative senescenceQ41583618
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjectcartilageQ502730
P304page(s)22628
P577publication date2016-03-04
P1433published inScientific ReportsQ2261792
P1476titleSIRT1 alleviates senescence of degenerative human intervertebral disc cartilage endo-plate cells via the p53/p21 pathway
P478volume6

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cites work (P2860)
Q93356270Cellular senescence in intervertebral disc aging and degeneration
Q40638170Fermented Chinese Formula Shuan-Tong-Ling Protects Brain Microvascular Endothelial Cells against Oxidative Stress Injury.
Q46322034Paeonol attenuates aging MRC-5 cells and inhibits epithelial-mesenchymal transition of premalignant HaCaT cells induced by aging MRC-5 cell-conditioned medium.
Q37723678ROS: Crucial Intermediators in the Pathogenesis of Intervertebral Disc Degeneration
Q51738168Repeated stimulation by LPS promotes the senescence of DPSCs via TLR4/MyD88-NF-κB-p53/p21 signaling.
Q52716396Silencing SUMO2 promotes protection against degradation and apoptosis of nucleus pulposus cells through p53 signaling pathway in intervertebral disc degeneration.
Q41339364The PI3K/Akt pathway: a critical player in intervertebral disc degeneration
Q46293920The nuclear mitotic apparatus protein NuMA controls rDNA transcription and mediates the nucleolar stress response in a p53-independent manner.
Q64057750The resistant effect of SIRT1 in oxidative stress-induced senescence of rat nucleus pulposus cell is regulated by Akt-FoxO1 pathway

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