Sphingosine 1-phosphate receptor modulators: a new class of immunosuppressants.

scientific article published on November 2006

Sphingosine 1-phosphate receptor modulators: a new class of immunosuppressants. is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1111/J.1399-0012.2006.00570.X
P698PubMed publication ID17100731

P50authorJordi OchandoQ48546528
P2093author name stringJonathan S Bromberg
Adam C Yopp
Levi G Ledgerwood
P2860cites workSphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangementQ24671831
Cell type-specific localization of human cardiac S1P receptorsQ28215436
Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonistsQ29618071
Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1Q29619644
Sphingosine 1-phosphate analogs as receptor antagonistsQ30435361
Regulatory T cells: key controllers of immunologic self-toleranceQ33941140
Sphingosine 1-phosphate signalling via the endothelial differentiation gene family of G-protein-coupled receptorsQ34126142
Phosphorylation and action of the immunomodulator FTY720 inhibits vascular endothelial cell growth factor-induced vascular permeability.Q34227743
Phosphorylation of the immunomodulatory drug FTY720 by sphingosine kinasesQ34234281
The immunosuppressant FTY720 is phosphorylated by sphingosine kinase type 2Q34274256
A rational utilization of high-throughput screening affords selective, orally bioavailable 1-benzyl-3-carboxyazetidine sphingosine-1-phosphate-1 receptor agonistsQ34379081
Synthesis and biological evaluation of 2,2-disubstituted 2-aminoethanols: analogues of FTY720.Q34756546
Leukotrienes, sphingolipids, and leukocyte traffickingQ35158397
FTY720: sphingosine 1-phosphate receptor-1 in the control of lymphocyte egress and endothelial barrier function.Q35804361
Update on liver transplantation using cyclosporineQ35994591
Sphingosine 1-phosphate and its receptors: an autocrine and paracrine networkQ36184401
Molecular mechanisms of lymphocyte homing to peripheral lymph nodesQ36400133
FTY720 stimulates multidrug transporter- and cysteinyl leukotriene-dependent T cell chemotaxis to lymph nodesQ39741057
The immune modulator FTY720 targets sphingosine 1-phosphate receptorsQ40736684
FTY 720 prevents ischemic reperfusion damage in rat kidneysQ43552719
Sphingosine 1-phosphate type 1 receptor agonism inhibits transendothelial migration of medullary T cells to lymphatic sinusesQ43746398
Long-term islet graft survival in streptozotocin- and autoimmune-induced diabetes models by immunosuppressive and potential insulinotropic agent FTY720.Q44002416
Sphingosine-1-phosphate receptor agonism impairs the efficiency of the local immune response by altering trafficking of naive and antigen-activated CD4+ T cellsQ44368643
Amelioration of experimental autoimmune encephalomyelitis in Lewis rats by FTY720 treatmentQ44370378
Pharmacodynamics of single doses of the novel immunosuppressant FTY720 in stable renal transplant patients.Q44482860
Randomized trial of tacrolimus + mycophenolate mofetil or azathioprine versus cyclosporine + mycophenolate mofetil after cadaveric kidney transplantation: results at three years.Q44493644
Pharmacodynamics, pharmacokinetics, and safety of multiple doses of FTY720 in stable renal transplant patients: a multicenter, randomized, placebo-controlled, phase I studyQ44616726
The natural history of chronic allograft nephropathyQ44688416
Sphingosine 1-phosphate (S1P) receptor subtypes S1P1 and S1P3, respectively, regulate lymphocyte recirculation and heart rateQ44734550
The effect of immunomodulators on prevention of autoimmune diabetes is stage dependent: FTY720 prevents diabetes at three different stages in the diabetes-resistant biobreeding rat.Q44813941
Potent S1P receptor agonists replicate the pharmacologic actions of the novel immune modulator FTY720.Q44900766
FTY720, a novel immunomodulator: efficacy and safety results from the first phase 2A study in de novo renal transplantationQ44956732
FTY720 attenuates hepatic ischemia-reperfusion injury in normal and cirrhotic livers.Q45214556
The heart rate decrease caused by acute FTY720 administration is mediated by the G protein-gated potassium channel I.Q45262225
The immune modulator FTY720 inhibits sphingosine-1-phosphate lyase activityQ46249644
A novel immunomodulator, FTY720, prevents development of experimental autoimmune myasthenia gravis in C57BL/6 mice.Q46415076
Lymph node occupancy is required for the peripheral development of alloantigen-specific Foxp3+ regulatory T cells.Q46499903
Cardiovascular risk estimates and risk factors in renal transplant recipientsQ46512845
Sphingosine 1-phosphate receptors regulate chemokine-driven transendothelial migration of lymph node but not splenic T cells.Q46664082
Sphingosine-1-phosphate agonists increase macrophage homing, lymphocyte contacts, and endothelial junctional complex formation in murine lymph nodesQ46815005
P433issue6
P921main subjectimmunosuppressionQ1455316
P304page(s)788-795
P577publication date2006-11-01
P1433published inClinical TransplantationQ15754920
P1476titleSphingosine 1-phosphate receptor modulators: a new class of immunosuppressants
P478volume20

Reverse relations

cites work (P2860)
Q46366717A ceramide-1-phosphate analogue, PCERA-1, simultaneously suppresses tumour necrosis factor-alpha and induces interleukin-10 production in activated macrophages
Q36875875Adhesion molecules in cutaneous immunity
Q36499684Airway CD8(+) T cells induced by pulmonary DNA immunization mediate protective anti-viral immunity
Q34974825Ceramide synthesis is modulated by the sphingosine analog FTY720 via a mixture of uncompetitive and noncompetitive inhibition in an Acyl-CoA chain length-dependent manner
Q34792987Diminished Memory T-Cell Expansion Due to Delayed Kinetics of Antigen Expression by Lentivectors
Q46914095Early attenuation of lesional interleukin-16 up-regulation by dexamethasone and FTY720 in experimental traumatic brain injury.
Q36462344FTY720 markedly increases alloengraftment but does not eliminate host anti-donor T cells that cause graft rejection on its withdrawal
Q43262877FTY720, a sphingosine 1-phosphate receptor modulator, inhibits CD1d-restricted NKT cells by suppressing cytokine production but not migration
Q24648847Immunomodulatory drug FTY720 induces regulatory CD4(+)CD25(+) T cells in vitro
Q36384836Insights into the mechanism of FTY720 and compatibility with regulatory T cells for the inhibition of graft-versus-host disease (GVHD).
Q37496801Lung-resident memory CD8 T cells (TRM) are indispensable for optimal cross-protection against pulmonary virus infection
Q26785848Lymphatic disorders after renal transplantation: new insights for an old complication
Q35214194Semaphorin 3F and neuropilin-2 control the migration of human T-cell precursors
Q46434977Sphingosine 1-phosphate receptor agonism impairs skin dendritic cell migration and homing to secondary lymphoid tissue: association with prolonged allograft survival
Q33651898Targeting S1P receptors in experimental autoimmune encephalomyelitis in mice improves early deficits in locomotor activity and increases ultrasonic vocalisations.
Q36473213The S1P1 receptor-selective agonist CYM-5442 reduces the severity of acute GVHD by inhibiting macrophage recruitment
Q44581309The expanding therapeutic armamentarium for inflammatory bowel disease: how to choose the right drug(s) for our patients?
Q84744062The sphingosine-1-phosphate receptor agonist FTY720 prevents the development of anti-glomerular basement membrane glomerulonephritis
Q36955927Update on immunosuppressive drugs used in solid-organ transplantation and their nutrition implications

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