Mutation of large T-antigen-binding site A, but not site B or C, eliminates stalling by RNA polymerase II in the intergenic region of polyomavirus DNA

scientific article published on October 1993

Mutation of large T-antigen-binding site A, but not site B or C, eliminates stalling by RNA polymerase II in the intergenic region of polyomavirus DNA is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1128/JVI.67.10.5766-5775.1993
P932PMC publication ID237994
P698PubMed publication ID8396655

P2093author name stringBertin J
Acheson NH
Sunstrom NA
P2860cites workMAZ, a zinc finger protein, binds to c-MYC and C2 gene sequences regulating transcriptional initiation and terminationQ24316955
Rapid and efficient site-specific mutagenesis without phenotypic selectionQ27860608
Selective extraction of polyoma DNA from infected mouse cell culturesQ29547500
The origin of bidirectional DNA replication in polyoma virusQ33929334
The biochemistry of 3'-end cleavage and polyadenylation of messenger RNA precursors.Q34243656
Promoter occlusion: Transcription through a promoter may inhibit its activityQ34250774
Transcriptional interference in avian retroviruses—implications for the promoter insertion model of leukaemogenesisQ34257238
A poly(A) addition site and a downstream termination region are required for efficient cessation of transcription by RNA polymerase II in the mouse beta maj-globin geneQ34369553
lac repressor blocks in vivo transcription of lac control region DNA.Q34622722
Inhibition of polyoma DNA synthesis by base pair substitutions at the replication originQ35446494
lac Repressor blocks transcribing RNA polymerase and terminates transcriptionQ35610301
The high affinity binding site on polyoma virus DNA for the viral large-T proteinQ35744991
An RNA polymerase I termination site can stimulate the adjacent ribosomal gene promoter by two distinct mechanisms in Xenopus laevisQ45433712
Regulation of polyoma virus early transcription in transformed cells by large T-antigenQ45799657
Regulatory mutants of polyoma virus defective in DNA replication and the synthesis of early proteinsQ45803505
Polyoma virus DNA replication requires an enhancerQ45807137
The uvrB gene of Escherichia coli has both lexA-repressed and lexA-independent promotersQ48405704
Role of transcriptional interference in the Drosophila melanogaster Adh promoter switch.Q52247655
The promoter-proximal rDNA terminator augments initiation by preventing disruption of the stable transcription complex caused by polymerase read-in.Q52487212
Transcription termination and chromatin structure of the active immunoglobulin kappa gene locus.Q52490268
A CCAAT box sequence in the adenovirus major late promoter functions as part of an RNA polymerase II termination signalQ64379160
Crystallization and preliminary X-ray study of blood coagulation factor IX/factor X-binding protein with anticoagulant activity from Habu snake venomQ67921692
Molecular requirements for transcriptional initiation of the murine c-myc geneQ69072694
A functional mRNA polyadenylation signal is required for transcription termination by RNA polymerase IIQ69827439
RNA polymerases stall and/or prematurely terminate nearby both early and late promoters on polyomavirus DNAQ69841567
A small segment of polyoma virus DNA enhances the expression of a cloned β-globin gene over a distance of 1400 base pairsQ35746409
DNA binding activity of polyoma virus large tumor antigenQ36265649
Deletion mutants of polyoma virus defining a nonessential region between the origin of replication and the initiation codon for early proteinsQ36505130
An intact histone 3'-processing site is required for transcription termination in a mouse histone H2a geneQ36681497
A DNA-binding protein is required for termination of transcription by RNA polymerase I in Xenopus laevisQ36710575
RNA polymerase II transcription termination is mediated specifically by protein binding to a CCAAT box sequenceQ36796710
Determination of the origin-specific DNA-binding domain of polyomavirus large T antigenQ36829046
Nucleotides in the polyomavirus enhancer that control viral transcription and DNA replicationQ36839906
Regulation of polyomavirus late promoter activity by viral early proteinsQ36883966
Essential nucleotides in the polyomavirus origin regionQ36893642
Sequences in the polyomavirus DNA regulatory region involved in viral DNA replication and early gene expressionQ36902040
DNA replication origin of polyoma virus: early proximal boundaryQ36907111
Polyomavirus origin for DNA replication comprises multiple genetic elementsQ36908040
Polyomavirus large T antigen binds independently to multiple, unique regions on the viral genomeQ36908071
A specific DNA sequence controls termination of transcription in the gastrin geneQ36911759
Polyomavirus and simian virus 40 large T antigens bind to common DNA sequences.Q36913417
DNA sequence requirements for replication of polyomavirus DNA in vivo and in vitroQ36922865
Regulation of polyomavirus transcription by large tumor antigenQ37576562
Binding and unwinding--how T antigen engages the SV40 origin of DNA replicationQ37870911
A protein-binding site in the c-myc promoter functions as a terminator of RNA polymerase II transcriptionQ38326933
Stalling by RNA polymerase II in the polyomavirus intergenic region is dependent on functional large T antigenQ38327249
Human CCAAT-binding proteins have heterologous subunitsQ38347504
How RNA polymerase II terminates transcription in higher eukaryotesQ38637923
Guanine nucleotide contacts within viral DNA sequences bound by polyomavirus large T antigen.Q40125633
Multiple binding sites for polyomavirus large T antigen within regulatory sequences of polyomavirus DNAQ40134530
Virus-specific early RNA in 3T6 cells infected by a tsA mutant of polyoma virusQ40143009
Direct demonstration of termination signals for RNA polymerase II from the sea urchin H2A histone geneQ40538201
Purification and characterization of TTFI, a factor that mediates termination of mouse ribosomal DNA transcriptionQ40660163
Interaction in vivo between strong closely spaced constitutive promotersQ41022421
A pause site for RNA polymerase II is associated with termination of transcriptionQ41081406
Transcriptional termination between the closely linked human complement genes C2 and factor B: common termination factor for C2 and c-myc?Q41083821
A rabbit beta-globin polyadenylation signal directs efficient termination of transcription of polyomavirus DNA.Q41107135
ATP induces the assembly of polyoma large tumor antigen into hexamersQ41667831
Identification of transcription stop sites at the 5' and 3' ends of the murine adenosine deaminase gene.Q41727698
RNA polymerase II transcription blocked by Escherichia coli lac repressorQ41736760
Characterization of the mouse beta maj globin transcription termination region: a spacing sequence is required between the poly(A) signal sequence and multiple downstream termination elementsQ41817304
Alpha-thalassaemia caused by a poly(A) site mutation reveals that transcriptional termination is linked to 3' end processing in the human alpha 2 globin geneQ41841618
Insertion of transposon Tn7 into the Escherichia coli glmS transcriptional terminatorQ41872134
Transcriptional interference and termination between duplicated alpha-globin gene constructs suggests a novel mechanism for gene regulationQ43993308
Binding of a simian virus 40 T antigen-related protein to DNAQ44167079
Elongation by Escherichia coli RNA polymerase is blocked in vitro by a site-specific DNA binding proteinQ44182261
Specific interaction of the murine transcription termination factor TTF I with class-I RNA polymerasesQ44379554
Promoter occlusion during ribosomal RNA transcriptionQ45118631
Promoter occlusion prevents transcription of adenovirus polypeptide IX mRNA until after DNA replicationQ45167232
Termination of transcription in human mitochondria: identification and purification of a DNA binding protein factor that promotes terminationQ45345563
P433issue10
P407language of work or nameEnglishQ1860
P304page(s)5766-5775
P577publication date1993-10-01
P1433published inJournal of VirologyQ1251128
P1476titleMutation of large T-antigen-binding site A, but not site B or C, eliminates stalling by RNA polymerase II in the intergenic region of polyomavirus DNA
P478volume67

Reverse relations

cites work (P2860)
Q40960502Enhanced binding to origin DNA at low pH enables easy detection of polyomavirus large T antigen by gel mobility shift assay of unfixed complexes
Q33853880Kinetic analysis of the steps of the polyomavirus lytic cycle
Q39580215Polyomavirus large T antigen binds cooperatively to its multiple binding sites in the viral origin of DNA replication.
Q39870748RNA footprint mapping of RNA polymerase II molecules stalled in the intergenic region of polyomavirus DNA.