PET Imaging of Tau Deposition in the Aging Human Brain.

scientific article published on March 2016

PET Imaging of Tau Deposition in the Aging Human Brain. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.NEURON.2016.01.028
P932PMC publication ID4779187
P698PubMed publication ID26938442

P50authorWilliam J. JagustQ56863004
Daniel R SchonhautQ57055541
Henry D SchwimmerQ87405441
Gil D RabinoviciQ87489631
Rik OssenkoppeleQ87490049
Mustafa JanabiQ88372236
Michael SchöllQ42334678
P2093author name stringJames P O'Neil
Suzanne L Baker
Jacob W Vogel
Samuel N Lockhart
Jamie Faria
P2860cites workRegional Distribution of Neurofibrillary Tangles and Senile Plaques in the Cerebral Cortex of Elderly Patients: A Quantitative Evaluation of a One-Year Autopsy Population from a Geriatric HospitalQ22242921
Neuropathological alterations in Alzheimer diseaseQ27003314
Neuropathological stageing of Alzheimer-related changesQ27860862
Trans-synaptic spread of tau pathology in vivoQ28732288
The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's diseaseQ29547554
Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's diseaseQ29617286
Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkersQ29620245
The intersection of amyloid beta and tau at synapses in Alzheimer's diseaseQ34054680
Neurofibrillary tangles, amyloid, and memory in aging and mild cognitive impairmentQ34198357
Neural compensation in older people with brain amyloid-β depositionQ34253028
Distribution of monoamine oxidase proteins in human brain: implications for brain imaging studiesQ34327435
Amyloid β deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: a prospective cohort studyQ34332159
Primary age-related tauopathy (PART): a common pathology associated with human agingQ34445021
Injury markers but not amyloid markers are associated with rapid progression from mild cognitive impairment to dementia in Alzheimer's disease.Q48718975
Tau and Abeta42 in cerebrospinal fluid from healthy adults 21-93 years of age: establishment of reference values.Q48784648
Stages of the pathologic process in Alzheimer disease: age categories from 1 to 100 years.Q48835886
Observations on the brains of non-demented old peopleQ49150147
Parahippocampal tau pathology in healthy aging, mild cognitive impairment, and early Alzheimer's diseaseQ77614817
PART is part of Alzheimer diseaseQ34460027
PART, a distinct tauopathy, different from classical sporadic Alzheimer diseaseQ34467464
Correction for partial volume effects in PET: principle and validationQ34468480
Tau mislocalization to dendritic spines mediates synaptic dysfunction independently of neurodegenerationQ34518577
Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistryQ34556945
National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's diseaseQ34635272
Alzheimer Disease Pathology in Middle Age Reveals a Spatial-Temporal Disconnect Between Amyloid-β and Phosphorylated TauQ35004256
Relationships between β-amyloid and functional connectivity in different components of the default mode network in agingQ35204334
Neuropathologically defined subtypes of Alzheimer's disease with distinct clinical characteristics: a retrospective studyQ35219292
Tau, amyloid, and hypometabolism in a patient with posterior cortical atrophyQ35241767
Not quite PIB-positive, not quite PIB-negative: slight PIB elevations in elderly normal control subjects are biologically relevantQ35592672
The behavioural/dysexecutive variant of Alzheimer's disease: clinical, neuroimaging and pathological featuresQ36217479
Relation of neuropathology to cognition in persons without cognitive impairmentQ36374970
Atrophy patterns in early clinical stages across distinct phenotypes of Alzheimer's diseaseQ36408912
Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the literatureQ36575903
Distribution volume ratios without blood sampling from graphical analysis of PET dataQ36817029
Validating novel tau positron emission tomography tracer [F-18]-AV-1451 (T807) on postmortem brain tissueQ36987267
Staging of neurofibrillary pathology in Alzheimer's disease: a study of the BrainNet Europe ConsortiumQ37137198
Episodic memory loss is related to hippocampal-mediated beta-amyloid deposition in elderly subjectsQ37181281
Amyloid deposition, hypometabolism, and longitudinal cognitive declineQ37207254
Linking Abeta and tau in late-onset Alzheimer's disease: a dual pathway hypothesisQ37336139
Neuropathology of older persons without cognitive impairment from two community-based studiesQ38405842
Cerebrospinal fluid biomarkers mirror rate of cognitive declineQ38457762
Episodic memory in normal aging and Alzheimer disease: Insights from imaging and behavioral studiesQ38575873
Cerebrospinal fluid tau/beta-amyloid(42) ratio as a prediction of cognitive decline in nondemented older adultsQ40253365
Kinetic modeling of amyloid binding in humans using PET imaging and Pittsburgh Compound-B.Q40415499
Soluble tau species, not neurofibrillary aggregates, disrupt neural system integration in a tau transgenic modelQ41868802
Frequency of stages of Alzheimer-related lesions in different age categoriesQ42445469
[(18)F]T807, a novel tau positron emission tomography imaging agent for Alzheimer's diseaseQ42712929
Age-associated cognitive declineQ43536493
Synthesis and evaluation of 11C-labeled 6-substituted 2-arylbenzothiazoles as amyloid imaging agentsQ44474556
Age, neurofibrillary changes, A beta-amyloid and the onset of Alzheimer's diseaseQ44657447
Early clinical PET imaging results with the novel PHF-tau radioligand [F-18]-T807.Q45810537
Pathological tau disrupts ongoing network activityQ47744611
Alzheimer neuropathologic alterations in aged cognitively normal subjectsQ48226793
Tangles and plaques in nondemented aging and "preclinical" Alzheimer's diseaseQ48266934
Tau conformational changes correspond to impairments of episodic memory in mild cognitive impairment and Alzheimer's disease.Q48448000
P433issue5
P407language of work or nameEnglishQ1860
P304page(s)971-982
P577publication date2016-03-01
P1433published inNeuronQ3338676
P1476titlePET Imaging of Tau Deposition in the Aging Human Brain
P478volume89

Reverse relations

cites work (P2860)
Q4661629318 F-flortaucipir tau positron emission tomography distinguishes established progressive supranuclear palsy from controls and Parkinson disease: A multicenter study
Q4160099718F-AV-1451 and CSF T-tau and P-tau as biomarkers in Alzheimer's disease
Q3773988718F-AV-1451 positron emission tomography in Alzheimer's disease and progressive supranuclear palsy.
Q3719856318F-AV-1451 tau PET imaging correlates strongly with tau neuropathology in MAPT mutation carriers
Q5339693918F-Flortaucipir Binding in Choroid Plexus: Related to Race and Hippocampus Signal.
Q39270980A Brief Overview of Tauopathy: Causes, Consequences, and Therapeutic Strategies
Q57927766A Closer Look into the Role of Protein Tau in the Identification of Promising Therapeutic Targets for Alzheimer's Disease
Q37590389A Conceptualization of the Utility of Subjective Cognitive Decline in Clinical Trials of Preclinical Alzheimer's Disease
Q39451637A Review of Biomarkers for Neurodegenerative Disease: Will They Swing Us Across the Valley?
Q39434968A clinicopathological approach to the diagnosis of dementia
Q38714558A comparison of five partial volume correction methods for Tau and Amyloid PET imaging with [18F]THK5351 and [11C]PIB.
Q90140035A multicentre longitudinal study of flortaucipir (18F) in normal ageing, mild cognitive impairment and Alzheimer's disease dementia
Q58778649A novel partial volume correction method for accurate quantification of [F] flortaucipir in the hippocampus
Q99623684A probabilistic atlas of locus coeruleus pathways to transentorhinal cortex for connectome imaging in Alzheimer's disease
Q42365992A protein homeostasis signature in healthy brains recapitulates tissue vulnerability to Alzheimer's disease.
Q39039980A state of delirium: Deciphering the effect of inflammation on tau pathology in Alzheimer's disease.
Q64245708A walk through tau therapeutic strategies
Q26745508A/T/N: An unbiased descriptive classification scheme for Alzheimer disease biomarkers
Q38653494AV-1451 PET imaging of tau pathology in preclinical Alzheimer disease: Defining a summary measure
Q37633577AV-1451 tau and β-amyloid positron emission tomography imaging in dementia with Lewy bodies
Q90198060Advances in CNS PET: the state-of-the-art for new imaging targets for pathophysiology and drug development
Q53397162Aerobic glycolysis and tau deposition in preclinical Alzheimer's disease.
Q38812890Age-specific and sex-specific prevalence of cerebral β-amyloidosis, tauopathy, and neurodegeneration in cognitively unimpaired individuals aged 50-95 years: a cross-sectional study
Q91045286Ageing and amyloidosis underlie the molecular and pathological alterations of tau in a mouse model of familial Alzheimer's disease
Q74439119Ageing protein imaged in brain
Q37504961Aging Affects Dopaminergic Neural Mechanisms of Cognitive Flexibility
Q91781242Alzheimer Disease Pathogenesis: Insights From Molecular and Cellular Biology Studies of Oligomeric Aβ and Tau Species
Q38893744Alzheimer Disease Signature Neurodegeneration and APOE Genotype in Mild Cognitive Impairment With Suspected Non-Alzheimer Disease Pathophysiology
Q53385578Alzheimer disease in 2016: Putting AD treatments and biomarkers to the test.
Q42656263Alzheimer's drug-development pipeline: 2016.
Q91744531Amide proton transfer-weighted magnetic resonance imaging of human brain aging at 3 Tesla
Q88755570Amyloid Accumulation and Cognitive Decline in Clinically Normal Older Individuals: Implications for Aging and Early Alzheimer's Disease
Q47194750Amyloid Associated Intermittent Network Disruptions in Cognitively Intact Older Subjects: Structural Connectivity Matters
Q38945395Amyloid and tau PET demonstrate region-specific associations in normal older people.
Q83225104Amyloid and tau accumulate across distinct spatial networks and are differentially associated with brain connectivity
Q92315625Amyloid and tau imaging biomarkers explain cognitive decline from late middle-age
Q60530541Amyloid, tau, pathogen infection and antimicrobial protection in Alzheimer's disease -conformist, nonconformist, and realistic prospects for AD pathogenesis
Q89751795Amyloid-β Positivity Predicts Cognitive Decline but Cognition Predicts Progression to Amyloid-β Positivity
Q47937013Amyloid-β plaques enhance Alzheimer's brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation
Q64107058Application of advanced brain positron emission tomography-based molecular imaging for a biological framework in neurodegenerative proteinopathies
Q89855898Assessment of Demographic, Genetic, and Imaging Variables Associated With Brain Resilience and Cognitive Resilience to Pathological Tau in Patients With Alzheimer Disease
Q57214180Assessment of Extent and Role of Tau in Subcortical Vascular Cognitive Impairment Using 18F-AV1451 Positron Emission Tomography Imaging
Q37600680Association between Aβ and tau accumulations and their influence on clinical features in aging and Alzheimer's disease spectrum brains: A [11C]PBB3-PET study
Q46158333Association between tau deposition and antecedent amyloid-β accumulation rates in normal and early symptomatic individuals
Q45974423Associations Between Tau, β-Amyloid, and Cognition in Parkinson Disease.
Q95278331Associations between NIH Toolbox Cognition Battery and in vivo brain amyloid and tau pathology in non-demented older adults
Q91615306Associations between quantitative [18F]flortaucipir tau PET and atrophy across the Alzheimer's disease spectrum
Q91999679Associations between self-reported sleep characteristics and incident mild cognitive impairment: The Heinz Nixdorf Recall Cohort Study
Q64261095Associations between tau, Aβ, and cortical thickness with cognition in Alzheimer disease
Q51766183Atypical Localization and Dissociation between Glucose Uptake and Amyloid Deposition in Cognitively Normal APOE*E4 Homozygotic Elders Compared with Patients with Late-Onset Alzheimer's Disease.
Q64106160Autoradiography validation of novel tau PET tracer [F-18]-MK-6240 on human postmortem brain tissue
Q95278387Aβ deposition is associated with increases in soluble and phosphorylated tau that precede a positive Tau PET in Alzheimer's disease
Q92017890Biomarker Localization, Analysis, Visualization, Extraction, and Registration (BLAzER) Methodology for Research and Clinical Brain PET Applications
Q64952063Biomarkers for tau pathology.
Q38979999Biomarkers for the Early Detection and Progression of Alzheimer's Disease
Q39413097Biomarkers in Neurodegenerative Diseases
Q93222023Blood phosphorylated tau 181 as a biomarker for Alzheimer's disease: a diagnostic performance and prediction modelling study using data from four prospective cohorts
Q64967643Brain Molecular Connectivity in Neurodegenerative Diseases: Recent Advances and New Perspectives Using Positron Emission Tomography.
Q90414751Brain Theranostics and Radiotheranostics: Exosomes and Graphenes In Vivo as Novel Brain Theranostics
Q64950892Brain network alterations in individuals with and without mild cognitive impairment: parallel independent component analysis of AV1451 and AV45 positron emission tomography.
Q50533425Brain volume change and cognitive trajectories in aging.
Q99631054CSF glucose tracks regional tau progression based on Alzheimer's disease risk factors
Q59807550CSF total tau levels are associated with hippocampal novelty irrespective of hippocampal volume
Q47587631Cerebrospinal fluid and blood biomarkers for neurodegenerative dementias: An update of the Consensus of the Task Force on Biological Markers in Psychiatry of the World Federation of Societies of Biological Psychiatry
Q88574025Characterization of 3 Novel Tau Radiopharmaceuticals, 11C-RO-963, 11C-RO-643, and 18F-RO-948, in Healthy Controls and in Alzheimer Subjects
Q53390673Cognition and anatomy of adult Niemann-Pick disease type C: Insights for the Alzheimer field.
Q51825935Cognitive Domain Dispersion Association with Alzheimer's Disease Pathology.
Q47658947Comparing 18F-AV-1451 with CSF t-tau and p-tau for diagnosis of Alzheimer disease
Q38739937Comparison of multiple tau-PET measures as biomarkers in aging and Alzheimer's disease
Q45752126Considerations and code for partial volume correcting [18F]-AV-1451 tau PET data
Q47285480Continuous measurement of object location memory is sensitive to effects of age and mild cognitive impairment and related to medial temporal lobe volume.
Q90214060Correlation of In Vivo [18F]Flortaucipir With Postmortem Alzheimer Disease Tau Pathology
Q83228796Cortical tau deposition follows patterns of entorhinal functional connectivity in aging
Q55003313Cross-sectional and longitudinal atrophy is preferentially associated with tau rather than amyloid β positron emission tomography pathology.
Q58120970Data-driven approaches for tau-PET imaging biomarkers in Alzheimer's disease
Q64058197Deep and Frequent Phenotyping study protocol: an observational study in prodromal Alzheimer's disease
Q38803637Defining imaging biomarker cut points for brain aging and Alzheimer's disease
Q58552911Dendritic spine remodeling accompanies Alzheimer's disease pathology and genetic susceptibility in cognitively normal aging
Q47619556Dendritic spines provide cognitive resilience against Alzheimer's disease
Q58706105Detection of Alzheimer's Disease
Q47824973Development of tau PET Imaging Ligands and their Utility in Preclinical and Clinical Studies.
Q57493164Discriminative Accuracy of [18F]flortaucipir Positron Emission Tomography for Alzheimer Disease vs Other Neurodegenerative Disorders
Q92265910Dissociable age and memory relationships with hippocampal subfield volumes in vivo:Data from the Irish Longitudinal Study on Ageing (TILDA)
Q90725338Dissociation of Tau Deposits and Brain Atrophy in Early Alzheimer's Disease: A Combined Positron Emission Tomography/Magnetic Resonance Imaging Study
Q38383420Distinct white matter injury associated with medial temporal lobe atrophy in Alzheimer's versus semantic dementia
Q92521608Down syndrome and Alzheimer's disease: common molecular traits beyond the amyloid precursor protein
Q92402592Effect of Off-Target Binding on 18F-Flortaucipir Variability in Healthy Controls Across the Life Span
Q91274849Effective connectivity in the default mode network is distinctively disrupted in Alzheimer's disease-A simultaneous resting-state FDG-PET/fMRI study
Q64998560Effects of amyloid pathology and neurodegeneration on cognitive change in cognitively normal adults.
Q46766203Elevated 18F-AV-1451 PET tracer uptake detected in incidental imaging findings
Q55311648Elevated medial temporal lobe and pervasive brain tau-PET signal in normal participants.
Q46075858Entorhinal tau pathology, episodic memory decline and neurodegeneration in aging.
Q64051857Epigenetic dysregulation of enhancers in neurons is associated with Alzheimer's disease pathology and cognitive symptoms
Q99412193Error propagation analysis of seven partial volume correction algorithms for [18F]THK-5351 brain PET imaging
Q64965222Evaluation of 18F-RO-948 PET for Quantitative Assessment of Tau Accumulation in the Human Brain.
Q42330310Evaluation of Tau Imaging in Staging Alzheimer Disease and Revealing Interactions Between β-Amyloid and Tauopathy
Q104463890Evaluation of a visual interpretation method for tau-PET with 18F-flortaucipir
Q41654319Evolution of neurodegeneration-imaging biomarkers from clinically normal to dementia in the Alzheimer disease spectrum
Q47353532Extracellular Vesicle Biology in Alzheimer's Disease and Related Tauopathy
Q39447040Extracellular Vesicles Containing P301L Mutant Tau Accelerate Pathological Tau Phosphorylation and Oligomer Formation but Do Not Seed Mature Neurofibrillary Tangles in ALZ17 Mice
Q64115558F-Flortaucipir in TDP-43 associated frontotemporal dementia
Q61804682F-flortaucipir (AV-1451) tau PET in frontotemporal dementia syndromes
Q47684719Flortaucipir tau PET imaging in semantic variant primary progressive aphasia
Q48284478Fluorodeoxyglucose metabolism associated with tau-amyloid interaction predicts memory decline
Q87865855Following the pathway to Alzheimer's disease
Q38663636Four Decades of Research in Alzheimer's Disease (1975-2014): A Bibliometric and Scientometric Analysis
Q92740033Functional brain architecture is associated with the rate of tau accumulation in Alzheimer's disease
Q91635608Functional connectivity associated with tau levels in ageing, Alzheimer's, and small vessel disease
Q31162702Future Directions in Imaging Neurodegeneration
Q90228188Genetic characterization of amyloid-β and tau network spread
Q90059833Genomic deletion of TLR2 induces aggravated white matter damage and deteriorated neurobehavioral functions in mouse models of Alzheimer's disease
Q45303896Gray matter asymmetries in aging and neurodegeneration: A review and meta-analysis
Q90707233Head-to-head comparison of tau positron emission tomography tracers [18F]flortaucipir and [18F]RO948
Q30100986Hierarchical Organization of Tau and Amyloid Deposits in the Cerebral Cortex
Q90196747Higher CSF Tau Levels Are Related to Hippocampal Hyperactivity and Object Mnemonic Discrimination in Older Adults
Q91961758Hippocampal [18F]flortaucipir BPND corrected for possible spill-in of the choroid plexus retains strong clinico-pathological relationships
Q37377931Hippocampal phospho-tau/MAPT neuropathology in the fornix in Alzheimer disease: an immunohistochemical autopsy study
Q60950130Imaging and Molecular Mechanisms of Alzheimer's Disease: A Review
Q49957645Imaging tau and amyloid-β proteinopathies in Alzheimer disease and other conditions.
Q39419877Imaging tau pathology in Parkinsonisms
Q91692580Imaging the aged brain: pertinence and methods
Q91860896Imaging the evolution and pathophysiology of Alzheimer disease
Q37096041In Vivo Tau, Amyloid, and Gray Matter Profiles in the Aging Brain
Q48687926In Vivo cortical tau in Parkinson's disease using 18F-AV-1451 positron emission tomography.
Q64228804In vivo evidence for pre-symptomatic neuroinflammation in a MAPT mutation carrier
Q90697133Influence of tau PET, amyloid PET, and hippocampal volume on cognition in Alzheimer disease
Q91959371Intra-individual correlations between quantitative THK-5351 PET and MRI-derived cortical volume in Alzheimer's disease differ according to disease severity and amyloid positivity
Q89688294Is tau in the absence of amyloid on the Alzheimer's continuum?: A study of discordant PET positivity
Q50422287Joint associations of β-amyloidosis and cortical thickness with cognition.
Q36970036Labeling Pathological Tau: An Important Quest for the Unknown
Q55254017Large inter- and intra-case variability of first generation tau PET ligand binding in neurodegenerative dementias.
Q92920915Linking Molecular Pathways and Large-Scale Computational Modeling to Assess Candidate Disease Mechanisms and Pharmacodynamics in Alzheimer's Disease
Q46682283Local and distant relationships between amyloid, tau and neurodegeneration in Alzheimer's Disease
Q50026423Locus coeruleus integrity in old age is selectively related to memories linked with salient negative events.
Q51758098Longitudinal accrual of neocortical amyloid burden is associated with microstructural changes of the fornix in cognitively normal adults.
Q50531762Longitudinal and cross-sectional structural magnetic resonance imaging correlates of AV-1451 uptake.
Q50583370Longitudinal changes of tau PET imaging in relation to hypometabolism in prodromal and Alzheimer's disease dementia.
Q51763159Longitudinal tau PET in ageing and Alzheimer's disease.
Q50061690MAO-B Inhibitors Do Not Block In Vivo Flortaucipir([(18)F]-AV-1451) Binding.
Q92649166MRI-Driven PET Image Optimization for Neurological Applications
Q26744646Magnetic Resonance Imaging to Detect Early Molecular and Cellular Changes in Alzheimer's Disease
Q50531249Metabolic brain networks in aging and preclinical Alzheimer's disease.
Q97521007Mini Review: Opposing Pathologies in Cancer and Alzheimer's Disease: Does the PI3K/Akt Pathway Provide Clues?
Q47308968Modeling Prion-Like Processing of Tau Protein in Alzheimer's Disease for Pharmaceutical Development
Q89918248Modelling prognostic trajectories of cognitive decline due to Alzheimer's disease
Q54946040Molecular biomarkers of Alzheimer's disease: progress and prospects.
Q95841093Mosaic Somatic Gene Recombination as a Potentially Unifying Hypothesis for Alzheimer's Disease
Q39346750Multimodal PET Imaging of Amyloid and Tau Pathology in Alzheimer Disease and Non-Alzheimer Disease Dementias
Q52589491NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease.
Q47190278Networks of tau distribution in Alzheimer's disease
Q55407312Neural correlates of episodic memory in the Memento cohort.
Q90095665Neuroanatomical spread of amyloid β and tau in Alzheimer's disease: implications for primary prevention
Q33907524Neurodegenerative disease: MRI biomarkers - a precision medicine tool in neurology?
Q90418013Neurofilament relates to white matter microstructure in older adults
Q58105827Neurogenetic contributions to amyloid beta and tau spreading in the human cortex
Q92591097Neuroimaging Biomarkers for Alzheimer's Disease
Q38646263Neuroimaging in aging: brain maintenance
Q87906376Neuronal Cell Death
Q64910410Neuropathologic Correlates of Psychiatric Symptoms in Alzheimer's Disease.
Q90244120Neurophysiological signatures in Alzheimer's disease are distinctly associated with TAU, amyloid-β accumulation, and cognitive decline
Q46566966PET Imaging of Tau Pathology and Relationship to Amyloid, Longitudinal MRI, and Cognitive Change in Down Syndrome: Results from the Down Syndrome Biomarker Initiative (DSBI).
Q38628805PET Tau and Amyloid-β Burden in Mild Alzheimer's Disease: Divergent Relationship with Age, Cognition, and Cerebrospinal Fluid Biomarkers
Q100490934PET amyloid in normal aging: direct comparison of visual and automatic processing methods
Q89642986PET and SPECT imaging of the brain: a review on the current status of nuclear medicine in Japan
Q51766173PET imaging of tau protein targets: a methodology perspective.
Q59544083PET staging of amyloidosis using striatum
Q90658867Parametric methods for [18F]flortaucipir PET
Q64062247Pathological Tau From Alzheimer's Brain Induces Site-Specific Hyperphosphorylation and SDS- and Reducing Agent-Resistant Aggregation of Tau
Q48389127Pathological correlations of [F-18]-AV-1451 imaging in non-alzheimer tauopathies
Q50054598Perspectives on How Human Simultaneous Multi-Modal Imaging Adds Directionality to Spread Models of Alzheimer's Disease.
Q38896981Phases of Hyperconnectivity and Hypoconnectivity in the Default Mode and Salience Networks Track with Amyloid and Tau in Clinically Normal Individuals
Q52969704Picture imperfect: Going beyond imaging amyloid in Alzheimer's disease.
Q47279644Pittsburgh Compound B and AV-1451 positron emission tomography assessment of molecular pathologies of Alzheimer's disease in progressive supranuclear palsy
Q64255065Positron emission tomography of tau in Iraq and Afghanistan Veterans with blast neurotrauma
Q92970068Precision Aging: Applying Precision Medicine to the Field of Cognitive Aging
Q64890013Preserved Structural Network Organization Mediates Pathology Spread in Alzheimer's Disease Spectrum Despite Loss of White Matter Tract Integrity.
Q91882184Prevalence of Biologically vs Clinically Defined Alzheimer Spectrum Entities Using the National Institute on Aging-Alzheimer's Association Research Framework
Q46311193Probing the correlation of neuronal loss, neurofibrillary tangles, and cell death markers across the Alzheimer's disease Braak stages: a quantitative study in humans
Q92707326Progressive Tau Accumulation in Alzheimer Disease: 2-Year Follow-up Study
Q90591155Protein transmission in neurodegenerative disease
Q40259674Quantification of Tau Load Using [(18)F]AV1451 PET.
Q39002052Quantifying the accretion of hyperphosphorylated tau in the locus coeruleus and dorsal raphe nucleus: the pathological building blocks of early Alzheimer's disease.
Q64993260Quantitative 18F-AV1451 Brain Tau PET Imaging in Cognitively Normal Older Adults, Mild Cognitive Impairment, and Alzheimer's Disease Patients.
Q57800439Questions concerning the role of amyloid-β in the definition, aetiology and diagnosis of Alzheimer's disease
Q92972077Qß Virus-like particle-based vaccine induces robust immunity and protects against tauopathy
Q39303669Radiological biomarkers for diagnosis in PSP: Where are we and where do we need to be?
Q36311817Raman Spectrometric Detection Methods for Early and Non-Invasive Diagnosis of Alzheimer's Disease
Q52670912Recent neuroimaging, neurophysiological, and neuropathological advances for the understanding of NPC.
Q49310065Reconsideration of Amyloid Hypothesis and Tau Hypothesis in Alzheimer's Disease.
Q47607239Region-Specific Association of Subjective Cognitive Decline With Tauopathy Independent of Global β-Amyloid Burden
Q60301491Regional tau pathology and loneliness in cognitively normal older adults
Q90732288Regional times to equilibria and their impact on semi-quantification of [18F]AV-1451 uptake
Q62830982Relationships Between Tau and Glucose Metabolism Reflect Alzheimer’s Disease Pathology in Cognitively Normal Older Adults
Q37739881Relationships between flortaucipir PET tau binding and amyloid burden, clinical diagnosis, age and cognition
Q91577860Scan-Time Corrections for 80-100-min Standardizetd Uptake Volume Ratios to Measure the 18F-AV-1451 Tracer for Tau Imaging
Q58092575Secondary prevention of Alzheimer's dementia: neuroimaging contributions
Q40277605Selective impairment of hippocampus and posterior hub areas in Alzheimer's disease: an MEG-based multiplex network study
Q92825260Sleep as a Potential Biomarker of Tau and β-Amyloid Burden in the Human Brain
Q38871392Sleep: A Novel Mechanistic Pathway, Biomarker, and Treatment Target in the Pathology of Alzheimer's Disease?
Q47926474Small-molecule PET Tracers for Imaging Proteinopathies
Q62830996Spatially Adaptive Varying Correlation Analysis for Multimodal Neuroimaging Data
Q95840152Spread of pathological tau proteins through communicating neurons in human Alzheimer's disease
Q47869824Spread of tau deposits: can we trust in vivo findings?
Q55431921Staging of amyloid β, t-tau, regional atrophy rates, and cognitive change in a nondemented cohort: Results of serial mediation analyses.
Q49165313Static and Dynamic Cognitive Reserve Proxy Measures: Interactions with Alzheimer's Disease Neuropathology and Cognition.
Q48102802Structural tract alterations predict downstream tau accumulation in amyloid-positive older individuals
Q46683905Subjective cognitive decline and β-amyloid burden predict cognitive change in healthy elderly
Q62830975Subthreshold Amyloid Predicts Tau Deposition in Aging
Q53398002Synaptic Tau Seeding Precedes Tau Pathology in Human Alzheimer's Disease Brain.
Q64054848Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models
Q62492915Tau Accumulation in Clinically Normal Older Adults Is Associated with Hippocampal Hyperactivity
Q39016306Tau Imaging in Alzheimer's Disease Diagnosis and Clinical Trials
Q90402876Tau PET Imaging for Staging of Alzheimer's Disease in Down Syndrome
Q48027609Tau PET and tauopathies
Q91011085Tau PET imaging in neurodegenerative tauopathies-still a challenge
Q47985518Tau PET imaging predicts cognition in atypical variants of Alzheimer's disease.
Q34680852Tau PET imaging: present and future directions
Q46634925Tau PET: the next frontier in molecular imaging of dementia
Q37731919Tau Pathology Distribution in Alzheimer's disease Corresponds Differentially to Cognition-Relevant Functional Brain Networks
Q64903876Tau Phosphorylation Rates Measured by Mass Spectrometry Differ in the Intracellular Brain vs. Extracellular Cerebrospinal Fluid Compartments and Are Differentially Affected by Alzheimer's Disease.
Q39365272Tau Positron Emission Tomographic Imaging in the Lewy Body Diseases
Q90610537Tau Positron Emission Tomography Binding Is Not Elevated in HIV-Infected Individuals
Q94393283Tau and Pet/Mri Imaging Biomarkers for Detecting and Diagnosing Early Dementia
Q48234728Tau and amyloid β proteins distinctively associate to functional network changes in the aging brain
Q92221490Tau and atrophy: domain-specific relationships with cognition
Q41700392Tau and β-Amyloid Are Associated with Medial Temporal Lobe Structure, Function, and Memory Encoding in Normal Aging.
Q47886903Tau burden and the functional connectome in Alzheimer's disease and progressive supranuclear palsy.
Q64071535Tau covariance patterns in Alzheimer's disease patients match intrinsic connectivity networks in the healthy brain
Q90950184Tau deposition is associated with functional isolation of the hippocampus in aging
Q64982207Tau impairs neural circuits, dominating amyloid-β effects, in Alzheimer models in vivo.
Q46008245Tau pathology and neurodegeneration contribute to cognitive impairment in Alzheimer's disease.
Q90089071Tau pathology in cognitively normal older adults
Q55416644Tau positron emission tomography imaging in tauopathies: The added hurdle of off-target binding.
Q47987344Tau, amyloid, and cascading network failure across the Alzheimer's disease spectrum
Q38990773Tau-PET uptake: Regional variation in average SUVR and impact of amyloid deposition
Q47689697Tau-based therapies in neurodegeneration: opportunities and challenges
Q38633337Tau-imaging in neurodegeneration
Q93018917The "rights" of precision drug development for Alzheimer's disease
Q31147579The Alzheimer's Disease Neuroimaging Initiative 3: Continued innovation for clinical trial improvement
Q61799060The Amazon rain forest plant Uncaria tomentosa (cat's claw) and its specific proanthocyanidin constituents are potent inhibitors and reducers of both brain plaques and tangles
Q46251905The Amygdala as a Locus of Pathologic Misfolding in Neurodegenerative Diseases
Q64109964The BIN1 rs744373 SNP is associated with increased tau-PET levels and impaired memory
Q88784001The Influence of Dopamine on Cognitive Flexibility Is Mediated by Functional Connectivity in Young but Not Older Adults
Q92187844The MAPT H1 Haplotype Is a Risk Factor for Alzheimer's Disease in APOE ε4 Non-carriers
Q52589490The National Institute on Aging and the Alzheimer's Association Research Framework for Alzheimer's disease: Perspectives from the Research Roundtable.
Q55437462The Relation Between Brain Amyloid Deposition, Cortical Atrophy, and Plasma Biomarkers in Amnesic Mild Cognitive Impairment and Alzheimer's Disease.
Q49322919The association between tau PET and retrospective cortical thinning in clinically normal elderly.
Q90006715The bivariate distribution of amyloid-β and tau: relationship with established neurocognitive clinical syndromes
Q56594907The development and validation of tau PET tracers: current status and future directions
Q42701971The emerging role of PET imaging in dementia.
Q90484535The impact of amyloid-beta and tau on prospective cognitive decline in older individuals
Q39004340The road to restoring neural circuits for the treatment of Alzheimer's disease
Q58725042The role of microglia in processing and spreading of bioactive tau seeds in Alzheimer's disease
Q33695122Time to Amyloid Positivity and Preclinical Changes in Brain Metabolism, Atrophy, and Cognition: Evidence for Emerging Amyloid Pathology in Alzheimer's Disease
Q55463444Topographic staging of tau positron emission tomography images.
Q93087930Topographical Heterogeneity of Alzheimer's Disease Based on MR Imaging, Tau PET, and Amyloid PET
Q38382307Typical and atypical appearance of early-onset Alzheimer's disease: A clinical, neuroimaging and neuropathological study
Q50193680Uptake of AV-1451 in meningiomas.
Q36871202What amyloid ligands can tell us about molecular polymorphism and disease
Q93000468White matter alterations in early-stage Alzheimer's disease: A tract-specific study
Q37707241Whole Genome Expression Analysis in a Mouse Model of Tauopathy Identifies MECP2 as a Possible Regulator of Tau Pathology.
Q47330246Widespread brain tau and its association with ageing, Braak stage and Alzheimer's dementia
Q57192742Widespread distribution of tauopathy in preclinical Alzheimer's disease
Q53397590[11C]PK11195 binding in Alzheimer disease and progressive supranuclear palsy.
Q41350096[18 F]AV-1451 tau positron emission tomography in progressive supranuclear palsy
Q90173686[18F]-AV-1451 tau PET imaging in Alzheimer's disease and suspected non-AD tauopathies using a late acquisition time window
Q47547648[18F]-THK5351 PET Correlates with Topology and Symptom Severity in Progressive Supranuclear Palsy.
Q47252490[18F]AV-1451 binding in vivo mirrors the expected distribution of TDP-43 pathology in the semantic variant of primary progressive aphasia.
Q50103609[Biomarker-based diagnostics of Alzheimer's disease : Concept of suspected non-Alzheimer pathology].
Q47694602[F-18]-AV-1451 binding correlates with postmortem neurofibrillary tangle Braak staging
Q42360584[F-18]AV-1451 positron emission tomography retention in choroid plexus: More than "off-target" binding
Q64261988rs242557 variant is associated with hippocampus tau uptake on F-AV-1451 PET in non-demented elders

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