On the selectivity of neuronal NOS inhibitors

scientific article published on March 2013

On the selectivity of neuronal NOS inhibitors is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1111/BPH.12016
P932PMC publication ID3594681
P698PubMed publication ID23072468
P5875ResearchGate publication ID232276880

P50authorKrzysztof BartuśQ114079238
P2093author name stringB Pigott
J Garthwaite
P2860cites workPotent, Highly Selective, and Orally Bioavailable Gem -Difluorinated Monocationic Inhibitors of Neuronal Nitric Oxide SynthaseQ27664466
Intramolecular hydrogen bonding: A potential strategy for more bioavailable inhibitors of neuronal nitric oxide synthaseQ27677512
Nitric oxide synthases: structure, function and inhibitionQ28207668
Effects of cannabinoid receptor-2 activation on accelerated gastrointestinal transit in lipopolysaccharide-treated ratsQ28271665
Inhibition of phosphodiesterase 2 increases neuronal cGMP, synaptic plasticity and memory performanceQ28294344
The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholineQ29547539
Nitric oxide and macrophage functionQ29615327
The influence of nitric oxide synthase 1 on blood flow and interstitial nitric oxide in the kidneyQ30992238
Pre-synaptic NO-cGMP pathway modulates vagal control of heart rate in isolated adult guinea pig atriaQ31442574
Inhibition of nitric oxide synthase as a potential therapeutic targetQ33636670
Potent and selective neuronal nitric oxide synthase inhibitors with improved cellular permeabilityQ33638377
Guide to Receptors and Channels (GRAC), 5th editionQ34228968
Tonic and phasic nitric oxide signals in hippocampal long-term potentiation.Q34580308
Activities of 7-nitroindazole and 1-(2-(trifluoromethylphenyl)-imidazole independent of neuronal nitric-oxide synthase inhibitionQ34749486
Symmetric double-headed aminopyridines, a novel strategy for potent and membrane-permeable inhibitors of neuronal nitric oxide synthaseQ34770661
Effects of Cerebral Ischemia in Mice Deficient in Neuronal Nitric Oxide SynthaseQ71647466
Potent and selective inhibition of human nitric oxide synthases. Selective inhibition of neuronal nitric oxide synthase by S-methyl-L-thiocitrulline and S-ethyl-L-thiocitrullineQ71650800
The inhibitory potency and selectivity of arginine substrate site nitric-oxide synthase inhibitors is solely determined by their affinity toward the different isoenzymesQ73097957
Discovery and development of neuronal nitric oxide synthase inhibitorsQ74114991
N5-(1-Imino-3-butenyl)-L-ornithine. A neuronal isoform selective mechanism-based inactivator of nitric oxide synthaseQ74424557
Design of isoform-selective inhibitors of nitric oxide synthaseQ77297321
Discovery of cis-N-(1-(4-(methylamino)cyclohexyl)indolin-6-yl)thiophene-2-carboximidamide: a 1,6-disubstituted indoline derivative as a highly selective inhibitor of human neuronal nitric oxide synthase (nNOS) without any cardiovascular liabilitiesQ82994594
Modulation of the myogenic response in renal blood flow autoregulation by NO depends on endothelial nitric oxide synthase (eNOS), but not neuronal or inducible NOSQ84719163
The neuronal NO synthase participation in the peripheral antinociception mechanism induced by several analgesic drugsQ84850873
More than a retrograde messenger: nitric oxide needs two cGMP pathways to induce hippocampal long-term potentiation.Q34993540
Blocking NO synthesis: how, where and why?Q35013972
Central nicotinic acetylcholine receptor involved in Ca(2+) -calmodulin-endothelial nitric oxide synthase pathway modulated hypotensive effects.Q35130526
Amelioration of renal injury and oxidative stress by the nNOS inhibitor L-VNIO in the salt-sensitive mRen2.Lewis congenic rat.Q36013066
Enlarged infarcts in endothelial nitric oxide synthase knockout mice are attenuated by nitro-L-arginineQ36817052
Concepts of neural nitric oxide-mediated transmissionQ37029494
Discovery of highly potent and selective inhibitors of neuronal nitric oxide synthase by fragment hopping.Q37147032
A cellular model for screening neuronal nitric oxide synthase inhibitorsQ37207509
PP2B-dependent NO production in the medullary thick ascending limb during diabetesQ37298520
Analogues of 2-aminopyridine-based selective inhibitors of neuronal nitric oxide synthase with increased bioavailabilityQ37416111
The function of NO-sensitive guanylyl cyclase: what we can learn from genetic mouse modelsQ37563705
Picomolar nitric oxide signals from central neurons recorded using ultrasensitive detector cells.Q39455068
The effect of nNOS inhibitors on toxin-induced cell death in dopaminergic cell lines depends on the extent of enzyme expression.Q39511180
Guidelines for reporting experiments involving animals: the ARRIVE guidelinesQ39512979
Supersensitivity to the cyclic GMP response to glutamate during cerebellar maturationQ40173230
L-arginine binding to nitric-oxide synthase. The role of H-bonds to the nonreactive guanidinium nitrogensQ40932895
Induction and expression of GluA1 (GluR-A)-independent LTP in the hippocampusQ41502449
Differential effects of nitric oxide synthase inhibitors on endothelium-dependent and nitrergic nerve-mediated vasodilatation in the bovine ciliary arteryQ41786597
Cholecystokinin CCK2 receptors mediate the peptide's inhibitory actions on the contractile activity of human distal colon via the nitric oxide pathwayQ41811038
Hypertension in mice lacking the gene for endothelial nitric oxide synthaseQ42478091
Presynaptic nitric oxide/cGMP facilitates glutamate release via hyperpolarization-activated cyclic nucleotide-gated channels in the hippocampusQ42485358
Potent and selective inhibition of neuronal nitric oxide synthase by N omega-propyl-L-arginineQ42546131
1400W is a slow, tight binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivoQ42551195
The antinociceptive effect of 1-(2-trifluoromethylphenyl) imidazole (TRIM), a potent inhibitor of neuronal nitric oxide synthase in vitro, in the mouseQ42707876
Direct blockade of inflammatory hypernociception by peripheral A1 adenosine receptors: involvement of the NO/cGMP/PKG/KATP signaling pathwayQ42919200
Role of endothelial nitric oxide synthase in aggravation of indomethacin-induced gastric damage in adjuvant arthritic rats.Q43197254
The effects of phosphodiesterase inhibition on cyclic GMP and cyclic AMP accumulation in the hippocampus of the rat.Q43517525
Peripheral vagal control of heart rate is impaired in neuronal NOS knockout miceQ43799971
Enhanced neuronal nitric oxide synthase expression is central to cardiac vagal phenotype in exercise-trained miceQ44267764
The neuronal nitric oxide synthase inhibitor 7-nitroindazole also inhibits the monoamine oxidase-B-catalyzed oxidation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridineQ45104121
Roles of nitric oxide in the homeostatic control of the excitation-inhibition balance in rat visual cortical networks.Q45932639
The opposite roles of nNOS in cardiac ischemia-reperfusion-induced injury and in ischemia preconditioning-induced cardioprotection in miceQ46064498
Neuronal nitric oxide synthase activation is involved in insulin-mediated cardiovascular effects in the nucleus tractus solitarii of ratsQ46148829
Brown Norway rats show impaired nNOS-mediated information transfer in renal autoregulationQ46164237
Nitric oxide is a volume transmitter regulating postsynaptic excitability at a glutamatergic synapseQ46225669
Structure-activity relationship of novel and known inhibitors of human dimethylarginine dimethylaminohydrolase-1: alkenyl-amidines as new leads.Q46243381
Neuronal nitric-oxide synthase inhibition facilitates adrenergic neurotransmission in rat mesenteric resistance arteriesQ46763770
Tubuloglomerular feedback-dependent modulation of renal myogenic autoregulation by nitric oxideQ46809194
mRNA expression patterns of the cGMP‐hydrolyzing phosphodiesterases types 2, 5, and 9 during development of the rat brainQ47378008
Norepinephrine increases cyclic GMP levels in cerebellar cells from neuronal nitric oxide synthase knockout miceQ47903375
NMDA receptor activation in rat hippocampus induces cyclic GMP formation through the l-arginine-nitric oxide pathwayQ48795375
Excitatory amino acid receptors and guanosine 3',5'-cyclic monophosphate in incubated slices of immature and adult rat cerebellumQ48894532
Nanomolar N(G)-nitroarginine inhibits NMDA-induced cyclic GMP formation in rat cerebellumQ48919196
The selective neuronal NO synthase inhibitor 7-nitro-indazole blocks both long-term potentiation and depotentiation of field EPSPs in rat hippocampal CA1 in vivo.Q51584368
Targeted disruption of the neuronal nitric oxide synthase gene.Q52507290
NMDA receptor activation induces nitric oxide synthesis from arginine in rat brain slicesQ69359908
P433issue5
P407language of work or nameEnglishQ1860
P304page(s)1255-1265
P577publication date2013-03-01
P1433published inBritish Journal of PharmacologyQ919631
P1476titleOn the selectivity of neuronal NOS inhibitors
P478volume168

Reverse relations

cites work (P2860)
Q33668740Association of endothelial nitric oxide synthase polymorphisms with an increased risk of erectile dysfunction
Q89952047Correction of arginine metabolism with sepiapterin-the precursor of nitric oxide synthase cofactor BH4-induces immunostimulatory-shift of breast cancer
Q37575908Inducible nitric oxide synthase inhibits oxygen consumption in collateral-dependent myocardium
Q41815879Nitric Oxide Is Required for L-Type Ca(2+) Channel-Dependent Long-Term Potentiation in the Hippocampus
Q42467382Nitric oxide targets oligodendrocytes and promotes their morphological differentiation
Q37150793Nitric oxide-dependent long-term depression but not endocannabinoid-mediated long-term potentiation is crucial for visual recognition memory
Q41087764Preinduction of heat shock protein 70 protects mice against post-infection irritable bowel syndrome via NF-κB and NOS/NO signaling pathways
Q64080512Reduced Basal Nitric Oxide Production Induces Precancerous Mammary Lesions via ERBB2 and TGFβ
Q39103641Targeting neuronal nitric oxide synthase as a valuable strategy for the therapy of neurological disorders
Q100443906nNOS-expressing interneurons control basal and behaviorally evoked arterial dilation in somatosensory cortex of mice

Search more.