Effect of ceritinib (LDK378) on enhancement of chemotherapeutic agents in ABCB1 and ABCG2 overexpressing cells in vitro and in vivo

scientific article published on 9 November 2015

Effect of ceritinib (LDK378) on enhancement of chemotherapeutic agents in ABCB1 and ABCG2 overexpressing cells in vitro and in vivo is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.18632/ONCOTARGET.5989
P932PMC publication ID4792582
P698PubMed publication ID26556876
P5875ResearchGate publication ID283717977

P2093author name stringFang Wang
Xu Zhang
Meng Xu
Jing Hu
Ke Yang
Qingshan Li
Xiaokun Wang
Kenneth K W To
Liwu Fu
P2860cites workHuman ATP-binding cassette (ABC) transporter familyQ21245457
Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell lineQ24338329
Apatinib (YN968D1) reverses multidrug resistance by inhibiting the efflux function of multiple ATP-binding cassette transportersQ24617999
The ALK Inhibitor Ceritinib Overcomes Crizotinib Resistance in Non-Small Cell Lung CancerQ27682565
Ceritinib in ALK-rearranged non-small-cell lung cancerQ27852989
Vandetanib (Zactima, ZD6474) antagonizes ABCC1- and ABCG2-mediated multidrug resistance by inhibition of their transport functionQ28475378
Targeting multidrug resistance in cancerQ29616803
Molecular cloning of cDNAs which are highly overexpressed in mitoxantrone-resistant cells: demonstration of homology to ABC transport genesQ31932176
The HER tyrosine kinase inhibitor CI1033 enhances cytotoxicity of 7-ethyl-10-hydroxycamptothecin and topotecan by inhibiting breast cancer resistance protein-mediated drug effluxQ32046906
Mutations at amino-acid 482 in the ABCG2 gene affect substrate and antagonist specificity.Q33194953
Imatinib mesylate (STI571) is a substrate for the breast cancer resistance protein (BCRP)/ABCG2 drug pumpQ33204719
Anthracenedione derivative 1403P-3 induces apoptosis in KB and KBv200 cells via reactive oxygen species-independent mitochondrial pathway and death receptor pathwayQ33296974
Biochemical, cellular, and pharmacological aspects of the multidrug transporterQ33636699
Interaction of tyrosine kinase inhibitors with the human multidrug transporter proteins, MDR1 and MRP1.Q34135435
Role of ABCG2/BCRP in biology and medicineQ34482976
Inhibition of P-glycoprotein (ABCB1)- and multidrug resistance-associated protein 1 (ABCC1)-mediated transport by the orally administered inhibitor, CBT-1((R)).Q34743441
Activation of the PI3K/Akt pathway and chemotherapeutic resistanceQ35046899
Afatinib circumvents multidrug resistance via dually inhibiting ATP binding cassette subfamily G member 2 in vitro and in vivoQ35067898
ABC transporter architecture and mechanism: implications from the crystal structures of BtuCD and BtuF.Q35757366
Crizotinib (PF-02341066) reverses multidrug resistance in cancer cells by inhibiting the function of P-glycoproteinQ36166672
Role of the breast cancer resistance protein (ABCG2) in drug transportQ36250753
The molecular basis of multidrug resistance in cancer: the early years of P-glycoprotein researchQ36365560
ZD6474 reverses multidrug resistance by directly inhibiting the function of P-glycoproteinQ36611278
Lapatinib (Tykerb, GW572016) reverses multidrug resistance in cancer cells by inhibiting the activity of ATP-binding cassette subfamily B member 1 and G member 2Q37119716
ERK activation by thymosin-beta-4 (TB4) overexpression induces paclitaxel-resistanceQ38510908
Nilotinib (AMN107, Tasigna) reverses multidrug resistance by inhibiting the activity of the ABCB1/Pgp and ABCG2/BCRP/MXR transportersQ39854362
Sensitization of ABCG2-overexpressing cells to conventional chemotherapeutic agent by sunitinib was associated with inhibiting the function of ABCG2.Q39881351
Akt and XIAP regulate the sensitivity of human uterine cancer cells to cisplatin, doxorubicin and taxolQ40036920
Erlotinib (Tarceva, OSI-774) antagonizes ATP-binding cassette subfamily B member 1 and ATP-binding cassette subfamily G member 2-mediated drug resistanceQ40050525
The calcium channel blockers, 1,4-dihydropyridines, are substrates of the multidrug resistance-linked ABC drug transporter, ABCG2.Q40254927
Reversal of MDR1/P-glycoprotein-mediated multidrug resistance by vector-based RNA interference in vitro and in vivoQ40345597
Gefitinib, an EGFR tyrosine kinase inhibitor, directly inhibits the function of P-glycoprotein in multidrug resistant cancer cells.Q40410062
Reversal of P-gp mediated multidrug resistance in-vitro and in-vivo by FG020318.Q40530013
Fumitremorgin C reverses multidrug resistance in cells transfected with the breast cancer resistance protein.Q40904151
Synthesis, structure-activity relationships, and in vivo efficacy of the novel potent and selective anaplastic lymphoma kinase (ALK) inhibitor 5-chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,Q42710837
Mechanisms of multidrug resistance in HL60 cells. Analysis of resistance associated membrane proteins and levels of mdr gene expressionQ42815260
Drug-stimulatable ATPase activity in crude membranes of human MDR1-transfected mammalian cellsQ42827076
HER2/PI-3K/Akt activation leads to a multidrug resistance in human breast adenocarcinoma cells.Q44450066
Characterization of tetrandrine, a potent inhibitor of P-glycoprotein-mediated multidrug resistanceQ44687014
Screening novel, potent multidrug-resistant modulators from imidazole derivativesQ45011364
P433issue42
P407language of work or nameEnglishQ1860
P921main subjectchemotherapyQ974135
ceritinibQ21011233
overexpressionQ61643320
P304page(s)44643-44659
P577publication date2015-11-09
P1433published inOncotargetQ1573155
P1476titleEffect of ceritinib (LDK378) on enhancement of chemotherapeutic agents in ABCB1 and ABCG2 overexpressing cells in vitro and in vivo
P478volume6

Reverse relations

cites work (P2860)
Q37563366ABCG2-overexpressing H460/MX20 cell xenografts in athymic nude mice maintained original biochemical and cytological characteristics
Q41576686Acacetin enhances the therapeutic efficacy of doxorubicin in non-small-cell lung carcinoma cells
Q37739472Alectinib (CH5424802) antagonizes ABCB1- and ABCG2-mediated multidrug resistance in vitro, in vivo and ex vivo
Q89145785Clinical Pharmacokinetics of Anaplastic Lymphoma Kinase Inhibitors in Non-Small-Cell Lung Cancer
Q93032460Reversal effect of FW-04-806, a macrolide dilactone compound, on multidrug resistance mediated by ABCB1 and ABCG2 in vitro and in vivo
Q46316359Structure Identification and In Vitro Anticancer Activity of Lathyrol-3-phenylacetate-5,15-diacetate
Q49888021Tyrosine kinase inhibitors enhanced the efficacy of conventional chemotherapeutic agent in multidrug resistant cancer cells.