RAS/MAPK Activation Is Associated with Reduced Tumor-Infiltrating Lymphocytes in Triple-Negative Breast Cancer: Therapeutic Cooperation Between MEK and PD-1/PD-L1 Immune Checkpoint Inhibitors

scientific article published on 29 October 2015

RAS/MAPK Activation Is Associated with Reduced Tumor-Infiltrating Lymphocytes in Triple-Negative Breast Cancer: Therapeutic Cooperation Between MEK and PD-1/PD-L1 Immune Checkpoint Inhibitors is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1158/1078-0432.CCR-15-1125
P932PMC publication ID4794351
P698PubMed publication ID26515496

P50authorSherene LoiQ42315566
Phillip K. DarcyQ42683557
Henry Leonidas GómezQ43270076
Mónica Valeria EstradaQ56851379
Roberto C Salgado-DelgadoQ87734996
Justin M. BalkoQ90244216
Paul A BeavisQ90856136
Simon A. MallalQ91272953
Sathana DushyanthenQ96251208
P2093author name stringKai Wang
Carsten Denkert
David L Rimm
Vincent A Miller
Carlos L Arteaga
Phil J Stephens
Sergey V Ryzhov
Melinda E Sanders
Peter Savas
Rebecca S Cook
Violeta Sánchez
Susan Combs
Roman Yelensky
Jennifer M Giltnane
Franco D Doimi
Mark A Pilkinton
P2860cites workComprehensive molecular portraits of human breast tumoursQ24630844
Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in CancerQ24633070
Safety and Activity of Anti–PD-L1 Antibody in Patients with Advanced CancerQ27860857
Ipilimumab plus dacarbazine for previously untreated metastatic melanomaQ28131634
PD-1 Blockade in Tumors with Mismatch-Repair DeficiencyQ28262647
The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics dataQ28266682
Combined Nivolumab and Ipilimumab or Monotherapy in Untreated MelanomaQ29615443
Activation of MAPK pathways due to DUSP4 loss promotes cancer stem cell-like phenotypes in basal-like breast cancerQ33875120
A public genome-scale lentiviral expression library of human ORFsQ33943308
Prognostic value of tumor-infiltrating lymphocytes in triple-negative breast cancers from two phase III randomized adjuvant breast cancer trials: ECOG 2197 and ECOG 1199.Q34172008
Expression of programmed death ligand 1 (PD-L1) is associated with poor prognosis in human breast cancerQ34270064
PD-L1 Expression Correlates with Tumor-Infiltrating Lymphocytes and Response to Neoadjuvant Chemotherapy in Breast CancerQ34454922
Multiplexed quantitative analysis of CD3, CD8, and CD20 predicts response to neoadjuvant chemotherapy in breast cancerQ34616067
The B7-H1 (PD-L1) T lymphocyte-inhibitory molecule is expressed in breast cancer patients with infiltrating ductal carcinoma: correlation with important high-risk prognostic factors.Q35052176
PD-L1 expression is increased in a subset of basal type breast cancer cellsQ35097436
Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumorsQ35906418
Improved antitumor activity of immunotherapy with BRAF and MEK inhibitors in BRAF(V600E) melanomaQ36612452
Mutant MHC class II epitopes drive therapeutic immune responses to cancerQ36817092
Molecular and genetic properties of tumors associated with local immune cytolytic activityQ36869059
Profiling of residual breast cancers after neoadjuvant chemotherapy identifies DUSP4 deficiency as a mechanism of drug resistanceQ36957198
CD73 promotes anthracycline resistance and poor prognosis in triple negative breast cancerQ36991010
(V600E)BRAF is associated with disabled feedback inhibition of RAF-MEK signaling and elevated transcriptional output of the pathwayQ37112466
The presence of programmed death 1 (PD-1)-positive tumor-infiltrating lymphocytes is associated with poor prognosis in human breast cancer.Q37451618
Prognostic value of tumor-infiltrating lymphocytes on residual disease after primary chemotherapy for triple-negative breast cancer: a retrospective multicenter studyQ37600494
Molecular profiling of the residual disease of triple-negative breast cancers after neoadjuvant chemotherapy identifies actionable therapeutic targetsQ37624234
PD-L1 expression in triple-negative breast cancerQ37724790
The evaluation of tumor-infiltrating lymphocytes (TILs) in breast cancer: recommendations by an International TILs Working Group 2014.Q39130461
MEK and EGFR inhibition demonstrate synergistic activity in EGFR-dependent NSCLC.Q39869672
Cancer cell-autonomous contribution of type I interferon signaling to the efficacy of chemotherapyQ42182888
Pivotal role of innate and adaptive immunity in anthracycline chemotherapy of established tumorsQ43546471
Tumor infiltrating lymphocytes are prognostic in triple negative breast cancer and predictive for trastuzumab benefit in early breast cancer: results from the FinHER trialQ43951696
Prognostic and predictive value of tumor-infiltrating lymphocytes in a phase III randomized adjuvant breast cancer trial in node-positive breast cancer comparing the addition of docetaxel to doxorubicin with doxorubicin-based chemotherapy: BIG 02-98Q46389190
Response to neoadjuvant therapy and long-term survival in patients with triple-negative breast cancerQ46771645
PD-L1 Expression and Tumor-Infiltrating Lymphocytes Define Different Subsets of MAPK Inhibitor-Treated Melanoma Patients.Q47573421
Automated subcellular localization and quantification of protein expression in tissue microarraysQ52030096
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectcooperationQ380962
triple-negative breast cancerQ7843332
P304page(s)1499-1509
P577publication date2015-10-29
P1433published inClinical Cancer ResearchQ332253
P1476titleRAS/MAPK Activation Is Associated with Reduced Tumor-Infiltrating Lymphocytes in Triple-Negative Breast Cancer: Therapeutic Cooperation Between MEK and PD-1/PD-L1 Immune Checkpoint Inhibitors
P478volume22

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cites work (P2860)
Q41918758A Comprehensive Review of Sequencing and Combination Strategies of Targeted Agents in Metastatic Colorectal Cancer
Q46894943A prognostic signature based on three-genes expression in triple-negative breast tumours with residual disease.
Q49721138Abundant tumor infiltrating lymphocytes after primary systemic chemotherapy predicts poor prognosis in estrogen receptor-positive/HER2-negative breast cancers
Q41701208Agonist immunotherapy restores T cell function following MEK inhibition improving efficacy in breast cancer
Q90023691Atezolizumab with or without cobimetinib versus regorafenib in previously treated metastatic colorectal cancer (IMblaze370): a multicentre, open-label, phase 3, randomised, controlled trial
Q57109579Autoantibodies as Potential Biomarkers in Breast Cancer
Q52679779BET proteins in abnormal metabolism, inflammation, and the breast cancer microenvironment.
Q92578246BRAFV600E-induced, tumor intrinsic PD-L1 can regulate chemotherapy-induced apoptosis in human colon cancer cells and in tumor xenografts
Q93335001Biological Consequences of MHC-II Expression by Tumor Cells in Cancer
Q38628198Breast Cancer Immunotherapy: Facts and Hopes
Q26745442Checkpoint Inhibitors and Their Application in Breast Cancer
Q38639746Clinical Validity and Utility of Tumor-Infiltrating Lymphocytes in Routine Clinical Practice for Breast Cancer Patients: Current and Future Directions
Q28072263Clinical impact of chemotherapy to improve tumor microenvironment of pancreatic cancer
Q38669465Clinical relevance of host immunity in breast cancer: from TILs to the clinic
Q60919807Clinical verification of the relationship between smoking and the immune microenvironment of breast cancer
Q38634557Combinatorial Therapies in Melanoma: MAPK Inhibitors and Beyond
Q89457550Comedications influence immune infiltration and pathological response to neoadjuvant chemotherapy in breast cancer
Q47217165Crk adaptor protein promotes PD-L1 expression, EMT and immune evasion in a murine model of triple-negative breast cancer
Q48231859DNA methyltransferase inhibition upregulates MHC-I to potentiate cytotoxic T lymphocyte responses in breast cancer
Q57071375Distribution of CD4 and CD8 exhausted tumor-infiltrating lymphocytes in molecular subtypes of Chinese breast cancer patients
Q42243444Dramatic response of metaplastic breast cancer to chemo-immunotherapy
Q65000057ERK is a Pivotal Player of Chemo-Immune-Resistance in Cancer.
Q55238772Effect of CCL5 expression in the recruitment of immune cells in triple negative breast cancer.
Q54978022Effect of aromatase inhibitor letrozole on the proliferation of spermatogonia by regulating the MAPK pathway.
Q41291930Effect of neoadjuvant chemotherapy on tumor-infiltrating lymphocytes and PD-L1 expression in breast cancer and its clinical significance.
Q50058145Emerging biomarkers for cancer immunotherapy in melanoma.
Q49710595Expression of MAGE-A and NY-ESO-1 cancer-testis antigens is enriched in triple-negative invasive breast cancers
Q55383509Extended Adjuvant Chemotherapy in Triple-Negative Breast Cancer.
Q60044568Gene code CD274/PD-L1: from molecular basis toward cancer immunotherapy
Q88684372Genetic, transcriptional and post-translational regulation of the programmed death protein ligand 1 in cancer: biology and clinical correlations
Q59800659Genomics of response to immune checkpoint therapies for cancer: implications for precision medicine
Q54965602How shall we treat early triple-negative breast cancer (TNBC): from the current standard to upcoming immuno-molecular strategies.
Q54947687Immune cell profiling in cancer: molecular approaches to cell-specific identification.
Q99408679Immunological Differences Between Immune-Rich Estrogen Receptor-Positive and Immune-Rich Triple-Negative Breast Cancers
Q53111596Immunotherapy for Colorectal Cancer
Q92503954Immunotherapy in breast cancer
Q99551766Immunotyping of tumor-infiltrating lymphocytes in triple-negative breast cancer and genetic characterization
Q90468395Inhibition of MEK with trametinib enhances the efficacy of anti-PD-L1 inhibitor by regulating anti-tumor immunity in head and neck squamous cell carcinoma
Q64103583Interaction of host immunity with HER2-targeted treatment and tumor heterogeneity in HER2-positive breast cancer
Q92857735Is There a Place for Immunotherapy for Metastatic Microsatellite Stable Colorectal Cancer?
Q48269487Is there a role for single-agent MEK inhibition in melanoma?
Q26751520KRAS Mutant Pancreatic Cancer: No Lone Path to an Effective Treatment
Q50513362Learning from PD-1 Resistance: New Combination Strategies.
Q56889985MEK inhibitors for the treatment of NRAS mutant melanoma
Q37712385Mechanism of immune evasion in breast cancer
Q98771234Mechanisms of Cancer Resistance to Immunotherapy
Q52707883Mechanisms of Resistance to PD-1 and PD-L1 Blockade.
Q55347716Mechanisms of immune evasion in breast cancer.
Q92875307Mechanisms of immunogenicity in colorectal cancer
Q42513445Metalloprotease-dependent activation of EGFR modulates CD44+/CD24- populations in triple negative breast cancer cells through the MEK/ERK pathway.
Q37691434MicroRNA-29c-5p suppresses gallbladder carcinoma progression by directly targeting CPEB4 and inhibiting the MAPK pathway
Q57815585Molecular determinants of post-mastectomy breast cancer recurrence
Q41660755Morphological Evaluation of Tumor-Infiltrating Lymphocytes (TILs) to Investigate Invasive Breast Cancer Immunogenicity, Reveal Lymphocytic Networks and Help Relapse Prediction: A Retrospective Study.
Q58613793Mutational activation of the EGFR down-regulates MHC class I expression via the ERK in non-small cell lung cancer
Q34549227New Immunotherapy Strategies in Breast Cancer
Q33869781New insights into the role of EMT in tumor immune escape.
Q88952320OncoKB: A Precision Oncology Knowledge Base
Q39438805Overcoming Oncogenic Mediated Tumor Immunity in Prostate Cancer
Q90722217Oxidation Stress-Mediated MAPK Signaling Pathway Activation Induces Neuronal Loss in the CA1 and CA3 Regions of the Hippocampus of Mice Following Chronic Cold Exposure
Q64120108PD-L1 Expression in Human Breast Cancer Stem Cells Is Epigenetically Regulated through Posttranslational Histone Modifications
Q91713968PTPN2 phosphatase deletion in T cells promotes anti-tumour immunity and CAR T-cell efficacy in solid tumours
Q38818203Pharmacodynamic endpoints as clinical trial objectives to answer important questions in oncology drug development
Q47701712Precision Immuno-Oncology: Prospects of Individualized Immunotherapy for Pancreatic Cancer
Q57105411Precision medicine based on tumorigenic signaling pathways for triple-negative breast cancer
Q41545839Predictive and prognostic impact of tumour-infiltrating lymphocytes in triple-negative breast cancer treated with neoadjuvant chemotherapy
Q47101836Predictive factors of response to immunotherapy-a review from the Spanish Melanoma Group (GEM).
Q92425490Profiling molecular regulators of recurrence in chemorefractory triple-negative breast cancers
Q55238969Prognostic impact of tumor infiltrating lymphocytes on patients with metastatic urothelial carcinoma receiving platinum based chemotherapy.
Q94483697Proimmunogenic impact of MEK inhibition synergizes with agonist anti-CD40 immunostimulatory antibodies in tumor therapy
Q90321516Quantitative Spatial Profiling of PD-1/PD-L1 Interaction and HLA-DR/IDO-1 Predicts Improved Outcomes of Anti-PD-1 Therapies in Metastatic Melanoma
Q90720634Recent Advances in the Clinical Development of Immune Checkpoint Blockade Therapy for Mismatch Repair Proficient (pMMR)/non-MSI-H Metastatic Colorectal Cancer
Q93147363Recent Findings in the Regulation of Programmed Death Ligand 1 Expression
Q64059605Recent advances in triple negative breast cancer: the immunotherapy era
Q49887919Receptor tyrosine kinases and downstream pathways as druggable targets for cancer treatment: the current arsenal of inhibitors
Q52725238Regulation and Function of the PD-L1 Checkpoint.
Q92316377Regulation of Immunity in Breast Cancer
Q64887142Relationship between Tumor Infiltrating Lymphocytes and Progression in Breast Cancer.
Q98466646Resistance Mechanisms of Anti-PD1/PDL1 Therapy in Solid Tumors
Q45974765Rho GTPase effectors and NAD metabolism in cancer immune suppression.
Q37675926Surveilling the Potential for Precision Medicine-driven PD-1/PD-L1-targeted Therapy in HNSCC.
Q92404971TLR9 Mediated Tumor-Stroma Interactions in Human Papilloma Virus (HPV)-Positive Head and Neck Squamous Cell Carcinoma Up-Regulate PD-L1 and PD-L2
Q39125149Targeting A2 adenosine receptors in cancer
Q54977309Targeting Forkhead Box M1 Transcription Factor in Breast Cancer.
Q92349505Targeting the Interplay between Epithelial-to-Mesenchymal-Transition and the Immune System for Effective Immunotherapy
Q90677046The Immune Landscape in Women Cancers
Q90133583The Immune Microenvironment of Breast Cancer Progression
Q38621231The MEK inhibitor selumetinib complements CTLA-4 blockade by reprogramming the tumor immune microenvironment
Q101574526The cutting-edge progress of immune-checkpoint blockade in lung cancer
Q91709281The impact of systemic precision medicine and immunotherapy treatments on brain metastases
Q59807467The role of autophagy in the treatment of BRAF mutant colorectal carcinomas differs based on microsatellite instability status
Q57060145Therapeutic strategies to target RAS-mutant cancers
Q54979386Trastuzumab upregulates PD-L1 as a potential mechanism of trastuzumab resistance through engagement of immune effector cells and stimulation of IFNγ secretion.
Q56594845Trial watch: Immunogenic cell death induction by anticancer chemotherapeutics
Q33769821Triple-negative breast cancer: challenges and opportunities of a heterogeneous disease
Q28554412Tumor Infiltrating Lymphocytes Affect the Outcome of Patients with Operable Triple-Negative Breast Cancer in Combination with Mutated Amino Acid Classes
Q92266207Tumor intrinsic immunity related proteins may be novel tumor suppressors in some types of cancer
Q94475710Tumor mutational burden and immune signatures interplay in renal cell carcinoma
Q38734804Tumor-infiltrating lymphocytes and breast cancer: Beyond the prognostic and predictive utility.
Q61456224Tumor-specific MHC-II expression drives a unique pattern of resistance to immunotherapy via LAG-3/FCRL6 engagement
Q90644277Two may be better than one: PD-1/PD-L1 blockade combination approaches in metastatic breast cancer
Q90108782USP11 promotes growth and metastasis of colorectal cancer via PPP1CA-mediated activation of ERK/MAPK signaling pathway
Q50186375Unconventional Approaches to Modulating the Immunogenicity of Tumor Cells.
Q47566725Wild-type KRAS is a novel therapeutic target for melanoma contributing to primary and acquired resistance to BRAF inhibition
Q89367022miR-135 promotes proliferation and stemness of oesophageal squamous cell carcinoma by targeting RERG

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