Substance use disorders and Schizophrenia: a question of shared glutamatergic mechanisms

scientific article published on December 2006

Substance use disorders and Schizophrenia: a question of shared glutamatergic mechanisms is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1007/BF03033359
P698PubMed publication ID17197372

P2093author name stringJoseph T Coyle
P2860cites workGenetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophreniaQ24308818
Genetic variation at the 22q11 PRODH2/DGCR6 locus presents an unusual pattern and increases susceptibility to schizophreniaQ24531526
Polymorphisms at the G72/G30 gene locus, on 13q33, are associated with bipolar disorder in two independent pedigree seriesQ24532007
Early-stage visual processing and cortical amplification deficits in schizophreniaQ24536566
A decrease of reelin expression as a putative vulnerability factor in schizophreniaQ24657918
Hypoxic-ischemia-related fetal/neonatal complications and risk of schizophrenia and other nonaffective psychoses: a 19-year longitudinal studyQ28144525
D-serine added to clozapine for the treatment of schizophreniaQ28146259
Genes for schizophrenia? Recent findings and their pathophysiological implicationsQ28207952
Human studies of prepulse inhibition of startle: normal subjects, patient groups, and pharmacological studiesQ28215775
Modulators of the glycine site on NMDA receptors, D-serine and ALX 5407, display similar beneficial effects to clozapine in mouse models of schizophreniaQ28239090
D-serine efficacy as add-on pharmacotherapy to risperidone and olanzapine for treatment-refractory schizophreniaQ28240880
Glycine transporter I inhibitor, N-methylglycine (sarcosine), added to antipsychotics for the treatment of schizophreniaQ28250711
Effectiveness of antipsychotic drugs in patients with chronic schizophreniaQ28273164
Immunocytochemical localization of N-acetyl-aspartate with monoclonal antibodiesQ28304567
Evidence of novel neuronal functions of dysbindin, a susceptibility gene for schizophreniaQ28568230
Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergenceQ29618819
Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans. Psychotomimetic, perceptual, cognitive, and neuroendocrine responsesQ29618915
Recent advances in the phencyclidine model of schizophreniaQ29618917
A.E. Bennett Research Award. Reversal of phencyclidine-induced effects by glycine and glycine transport inhibitorsQ48247770
Up-regulation of GABAA receptor binding on neurons of the prefrontal cortex in schizophrenic subjectsQ48855793
Functional comparison of D-serine and glycine in rodents: the effect on cloned NMDA receptors and the extracellular concentration.Q49047741
NMDA-dependent modulation of CA1 local circuit inhibition.Q49058538
Does ketamine-mediated N-methyl-D-aspartate receptor antagonism cause schizophrenia-like oculomotor abnormalities?Q49093044
D-cycloserine acts as a partial agonist at the glycine modulatory site of the NMDA receptor expressed in Xenopus oocytesQ49095632
M50 sensory gating predicts negative symptoms in schizophreniaQ49143378
A single dominant gene can account for eye tracking dysfunctions and schizophrenia in offspring of discordant twins.Q50800943
Examination of G72 and D-amino-acid oxidase as genetic risk factors for schizophrenia and bipolar affective disorder.Q51034630
Brain uptake of radiolabeled amino acids, amines, and hexoses after arterial injectionQ51116341
Effect of Phencyclidine in Chronic SchizophrenicsQ51215455
Ketamine-induced deficits in auditory and visual context-dependent processing in healthy volunteers: implications for models of cognitive deficits in schizophrenia.Q51370914
Modulation of amphetamine-induced striatal dopamine release by ketamine in humans: implications for schizophrenia.Q51375205
Ketamine-induced NMDA receptor hypofunction as a model of memory impairment and psychosis.Q51481467
Functional significance of long-term potentiation for sequence learning and prediction.Q52048346
Acute but not chronic activation of the NMDA-coupled glycine receptor with D-cycloserine facilitates learning and retention.Q52057976
Study of a new schizophrenomimetic drug; sernyl.Q52771570
D-cycloserine added to clozapine for patients with schizophreniaQ57131290
Findings in an independent sample support an association between bipolar affective disorder and the G72/G30 locus on chromosome 13q33Q57405103
Support for involvement of neuregulin 1 in schizophrenia pathophysiologyQ59192038
Transmission disequilibrium and haplotype analyses of the G72/G30 locus: Suggestive linkage to schizophrenia in Palestinian Arabs living in the North of IsraelQ60719829
[3H]muscimol binding sites increased in autopsied brains of chronic schizophrenicsQ70158501
Preliminary investigation of high-dose oral glycine on serum levels and negative symptoms in schizophrenia: an open-label trialQ71607775
Dose-finding trial of D-cycloserine added to neuroleptics for negative symptoms in schizophreniaQ71933595
Dopamine receptors, neuroleptics, and schizophreniaQ72461206
N-acetylaspartylglutamate selectively activates mGluR3 receptors in transfected cellsQ73456893
Interaction of acamprosate with ethanol and spermine on NMDA receptors in primary cultured neuronsQ73689679
Placebo-controlled trial of glycine added to clozapine in schizophreniaQ73719184
The effects of clozapine on alcohol and drug use disorders among patients with schizophreniaQ73967057
Impaired P3 generation reflects high-level and progressive neurocognitive dysfunction in schizophreniaQ76392641
A placebo-controlled trial of D-cycloserine added to conventional neuroleptics in patients with schizophreniaQ77805002
Localized volume reduction in prefrontal, temporolimbic, and paralimbic regions in schizophrenia: an MRI parcellation studyQ80822000
Neuroimaging studies of the hippocampus in schizophreniaQ30666577
A review of diffusion tensor imaging studies in schizophreniaQ30994764
Effects of a novel uncompetitive NMDA receptor antagonist, MRZ 2/579 on ethanol self-administration and ethanol withdrawal seizures in the rat.Q31925767
Significant interaction between clozapine and cocaine in cocaine addictsQ33145592
The effects of clozapine, risperidone, and olanzapine on cognitive function in schizophreniaQ33693516
Effects of clozapine on substance use in patients with schizophrenia and schizoaffective disorder: a retrospective surveyQ33827207
Finding schizophrenia genesQ33831956
Genome-wide expression analysis reveals dysregulation of myelination-related genes in chronic schizophreniaQ33941953
GABAergic interneurons: implications for understanding schizophrenia and bipolar disorderQ33948632
The N-methyl-D-aspartate receptor channel blockers memantine, MRZ 2/579 and other amino-alkyl-cyclohexanes antagonise 5-HT(3) receptor currents in cultured HEK-293 and N1E-115 cell systems in a non-competitive mannerQ33951128
Atypical antipsychotics: mechanism of action.Q33957716
Ionotropic glutamate receptors as therapeutic targets in schizophreniaQ33966231
Decreased serum levels of D-serine in patients with schizophrenia: evidence in support of the N-methyl-D-aspartate receptor hypofunction hypothesis of schizophrenia.Q33966453
LTP may trigger addictionQ33976331
Reduced D-serine to total serine ratio in the cerebrospinal fluid of drug naive schizophrenic patientsQ33987618
D-serine added to antipsychotics for the treatment of schizophreniaQ34068005
The NMDA antagonist memantine attenuates the expression of opioid physical dependence in humansQ34087393
Effects of ketamine in normal and schizophrenic volunteersQ34091266
Substance abuse in schizophrenia: a review of the literature and a study of correlates in SwedenQ34201663
Association of G72/G30 with schizophrenia in the Chinese populationQ34326702
The NMDA receptor glycine modulatory site: a therapeutic target for improving cognition and reducing negative symptoms in schizophreniaQ34327773
Density of glutamic acid decarboxylase 67 messenger RNA-containing neurons that express the N-methyl-D-aspartate receptor subunit NR2A in the anterior cingulate cortex in schizophrenia and bipolar disorderQ34331509
Is the G72/G30 locus associated with schizophrenia? single nucleotide polymorphisms, haplotypes, and gene expression analysisQ34335482
Cognitive enhancers as adjuncts to psychotherapy: use of D-cycloserine in phobic individuals to facilitate extinction of fearQ34364137
How does drug and alcohol misuse develop among people with psychotic illness? A literature reviewQ34388833
The molecular basis of memantine action in Alzheimer's disease and other neurologic disorders: low-affinity, uncompetitive antagonismQ34428531
Is there a common molecular pathway for addiction?Q34463226
A meta-analysis of the efficacy of second-generation antipsychoticsQ34534321
Substance misuse in patients with schizophrenia: epidemiology and managementQ34585142
Efficacy of high-dose glycine in the treatment of enduring negative symptoms of schizophreniaQ34756417
Neuregulins: functions, forms, and signaling strategiesQ35089314
N-methyl-D-aspartate glutamate receptors and alcoholism: reward, dependence, treatment, and vulnerabilityQ35153745
The neurobiology of opiate tolerance, dependence and sensitization: mechanisms of NMDA receptor-dependent synaptic plasticityQ35164063
NMDA receptors in alcoholismQ35616724
Selective alterations in prefrontal cortical GABA neurotransmission in schizophrenia: a novel target for the treatment of working memory dysfunctionQ35810087
The N-methyl D-aspartate receptor glycine site and D-serine metabolism: an evolutionary perspectiveQ35861036
Effects of D-cycloserine on negative symptoms in schizophreniaQ35913587
A subclass of prefrontal gamma-aminobutyric acid axon terminals are selectively altered in schizophreniaQ36070114
Acamprosate: a review of its use in the maintenance of abstinence in patients with alcohol dependenceQ36133836
Dysbindin-1 is reduced in intrinsic, glutamatergic terminals of the hippocampal formation in schizophreniaQ37698891
Ketamine: an update on the first twenty-five years of clinical experienceQ38618138
Impact of schizophrenia and chronic antipsychotic treatment on [123I]CNS-1261 binding to N-methyl-D-aspartate receptors in vivoQ40408851
Inhibition of system A-mediated glycine transport in cortical synaptosomes by therapeutic concentrations of clozapine: implications for mechanisms of actionQ40531131
Decoding neuronal firing and modelling neural networksQ40617076
Evidence for abnormal cortical functional connectivity during working memory in schizophreniaQ40678204
Abnormal excitatory neurotransmitter metabolism in schizophrenic brainsQ41670269
Comparison of ketamine-induced thought disorder in healthy volunteers and thought disorder in schizophreniaQ41695764
A comparison of smoking behaviours between patients treated with clozapine and depot neurolepticsQ43734438
Reduced NAA in the thalamus and altered membrane and glial metabolism in schizophrenic patients detected by 1H-MRS and tissue segmentationQ43762654
Increased cortical kynurenate content in schizophreniaQ43766055
Kynurenic acid levels are elevated in the cerebrospinal fluid of patients with schizophreniaQ43783037
Concomitant clozapine reduces smoking in patients treated with risperidoneQ43852515
Adjunctive high-dose glycine in the treatment of schizophreniaQ43863838
Placebo-controlled trial of D-cycloserine added to conventional neuroleptics, olanzapine, or risperidone in schizophreniaQ43899475
NMDA receptor antagonists disinhibit rat posterior cingulate and retrosplenial cortices: a potential mechanism of neurotoxicity.Q43954489
Reciprocal alterations in pre- and postsynaptic inhibitory markers at chandelier cell inputs to pyramidal neurons in schizophreniaQ44129418
Alcohol and cannabis use in schizophrenia: effects of clozapine vs. risperidoneQ44264708
Clozapine treatment for suicidality in schizophrenia: International Suicide Prevention Trial (InterSePT).Q44268852
Comparative genome- and proteome analysis of cerebral cortex from MK-801-treated ratsQ44291905
Local acamprosate modulates dopamine release in the rat nucleus accumbens through NMDA receptors: an in vivo microdialysis study.Q44321771
The NMDA receptor channel blocker memantine and opioid receptor antagonist naltrexone inhibit the saccharin deprivation effect in ratsQ44346065
Differential effects of atypical and typical antipsychotic drugs on N-methyl-D-aspartate- and electrically evoked responses in the pyramidal cells of the rat medial prefrontal cortexQ44347334
The effect of acamprosate on the development of morphine-induced behavioral sensitization in ratsQ44499626
Memantine presents different effects from MK-801 in motivational and physical signs of morphine withdrawal.Q44567442
Frontal lobe N-acetylaspartate correlates with psychopathology in schizophrenia: a proton magnetic resonance spectroscopy studyQ44597810
Effect of systemic administration of D-serine on the levels of D- and L-serine in several brain areas and periphery of rat.Q44974843
Endogenous kynurenic acid disrupts prepulse inhibitionQ45019400
NAAG reduces NMDA receptor current in CA1 hippocampal pyramidal neurons of acute slices and dissociated neuronsQ45049155
Clozapine reduces alcohol drinking in Syrian golden hamstersQ45080179
A six-month, placebo-controlled trial of D-cycloserine co-administered with conventional antipsychotics in schizophrenia patientsQ45122746
Functional magnetic resonance imaging studies of schizophrenic patients during word production: effects of D-cycloserineQ45262973
Regulation of NMDA receptors by neuregulin signaling in prefrontal cortex.Q46497163
Effect of catechol-O-methyltransferase val158met genotype on attentional control.Q46497177
Cerebral ventricular change over the first 10 years after the onset of schizophreniaQ47198232
Human dysbindin (DTNBP1) gene expression in normal brain and in schizophrenic prefrontal cortex and midbrainQ47378030
Polymorphisms in the 13q33.2 gene G72/G30 are associated with childhood-onset schizophrenia and psychosis not otherwise specifiedQ47664212
Comparison of progressive cortical gray matter loss in childhood-onset schizophrenia with that in childhood-onset atypical psychosesQ48100357
MRI assessment of gray and white matter distribution in Brodmann's areas of the cortex in patients with schizophrenia with good and poor outcomesQ48135275
Reduced hippocampal N-acetylaspartate without volume loss in schizophreniaQ48165321
P433issue3-4
P921main subjectschizophreniaQ41112
P1104number of pages13
P304page(s)221-233
P577publication date2006-12-01
P1433published inNeurotoxicity ResearchQ15764278
P1476titleSubstance use disorders and Schizophrenia: a question of shared glutamatergic mechanisms
P478volume10

Reverse relations

cites work (P2860)
Q99612947Alpha7 nicotinic-N-methyl-D-aspartate hypothesis in the treatment of schizophrenia and beyond
Q36234265Altered acquisition and extinction of amphetamine-paired context conditioning in genetic mouse models of altered NMDA receptor function
Q92997044Attenuation Effects of Alpha-Pinene Inhalation on Mice with Dizocilpine-Induced Psychiatric-Like Behaviour
Q35600223Availability of N-Methyl-d-Aspartate Receptor Coagonists Affects Cocaine-Induced Conditioned Place Preference and Locomotor Sensitization: Implications for Comorbid Schizophrenia and Substance Abuse
Q59805026Changes in Serine Racemase-Dependent Modulation of NMDA Receptor: Impact on Physiological and Pathological Brain Aging
Q47945952Cognitive functioning associated with stimulant use in patients with non-affective psychosis, their unaffected siblings and healthy controls
Q38124448Comorbid substance use disorder in schizophrenia: a selective overview of neurobiological and cognitive underpinnings
Q33285122Comorbidity of substance abuse with other psychiatric disorders
Q37118079D-serine signalling as a prominent determinant of neuronal-glial dialogue in the healthy and diseased brain
Q57729902Effect of ketamine on oxidative stress following lipopolysaccharide administration
Q46560369Effects of nicotine on sensorimotor gating impairment induced by long-term treatment with neurotoxic NMDA antagonism
Q37159920Effects of topiramate and other anti-glutamatergic drugs on the acute intoxicating actions of ethanol in mice: modulation by genetic strain and stress
Q46364104Elevated levels of kynurenic acid change the dopaminergic response to amphetamine: implications for schizophrenia
Q47791708Glycine Transporters and Its Coupling with NMDA Receptors
Q30873588In vivo magnetic resonance studies reveal neuroanatomical and neurochemical abnormalities in the serine racemase knockout mouse model of schizophrenia
Q59355241Is the History of Substance Abuse Correlated with Neuropsychiatric Disorders and Co-morbid HIV Infection? An Urban Population Study
Q48262648Ketamine Self-Administration Reduces the Homeostasis of the Glutamate Synapse in the Rat Brain
Q45937104Ketamine modulates theta and gamma oscillations.
Q33302997Limbic structures and networks in children and adolescents with schizophrenia
Q37617476Modulation of Synaptic Plasticity in the Cortex Needs to Understand All the Players
Q26752246Mouse Genetic Models of Human Brain Disorders
Q47305639N-Methyl-d-aspartate receptor co-agonist availability affects behavioral and neurochemical responses to cocaine: insights into comorbid schizophrenia and substance abuse.
Q41879463NMDA receptor hypofunction phase couples independent γ-oscillations in the rat visual cortex
Q37714963NR1 knockdown mice as a representative model of the glutamate hypothesis of schizophrenia.
Q37059455Nicotine and nicotinic system in hypoglutamatergic models of schizophrenia
Q37268726Oral glycine administration increases brain glycine/creatine ratios in men: a proton magnetic resonance spectroscopy study
Q51899658Predictors of psychosis severity in individuals with primary stimulant addictions
Q37251428Promoter analysis of human glutamate carboxypeptidase II.
Q47677836Schizophrenia: Basic and Clinical
Q33738332Serine racemase deletion protects against cerebral ischemia and excitotoxicity
Q30418618Sustained N-methyl-d-aspartate receptor hypofunction remodels the dopamine system and impairs phasic signaling.
Q50138246The Role of Serine Racemase in the Pathophysiology of Brain Disorders
Q36826802Treatment consideration and manifest complexity in comorbid neuropsychiatric disorders
Q47957231U-shaped curve of psychosis according to cannabis use: New evidence from a snowball sample.
Q33618070Vitamin D deficiency is common in psychogeriatric patients, independent of diagnosis.
Q42278446Zebrafish reward mutants reveal novel transcripts mediating the behavioral effects of amphetamine