Retigabine

scientific article published on January 2007

Retigabine is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P6179Dimensions Publication ID1047330083
P356DOI10.1016/J.NURT.2006.11.012
P698PubMed publication ID17199031
P5875ResearchGate publication ID6601899

P2093author name stringRoger J Porter
Chris Rundfeldt
Virinder Nohria
P2860cites workA potassium channel mutation in neonatal human epilepsyQ24320244
The novel anticonvulsant retigabine activates M-currents in Chinese hamster ovary-cells tranfected with human KCNQ2/3 subunitsQ28138343
Moderate loss of function of cyclic-AMP-modulated KCNQ2/KCNQ3 K+ channels causes epilepsyQ28292575
Therapeutic potential of excitatory amino acid antagonists: channel blockers and 2,3-benzodiazepinesQ34290637
The new anticonvulsant retigabine (D-23129) acts as an opener of K+ channels in neuronal cellsQ34447899
General pharmacologic studies on the analgesic flupirtineQ34695580
The therapeutic potential of neuronal KCNQ channel modulatorsQ35593939
KCNQ4, a K+ channel mutated in a form of dominant deafness, is expressed in the inner ear and the central auditory pathway.Q35682356
Clinical aspects of epilepsyQ36956685
Which animal models should be used in the search for new antiepileptic drugs? A proposal based on experimental and clinical considerationsQ39544980
Strategies in antiepileptic drug development: is rational drug design superior to random screening and structural variation?Q40758069
New visions in the pharmacology of anticonvulsionQ41739650
D-23129: a potent anticonvulsant in the amygdala kindling model of complex partial seizuresQ42638756
Effects of retigabine on rhythmic synchronous activity of human neocortical slicesQ43590386
Delayed sclerosis, neuroprotection, and limbic epileptogenesis after status epilepticus in the rat.Q44066396
The anticonvulsant retigabine attenuates nociceptive behaviours in rat models of persistent and neuropathic painQ44297459
The anti-hyperalgesic activity of retigabine is mediated by KCNQ potassium channel activationQ44791007
Effects of retigabine (D-23129) on different patterns of epileptiform activity induced by 4-aminopyridine in rat entorhinal cortex hippocampal slicesQ48290379
Synthesis and quantitative structure-activity relationships of anticonvulsant 2,3,6-triaminopyridines.Q52371259
Effects of retigabine (D-23129) on different patterns of epileptiform activity induced by low magnesium in rat entorhinal cortex hippocampal slices.Q52974740
Investigations into the mechanism of action of the new anticonvulsant retigabine. Interaction with GABAergic and glutamatergic neurotransmission and with voltage gated ion channels.Q53897724
D-23129: a new anticonvulsant with a broad spectrum activity in animal models of epileptic seizures.Q53989493
Antiepileptic drug development program: a cooperative effort of government and industryQ69720692
Anticonvulsant properties of D-20443 in genetically epilepsy-prone rats: prediction of clinical responseQ71526090
Characterization of the K+ channel opening effect of the anticonvulsant retigabine in PC12 cellsQ77893179
P433issue1
P304page(s)149-154
P577publication date2007-01-01
P1433published inNeurotherapeuticsQ15716631
P1476titleRetigabine.
P478volume4

Reverse relations

cites work (P2860)
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Q30429603A swell in the armamentarium of antiepileptic drug targets
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Q49882750Antiepileptic drugs in development pipeline: A recent update
Q36033788Atomic basis for therapeutic activation of neuronal potassium channels
Q42424886Bimodal effects of the Kv7 channel activator retigabine on vascular K+ currents
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Q55562302Copper mediated C-H amination with oximes: en route to primary anilines.
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Q37754477Emerging drugs for partial onset seizures.
Q44669252Expression and function of K(v)7 channels in murine myometrium throughout oestrous cycle.
Q46035841Inhibition by an excitatory conductance: a paradox explained.
Q46387953Isobolographic characterization of interactions of retigabine with carbamazepine, lamotrigine, and valproate in the mouse maximal electroshock-induced seizure model.
Q37162392K+ channel modulators for the treatment of neurological disorders and autoimmune diseases
Q35683922Neuronal potassium channel openers in the management of epilepsy: role and potential of retigabine.
Q37638688New and investigational antiepileptic drugs
Q24654230New molecular targets for antiepileptic drugs: alpha(2)delta, SV2A, and K(v)7/KCNQ/M potassium channels
Q37950518Novel medications for epilepsy
Q42972474Participation of KCNQ (Kv7) potassium channels in myogenic control of cerebral arterial diameter
Q34823174Pharmacological management of epilepsy: recent advances and future prospects
Q37992162Pharmacotherapy of the third-generation AEDs: lacosamide, retigabine and eslicarbazepine acetate
Q38059092Potassium channels: a review of broadening therapeutic possibilities for neurological diseases
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Q36548403The Sensorless Pore Module of Voltage-gated K+ Channel Family 7 Embodies the Target Site for the Anticonvulsant Retigabine
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Q28245021Third-generation antiepileptic drugs: mechanisms of action, pharmacokinetics and interactions
Q37464784Voltage-gated potassium channels as therapeutic targets

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