Inhibition of nuclear translocation of transcription factor NF-kappa B by a synthetic peptide containing a cell membrane-permeable motif and nuclear localization sequence

scientific article published on June 1995

Inhibition of nuclear translocation of transcription factor NF-kappa B by a synthetic peptide containing a cell membrane-permeable motif and nuclear localization sequence is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.270.24.14255
P698PubMed publication ID7782278
P5875ResearchGate publication ID15417475

P50authorJacek J. HawigerQ88341029
P2093author name stringLin YZ
Yao SY
Veach RA
Torgerson TR
P4510describes a project that usessynthetic peptideQ104631433
P433issue24
P407language of work or nameEnglishQ1860
P921main subjectNF-κBQ411114
P304page(s)14255-14258
P577publication date1995-06-01
P1433published inJournal of Biological ChemistryQ867727
P1476titleInhibition of nuclear translocation of transcription factor NF-kappa B by a synthetic peptide containing a cell membrane-permeable motif and nuclear localization sequence
P478volume270

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Q40313746Nuclear factor-kappaB activated by capacitative Ca2+ entry enhances muscarinic receptor-mediated soluble amyloid precursor protein (sAPPalpha) release in SH-SY5Y cells
Q73163356Nuclear factor-kappaB activates dual inhibition sites in the regulation of tumor necrosis factor-alpha-induced neutrophil apoptosis
Q46559738Nuclear factor-kappaB activation by reactive oxygen species mediates voltage-gated K+ current enhancement by neurotoxic beta-amyloid peptides in nerve growth factor-differentiated PC-12 cells and hippocampal neurones
Q28570494Nuclear factor-kappaB activation leads to down-regulation of fatty acid oxidation during cardiac hypertrophy
Q40616747Nuclear factor-kappaB inhibitor peptide inhibits spontaneous and interleukin-1beta-induced sleep
Q35111621Nuclear factor-κB contributes to neuron-dependent induction of glutamate transporter-1 expression in astrocytes
Q28201984Nuclear transcription factor-kappaB as a target for cancer drug development
Q36824716Nuclear transport modulation reduces hypercholesterolemia, atherosclerosis, and fatty liver
Q46557903Oxidative stress activates transcription factor NF-kB-mediated protective signaling in primary rat neuronal cultures
Q45275681P2Y6 nucleotide receptors activate NF-kappaB and increase survival of osteoclasts
Q64945936PML-Nuclear Bodies Regulate the Stability of the Fusion Protein Dendra2-Nrf2 in the Nucleus.
Q41768013PMN transendothelial migration decreases nuclear NFkappaB in IL-1beta-activated endothelial cells: role of PECAM-1.
Q34241510PNA oligomers as tools for specific modulation of gene expression.
Q39658915Palmitate-induced skeletal muscle insulin resistance does not require NF-κB activation
Q45731678Peptides containing membrane-transiting motifs inhibit virus entry
Q36659979Peptides targeting protein kinases: strategies and implications
Q40628558Phosphatidylcholine-Specific Phospholipase C Activity Is Necessary for the Activation of STAT6
Q36461618Phosphoinositide 3-kinase/Akt signaling pathway and its therapeutical implications for human acute myeloid leukemia.
Q28480675Photodynamic therapy can induce a protective innate immune response against murine bacterial arthritis via neutrophil accumulation
Q88868397Piperlongumine Improves Lipopolysaccharide-Induced Amyloidogenesis by Suppressing NF-KappaB Pathway
Q39477781Pitx3 is a critical mediator of GDNF-induced BDNF expression in nigrostriatal dopaminergic neurons.
Q43181382Poly-arginine and arginine-rich peptides are neuroprotective in stroke models.
Q36003987Polyphosphate elicits pro-inflammatory responses that are counteracted by activated protein C in both cellular and animal models
Q40639356Polysaccharide isolated from Poria cocos sclerotium induces NF-kappaB/Rel activation and iNOS expression in murine macrophages
Q32046357Preparation of functionally active cell-permeable peptides by single-step ligation of two peptide modules
Q42813660Prevention of NF-kappaB activation in vivo by a cell-permeable NF-kappaB inhibitor peptide
Q40863726Prevention of etoposide-induced apoptosis by proteasome inhibitors in a human leukemic cell line but not in fresh acute leukemia blasts. A differential role of NF-kappab activation
Q33590672Prostaglandin F(2alpha)-F-prostanoid receptor regulates CXCL8 expression in endometrial adenocarcinoma cells via the calcium-calcineurin-NFAT pathway
Q30321287Protease inhibitors protect macrophages from lipopolysaccharide-induced cytotoxicity: possible role for NF-kappaB.
Q46761334Protein-tyrosine phosphatase 1B deficiency protects against Fas-induced hepatic failure
Q45109540Purification and in vitro functional analyses of RGS12 and RGS14 GoLoco motif peptides.
Q39881718R-roscovitine sensitizes anaplastic thyroid carcinoma cells to TRAIL-induced apoptosis via regulation of IKK/NF-kappaB pathway
Q39166741Radiation-induced TNFα cross signaling-dependent nuclear import of NFκB favors metastasis in neuroblastoma
Q37090097Radicicol Inhibits iNOS Expression in Cytokine-Stimulated Pancreatic Beta Cells
Q34183422Reactive bone marrow stromal cells attenuate systemic inflammation via sTNFR1.
Q81045070Real-time imaging of ligand-induced IKK activation in intact cells and in living mice
Q40603207Receptor/transporter-independent targeting of functional peptides across the plasma membrane
Q34964906Reciprocal activation of transcription factors underlies the dichotomy between proliferation and invasion of glioma cells
Q41008655Reconstitution of gene expression from a regulatory-protein-deficient hepatitis B virus genome by cell-permeable HBx protein
Q40788714Regulation of MARCKS and MARCKS-related protein expression in BV-2 microglial cells in response to lipopolysaccharide
Q38642386Regulation of Survival Motor Neuron Protein by the Nuclear Factor-Kappa B Pathway in Mouse Spinal Cord Motoneurons.
Q40484671Regulation of cyclin D1 expression by autocrine IGF-I in human BON neuroendocrine tumour cells
Q29615580Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation
Q39863204RelB enhances prostate cancer growth: implications for the role of the nuclear factor-kappaB alternative pathway in tumorigenicity
Q37392081Requirement of TLR4 and CD14 in dendritic cell activation by Hemagglutinin B from Porphyromonas gingivalis
Q46184588Rituximab inhibits p38 MAPK activity in 2F7 B NHL and decreases IL-10 transcription: pivotal role of p38 MAPK in drug resistance.
Q96348513Robust combination of liver stereotactic body radiotherapy modulates pharmacokinetics of sorafenib toward preferable parameters
Q41296267Role for activating transcription factor 3 in stress-induced beta-cell apoptosis
Q44361938Role for complement in mediating intestinal nitric oxide synthase-2 and superoxide dismutase expression
Q50449872Role for nuclear factor-kappaB in augmented lung injury because of interaction between hyperoxia and high stretch ventilation
Q34361301Role of nuclear factor kappa B in neuropathological mechanisms
Q40639364Role of nuclear factor-kappa B in the regulation of intercellular adhesion molecule 1 after infection of human bronchial epithelial cells by Bordetella pertussis
Q23918916Role of transcription factor NF-KB in asbestos-induced TNF-alpha response from macrophages
Q34129079Roles of p38 mitogen-activated protein kinase, NF-kappaB, and protein kinase C in proinflammatory cytokine mRNA expression by human peripheral blood leukocytes, monocytes, and neutrophils in response to Anaplasma phagocytophila
Q39496480Roxatidine suppresses inflammatory responses via inhibition of NF-κB and p38 MAPK activation in LPS-induced RAW 264.7 macrophages
Q40601069S100A4 regulates membrane induced activation of matrix metalloproteinase-2 in osteosarcoma cells
Q24338574S100B and S100A6 differentially modulate cell survival by interacting with distinct RAGE (receptor for advanced glycation end products) immunoglobulin domains
Q39947748SN52, a novel nuclear factor-kappaB inhibitor, blocks nuclear import of RelB:p52 dimer and sensitizes prostate cancer cells to ionizing radiation
Q35989495SNAP-23 and syntaxin-2 localize to the extracellular surface of the platelet plasma membrane
Q27469944Salicylates inhibit flavivirus replication independently of blocking nuclear factor kappa B activation
Q33461893Salivary gland branching morphogenesis: a quantitative systems analysis of the Eda/Edar/NFkappaB paradigm
Q92711767Scopoletin Suppresses Activation of Dendritic Cells and Pathogenesis of Experimental Autoimmune Encephalomyelitis by Inhibiting NF-κB Signaling
Q42820490Selective in vivo inhibition of mitogen-activated protein kinase activation using cell-permeable peptides
Q42477193Selective inhibition of rat mesangial cell proliferation by a synthetic peptide derived from the sequence of the C2 region of PKCbeta
Q34526352Sensing nerve injury at the axonal ER: activated Luman/CREB3 serves as a novel axonally synthesized retrograde regeneration signal
Q55471801Sensitization of human glioblastomas to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) by NF-kappaB inhibitors.
Q39608525Sensitization to TRAIL-induced apoptosis in human neuroblastoma SK-N-AS cells by NF-κB inhibitors is dependent on reactive oxygen species (ROS).
Q36546794Shh and p50/Bcl3 signaling crosstalk drives pathogenesis of BCCs in Gorlin syndrome
Q42086318Signal regulatory protein alpha ligation induces macrophage nitric oxide production through JAK/STAT- and phosphatidylinositol 3-kinase/Rac1/NAPDH oxidase/H2O2-dependent pathways
Q42452880Signalling pathways influencing basal and H2O2‐induced P‐glycoprotein expression in endothelial cells derived from the blood–brain barrier
Q33243843Small, nonpeptide p75NTR ligands induce survival signaling and inhibit proNGF-induced death.
Q52611789Soluble TNFα Signaling within the Spinal Cord Contributes to the Development of Autonomic Dysreflexia and Ensuing Vascular and Immune Dysfunction after Spinal Cord Injury.
Q28306424Sp1 and Sp3 mediate constitutive transcription of the human hyaluronan synthase 2 gene
Q40885900Spatial transcriptional profile of the chick and mouse endocardial cushions identify novel regulators of endocardial EMT in vitro
Q44016790Specific Inhibition of IkappaB kinase reduces hyperalgesia in inflammatory and neuropathic pain models in rats.
Q73762869Stretch-induced IL-6 secretion from endothelial cells requires NF-kappaB activation
Q40652079Stretch-induced IL-8 depends on c-Jun NH2-terminal and nuclear factor-κB-inducing kinases
Q48336488Strong suppression of feeding by a peptide containing both the nuclear localization sequence of fibroblast growth factor-1 and a cell membrane-permeable sequence
Q41517113Structural and calorimetric studies demonstrate that the hepatocyte nuclear factor 1β (HNF1β) transcription factor is imported into the nucleus via a monopartite NLS sequence
Q52979076Structural requirements for cellular uptake of alpha-helical amphipathic peptides.
Q36857817Structure, topology, and tilt of cell-signaling peptides containing nuclear localization sequences in membrane bilayers determined by solid-state NMR and molecular dynamics simulation studies
Q35764786Sublytic concentrations of the membrane attack complex of complement induce endothelial interleukin-8 and monocyte chemoattractant protein-1 through nuclear factor-kappa B activation
Q37053448Sunitinib enhances neuronal survival in vitro via NF-κB-mediated signaling and expression of cyclooxygenase-2 and inducible nitric oxide synthase
Q75296075Suppression of Staphylococcal Enterotoxin B-induced Toxicity by a Nuclear Import Inhibitor
Q24625983Surfactant protein secreted by the maturing mouse fetal lung acts as a hormone that signals the initiation of parturition
Q38318310Sustained activation of phosphatidylinositol 3-kinase/Akt/nuclear factor kappaB signaling mediates G protein-coupled delta-opioid receptor gene expression
Q43741871Synthesis of peptide-oligonucleotide phosphorothioate conjugates by convergent or stepwise solid-phase strategies
Q79227602TGF-beta-induced apoptosis in human thyrocytes is mediated by p27kip1 reduction and is overridden in neoplastic thyrocytes by NF-kappaB activation
Q28189886TL1A-induced NF-kappaB activation and c-IAP2 production prevent DR3-mediated apoptosis in TF-1 cells
Q37297752TNF-alpha preconditioning protects neurons via neuron-specific up-regulation of CREB-binding protein
Q39407549TNF-alpha stimulates activation of pro-MMP2 in human skin through NF-(kappa)B mediated induction of MT1-MMP.
Q53398515TNFalpha induces NFkappaB/p50 in association with the growth and morphogenesis of normal and transformed rat mammary epithelial cells.
Q35674374TNFα signaling regulates cystic epithelial cell proliferation through Akt/mTOR and ERK/MAPK/Cdk2 mediated Id2 signaling
Q44540672TRAIL/Apo2L ligands induce apoptosis in malignant rhabdoid tumor cell lines
Q37328803Targeting nuclear import shuttles, importins/karyopherins alpha by a peptide mimicking the NFκB1/p50 nuclear localization sequence
Q35955008Targeting nuclear transporters in cancer: Diagnostic, prognostic and therapeutic potential.
Q34398166Targeting nucleocytoplasmic transport in cancer therapy
Q41099705Targeting signal transduction for disease therapy
Q71533621Template-directed ligation of peptides to oligonucleotides
Q34521878Temporal activation of anti- and pro-apoptotic factors in human gingival fibroblasts infected with the periodontal pathogen, Porphyromonas gingivalis: potential role of bacterial proteases in host signalling
Q42516567Temporal changes in glutathione biosynthesis during the lipopolysaccharide-induced inflammatory response of THP-1 macrophages
Q34374054The "genomic storm" induced by bacterial endotoxin is calmed by a nuclear transport modifier that attenuates localized and systemic inflammation
Q41652035The IkappaB kinase regulates chromatin structure during reconsolidation of conditioned fear memories.
Q40876082The NF-kappa B signaling pathway is not required for Fas ligand gene induction but mediates protection from activation-induced cell death
Q33631488The NFκB inhibitor, SN50, induces differentiation of glioma stem cells and suppresses their oncogenic phenotype
Q38340819The Pharmacokinetics of Cell-Penetrating Peptides
Q50521934The canonical nuclear factor-κB pathway regulates cell survival in a developmental model of spinal cord motoneurons
Q37278005The design, synthesis, and evaluation of molecules that enable or enhance cellular uptake: peptoid molecular transporters
Q33947251The development and maintenance of paclitaxel-induced neuropathic pain require activation of the sphingosine 1-phosphate receptor subtype 1.
Q41023960The efficient and rapid import of a peptide into primary B and T lymphocytes and a lymphoblastoid cell line
Q36458661The fibroblast growth factor-inducible 14 receptor is highly expressed in HER2-positive breast tumors and regulates breast cancer cell invasive capacity
Q24794871The functional genomic response of developing embryonic submandibular glands to NF-kappa B inhibition
Q43832329The loss of susceptibility to apoptosis in exudated tissue neutrophils is associated with their nuclear factor-kappa B activation
Q35977809The opioid antagonist, β-funaltrexamine, inhibits NF-κB signaling and chemokine expression in human astrocytes and in mice
Q31881213The p38 mitogen-activated protein kinase pathway regulates interleukin-6 synthesis in response to tumor necrosis factor in osteoblasts
Q42962015The proinflammatory cytokines IL-1beta and TNF-alpha induce the expression of Synoviolin, an E3 ubiquitin ligase, in mouse synovial fibroblasts via the Erk1/2-ETS1 pathway
Q64110255The protective role of IL-1Ra on intestinal ischemia reperfusion injury by anti-oxidative stress via Nrf2/HO-1 pathway in rat
Q34102964The role of NF-kappaB/IkappaB proteins in cancer: implications for novel treatment strategies
Q28299334The tumor necrosis factor-like weak inducer of apoptosis (TWEAK)-fibroblast growth factor-inducible 14 (Fn14) signaling system regulates glioma cell survival via NFkappaB pathway activation and BCL-XL/BCL-W expression
Q44990756The use of membrane translocating peptides to identify sites of interaction between the C5a receptor and downstream effector proteins
Q39678336The virucidal EB peptide protects host cells from herpes simplex virus type 1 infection in the presence of serum albumin and aggregates proteins in a detergent-like manner
Q28391341Therapeutic effect of topical administration of SN50, an inhibitor of nuclear factor-kappaB, in treatment of corneal alkali burns in mice
Q37564522Therapeutic peptides for cancer therapy. Part I - peptide inhibitors of signal transduction cascades.
Q37594770Therapeutic peptides for cancer therapy. Part II - cell cycle inhibitory peptides and apoptosis-inducing peptides
Q41457843Toll-like receptor 4-mediated nuclear factor-κB activation in spinal cord contributes to chronic morphine-induced analgesic tolerance and hyperalgesia in rats
Q36065969TransMabs: cell-penetrating antibodies, the next generation
Q36409033Transactivating transcriptional activator-mediated drug delivery
Q28345627Transcription factor NF kappa B expression and postsurgical organ dysfunction
Q40473360Transcriptional activation of the human Galphai2 gene promoter through nuclear factor-kappaB and antioxidant response elements.
Q38339192Transcriptional activation of the human prostatic acid phosphatase gene by NF-kappaB via a novel hexanucleotide-binding site
Q40189750Transcriptional regulation of FasL expression and participation of sTNF-alpha in response to sertoli cell injury.
Q38303239Transcriptional regulation of intronic calcium-activated potassium channel SK2 promoters by nuclear factor-kappa B and glucocorticoids.
Q36190256Transcriptional regulation of microRNA-100, -146a, and -150 genes by p53 and NFκB p65/RelA in mouse striatal STHdh(Q7)/ Hdh(Q7) cells and human cervical carcinoma HeLa cells
Q34308241Transduction peptides: from technology to physiology
Q40450822Translocation of nuclear factor-kappaB on corneal epithelial cells induced by ultraviolet B irradiation.
Q42779520Troglitazone-activated PPARγ inhibits LPS-induced lung alveolar type II epithelial cells injuries via TNF-α.
Q44197090Tumor necrosis factor alpha induces three-dimensional cytomorphologic differentiation of human anaplastic thyroid carcinoma cells through activation of nuclear factor kappaB.
Q40816417Tumor necrosis factor-alpha inhibits aquaporin 5 expression in mouse lung epithelial cells.
Q77726396Tumor necrosis factor-alpha-induced proliferation of human Mo7e leukemic cells occurs via activation of nuclear factor kappaB transcription factor
Q54364555VPAC1 overexpression is associated with poor differentiation in colon cancer.
Q34123245Vectorial delivery of macromolecules into cells using peptide-based vehicles
Q34070134Virus resistance mediated by ribosome inactivating proteins
Q36144944Wnt10b Gain-of-Function Improves Cardiac Repair by Arteriole Formation and Attenuation of Fibrosis.
Q35030172ZBP-89 reduces histone deacetylase 3 by degrading IkappaB in the presence of Pin1
Q31840031beta-Amyloid stimulation of microglia and monocytes results in TNFalpha-dependent expression of inducible nitric oxide synthase and neuronal apoptosis.
Q40725776c-Fos activated phospholipid synthesis is required for neurite elongation in differentiating PC12 cells.
Q35042902p38 MAP kinase and MKK-1 co-operate in the generation of GM-CSF from LPS-stimulated human monocytes by an NF-kappa B-independent mechanism.
Q36703869Β-funaltrexamine inhibits chemokine (CXCL10) expression in normal human astrocytes

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