Mapping structural landmarks, ligand binding sites, and missense mutations to the collagen IV heterotrimers predicts major functional domains, novel interactions, and variation in phenotypes in inherited diseases affecting basement membranes.

scientific article published on February 2011

Mapping structural landmarks, ligand binding sites, and missense mutations to the collagen IV heterotrimers predicts major functional domains, novel interactions, and variation in phenotypes in inherited diseases affecting basement membranes. is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1002/HUMU.21401
P932PMC publication ID4800984
P698PubMed publication ID21280145
P5875ResearchGate publication ID49797361

P50authorJudy SavigeQ55692111
Billy G. HudsonQ60729372
P2093author name stringVadim Pedchenko
Shane T Jensen
James D San Antonio
J Des Parkin
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Human tumstatin and human endostatin exhibit distinct antiangiogenic activities mediated by alpha v beta 3 and alpha 5 beta 1 integrinsQ24299560
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Short amino acid sequences derived from C1q receptor (C1q-R) show homology with the alpha chains of fibronectin and vitronectin receptors and collagen type IVQ28187337
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Regulation of protease nexin-1 target protease specificity by collagen type IVQ28243645
Binding of nidogen and the laminin-nidogen complex to basement membrane collagen type IVQ28244654
Microfibril-associated glycoprotein-1 (MAGP-1) binds to the pepsin-resistant domain of the alpha3(VI) chain of type VI collagenQ28247738
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The arrangement of intra- and intermolecular disulfide bonds in the carboxyterminal, non-collagenous aggregation and cross-linking domain of basement-membrane type IV collagenQ28281372
Stability related bias in residues replacing glycines within the collagen triple helix (Gly-Xaa-Yaa) in inherited connective tissue disordersQ28282010
Binding of mouse and human fibulin-2 to extracellular matrix ligandsQ28285197
The zipper-like folding of collagen triple helices and the effects of mutations that disrupt the zipperQ28289646
The complete primary structure of the alpha 2 chain of human type IV collagen and comparison with the alpha 1(IV) chainQ28292770
Characterization of high affinity binding between laminin and the acute-phase protein, serum amyloid AQ28301233
Role of laminin terminal globular domains in basement membrane assemblyQ28587702
Binding of laminin to type IV collagen: a morphological studyQ28645694
Interaction of type IV collagen with the isolated integrins alpha 1 beta 1 and alpha 2 beta 1Q28647294
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Molecular mapping of the Goodpasture's epitope for glomerulonephritisQ30439840
The alpha 5 chain of type IV collagen is the target of IgG autoantibodies in a novel autoimmune disease with subepidermal blisters and renal insufficiencyQ73815597
Nonenzymatic glycation of type IV collagen and matrix metalloproteinase susceptibilityQ73831601
Osteogenesis imperfecta mutations may probe vital functional domains (e.g. proteoglycan binding sites) of type 1 collagen fibrilsQ73989689
Presentation of the Goodpasture autoantigen to CD4 T cells is influenced more by processing constraints than by HLA class II peptide binding preferencesQ74495034
Non-helical type IV collagen polypeptides in human placentaQ75235365
Conformational studies on the specific cleavage site of Type I collagen (alpha-1) fragment (157-192) by cathepsins K and L by proton NMR spectroscopyQ77370690
The collagenolytic activity of cathepsin K is unique among mammalian proteinasesQ77581104
Specific inhibition of T-cell adhesion to extracellular matrix and proinflammatory cytokine secretion by human recombinant galectin-1Q78127337
The alloantigenic sites of alpha3alpha4alpha5(IV) collagen: pathogenic X-linked alport alloantibodies target two accessible conformational epitopes in the alpha5NC1 domainQ79758491
Sequence dependence of renucleation after a Gly mutation in model collagen peptidesQ80335925
Mice lacking the extracellular matrix adaptor protein matrilin-2 develop without obvious abnormalitiesQ80421847
Collagen matrix assembly is driven by the interaction of von Hippel-Lindau tumor suppressor protein with hydroxylated collagen IV alpha 2Q80799407
Oncothanin, a peptide from the alpha3 chain of type IV collagen, modifies endothelial cell function and inhibits angiogenesisQ80927165
Mechanism of chain selection in the assembly of collagen IV: a prominent role for the alpha2 chainQ82062563
Acetylcholinesterase readthrough peptide shares sequence similarity to the 28-53 peptide sequence of the acetylcholinesterase adhesion-mediating site and competes for ligand binding in vitroQ94526199
Selective binding of collagen subtypes by integrin alpha 1I, alpha 2I, and alpha 10I domainsQ38296534
Different adhesins for type IV collagen on Candida albicans: identification of a lectin-like adhesin recognizing the 7S(IV) domainQ38299430
Structure and biological activity of basement membrane proteinsQ38625595
Nm23-H1 promotes adhesion of CAL 27 cells in vitroQ39876921
Characterization of the anti-angiogenic properties of arresten, an alpha1beta1 integrin-dependent collagen-derived tumor suppressorQ39942587
Bovine prolactin-related protein-I is anchored to the extracellular matrix through interactions with type IV collagenQ40016190
Interaction of hydroxylated collagen IV with the von hippel-lindau tumor suppressor.Q40163119
Integrin alpha3beta1, a novel receptor for alpha3(IV) noncollagenous domain and a trans-dominant Inhibitor for integrin alphavbeta3.Q40274571
Specific recognition of the collagen triple helix by chaperone HSP47. II. The HSP47-binding structural motif in collagens and related proteinsQ40315228
Integrin activation state determines selectivity for novel recognition sites in fibrillar collagensQ40519430
Nucleosomes possess a high affinity for glomerular laminin and collagen IV and bind nephritogenic antibodies in murine lupus-like nephritisQ40680465
The alpha 1 beta 1 integrin recognition site of the basement membrane collagen molecule [alpha 1(IV)]2 alpha 2(IV).Q40875207
Anti-angiogenic cues from vascular basement membrane collagenQ40879854
The goodpasture autoantigen. Mapping the major conformational epitope(s) of alpha3(IV) collagen to residues 17-31 and 127-141 of the NC1 domain.Q40962039
Goodpasture syndrome. Localization of the epitope for the autoantibodies to the carboxyl-terminal region of the alpha 3(IV) chain of basement membrane collagenQ41135760
Interaction of enteropathogenic Yersinia enterocolitica with complex basement membranes and the extracellular matrix proteins collagen type IV, laminin-1 and -2, and nidogen/entactinQ41497313
Differential effects of laminin, intact type IV collagen, and specific domains of type IV collagen on endothelial cell adhesion and migrationQ41546361
Characterization of a type IV collagen major cell binding site with affinity to the alpha 1 beta 1 and the alpha 2 beta 1 integrinsQ41683198
Transforming growth factor beta type 1 binds to collagen IV of basement membrane matrix: implications for developmentQ41696868
New functions for non-collagenous domains of human collagen type IV. Novel integrin ligands inhibiting angiogenesis and tumor growth in vivo.Q41724444
Biochemical alterations in collagen IV induced by in vitro glycationQ41782428
Comparative analysis of the noncollagenous NC1 domain of type IV collagen: identification of structural features important for assembly, function, and pathogenesisQ41854234
Non-enzymatic glycation of type I collagen diminishes collagen-proteoglycan binding and weakens cell adhesionQ41896828
Binding of human plasminogen to basement-membrane (type IV) collagenQ42203962
Binding of lymphoid chemokines to collagen IV that accumulates in the basal lamina of high endothelial venules: its implications in lymphocyte traffickingQ42518984
A comparative analysis of the fibulin protein family. Biochemical characterization, binding interactions, and tissue localizationQ42613103
Extracellular matrix proteins (fibronectin, laminin, and type IV collagen) bind and aggregate bacteriaQ42752920
Nonenzymatic glycation of type I collagen. The effects of aging on preferential glycation sitesQ43559656
The collagen binding domain of gelatinase A modulates degradation of collagen IV by gelatinase B.Q44037422
Meta-analysis of genotype-phenotype correlation in X-linked Alport syndrome: impact on clinical counsellingQ44053821
Alport syndrome mutations in type IV tropocollagen alter molecular structure and nanomechanical propertiesQ44448354
Alpha(v)beta3 and alpha(v)beta5 integrins bind both the proximal RGD site and non-RGD motifs within noncollagenous (NC1) domain of the alpha3 chain of type IV collagen: implication for the mechanism of endothelia cell adhesionQ44650500
Identification of S-hydroxylysyl-methionine as the covalent cross-link of the noncollagenous (NC1) hexamer of the alpha1alpha1alpha2 collagen IV network: a role for the post-translational modification of lysine 211 to hydroxylysine 211 in hexamer asQ46542176
Mechanism of perturbation of integrin-mediated cell-matrix interactions by reactive carbonyl compounds and its implication for pathogenesis of diabetic nephropathyQ46722530
Interaction of extracellular matrix protein 1 with extracellular matrix components: ECM1 is a basement membrane protein of the skin.Q46804676
Type IV collagens regulate BMP signalling in DrosophilaQ47070333
The collagen-binding A-domains of integrins alpha(1)beta(1) and alpha(2)beta(1) recognize the same specific amino acid sequence, GFOGER, in native (triple-helical) collagensQ48564306
Identification in collagen type I of an integrin alpha2 beta1-binding site containing an essential GER sequenceQ48566472
Structural basis for the platelet-collagen interaction: the smallest motif within collagen that recognizes and activates platelet Glycoprotein VI contains two glycine-proline-hydroxyproline triplets.Q48697081
Autosomal dominant Alport syndrome: molecular analysis of the COL4A4 gene and clinical outcome.Q50447866
X-linked Alport syndrome: natural history in 195 families and genotype- phenotype correlations in males.Q50496896
Molecular modeling of protein-glycosaminoglycan interactions.Q52546742
Mutations in Col4a1 cause perinatal cerebral hemorrhage and porencephaly.Q52564340
Interstitial collagens I, III, and VI sequester and modulate the multifunctional cytokine oncostatin M.Q52960794
Localization of binding sites for laminin, heparan sulfate proteoglycan and fibronectin on basement membrane (type IV) collagen.Q54146035
Type IV collagen α6 chain-derived noncollagenous domain 1 (α6(IV)NC1) inhibits angiogenesis and tumor growthQ58214810
COL4A1 mutation in Axenfeld-Rieger anomaly with leukoencephalopathy and strokeQ59697997
Heparin type IV collagen interactions: equilibrium binding and inhibition of type IV collagen self-assemblyQ67980838
Identification of the Goodpasture antigen as the alpha 3(IV) chain of collagen IVQ68506540
Decreased interaction of fibronectin, type IV collagen, and heparin due to nonenzymatic glycation. Implications for diabetes mellitusQ68983713
The O75X adhesin of uropathogenic Escherichia coli is a type IV collagen-binding proteinQ69371796
Binding domain for laminin on type IV collagenQ69942003
Calcium-dependent binding of basement membrane protein BM-40 (osteonectin, SPARC) to basement membrane collagen type IVQ70168568
Studies on human laminin and laminin-collagen complexesQ70212561
Compressed microfibril models of the native collagen fibrilQ71275394
A peptide model of basement membrane collagen alpha 1 (IV) 531-543 binds the alpha 3 beta 1 integrinQ71573426
The alpha 3 chain of type IV collagen prevents activation of human polymorphonuclear leukocytesQ72724307
Human keratinocyte migration on type IV collagen. Roles of heparin-binding site and alpha 2 beta 1 integrinQ72736007
Identification of CD47/integrin-associated protein and alpha(v)beta3 as two receptors for the alpha3(IV) chain of type IV collagen on tumor cellsQ73010293
Effect of HSP47 on prolyl 4-hydroxylation of collagen model peptidesQ73109631
Human factor IX binds to specific sites on the collagenous domain of collagen IVQ73456220
Identification of alpha3, alpha4, and alpha5 chains of type IV collagen as alloantigens for Alport posttransplant anti-glomerular basement membrane antibodiesQ73524039
A cell binding domain from the alpha3 chain of type IV collagen inhibits proliferation of melanoma cellsQ73575354
Substrate specificity of human collagenase 3 assessed using a phage-displayed peptide libraryQ30656278
Melanoma cell CD44 interaction with the alpha 1(IV)1263-1277 region from basement membrane collagen is modulated by ligand glycosylationQ30885646
Multiple binding sites in collagen type I for the integrins alpha1beta1 and alpha2beta1.Q30924957
Crucial role of the CB3-region of collagen IV in PARF-induced acute rheumatic feverQ33413755
Consortium for osteogenesis imperfecta mutations in the helical domain of type I collagen: regions rich in lethal mutations align with collagen binding sites for integrins and proteoglycans.Q34088135
Molecular architecture of the Goodpasture autoantigen in anti-GBM nephritisQ34088479
Mapping the ligand-binding sites and disease-associated mutations on the most abundant protein in the human, type I collagenQ34101398
Tumstatin, an endothelial cell-specific inhibitor of protein synthesisQ34107979
Protein glycosylation: nature, distribution, enzymatic formation, and disease implications of glycopeptide bondsQ34131204
alpha 11beta 1 integrin recognizes the GFOGER sequence in interstitial collagensQ34166441
The role of collagen-derived proteolytic fragments in angiogenesisQ34375953
Collagens, modifying enzymes and their mutations in humans, flies and wormsQ34544297
Mammalian collagen receptorsQ34586505
The von Hippel-Lindau tumor suppressor protein is required for proper assembly of an extracellular fibronectin matrixQ34748818
Collagen polymorphism: Its origins in the amino acid sequenceQ35110984
Alport's syndrome, Goodpasture's syndrome, and type IV collagen.Q35157829
Synthetic heterotrimeric collagen peptides as mimics of cell adhesion sites of the basement membrane.Q35680922
The collagen receptor subfamily of the integrinsQ35775496
Procollagen trafficking, processing and fibrillogenesis.Q36078993
Interaction of human thrombospondin with types I-V collagen: direct binding and electron microscopyQ36216111
Basement membrane structure in situ: evidence for lateral associations in the type IV collagen network.Q36217206
Identification of a multifunctional, cell-binding peptide sequence from the a1(NC1) of type IV collagenQ36223629
Novel roles for alpha3beta1 integrin as a regulator of cytoskeletal assembly and as a trans-dominant inhibitor of integrin receptor function in mouse keratinocytesQ36290617
The binding of heparin to type IV collagen: domain specificity with identification of peptide sequences from the alpha 1(IV) and alpha 2(IV) which preferentially bind heparin.Q36417079
Interaction of Dr adhesin with collagen type IV is a critical step in Escherichia coli renal persistenceQ36446772
Molecular recognition in the assembly of collagens: terminal noncollagenous domains are key recognition modules in the formation of triple helical protomers.Q36643333
Human podocytes adhere to the KRGDS motif of the alpha3alpha4alpha5 collagen IV networkQ36666850
Is SPARC an evolutionarily conserved collagen chaperone?Q36769633
Type IV collagen-derived angiogenesis inhibitorsQ36865710
The major pilin subunit of the AAF/II fimbriae from enteroaggregative Escherichia coli mediates binding to extracellular matrix proteinsQ36898489
Acetylcholinesterase in cell adhesion, neurite growth and network formationQ37060536
Goodpasture antigen-binding protein is a soluble exportable protein that interacts with type IV collagen. Identification of novel membrane-bound isoformsQ37142570
Inhibition of tumor angiogenesis by tumstatin: insights into signaling mechanisms and implications in cancer regressionQ37190487
Identification of the endothelial cell binding site for factor IX.Q37309632
P433issue2
P921main subjectligand bindingQ61659151
P304page(s)127-143
P577publication date2011-02-01
P1433published inHuman MutationQ5937269
P1476titleMapping structural landmarks, ligand binding sites, and missense mutations to the collagen IV heterotrimers predicts major functional domains, novel interactions, and variation in phenotypes in inherited diseases affecting basement membranes
P478volume32

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