Enhancer of zeste homologue 2 (EZH2) down-regulates RUNX3 by increasing histone H3 methylation

scientific article published on 22 April 2008

Enhancer of zeste homologue 2 (EZH2) down-regulates RUNX3 by increasing histone H3 methylation is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1074/JBC.M800224200
P932PMC publication ID2427338
P698PubMed publication ID18430739

P50authorAtsushi OchiaiQ88335769
Satoshi FujiiQ114834103
P2093author name stringYoshiaki Ito
Kosei Ito
P2860cites workThe Polycomb group protein EZH2 directly controls DNA methylationQ24299020
Mammalian homologues of the Polycomb-group gene Enhancer of zeste mediate gene silencing in Drosophila heterochromatin and at S. cerevisiae telomeresQ24532237
Methylation-specific PCR: a novel PCR assay for methylation status of CpG islandsQ24631957
EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cellsQ24672969
Causal relationship between the loss of RUNX3 expression and gastric cancerQ28509530
Runx3 controls the axonal projection of proprioceptive dorsal root ganglion neuronsQ28591148
The polycomb group protein EZH2 is involved in progression of prostate cancerQ29614514
Silencing of human polycomb target genes is associated with methylation of histone H3 Lys 27.Q33979536
RUNX3 suppresses gastric epithelial cell growth by inducing p21(WAF1/Cip1) expression in cooperation with transforming growth factor {beta}-activated SMAD.Q34042783
EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancerQ34268216
Transcriptional silencing of the RUNX3 gene by CpG hypermethylation is associated with lung cancer.Q34288901
Hemizygous deletion and hypermethylation of RUNX3 gene in hepatocellular carcinomaQ34294657
Promoter hypermethylation downregulates RUNX3 gene expression in colorectal cancer cell linesQ34335798
RUNX1 (AML-1) and RUNX2 (AML-3) cooperate with prostate-derived Ets factor to activate transcription from the PSA upstream regulatory region.Q34461329
Programming off and on states in chromatin: mechanisms of Polycomb and trithorax group complexesQ34563280
The RUNX3 tumor suppressor upregulates Bim in gastric epithelial cells undergoing transforming growth factor beta-induced apoptosisQ34718167
Runx3 and Runx1 are required for CD8 T cell development during thymopoiesisQ35146679
Oncogenic potential of the RUNX gene family: 'overview'.Q35779678
Coexpression of BMI-1 and EZH2 polycomb group genes in Reed-Sternberg cells of Hodgkin's diseaseQ35829466
The Runx3 transcription factor regulates development and survival of TrkC dorsal root ganglia neuronsQ39644959
RUNX3 is frequently inactivated by dual mechanisms of protein mislocalization and promoter hypermethylation in breast cancerQ40259898
Ezh2 reduces the ability of HDAC1-dependent pRb2/p130 transcriptional repression of cyclin A.Q40568073
Methylation of RUNX3 in various types of human cancers and premalignant stages of gastric carcinomaQ40589141
Poorly differentiated breast carcinoma is associated with increased expression of the human polycomb group EZH2 geneQ41602005
Inhibition of growth of mouse gastric cancer cells by Runx3, a novel tumor suppressorQ44226611
Reactivation of the silenced and imprinted alleles of ARHI is associated with increased histone H3 acetylation and decreased histone H3 lysine 9 methylationQ44521169
EZH2 expression is associated with high proliferation rate and aggressive tumor subgroups in cutaneous melanoma and cancers of the endometrium, prostate, and breastQ44864337
Aberrant CpG island hypermethylation of multiple genes in prostate cancer and prostatic intraepithelial neoplasiaQ47242342
Frequent loss of RUNX3 gene expression in human bile duct and pancreatic cancer cell linesQ47242721
Activated p53 suppresses the histone methyltransferase EZH2 geneQ47314793
RUNX3, a novel tumor suppressor, is frequently inactivated in gastric cancer by protein mislocalization.Q50335772
Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development.Q52111650
P433issue25
P407language of work or nameEnglishQ1860
P304page(s)17324-17332
P577publication date2008-04-22
P1433published inJournal of Biological ChemistryQ867727
P1476titleEnhancer of zeste homologue 2 (EZH2) down-regulates RUNX3 by increasing histone H3 methylation
P478volume283