Up-regulated expression and aberrant DNA methylation of LEP and SH3PXD2A in pre-eclampsia

scientific article published on 27 March 2013

Up-regulated expression and aberrant DNA methylation of LEP and SH3PXD2A in pre-eclampsia is …
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scholarly articleQ13442814

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P819ADS bibcode2013PLoSO...859753X
P356DOI10.1371/JOURNAL.PONE.0059753
P932PMC publication ID3609796
P698PubMed publication ID23544093
P5875ResearchGate publication ID236095385

P2093author name stringLei Wang
Lin He
Yan Cheng
Yun Liu
Qinghe Xing
Qiaoli Li
Junyu Zhang
Xinzhi Zhao
Jiawei Xu
Xiaotian Li
Yuqian Xiang
P2860cites workPreeclampsia 2012Q21285024
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The adaptor protein fish associates with members of the ADAMs family and localizes to podosomes of Src-transformed cellsQ28180409
The epigenomics of cancerQ28289975
Functions of DNA methylation: islands, start sites, gene bodies and beyondQ29547260
Phenotypic plasticity and the epigenetics of human diseaseQ29614515
Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsiaQ29615916
Prognostic significance of Tks5 expression in gliomas.Q30010180
The adaptor protein Tks5/Fish is required for podosome formation and function, and for the protease-driven invasion of cancer cellsQ30160317
A deficiency of placental IL-10 in preeclampsia.Q30768017
The DNA methylation paradoxQ33543982
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DNA methylation profiling of human placentas reveals promoter hypomethylation of multiple genes in early-onset preeclampsiaQ34329498
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Transcriptional profiling of human placentas from pregnancies complicated by preeclampsia reveals disregulation of sialic acid acetylesterase and immune signalling pathways.Q34574298
Endovascular trophoblast invasion: implications for the pathogenesis of intrauterine growth retardation and preeclampsiaQ35079406
Formation of atypical podosomes in extravillous trophoblasts regulates extracellular matrix degradationQ35931593
Preeclampsia up-regulates angiogenesis-associated microRNA (i.e., miR-17, -20a, and -20b) that target ephrin-B2 and EPHB4 in human placentaQ36069875
Leptin system in embryo development and implantation: a protein in search of a functionQ36094992
The elevation in circulating anti-angiogenic factors is independent of markers of neutrophil activation in preeclampsiaQ36131296
Preeclampsia is associated with alterations in DNA methylation of genes involved in collagen metabolismQ36295472
The role of the immune system in preeclampsiaQ36791219
Differential placental gene expression in severe preeclampsia.Q51794890
Expressional and epigenetic alterations of placental serine protease inhibitors: SERPINA3 is a potential marker of preeclampsia.Q52002583
Preeclampsia leads to dysregulation of various signaling pathways in placenta.Q53432665
Whole-genome microarray and targeted analysis of angiogenesis-regulating gene expression (ENG, FLT1, VEGF, PlGF) in placentas from pre-eclamptic and small-for-gestational-age pregnanciesQ57248848
Genome-wide expression profiling of placentas in the p57Kip2 model of pre-eclampsiaQ79750021
DNA methylation changes in sera of women in early pregnancy are similar to those in advanced breast cancer patientsQ80130273
Homocysteine, folic acid and B12 serum levels in pregnancy complicated with preeclampsiaQ80186758
Altered expression of angiogenesis-related placental genes in pre-eclampsia associated with intrauterine growth restrictionQ80580266
Circulating leptin and angiogenic factors in preeclampsia patientsQ81306170
Pre-eclampsiaQ81446389
Global DNA methylation patterns in placenta and its association with maternal hypertension in pre-eclampsiaQ82276396
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DNA methylation in development and human diseaseQ37110130
Differential placental gene expression in preeclampsiaQ37242824
Epigenetic mechanisms that underpin metabolic and cardiovascular diseasesQ37504694
Microarray profiling reveals that placental transcriptomes of early-onset HELLP syndrome and preeclampsia are similarQ37567589
Epigenetic mechanisms in neurological diseases: genes, syndromes, and therapiesQ37615626
Epigenetics and the placentaQ37801493
Review: Leptin gene expression in the placenta--regulation of a key hormone in trophoblast proliferation and survival.Q37838056
Leptin gene expression in human preadipocytes is switched on by maturation-induced demethylation of distinct CpGs in its proximal promoterQ38363272
Up-regulation of placental leptin by human chorionic gonadotropin.Q39940783
Fetal nutrition and cardiovascular disease in adult lifeQ40708848
Association of maternal serum CRP, IL-6, TNF-alpha, homocysteine, folic acid and vitamin B12 levels with the severity of preeclampsia and fetal birth weightQ42167645
Regulation of placental leptin expression by cyclic adenosine 5'-monophosphate involves cross talk between protein kinase A and mitogen-activated protein kinase signaling pathwaysQ43059524
Promoter hypomethylation of COMT in human placenta is not associated with the development of pre-eclampsiaQ43530640
Effects of estrogen on leptin gene promoter activation in MCF-7 breast cancer and JEG-3 choriocarcinoma cells: selective regulation via estrogen receptors alpha and betaQ43615182
Promoter hypomethylation of TIMP3 is associated with pre-eclampsia in a Chinese populationQ44037768
A study of changes in homocysteine levels during normal pregnancy and pre-eclampsia.Q46271609
Endothelial dysfunction in preeclampsiaQ47879591
Two-stage elevation of cell-free fetal DNA in maternal sera before onset of preeclampsia.Q47889241
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectpre-eclampsiaQ61335
DNA methylationQ874745
P304page(s)e59753
P577publication date2013-03-27
P1433published inPLOS OneQ564954
P1476titleUp-regulated expression and aberrant DNA methylation of LEP and SH3PXD2A in pre-eclampsia
P478volume8

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cites work (P2860)
Q28109684An Integrative Analysis of Preeclampsia Based on the Construction of an Extended Composite Network Featuring Protein-Protein Physical Interactions and Transcriptional Relationships
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Q35094987Large scale aggregate microarray analysis reveals three distinct molecular subclasses of human preeclampsia.
Q38584627Potential role of folate in pre-eclampsia
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Q97419307Systematic review supports the role of DNA methylation in the pathophysiology of preeclampsia: a call for analytical and methodological standardization
Q92852980The Role of Epigenetics in Placental Development and the Etiology of Preeclampsia
Q36517166The aberrantly expressed miR-193b-3p contributes to preeclampsia through regulating transforming growth factor-β signaling
Q90430866Transcriptome sequencing of adenomyosis eutopic endometrium: A new insight into its pathophysiology