An alternate pathway for androgen regulation of brain function: activation of estrogen receptor beta by the metabolite of dihydrotestosterone, 5alpha-androstane-3beta,17beta-diol

scientific article published on 11 December 2007

An alternate pathway for androgen regulation of brain function: activation of estrogen receptor beta by the metabolite of dihydrotestosterone, 5alpha-androstane-3beta,17beta-diol is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.1016/J.YHBEH.2007.09.012
P932PMC publication ID2430080
P698PubMed publication ID18067894
P5875ResearchGate publication ID5780248

P2093author name stringRobert J Handa
Toni R Pak
Trent D Lund
Laura Hinds
Andrea E Kudwa
P2860cites workDifferential expression of estrogen receptor beta splice variants in rat brain: identification and characterization of a novel variant missing exon 4Q73093493
Detection of estrogen receptor alpha and beta messenger ribonucleic acids in adult gonadotropin-releasing hormone neuronsQ73120950
Detection of estrogen receptor-beta messenger ribonucleic acid and 125I-estrogen binding sites in luteinizing hormone-releasing hormone neurons of the rat brainQ74244393
Brain androgen and progesterone metabolizing enzymes: biosynthesis, distribution and functionQ77354233
The testosterone metabolite and neurosteroid 3alpha-androstanediol may mediate the effects of testosterone on conditioned place preferenceQ77354291
Proceedings: Studies on the maintenance of sexual behaviour in castrated rats treated with various androgensQ95780462
An endocrine pathway in the prostate, ERbeta, AR, 5alpha-androstane-3beta,17beta-diol, and CYP7B1, regulates prostate growthQ24536103
GRIP1, a novel mouse protein that serves as a transcriptional coactivator in yeast for the hormone binding domains of steroid receptorsQ24600501
Cloning of a novel receptor expressed in rat prostate and ovaryQ24607949
Some rewarding effects of androgens may be mediated by actions of its 5alpha-reduced metabolite 3alpha-androstanediolQ24679317
Differential colocalization of estrogen receptor beta (ERbeta) with oxytocin and vasopressin in the paraventricular and supraoptic nuclei of the female rat brain: an immunocytochemical studyQ24684943
Pseudo-symmetry of C19 steroids, alternative binding orientations, and multispecificity in human estrogenic 17beta-hydroxysteroid dehydrogenaseQ27640194
Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor betaQ28283637
AVP V1b selective antagonist SSR149415 blocks aggressive behaviors in hamstersQ28302527
Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and betaQ28304508
Novel actions of estrogen receptor-beta on anxiety-related behaviorsQ28564421
Regulation of estrogen receptor-beta expression in the female rat hypothalamus: differential effects of dexamethasone and estradiolQ28569519
Estrogen receptor (ER)beta isoforms rather than ERalpha regulate corticotropin-releasing hormone promoter activity through an alternate pathwayQ28572288
Depletion of oestrogen receptor-beta expression in magnocellular arginine vasopressin neurones by hypovolaemia and dehydrationQ28578386
The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R)Q29547223
Mortality by cause for eight regions of the world: Global Burden of Disease StudyQ29615121
Gene regulation by steroid hormonesQ29618291
Novel effects of estradiol and estrogen receptor alpha and beta on cognitive functionQ30306361
Aggression and arginine vasopressin immunoreactivity regulation by androgen receptor and estrogen receptor alphaQ30312101
Roles of estrogen receptors alpha and beta in differentiation of mouse sexual behaviorQ30438902
Dissection of the LXXLL nuclear receptor-coactivator interaction motif using combinatorial peptide libraries: discovery of peptide antagonists of estrogen receptors alpha and betaQ30815190
Neuroactive steroids: mechanisms of action and neuropsychopharmacological perspectivesQ33707601
Increased anxiety and synaptic plasticity in estrogen receptor beta -deficient mice.Q33947181
Steroid 5alpha-reductases and 3alpha-hydroxysteroid dehydrogenases: key enzymes in androgen metabolismQ34084870
Major depressive disorderQ34122147
Comparative distribution of estrogen receptor-alpha and -beta mRNA in the rat central nervous systemQ48590882
Absence of oestradiol concentration in cell nuclei of LHRH-immunoreactive neuronesQ48778335
Estrogen-concentrating neurophysin-containing hypothalamic magnocellular neurons in the vasopressin-deficient (Brattleboro) rat: a study combining steroid autoradiography and immunocytochemistry.Q48866063
Estrogen-neurons and estrogen-neuron systems in the periventricular brainQ48893674
Corticotropin releasing activity of the new CRF is potentiated several times by vasopressinQ48895608
The inhibitory effect of testosterone on hypothalamic-pituitary-adrenal responses to stress is mediated by the medial preoptic area.Q49085286
Increased number of vasopressin- and oxytocin-expressing neurons in the paraventricular nucleus of the hypothalamus in depressionQ49151158
Effect of fasting and immobilization stress on estrogen receptor immunoreactivity in the brain in ovariectomized female rats.Q51581856
A splice variant of estrogen receptor beta missing exon 3 displays altered subnuclear localization and capacity for transcriptional activation.Q52542866
Depression of adrenal corticosterone production in oophorectomized rats.Q53753275
Global burden of depressive disorders in the year 2000Q56814477
Failure of 5α-Dihydrotestosterone to initiate Sexual Behaviour in the Castrated Male RatQ59070189
Steroid binding and metabolism in the luteinizing hormone-releasing hormone-producing neuronal cell line GT1-1Q60617699
A key enzyme in the biosynthesis of neurosteroids, 3β-hydroxysteroid dehydrogenase/Δ5-Δ4-isomerase (3β-HSD), is expressed in rat brainQ60683595
Differential effects of the anti-estrogen MER-25 and of three 5α-reduced androgens on mounting and lordosis behavior in the ratQ67463442
The quantitative distribution of cytosolic androgen receptors in microdissected areas of the male rat brain: effects of estrogen treatmentQ68822662
Effect of estrogen on androgen receptor dynamics in female rat pituitaryQ68822671
Neuroendocrine aspects of primary endogenous depression. I. Cortisol secretory dynamics in patients and matched controlsQ68982294
Isolation and catalytic activity of cytochrome P-450 from ventral prostate of control ratsQ69222440
Copulation in Castrated Male Rats following Combined Treatment with Estradiol and DihydrotestosteroneQ69591176
Interaction of Corticotropin-Releasing Factor and Arginine Vasopressin on Adrenocorticotropin Secretionin Vivo*Q70153165
Simultaneous localization of [3H]estradiol and neurophysin I or arginine vasopressin in hypothalamic neurons demonstrated by a combined technique of dry-mount autoradiography and immunohistochemistryQ71483902
Distribution and hormonal regulation of androgen receptor (AR) and AR messenger ribonucleic acid in the rat hippocampusQ71940240
Distribution of estrogen receptor-immunoreactive cells in monkey hypothalamus: relationship to neurones containing luteinizing hormone-releasing hormone and tyrosine hydroxylaseQ72193873
Do gonadotropin-releasing hormone, tyrosine hydroxylase-, and beta-endorphin-immunoreactive neurons contain estrogen receptors? A double-label immunocytochemical study in the Suffolk eweQ72227755
Effects of Estrogen on the Sexual Behavior of Male RatsQ72379200
Increased numbers of corticotropin-releasing hormone expressing neurons in the hypothalamic paraventricular nucleus of depressed patientsQ72415584
Localization of androgen receptor within peptidergic neurons of the rat forebrainQ72531874
Absence of androgen receptors in LHRH immunoreactive neuronsQ72636251
Toward a comprehensive developmental model for major depression in men.Q44916290
Restoration of male sexual behavior by adult exogenous estrogens in male aromatase knockout miceQ44950318
Dihydrotestosterone may inhibit hypothalamo-pituitary-adrenal activity by acting through estrogen receptor in the male mouseQ44964130
Localization of oestrogen receptors in preoptic neurons containing neurotensin but not tyrosine hydroxylase, cholecystokinin or luteinizing hormone-releasing hormone in the male and female rat.Q44987106
Effect of orchiectomy on pituitary secretion of ACTH.Q45000791
Distribution of androgen and estrogen receptor mRNA-containing cells in the rat brain: an in situ hybridization studyQ45020200
Analysis of estrogen receptor alpha-Sp1 interactions in breast cancer cells by fluorescence resonance energy transferQ45214828
Estrogen receptor-beta, but not estrogen receptor-alpha, is expressed in prolactin neurons of the female rat paraventricular and supraoptic nuclei: comparison with other neuropeptidesQ45270689
Identification of the major oxidative 3alpha-hydroxysteroid dehydrogenase in human prostate that converts 5alpha-androstane-3alpha,17beta-diol to 5alpha-dihydrotestosterone: a potential therapeutic target for androgen-dependent diseaseQ46716649
The combined dexamethasone/CRH test: a refined laboratory test for psychiatric disordersQ48101414
Distribution of androgen receptor immunoreactivity in vasopressin- and oxytocin-immunoreactive neurons in the male rat brainQ48108911
Androgen inhibits the increases in hypothalamic corticotropin-releasing hormone (CRH) and CRH-immunoreactivity following gonadectomyQ48161728
Intracellular partitioning of androgen receptor immunoreactivity in the brain of the male Syrian hamster: effects of castration and steroid replacementQ48261290
Alteration in sex-specific behaviors in male mice lacking the aromatase geneQ48261689
Steroid hormone target sites in the brain: the differential distribution of estrogin, progestin, androgen and glucocorticosteroidQ48352038
Androgen and estrogen receptor-beta distribution within spinal-projecting and neurosecretory neurons in the paraventricular nucleus of the male rat.Q48383923
Expression and neuropeptidergic characterization of estrogen receptors (ERalpha and ERbeta) throughout the rat brain: anatomical evidence of distinct roles of each subtypeQ48397592
Distribution and regulation of aromatase activity in the rat hypothalamus and limbic systemQ48430868
Chronic estrogen-induced alterations in adrenocorticotropin and corticosterone secretion, and glucocorticoid receptor-mediated functions in female ratsQ48442674
Expression of estrogen receptor-beta messenger ribonucleic acid in oxytocin and vasopressin neurons of the rat supraoptic and paraventricular nucleiQ48471771
Anatomic distribution and regulation of aromatase gene expression in the rat brainQ48529880
Production, purification, and functional analysis of recombinant human and mouse 17beta-hydroxysteroid dehydrogenase type 7.Q34194943
Anticonvulsant activity of the testosterone-derived neurosteroid 3alpha-androstanediol.Q34314656
Anxiolytic-like actions of testosterone in the burying behavior test: role of androgen and GABA-benzodiazepine receptorsQ34421784
Estrogen action in mood and neurodegenerative disorders: estrogenic compounds with selective properties-the next generation of therapeuticsQ34481021
Stress history and pubertal development interact to shape hypothalamic-pituitary-adrenal axis plasticityQ34484253
The androgen 5alpha-dihydrotestosterone and its metabolite 5alpha-androstan-3beta, 17beta-diol inhibit the hypothalamo-pituitary-adrenal response to stress by acting through estrogen receptor beta-expressing neurons in the hypothalamus.Q34490663
Non-genomic actions of androgens.Q34727863
Neurochemical regulation of pair bonding in male prairie volesQ35920167
Estrogen receptor beta in the brain: from form to functionQ36642471
Androgens selectively modulate C-fos messenger RNA induction in the rat hippocampus following noveltyQ38352646
Human corticotropin releasing hormone: clinical studies in patients with affective disorders, alcoholism, panic disorder and in normal controlsQ39332760
New androgen receptor genomic targets show an interaction with the ETS1 transcription factor.Q40089132
Estrogen receptor-beta mediates dihydrotestosterone-induced stimulation of the arginine vasopressin promoter in neuronal cells.Q40148711
Ligand-independent effects of estrogen receptor beta on mouse gonadotropin-releasing hormone promoter activity.Q40324588
The androgen metabolite, 5alpha-androstane-3beta, 17beta-diol, is a potent modulator of estrogen receptor-beta1-mediated gene transcription in neuronal cells.Q40506514
Gonadal steroid hormone receptors and sex differences in the hypothalamo-pituitary-adrenal axisQ40513551
Human cytosolic 3alpha-hydroxysteroid dehydrogenases of the aldo-keto reductase superfamily display significant 3beta-hydroxysteroid dehydrogenase activity: implications for steroid hormone metabolism and actionQ40607849
Distribution of estrogen receptor beta immunoreactivity in the rat central nervous systemQ40701784
The formation of estrogens by central neuroendocrine tissuesQ40721203
Oestrogen receptor beta-immunoreactivity in gonadotropin releasing hormone-expressing neurones: regulation by oestrogenQ40777875
Puberty onset of gender differences in rates of depression: a developmental, epidemiologic and neuroendocrine perspectiveQ40811125
Differential transcriptional regulation of rat vasopressin gene expression by estrogen receptor alpha and betaQ40840844
Antidepressants and hypothalamic-pituitary-adrenocortical regulationQ41032512
Enhancement of estrogen receptor transcriptional activity by the coactivator GRIP-1 highlights the role of activation function 2 in determining estrogen receptor pharmacologyQ41050885
Steroid binding and metabolism in the luteinizing hormone-releasing hormone-producing neuronal cell line GT1-1.Q41414928
Elevated Concentrations of CSF Corticotropin-Releasing Factor-Like Immunoreactivity in Depressed PatientsQ41561553
Biological and social contributions to negative affect in young adolescent girlsQ41998572
Modulation of oestrogen receptor-beta mRNA expression in rat paraventricular and supraoptic nucleus neurones following adrenal steroid manipulation and hyperosmotic stimulationQ42460962
Gender and puberty interact on the stress-induced activation of parvocellular neurosecretory neurons and corticotropin-releasing hormone messenger ribonucleic acid expression in the rat.Q42467748
Immunocytochemical distribution of aromatase cytochrome P450 in the rat brain using peptide-generated polyclonal antibodiesQ42474194
Oxytocin-stimulated release of adrenocorticotropin from the rat pituitary is mediated by arginine vasopressin receptors of the V1b typeQ42492819
Identification of estrogen receptor beta2, a functional variant of estrogen receptor beta expressed in normal rat tissuesQ42544665
Androgen regulation of adrenocorticotropin and corticosterone secretion in the male rat following novelty and foot shock stressorsQ42603662
Tamoxifen activation of the estrogen receptor/AP-1 pathway: potential origin for the cell-specific estrogen-like effects of antiestrogensQ42828921
Evidence for novel estrogen binding sites in the rat hippocampusQ43506804
Conformational changes and coactivator recruitment by novel ligands for estrogen receptor-alpha and estrogen receptor-beta: correlations with biological character and distinct differences among SRC coactivator family membersQ43507765
Combined administration of human corticotropin-releasing factor and lysine vasopressin induces cortisol escape from dexamethasone suppression in healthy subjectsQ43507948
Androgen- and estrogen-induced copulatory behavior and inhibition of luteinizing hormone (LH) secretion in the male ratQ43536560
Estrogen receptor-beta immunoreactivity in luteinizing hormone-releasing hormone neurons of the rat brainQ43646714
Adrenocortical function in the hamster. Sex differences and effects of gonadal hormonesQ43723601
Effect of ovariectomy on pituitary secretion of ACTH.Q44094941
Peripheral and central sex steroids have differential effects on the HPA axis of male and female ratsQ44244695
Aromatizable and 5α-reduced androgens: Differentiation between central and peripheral effects on male rat sexual behaviorQ44279120
A testicular influence on restraint-induced activation of medial parvocellular neurons in the paraventricular nucleus in the male rat.Q44480645
Estrogen receptor β in the paraventricular nucleus of hypothalamus regulates the neuroendocrine response to stress and is regulated by corticosteroneQ44633532
Aromatization and 5alpha-reduction of androgens in discrete hypothalamic and limbic regions of the male and female ratQ44633785
Lack of functional estrogen receptor beta gene disrupts pubertal male sexual behaviorQ44673601
Androgen inhibits, while oestrogen enhances, restraint-induced activation of neuropeptide neurones in the paraventricular nucleus of the hypothalamusQ44818544
Testosterone cannot activate an adult-like stress response in prepubertal male ratsQ44855182
Genetic risk factors for major depression in men and women: similar or different heritabilities and same or partly distinct genes?Q44881239
Testosterone-dependent variations in plasma and intrapituitary corticosteroid binding globulin and stress hypothalamic-pituitary-adrenal activity in the male rat.Q44884623
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectestrogenQ277954
P304page(s)741-752
P577publication date2007-12-11
P1433published inHormones and BehaviourQ15760887
P1476titleAn alternate pathway for androgen regulation of brain function: activation of estrogen receptor beta by the metabolite of dihydrotestosterone, 5alpha-androstane-3beta,17beta-diol
P478volume53

Reverse relations

cites work (P2860)
Q49144664Activity and expression of steroidogenic enzymes in the brain of adult zebrafish
Q38571198Adverse effects of 5α-reductase inhibitors: What do we know, don't know, and need to know?
Q48330269Ameliorative Effects of Endurance Exercise with Two Different Intensities on Nandrolone Decanoate-Induced Neurodegeneration in Rats: Involving Redox and Apoptotic Systems
Q30423173Anabolic androgenic steroid abuse: multiple mechanisms of regulation of GABAergic synapses in neuroendocrine control regions of the rodent forebrain
Q34513208Androgen decreases dopamine neurone survival in rat midbrain
Q34773092Androgen inhibition of sexual receptivity is modulated by estrogen
Q33937681Androgen regulation of corticotropin-releasing hormone receptor 2 (CRHR2) mRNA expression and receptor binding in the rat brain
Q38100664Androgens and the cerebrovasculature: modulation of vascular function during normal and pathophysiological conditions
Q37178245Androgens in health and disease: an overview
Q64859151Androgens modulate chronic intermittent hypoxia effects on brain and behavior
Q39897838Androgens upregulate cyp19a1b (aromatase B) gene expression in the brain of zebrafish (Danio rerio) through estrogen receptors
Q34822652Androgens with activity at estrogen receptor beta have anxiolytic and cognitive-enhancing effects in male rats and mice
Q27024884Animal models of the polycystic ovary syndrome phenotype
Q48019029Anti-androgenic effects of bisphenol-A on spatial memory and synaptic plasticity of the hippocampus in mice
Q36787501Anti-anxiety, cognitive, and steroid biosynthetic effects of an isoflavone-based dietary supplement are gonad and sex-dependent in rats
Q37684160Aromatase in the brain of teleost fish: expression, regulation and putative functions.
Q34407307Astrocytes in the rat medial amygdala are responsive to adult androgens.
Q88736639Bisphenol-A inhibits improvement of testosterone in anxiety- and depression-like behaviors in gonadectomied male mice
Q35603332CYP7B1 Enzyme Deletion Impairs Reproductive Behaviors in Male Mice
Q37220801Chronic administration of androgens with actions at estrogen receptor beta have anti-anxiety and cognitive-enhancing effects in male rats
Q37324578Chronic administration of androgens with actions at estrogen receptor beta have anti-anxiety and cognitive-enhancing effects in male rats
Q30425290Chronic exposure to anabolic androgenic steroids alters activity and synaptic function in neuroendocrine control regions of the female mouse
Q47841265Cognition in female rats after blocking conversion of androgens to estrogens.
Q60499987Consumo de cannabis y neurodesarrollo: ¿por qué son relevantes las diferencias de género?
Q64882271Developmental Programming of Ovarian Functions and Dysfunctions.
Q36455236Developmental Programming: Does Prenatal Steroid Excess Disrupt the Ovarian VEGF System in Sheep?
Q89660256Developmental Programming: Prenatal Testosterone Excess on Ovarian SF1/DAX1/FOXO3
Q36907318Developmental origin of reproductive and metabolic dysfunctions: androgenic versus estrogenic reprogramming.
Q33881713Developmental programing: impact of testosterone on placental differentiation.
Q33583733Developmental programming: contribution of prenatal androgen and estrogen to estradiol feedback systems and periovulatory hormonal dynamics in sheep
Q33634370Developmental programming: impact of prenatal testosterone excess and postnatal weight gain on insulin sensitivity index and transfer of traits to offspring of overweight females
Q42428705Developmental programming: postnatal estradiol modulation of prenatally organized reproductive neuroendocrine function in sheep.
Q35986009Developmental programming: prenatal and postnatal contribution of androgens and insulin in the reprogramming of estradiol positive feedback disruptions in prenatal testosterone-treated sheep
Q37670372Developmental programming: prenatal androgen excess disrupts ovarian steroid receptor balance.
Q35645920Dihydrotestosterone differentially modulates the cortisol response of the hypothalamic-pituitary-adrenal axis in male and female rhesus macaques, and restores circadian secretion of cortisol in females
Q38945304Does puberty mark a transition in sensitive periods for plasticity in the associative neocortex?
Q42140478Dose-dependent effects of androgens on the circadian timing system and its response to light.
Q30417561Dysregulation of neonatal hippocampal cell genesis in the androgen insensitive Tfm rat
Q92718595Effect of adolescent androgen manipulation on psychosis-like behaviour in adulthood in BDNF heterozygous and control mice
Q48811679Effects of androgen and leptin on behavioral and cellular responses in female rats.
Q47356219Estrogen Receptors Modulation of Anxiety-Like Behavior
Q33709986Estrogen action: a historic perspective on the implications of considering alternative approaches
Q30478476Estrogen actions in the brain and the basis for differential action in men and women: a case for sex-specific medicines
Q28649589Estrogen receptor signaling during vertebrate development
Q30436573Estrogen receptor-beta agonist diarylpropionitrile: biological activities of R- and S-enantiomers on behavior and hormonal response to stress.
Q30354013Framework for sex differences in adolescent neurobiology: a focus on cannabinoids.
Q37721503Genes, Gender, Environment, and Novel Functions of Estrogen Receptor Beta in the Susceptibility to Neurodevelopmental Disorders.
Q37850100Hormones of choice: the neuroendocrinology of partner preference in animals
Q33493432Hypothalamic neuroendocrine functions in rats with dihydrotestosterone-induced polycystic ovary syndrome: effects of low-frequency electro-acupuncture
Q37666517Impacts of stress and sex hormones on dopamine neurotransmission in the adolescent brain
Q98394783In vitro model of perimenopausal depression implicates steroid metabolic and proinflammatory genes
Q51762451Interactive effects of testosterone and cortisol on hippocampal volume and episodic memory in middle-aged men.
Q37446868Lipid peroxidation and apoptotic response in rat brain areas induced by long-term administration of nandrolone: the mutual crosstalk between ROS and NF-kB
Q35779861Long Term Hippocampal and Cortical Changes Induced by Maternal Deprivation and Neonatal Leptin Treatment in Male and Female Rats
Q30454488Maternal deprivation and adolescent cannabinoid exposure impact hippocampal astrocytes, CB1 receptors and brain-derived neurotrophic factor in a sexually dimorphic fashion
Q35078612Neonatal agonism of ERβ impairs male reproductive behavior and attractiveness
Q35915870Neural Androgen Receptor Deletion Impairs the Temporal Processing of Objects and Hippocampal CA1-Dependent Mechanisms.
Q39455313Neuroactive steroids and diabetic complications in the nervous system.
Q91744388Neuroendocrine drivers of risk and resilience: The influence of metabolism & mitochondria
Q35710568Neurotoxicity by synthetic androgen steroids: oxidative stress, apoptosis, and neuropathology: A review.
Q34972115New knockout model confirms a role for androgen receptors in regulating anxiety-like behaviors and HPA response in mice.
Q38866162Oestrogens and Progestagens: Synthesis and Action in the Brain.
Q90685179Physiopathological role of the enzymatic complex 5α-reductase and 3α/β-hydroxysteroid oxidoreductase in the generation of progesterone and testosterone neuroactive metabolites
Q36411087Polygenic inheritance of cryptorchidism susceptibility in the LE/orl rat.
Q88416994Post-finasteride syndrome and post-SSRI sexual dysfunction: two sides of the same coin?
Q30421731Prenatal androgen exposure programs metabolic dysfunction in female mice
Q30417384Prenatal exposure to low levels of androgen accelerates female puberty onset and reproductive senescence in mice
Q51543558Pulp and paper mill effluents induce distinct gene expression changes linked to androgenic and estrogenic responses in the fathead minnow (Pimephales promelas)
Q36761985Rapid and estrogen receptor beta mediated actions in the hippocampus mediate some functional effects of estrogen
Q33902974Regulation of aromatase expression in the anterior amygdala of the developing mouse brain depends on ERβ and sex chromosome complement
Q34127494Reproduction Symposium: developmental programming of reproductive and metabolic health
Q98163681Roles for androgens in mediating the sex differences of neuroendocrine and behavioral stress responses
Q94464833Senolytic compounds control a distinct fate of androgen receptor agonist- and antagonist-induced cellular senescent LNCaP prostate cancer cells
Q38724775Sex and stress steroids in adolescence: Gonadal regulation of the hypothalamic-pituitary-adrenal axis in the rat.
Q36357671Sex differences and effects of prenatal exposure to excess testosterone on ventral tegmental area dopamine neurons in adult sheep
Q30420095Sex differences in social investigation: effects of androgen receptors, hormones and test partner
Q38221452Sex differences in the HPA axis
Q35102196Sex differences in the effect of puberty on hippocampal morphology
Q34616106Sex differences in the neurobiology of epilepsy: a preclinical perspective
Q36889958Sex differences in the serum level of endogenous ligands for estrogen receptor β in the elderly population
Q38779220Sex hormones and adult hippocampal neurogenesis: Regulation, implications, and potential mechanisms.
Q103017700Sex steroids modulate circadian behavioral rhythms in captive animals, but does this matter in the wild?
Q36597826Sheep models of polycystic ovary syndrome phenotype.
Q35988699Suprachiasmatic nucleus as the site of androgen action on circadian rhythms
Q35050694Synaptic long-term potentiation and depression in the rat medial vestibular nuclei depend on neural activation of estrogenic and androgenic signals
Q37126074Systemic administration of diarylpropionitrile (DPN) or phytoestrogens does not affect anxiety-related behaviors in gonadally intact male rats
Q37013602Testosterone depletion in adult male rats increases mossy fiber transmission, LTP, and sprouting in area CA3 of hippocampus
Q35117468Testosterone induces molecular changes in dopamine signaling pathway molecules in the adolescent male rat nigrostriatal pathway
Q34245667Testosterone regulation of Alzheimer-like neuropathology in male 3xTg-AD mice involves both estrogen and androgen pathways
Q36770994The androgen metabolite, 5α-androstane-3β,17β-diol (3β-diol), activates the oxytocin promoter through an estrogen receptor-β pathway
Q30439036The androgen receptor is selectively involved in organization of sexually dimorphic social behaviors in mice
Q41387586The effect of androgen excess on maternal metabolism, placental function and fetal growth in obese dams
Q37888955The endocannabinoid system in critical neurodevelopmental periods: sex differences and neuropsychiatric implications.
Q24652658The role of androgen receptors in the masculinization of brain and behavior: what we've learned from the testicular feminization mutation
Q43582589The role of the androgen receptor in anabolic androgenic steroid-induced aggressive behavior in C57BL/6J and Tfm mice
Q35046917Visualization of estrogen receptor transcriptional activation in zebrafish

Search more.