Association of Pro12Ala polymorphism in peroxisome proliferator activated receptor gamma with proliferative diabetic retinopathy

scientific article published on 21 March 2013

Association of Pro12Ala polymorphism in peroxisome proliferator activated receptor gamma with proliferative diabetic retinopathy is …
instance of (P31):
scholarly articleQ13442814

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P932PMC publication ID3611930
P698PubMed publication ID23559865

P2093author name stringRaheel Qamar
Maleeha Azam
Nadia Khalida Waheed
Syeda Hafiza Benish Ali
Aisha Azam
Irfan Muslim
Muhammad Shakil Khan
Sundas Ejaz Maqsood
Khadija Tariq
Saira Bano Malik
P2860cites workThe common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetesQ24290189
Global prevalence of diabetes: estimates for the year 2000 and projections for 2030Q27860575
Retinopathy in diabetesQ28166601
The peroxisome proliferator-activated receptor-gamma2 Pro12Ala polymorphismQ28216175
mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancerQ29617271
Whole genome assessment of the retinal response to diabetes reveals a progressive neurovascular inflammatory responseQ33343728
Risk factors associated with diabetic retinopathy in patients with diabetes mellitus type 2.Q33591693
PPARgamma, the ultimate thrifty geneQ33711175
The Pro12Ala polymorphism in PPAR gamma2 may confer resistance to type 2 diabetesQ33899154
PPAR gamma and human metabolic diseaseQ34416432
Alanine for proline substitution in the peroxisome proliferator-activated receptor gamma-2 (PPARG2) gene and the risk of incident myocardial infarctionQ34509923
Is the Ala12 variant of the PPARG gene an "unthrifty allele"?Q35448715
Microvascular complications of impaired glucose tolerance.Q35591509
Peroxisome proliferator-activated receptor γ polymorphism Pro12Ala Is associated with nephropathy in type 2 diabetes: evidence from meta-analysis of 18 studiesQ35976372
Effect of novel water soluble curcumin derivative on experimental type- 1 diabetes mellitus (short term study)Q36499074
Characterization of a novel polymorphism in PPARG regulatory region associated with type 2 diabetes and diabetic retinopathy in Italy.Q37029158
A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivityQ38331543
Role of fatty acids in the pathogenesis of insulin resistance and NIDDM.Q41275648
Diabetes reduces basal retinal insulin receptor signaling: reversal with systemic and local insulinQ42492673
Inhibitory effect of a proline-to-alanine substitution at codon 12 of peroxisome proliferator-activated receptor-gamma 2 on thiazolidinedione-induced adipogenesisQ42806100
Pro12Ala polymorphism in the peroxisome proliferator-activated receptor-gamma2 gene is associated with increased antilipolytic insulin sensitivityQ43566173
Studies of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-gamma2 (PPAR-gamma2) gene in relation to insulin sensitivity among glucose tolerant caucasiansQ43763530
Reduced lipolysis as possible cause for greater weight gain in subjects with the Pro12Ala polymorphism in PPARgamma2?Q43886617
Peroxisome proliferator-activated receptor-gamma2 polymorphism Pro12Ala is associated with nephropathy in type 2 diabetes: The Berlin Diabetes Mellitus (BeDiaM) StudyQ44081051
Alanine variant of the Pro12Ala polymorphism of the PPARgamma gene might be associated with decreased risk of diabetic retinopathy in type 2 diabetesQ44509605
The human peroxisome proliferator-activated receptor gamma2 (PPARgamma2) Pro12Ala polymorphism is associated with decreased risk of diabetic nephropathy in patients with type 2 diabetesQ44666346
A central role for inflammation in the pathogenesis of diabetic retinopathyQ44961996
Ala12Ala genotype of the peroxisome proliferator-activated receptor gamma2 protects against atherosclerosisQ45050542
Insulin resistance and proliferative retinopathy: a cross-sectional, case-control study in 115 patients with type 2 diabetesQ45050575
Molecular scanning of the human peroxisome proliferator activated receptor gamma (hPPAR gamma) gene in diabetic Caucasians: identification of a Pro12Ala PPAR gamma 2 missense mutationQ46671380
Lack of association between the Pro12Ala polymorphism in PPAR-gamma2 gene and body weight changes, insulin resistance and chronic diabetic complications in obese patients with type 2 diabetesQ47330796
Role of genetic polymorphism peroxisome proliferator-activated receptor-gamma2 Pro12Ala on ethnic susceptibility to diabetes in South-Asian and Caucasian subjects: Evidence for heterogeneity.Q51499010
Association of the Pro12Ala and C1431T variants of PPARG and their haplotypes with susceptibility to Type 2 diabetesQ57639011
Insulin acutely regulates the expression of the peroxisome proliferator-activated receptor-gamma in human adipocytesQ74671754
The PPARgamma2 amino acid polymorphism Pro 12 Ala is prevalent in offspring of Type II diabetic patients and is associated to increased insulin sensitivity in a subgroup of obese subjectsQ77924533
Effects of peroxisome proliferator-activated receptor gamma and its ligand on blood-retinal barrier in a streptozotocin-induced diabetic modelQ79143850
An analysis of peroxisome proliferator-activated receptor gamma (PPAR-gamma 2) Pro12Ala polymorphism distribution and prevalence of type 2 diabetes mellitus (T2DM) in world populations in relation to dietary habitsQ80159483
Gly482Ser polymorphism of the peroxisome proliferator-activated receptor-gamma coactivator-1 gene might be a risk factor for diabetic retinopathy in Slovene population (Caucasians) with type 2 diabetes and the Pro12Ala polymorphism of the PPARgammaQ81554853
P921main subjectdiabetic retinopathyQ631361
proliferative diabetic retinopathyQ18967481
P304page(s)710-717
P577publication date2013-03-21
P1433published inMolecular VisionQ6895981
P1476titleAssociation of Pro12Ala polymorphism in peroxisome proliferator activated receptor gamma with proliferative diabetic retinopathy
P478volume19

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cites work (P2860)
Q39089813A polymorphism of HMGA1 protects against proliferative diabetic retinopathy by impairing HMGA1-induced VEGFA expression
Q90446393Association of Peroxisome Proliferator-Activated Receptors (PPARs) with Diabetic Retinopathy in Human and Animal Models: Analysis of the Literature and Genome Browsers
Q28073127Candidate gene studies of diabetic retinopathy in human
Q35110729GRK5 intronic (CA)n polymorphisms associated with type 2 diabetes in Chinese Hainan Island
Q36493240Interaction between peroxisome proliferator- activated receptor gamma polymorphism and overweight on diabetic retinopathy in a Chinese case-control study
Q98164364PPARG (Pro12Ala) genetic variant and risk of T2DM: a systematic review and meta-analysis
Q35867091Role of ACE and PAI-1 Polymorphisms in the Development and Progression of Diabetic Retinopathy
Q26773225Update on genetics and diabetic retinopathy
Q36374238ω-3 and ω-6 long-chain PUFAs and their enzymatic metabolites in neovascular eye diseases.

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