Uterine RAC1 via Pak1-ERM signaling directs normal luminal epithelial integrity conducive to on-time embryo implantation in mice

scientific article published on 17 July 2015

Uterine RAC1 via Pak1-ERM signaling directs normal luminal epithelial integrity conducive to on-time embryo implantation in mice is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1017584770
P356DOI10.1038/CDD.2015.98
P932PMC publication ID4815987
P698PubMed publication ID26184908
P5875ResearchGate publication ID280117357

P50authorFrancesco J DeMayoQ62942908
P2093author name stringX Wu
H Wang
B Wang
J Wang
J Lu
Q Wang
S Zhang
T Cui
H Ran
H Bao
J P Lydon
S Kong
Z Tu
P2860cites workThe mammalian homologue of the Caenorhabditis elegans polarity protein PAR-6 is a binding partner for the Rho GTPases Cdc42 and Rac1Q24290129
Human p21-activated kinase (Pak1) regulates actin organization in mammalian cellsQ24312369
A positive feedback loop involving Gcm1 and Fzd5 directs chorionic branching morphogenesis in the placentaQ24338902
Bves directly interacts with GEFT, and controls cell shape and movement through regulation of Rac1/Cdc42 activityQ24658017
Molecular determinants of uterine receptivityQ26821971
ERM proteins in cancer progressionQ26859107
Rac activation by the T-cell receptor inhibits T cell migrationQ27320959
Rho GTPases and the actin cytoskeletonQ27860579
p21-activated kinase links Rac/Cdc42 signaling to merlinQ28207198
Organizing the cell cortex: the role of ERM proteinsQ28277373
Ovarian hormones control the changing expression of claudins and occludin in rat uterine epithelial cells during early pregnancyQ28564420
STAT3 regulates uterine epithelial remodeling and epithelial-stromal crosstalk during implantationQ30409357
Apoptotic cell clearance by bronchial epithelial cells critically influences airway inflammationQ30415188
The Rac activator Tiam1 controls tight junction biogenesis in keratinocytes through binding to and activation of the Par polarity complexQ30443412
Implantation of the human embryo requires Rac1-dependent endometrial stromal cell migrationQ30483941
Apoptosis at the time of embryo implantation in mouse and rat.Q33669477
Uterine disorders and pregnancy complications: insights from mouse modelsQ33755385
Molecular signaling in uterine receptivity for implantationQ33954373
Blastocyst implantation: the adhesion cascade.Q33954380
ERM proteins at a glanceQ33980498
Apoptosis as the mode of uterine epithelial cell death during embryo implantation in mice and ratsQ68984033
Rac1 mutations produce aberrant epithelial differentiation in the developing and adult mouse small intestineQ73815412
Alterations in tight junction molecules of uterine epithelial cells during early pregnancy in the ratQ74370927
Hematopoietic Cell Regulation by Rac1 and Rac2 Guanosine TriphosphatasesQ79176492
Differential expression of ezrin/radixin/moesin (ERM) and ERM-associated adhesion molecules in the blastocyst and uterus suggests their functions during implantationQ79289559
SnapShot: Noncanonical Wnt Signaling PathwaysQ80411299
Rac1 mediates collapse of microvilli on chemokine-activated T lymphocytesQ80833051
Appropriate crypt formation in the uterus for embryo homing and implantation requires Wnt5a-ROR signalingQ33995495
Uterine Rbpj is required for embryonic-uterine orientation and decidual remodeling via Notch pathway-independent and -dependent mechanismsQ34008446
Physiological and molecular determinants of embryo implantationQ34320970
Activation and signaling of the p38 MAP kinase pathwayQ34390191
Importance of uterine cell death, renewal, and their hormonal regulation in hamsters that show progesterone-dependent implantationQ34587563
Balanced Rac1 and RhoA activities regulate cell shape and drive invagination morphogenesis in epitheliaQ35546873
Rac1 GTPase-deficient mouse lens exhibits defects in shape, suture formation, fiber cell migration and survivalQ35549266
Conditional deletion of Msx homeobox genes in the uterus inhibits blastocyst implantation by altering uterine receptivity.Q35621569
Impaired cell death and mammary gland involution in the absence of Dock1 and Rac1 signaling.Q35679546
Kruppel-like factor 5 (KLF5) is critical for conferring uterine receptivity to implantationQ35708828
Mitogen-activated protein kinases in apoptosis regulationQ35743118
Molecular cues to implantationQ35794396
Uterine receptivity and the plasma membrane transformation.Q35880512
Commonality within diversity: the plasma membrane transformation of uterine epithelial cells during early placentationQ36268323
Roadmap to embryo implantation: clues from mouse modelsQ36399435
Blastocyst's state of activity determines the "window" of implantation in the receptive mouse uterusQ36636796
Rac1 activation controls nuclear localization of beta-catenin during canonical Wnt signaling.Q36666693
Understanding ERM proteins--the awesome power of genetics finally brought to bearQ36686692
Adhesiveness of the free surface of a human endometrial monolayer for trophoblast as related to actin cytoskeleton.Q36873065
Wnt-5a-CKI{alpha} signaling promotes {beta}-catenin/E-cadherin complex formation and intercellular adhesion in human breast epithelial cellsQ37155506
Mechanisms of implantation: strategies for successful pregnancy.Q38065918
Multiple functions of the noncanonical Wnt pathway.Q38120949
Cre-mediated recombination in cell lineages that express the progesterone receptorQ38521008
The Rac1 regulator ELMO controls basal body migration and docking in multiciliated cells through interaction with EzrinQ39074370
Bacterial toxins that target Rho proteinsQ39779551
Anti-fas activating antibody enhances trophoblast outgrowth on endometrial epithelial cells by induction of P38 MAPK/JNK-mediated apoptosisQ40002197
Rac1 mediates intestinal epithelial cell apoptosis via JNK.Q40263028
Plasma membrane transformation: a common response of uterine epithelial cells during the peri-implantation period.Q40498785
Rac GTPase activity is essential for lipopolysaccharide signaling to extracellular signal-regulated kinase and p38 MAP kinase activation in rat-2 fibroblastsQ40716719
Epithelial cell polarity and embryo implantation in mammalsQ41232174
The cytoskeleton of uterine epithelial cells: a new player in uterine receptivity and the plasma membrane transformationQ41394458
Fibroblast growth factor receptor two (FGFR2) regulates uterine epithelial integrity and fertility in mice.Q42448836
Force-induced apoptosis mediated by the Rac/Pak/p38 signalling pathway is regulated by filamin A.Q42795953
Nitric oxide induces extensive apoptosis in endometrial epithelial cells in the presence of progesterone: involvement of mitogen-activated protein kinase pathwaysQ43686345
Wnt6 is essential for stromal cell proliferation during decidualization in mice.Q50774351
Expression and activation of the membrane-cytoskeleton protein ezrin during the normal endometrial cycle.Q50983313
Rac1 is required for the formation of three germ layers during gastrulation.Q52179195
Proprotein convertase 5/6 is critical for embryo implantation in women: regulating receptivity by cleaving EBP50, modulating ezrin binding, and membrane-cytoskeletal interactions.Q53214973
ERM proteins regulate cytoskeleton relaxation promoting T cell–APC conjugationQ63408325
P4510describes a project that usesImageJQ1659584
P433issue1
P1104number of pages13
P304page(s)169-181
P577publication date2015-07-17
P1433published inCell Death & DifferentiationQ2943974
P1476titleUterine RAC1 via Pak1-ERM signaling directs normal luminal epithelial integrity conducive to on-time embryo implantation in mice
P478volume23

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cites work (P2860)
Q64271183BMP7 coordinates endometrial epithelial cell receptivity for blastocyst implantation through the endoglin pathway in cell lines and a mouse model
Q33689671Integrin beta8 (ITGB8) activates VAV-RAC1 signaling via FAK in the acquisition of endometrial epithelial cell receptivity for blastocyst implantation
Q47140295Loci and pathways associated with uterine capacity for pregnancy and fertility in beef cattle.
Q39135838Mechanisms controlling germline cyst breakdown and primordial follicle formation
Q91105584Nucleolar stress regulation of endometrial receptivity in mouse models and human cell lines
Q36769039Rac1 modulates the formation of primordial follicles by facilitating STAT3-directed Jagged1, GDF9 and BMP15 transcription in mice.

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