Targeted disruption of influenza A virus hemagglutinin in genetically modified mice reduces viral replication and improves disease outcome

scientific article published on April 2016

Targeted disruption of influenza A virus hemagglutinin in genetically modified mice reduces viral replication and improves disease outcome is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/SREP23746
P932PMC publication ID4817130
P698PubMed publication ID27033724
P5875ResearchGate publication ID299568038

P50authorSong WangQ118432586
Xiaojuan ChiQ118432648
Ji-Long ChenQ40092542
P2093author name stringJing Zhang
Chao Chen
Zhou Yang
P2860cites workPandemic Threat Posed by Avian Influenza A VirusesQ22299330
Vaccines and antiviral drugs in pandemic preparednessQ22305646
The structure and receptor binding properties of the 1918 influenza hemagglutininQ27643092
Structure of the uncleaved human H1 hemagglutinin from the extinct 1918 influenza virusQ27643093
Structure of a Classical Broadly Neutralizing Stem Antibody in Complex with a Pandemic H2 Influenza Virus HemagglutininQ27677191
Mechanisms of gene silencing by double-stranded RNAQ28282560
Equine influenza: A review of an unpredictable virusQ37777772
An overview of influenza A virus receptorsQ37857873
T cell mediated immunity to influenza: mechanisms of viral controlQ38231916
In vitro validation of self designed "universal human Influenza A siRNA".Q38837014
NRAV, a long noncoding RNA, modulates antiviral responses through suppression of interferon-stimulated gene transcriptionQ38926956
eIF4B phosphorylation by pim kinases plays a critical role in cellular transformation by Abl oncogenesQ39142024
Suppression of avian influenza transmission in genetically modified chickens.Q39608141
Transgenic mouse model integrating siRNA targeting the foot and mouth disease virusQ39736605
The use of RNAi and transgenics to develop viral disease resistant livestockQ39935831
Variation of influenza A, B, and C virusesQ40326626
Synergic and antagonistic effect of small hairpin RNAs targeting the NS gene of the influenza A virus in cells and mice.Q41752306
Lethal toxicity caused by expression of shRNA in the mouse striatum: implications for therapeutic design.Q41983597
Oseltamivir resistance during treatment of H7N9 infectionQ42287342
Role of Itk signalling in the interaction between influenza A virus and T-cellsQ45359929
Viral infection resistance conferred on mice by siRNA transgenesisQ48383529
Molecular mechanisms of RNA interferenceQ28290306
Influenza: old and new threatsQ28296381
Strategies for mitigating an influenza pandemicQ29615422
Structure and receptor specificity of the hemagglutinin from an H5N1 influenza virusQ29622936
Development of effective vaccines against pandemic influenza.Q30352566
Cell-mediated protection in influenza infection.Q30353071
Cross-protective immunity against influenza A/H1N1 virus challenge in mice immunized with recombinant vaccine expressing HA gene of influenza A/H5N1 virus.Q30353786
Antiviral agents active against influenza A viruses.Q30358429
Medical management of influenza infection.Q30365221
Antivirals and the control of influenza outbreaks.Q30365466
Reassortment patterns in Swine influenza viruses.Q30381424
Drugs in development for influenzaQ30391218
Influenza virus resistance to neuraminidase inhibitors.Q30428660
Antigenic drift of the pandemic 2009 A(H1N1) influenza virus in A ferret modelQ30430458
Molecular basis for the generation in pigs of influenza A viruses with pandemic potentialQ30431215
Small interfering RNA targeting m2 gene induces effective and long term inhibition of influenza A virus replication.Q33455759
Artificial microRNAs as siRNA shuttles: improved safety as compared to shRNAs in vitro and in vivoQ33712990
In vivo RNAi: today and tomorrowQ34014698
Influenza A virus-induced degradation of eukaryotic translation initiation factor 4B contributes to viral replication by suppressing IFITM3 protein expression.Q34057790
Permissive secondary mutations enable the evolution of influenza oseltamivir resistanceQ34118992
Transport of influenza virus neuraminidase (NA) to host cell surface is regulated by ARHGAP21 and Cdc42 proteinsQ34253111
Inhibition of influenza virus production in virus-infected mice by RNA interferenceQ34514513
Protection against lethal influenza virus challenge by RNA interference in vivo.Q34514565
Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathwaysQ34530552
DNA constructs designed to produce short hairpin, interfering RNAs in transgenic mice sometimes show early lethality and an interferon response.Q34557389
Artificial miRNAs mitigate shRNA-mediated toxicity in the brain: implications for the therapeutic development of RNAiQ34768688
RNA interference of influenza virus production by directly targeting mRNA for degradation and indirectly inhibiting all viral RNA transcriptionQ34808200
Suppression of interferon lambda signaling by SOCS-1 results in their excessive production during influenza virus infectionQ35082203
Adamantane-resistant influenza a viruses in the world (1902-2013): frequency and distribution of M2 gene mutationsQ35175284
Entry of influenza A Virus with a α2,6-linked sialic acid binding preference requires host fibronectinQ36276551
5'-Triphosphate-short interfering RNA: potent inhibition of influenza A virus infection by gene silencing and RIG-I activation.Q36276670
Severe influenza A(H1N1)pdm09 infection induces thymic atrophy through activating innate CD8(+)CD44(hi) T cells by upregulating IFN-γ.Q36291097
An overlapping protein-coding region in influenza A virus segment 3 modulates the host responseQ36554219
The origin and global emergence of adamantane resistant A/H3N2 influenza virusesQ37250829
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjectinfluenza A virusQ834390
P304page(s)23746
P577publication date2016-04-01
P1433published inScientific ReportsQ2261792
P1476titleTargeted disruption of influenza A virus hemagglutinin in genetically modified mice reduces viral replication and improves disease outcome
P478volume6

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cites work (P2860)
Q30234600Drug resistance in influenza A virus: the epidemiology and management
Q40092344Evolution of Influenza A Virus by Mutation and Re-Assortment
Q92099111Host Cell Mimic Polymersomes for Rapid Detection of Highly Pathogenic Influenza Virus via a Viral Fusion and Cell Entry Mechanism
Q57063400Identification of two residues within the NS1 of H7N9 influenza A virus that critically affect the protein stability and function
Q52594783Molecular cloning, polymorphism, and expression analysis of the LKB1/STK11 gene and its association with non-specific digestive disorder in rabbits.
Q63246353Recent Updates on Mouse Models for Human Immunodeficiency, Influenza, and Dengue Viral Infections

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