Disruption of the Hbs1l-Myb locus causes hereditary persistence of fetal hemoglobin in a mouse model

scientific article published on 19 February 2013

Disruption of the Hbs1l-Myb locus causes hereditary persistence of fetal hemoglobin in a mouse model is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/MCB.01617-12
P932PMC publication ID3624254
P698PubMed publication ID23428869

P2093author name stringHozumi Motohashi
James Douglas Engel
Lihong Shi
Masayuki Yamamoto
Osamu Tanabe
Mikiko Suzuki
Harumi Y Mukai
Hiromi Yamazaki
P2860cites workThe product of the mammalian orthologue of the Saccharomyces cerevisiae HBS1 gene is phylogenetically related to eukaryotic release factor 3 (eRF3) but does not carry eRF3-like activityQ22008594
Haploinsufficiency for the erythroid transcription factor KLF1 causes hereditary persistence of fetal hemoglobinQ24293797
An embryonic/fetal beta-type globin gene repressor contains a nuclear receptor TR2/TR4 heterodimerQ24537021
MicroRNA-15a and -16-1 act via MYB to elevate fetal hemoglobin expression in human trisomy 13Q24633081
Conditional c-myb knockout in adult hematopoietic stem cells leads to loss of self-renewal due to impaired proliferation and accelerated differentiationQ24646904
Multiple loci influence erythrocyte phenotypes in the CHARGE ConsortiumQ24655591
Sickle-cell diseaseQ28287003
Developmental and species-divergent globin switching are driven by BCL11AQ28506497
Bcl11a is essential for normal lymphoid developmentQ28511014
A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screenQ29615061
c-Myb is critical for B cell development and maintenance of follicular B cellsQ30438061
c-Myb is essential for early T cell developmentQ30448775
A GATA box in the GATA-1 gene hematopoietic enhancer is a critical element in the network of GATA factors and sites that regulate this geneQ33961661
Genome-wide association study of hematological and biochemical traits in a Japanese populationQ34097468
Ineffective erythropoiesis in Stat5a(-/-)5b(-/-) mice due to decreased survival of early erythroblastsQ34102833
A QTL influencing F cell production maps to a gene encoding a zinc-finger protein on chromosome 2p15.Q34674466
A 3-bp deletion in the HBS1L-MYB intergenic region on chromosome 6q23 is associated with HbF expressionQ35001653
A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortiumQ35025798
Dynamic long-range chromatin interactions control Myb proto-oncogene transcription during erythroid developmentQ35759986
Intergenic variants of HBS1L-MYB are responsible for a major quantitative trait locus on chromosome 6q23 influencing fetal hemoglobin levels in adultsQ36090188
GATA-1 transcription is controlled by distinct regulatory mechanisms during primitive and definitive erythropoiesisQ36136740
Differential contribution of the Gata1 gene hematopoietic enhancer to erythroid differentiationQ37099963
MYB function in normal and cancer cellsQ37198576
A functional c-myb gene is required for normal murine fetal hepatic hematopoiesisQ38335144
Transgene insertion in proximity to the c-myb gene disrupts erythroid-megakaryocytic lineage bifurcationQ39124965
Human fetal hemoglobin expression is regulated by the developmental stage-specific repressor BCL11A.Q39908659
Thalassemia: recent insights into molecular mechanismsQ40128610
Embryonic and fetal beta-globin gene repression by the orphan nuclear receptors, TR2 and TR4.Q40146211
An erythroid specific enhancer upstream to the gene encodin the cell-type specific transcription factor GATA-1Q40507505
c-myb supports erythropoiesis through the transactivation of KLF1 and LMO2 expression.Q42946150
KLF1 regulates BCL11A expression and γ- to β-globin gene switchingQ42950072
A minigene containing four discrete cis elements recapitulates GATA-1 gene expression in vivoQ44251132
The HBS1L-MYB intergenic interval associated with elevated HbF levels shows characteristics of a distal regulatory region in erythroid cellsQ45853151
Different sequence requirements for expression in erythroid and megakaryocytic cells within a regulatory element upstream of the GATA-1 gene.Q47962866
The HBS1L-MYB intergenic region on chromosome 6q23.3 influences erythrocyte, platelet, and monocyte counts in humans.Q53533032
cMYB is involved in the regulation of fetal hemoglobin production in adults.Q54591078
Mortality in sickle cell disease. Life expectancy and risk factors for early death.Q55065788
Beta-thalassaemia intermedia: is it possible consistently to predict phenotype from genotype?Q74122253
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectHereditary persistence of fetal hemoglobinQ4351777
P304page(s)1687-1695
P577publication date2013-02-19
P1433published inMolecular and Cellular BiologyQ3319478
P1476titleDisruption of the Hbs1l-Myb locus causes hereditary persistence of fetal hemoglobin in a mouse model
P478volume33

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cites work (P2860)
Q47261747A long noncoding RNA from the HBS1L-MYB intergenic region on chr6q23 regulates human fetal hemoglobin expression
Q33850615An international effort to cure a global health problem: A report on the 19th Hemoglobin Switching Conference
Q37071189Cell signaling pathways involved in drug-mediated fetal hemoglobin induction: Strategies to treat sickle cell disease
Q38167823Diagnosis and prevention of thalassemia
Q37517470Dissection of the Major Hematopoietic Quantitative Trait Locus in Chromosome 6q23.3 Identifies miR-3662 as a Player in Hematopoiesis and Acute Myeloid Leukemia
Q26822810Fetal globin gene repressors as drug targets for molecular therapies to treat the β-globinopathies
Q38995849Fetal hemoglobin regulation in β-thalassemia: heterogeneity, modifiers and therapeutic approaches
Q50061134Genetic Basis and Genetic Modifiers of β-Thalassemia and Sickle Cell Disease
Q51080070Genetic Variants at BCL11A and HBS1L-MYB loci Influence Hb F Levels in Chinese Zhuang β-Thalassemia Intermedia Patients.
Q35087288Genotyping of BCL11A and HBS1L-MYB SNPs associated with fetal haemoglobin levels: a SNaPshot minisequencing approach
Q38592271HBS1L-MYB intergenic variants modulate fetal hemoglobin via long-range MYB enhancers
Q36777717Hydroxyurea down-regulates BCL11A, KLF-1 and MYB through miRNA-mediated actions to induce γ-globin expression: implications for new therapeutic approaches of sickle cell disease
Q89184052Impact of Genetic Determinants of HbA1c on Type 2 Diabetes Risk and Diagnosis
Q39399184Molecular basis of β thalassemia and potential therapeutic targets
Q41232448Multiple Testing in the Context of Gene Discovery in Sickle Cell Disease Using Genome-Wide Association Studies.
Q47447659Ribosomopathies: There's strength in numbers.
Q35656305Variation in Gamma-Globin Expression before and after Induction with Hydroxyurea Associated with BCL11A, KLF1 and TAL1.

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