Molecular basis for defective secretion of the Z variant of human alpha-1-proteinase inhibitor: secretion of variants having altered potential for salt bridge formation between amino acids 290 and 342.

scientific article published on April 1989

Molecular basis for defective secretion of the Z variant of human alpha-1-proteinase inhibitor: secretion of variants having altered potential for salt bridge formation between amino acids 290 and 342. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/MCB.9.4.1406
P932PMC publication ID362557
P698PubMed publication ID2786139
P5875ResearchGate publication ID20370384

P50authorKristina B. KruseQ62635606
Ardythe A. McCrackenQ63183185
P2093author name stringJ L Brown
P2860cites workExpression of wild-type and mutant forms of influenza hemagglutinin: the role of folding in intracellular transportQ27865283
Prediction of protein antigenic determinants from amino acid sequencesQ29547548
The presence of malfolded proteins in the endoplasmic reticulum signals the induction of glucose-regulated proteinsQ29620170
Intracellular transport of membrane glycoproteins: two closely related histocompatibility antigens differ in their rates of transit to the cell surfaceQ30406892
Characterization of the polypeptide composition of human factor VIII:C and the nucleotide sequence and expression of the human kidney cDNA.Q34195807
Human alpha 1-proteinase inhibitor. Crystal structure analysis of two crystal modifications, molecular model and preliminary analysis of the implications for functionQ34255957
Structure and variation of human alpha 1-antitrypsinQ34277158
Molecular abnormality of human alpha1-antitrypsin variant (Pi-ZZ) associated with plasma activity deficiencyQ34998276
Tissue specific expression of the human alpha-1-antitrypsin gene in transgenic miceQ36118723
The cellular defect in alpha 1-proteinase inhibitor (alpha 1-PI) deficiency is expressed in human monocytes and in Xenopus oocytes injected with human liver mRNA.Q37536001
63 endo-β-N-Acetylglucosaminidase from Streptomyces plicatusQ39197514
Rapid isolation of antigens from cells with a staphylococcal protein A-antibody adsorbent: parameters of the interaction of antibody-antigen complexes with protein AQ39513417
The Pi polymorphism: genetic, biochemical, and clinical aspects of human alpha 1-antitrypsin.Q40101093
Subcellular compartmentalization of saccharide moieties in cultured normal and malignant cellsQ41267818
Disruption of the Lys-290--Glu-342 salt bridge in human alpha 1-antitrypsin does not prevent its synthesis and secretionQ41344146
Posttranslational association of immunoglobulin heavy chain binding protein with nascent heavy chains in nonsecreting and secreting hybridomasQ41506259
Assembly and secretion of heavy chains that do not associate posttranslationally with immunoglobulin heavy chain-binding proteinQ41519186
Four secretory proteins synthesized by hepatocytes are transported from endoplasmic reticulum to Golgi complex at different rates.Q41560898
Exit of nonglycosylated secretory proteins from the rough endoplasmic reticulum is asynchronous in the exocrine pancreas.Q42002181
The rate of bulk flow from the endoplasmic reticulum to the cell surfaceQ45345734
Evidence for a glycoprotein "signal" involved in transport between subcellular organelles. Two membrane glycoproteins encoded by murine leukemia virus reach the cell surface at different rates.Q45792549
Identification of a second mutation in the protein-coding sequence of the Z type alpha 1-antitrypsin geneQ48355002
Hepatoma secretory proteins migrate from rough endoplasmic reticulum to Golgi at characteristic ratesQ59066067
Amino acid substitution Glu→Lys in α1-antitrypsin PiZQ66884920
Comparison of the chemical, physical, and survival properties of normal and Z-variant alpha-1-antitrypsinsQ66886151
Carbohydrate composition of normal and variant human alpha 1-protease inhibitorsQ66920331
Secretion of C-reactive protein becomes more efficient during the course of the acute phase responseQ70073719
Secretion of rat serum albumin by COS cells transfected with a spliced cDNA gene. A system to study protein sortingQ70118754
Biosynthesis, processing, and secretion of M and Z variant human alpha 1-antitrypsinQ70144303
Structural and functional characterization of the abnormal Z alpha 1-antitrypsin isolated from human liverQ70228345
Alpha-1-antitrypsin (AAT) and its stimulation in the liver of PiMZ phenotype individuals. A "recruitment-secretory block" ("R-SB") phenomenonQ70228960
P433issue4
P407language of work or nameEnglishQ1860
P304page(s)1406-1414
P577publication date1989-04-01
P1433published inMolecular and Cellular BiologyQ3319478
P1476titleMolecular basis for defective secretion of the Z variant of human alpha-1-proteinase inhibitor: secretion of variants having altered potential for salt bridge formation between amino acids 290 and 342.
P478volume9

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cites work (P2860)
Q44402969A class of mutant CHO cells resistant to cholera toxin rapidly degrades the catalytic polypeptide of cholera toxin and exhibits increased endoplasmic reticulum-associated degradation.
Q35759026A lag in intracellular degradation of mutant alpha 1-antitrypsin correlates with the liver disease phenotype in homozygous PiZZ alpha 1-antitrypsin deficiency
Q36278201A study of the effects of altering the sites for N-glycosylation in alpha-1-proteinase inhibitor variants M and S.
Q27932696ADD66, a gene involved in the endoplasmic reticulum-associated degradation of alpha-1-antitrypsin-Z in yeast, facilitates proteasome activity and assembly.
Q38784755Alpha-1-antitrypsin deficiency: accumulation or degradation of mutant variants within the hepatic endoplasmic reticulum
Q41505232Approaches to maximizing stable expression of alpha 1-antitrypsin in transformed CHO cells
Q41236581BiP expression is not increased by the accumulation of PiZ alpha 1-antitrypsin in the endoplasmic reticulum
Q91386795Calcium signalling in mammalian cell lines expressing wild type and mutant human α1-Antitrypsin
Q41718232Comparative properties of human alpha-1-proteinase inhibitor glycosylation variants
Q41835060Conformational instability of the cholera toxin A1 polypeptide
Q34408182Increased PiZ gene frequency for alpha 1 antitrypsin in patients with genetic haemochromatosis
Q37694671Inhibition of cellular protein secretion by poliovirus proteins 2B and 3A
Q34186098Inhibition of endoplasmic reticulum-associated degradation in CHO cells resistant to cholera toxin, Pseudomonas aeruginosa exotoxin A, and ricin
Q40015288Inhibition of endoplasmic reticulum-to-Golgi traffic by poliovirus protein 3A: genetic and ultrastructural analysis
Q37383352Inhibition of intracellular degradation increases secretion of a mutant form of alpha1-antitrypsin associated with profound deficiency
Q41561414Intracellular retention and degradation of human mutant variant of a alpha 1-antitrypsin in stably transfected Chinese hamster ovary cell lines
Q26851374Is there a therapeutic role for selenium in alpha-1 antitrypsin deficiency?
Q36712966Molecular basis of alpha 1-antitrypsin deficiency and emphysema associated with the alpha 1-antitrypsin Mmineral springs allele
Q28572278Negative regulatory activity of a prostaglandin F2 alpha receptor associated protein (FPRP)
Q49171266Protein secretion in plant cells can occur via a default pathway
Q41509050Review: alpha 1-antitrypsin deficiency associated liver disease
Q24313226Role of the lectin VIP36 in post-ER quality control of human alpha1-antitrypsin
Q44326218Secretion of pigment epithelium-derived factor. Mutagenic study
Q34438486Selective protein degradation in the yeast exocytic pathway
Q34579205Synthesis of stress proteins is increased in individuals with homozygous PiZZ alpha 1-antitrypsin deficiency and liver disease
Q53547782Tauroursodeoxycholic acid inhibits apoptosis induced by Z alpha-1 antitrypsin via inhibition of Bad.
Q41727618The effect of amino acid substitutions at position 342 on the secretion of human alpha 1-antitrypsin from Xenopus oocytes
Q37204565The molecular genetics of ?1 antitrypsin deficiency
Q37623472Vesicular transport is not required for the cytoplasmic pool of cholera toxin to interact with the stimulatory alpha subunit of the heterotrimeric g protein.
Q52226310Vitamin E and liver damage in MZ heterozygous infants with alpha 1-antitrypsin deficiency.
Q42967230Yeast mutants deficient in ER-associated degradation of the Z variant of alpha-1-protease inhibitor.
Q34962759Z α-1 antitrypsin deficiency and the endoplasmic reticulum stress response
Q36816779α 1 ‐antitrypsin deficiency and liver disease