Role of connexins in metastatic breast cancer and melanoma brain colonization

scientific article published on 15 January 2013

Role of connexins in metastatic breast cancer and melanoma brain colonization is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1242/JCS.112748
P8608Fatcat IDrelease_qhlac2ck6nbojaxrhpx2y2shti
P932PMC publication ID3625812
P698PubMed publication ID23321642
P5875ResearchGate publication ID234141880

P2093author name stringDonald P Pizzo
Jan Strnadel
Frederick D Park
Scott R VandenBerg
Masashi Momiyama
Richard L Klemke
Jonathan A Kelber
Robert Hoffman
Konstantin Stoletov
Erin Zardouzian
P2860cites workLife cycle of connexins in health and diseaseQ24541428
Effect of central microinjection of carbenoxolone in an experimental model of focal cerebral ischemiaQ43270683
A quantitative analysis of rate-limiting steps in the metastatic cascade using human-specific real-time polymerase chain reaction.Q46119620
Gap junctional communication is required to maintain mouse cortical neural progenitor cells in a proliferative stateQ47225912
The development of the blood-brain barrier in the chick. Studies with evans blue and horseradish peroxidase.Q48334824
Gap junctions modulate apoptosis and colony growth of human embryonic stem cells maintained in a serum-free system.Q51225856
Gap junctional intercellular communication is required to maintain embryonic stem cells in a non-differentiated and proliferative state.Q51980016
Implications and challenges of connexin connections to cancer.Q55052930
Breast Cancer Metastasis: Challenges and OpportunitiesQ57591118
Cx43 suppresses mammary tumor metastasis to the lung in a Cx43 mutant mouse model of human diseaseQ60585237
Deficiency of connexin43 gap junctions is an independent marker for breast tumorsQ78175509
Connexin26 expression is associated with lymphatic vessel invasion and poor prognosis in human breast cancerQ79489202
Melanoma progression exhibits a significant impact on connexin expression patterns in the epidermal tumor microenvironmentQ84756817
Genes that mediate breast cancer metastasis to the brainQ24644008
The epithelial-mesenchymal transition generates cells with properties of stem cellsQ24650786
The vascular basement membrane as "soil" in brain metastasisQ27348725
Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasisQ28131703
Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traitsQ28237197
Cancer stem cells in solid tumours: accumulating evidence and unresolved questionsQ28293535
Dissemination and growth of cancer cells in metastatic sitesQ29555846
Metastasis: from dissemination to organ-specific colonizationQ29614295
Gap junctions in the control of vascular functionQ30434810
Connexins in vascular physiology and pathologyQ30437099
High-resolution imaging of the dynamic tumor cell vascular interface in transparent zebrafishQ30480643
Visualizing extravasation dynamics of metastatic tumor cellsQ30494902
An attempt to isolate genes responsible for spontaneous and experimental metastasis in the mouse modelQ31102710
Connexin-43 upregulation in micrometastases and tumor vasculature and its role in tumor cell attachment to pulmonary endotheliumQ33353861
Imagable 4T1 model for the study of late stage breast cancerQ33358981
Real-time imaging reveals the single steps of brain metastasis formationQ33519908
Capturing changes in the brain microenvironment during initial steps of breast cancer brain metastasis.Q33882549
Role of the CNS microvascular pericyte in the blood-brain barrierQ34067528
Functional microRNA is transferred between glioma cellsQ34137987
Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells.Q35076272
Contribution of connexins to the function of the vascular wall.Q35749995
Molecular MRI enables early and sensitive detection of brain metastasesQ35921996
Inhibition of metastatic outgrowth from single dormant tumor cells by targeting the cytoskeleton.Q36922699
New clinical and experimental approaches for studying tumor dormancy: does tumor dormancy offer a therapeutic target?Q37286235
Properties of gap junction blockers and their behavioural, cognitive and electrophysiological effects: animal and human studiesQ37375210
Connexins, cell motility, and the cytoskeletonQ37526742
Cancer stem cells in breast cancer and metastasisQ37592022
Cancer stem cells and aneuploid populations within developing tumors are the major determinants of tumor dormancyQ39768597
Mouse 4T1 breast tumor modelQ39989082
Role for connexin 26 in metastasis of human malignant melanoma: communication between melanoma and endothelial cells via connexin 26.Q40110789
Functional gap junctions facilitate melanoma antigen transfer and cross-presentation between human dendritic cellsQ40130335
Possible involvement of gap junctions in the barrier function of tight junctions of brain and lung endothelial cellsQ40302090
Brain metastases. Histology, multiplicity, surgery, and survivalQ40923255
In vitro model of angiogenesis using a human endothelium‐derived permanent cell line: Contributions of induced gene expression, G‐proteins, and integrinsQ41593571
Synthesis and anti-ulcer activity of new derivatives of glycyrrhetic, oleanolic and ursolic acidsQ41739099
Partial mesenchymal to epithelial reverting transition in breast and prostate cancer metastasesQ42145874
Signaling at the gliovascular interface.Q42451204
The tumor-suppressive function of Connexin43 in keratinocytes is mediated in part via interaction with caveolin-1.Q43091576
Intrathecal injection of carbenoxolone, a gap junction decoupler, attenuates the induction of below-level neuropathic pain after spinal cord injury in ratsQ43131048
P433issuePt 4
P407language of work or nameEnglishQ1860
P921main subjectmetastatic breast cancerQ12859063
P304page(s)904-913
P577publication date2013-01-15
P1433published inJournal of Cell ScienceQ1524177
P1476titleRole of connexins in metastatic breast cancer and melanoma brain colonization
P478volume126

Reverse relations

cites work (P2860)
Q28119656Akirin2 is essential for the formation of the cerebral cortex
Q52646854Angiopoietin-2 mediates blood-brain barrier impairment and colonization of triple-negative breast cancer cells in brain.
Q41851951Automated analysis of invadopodia dynamics in live cells.
Q34538155Blood vessels and cancer much more than just angiogenesis
Q60938845Cancer Connectors: Connexins, Gap Junctions, and Communication
Q46900302Cancer Immunotherapy Getting Brainy: Visualizing the Distinctive CNS Metastatic Niche to Illuminate Therapeutic Resistance.
Q52594210Conflicting Roles of Connexin43 in Tumor Invasion and Growth in the Central Nervous System.
Q36150015Connexin 43 expression predicts poor progression-free survival in patients with non-muscle invasive urothelial bladder cancer
Q93362037Connexin 43 is an independent predictor of patient outcome in breast cancer patients
Q36031173Connexin and pannexin channels in cancer.
Q28073076Connexin's Connection in Breast Cancer Growth and Progression
Q37488508Connexin43 reduces melanoma growth within a keratinocyte microenvironment and during tumorigenesis in vivo
Q59359881Connexins and Pannexins: Important Players in Tumorigenesis, Metastasis and Potential Therapeutics
Q91986688Connexins in cancer: bridging the gap to the clinic
Q38206124Connexins in colorectal cancer pathogenesis
Q38305679Connexins in migration during development and cancer
Q26861688Connexins, gap junctions and tissue invasion
Q41389665Connexin 43 in the development and progression of breast cancer: What's the connection? (Review).
Q34482866Correlations of differentially expressed gap junction connexins Cx26, Cx30, Cx32, Cx43 and Cx46 with breast cancer progression and prognosis
Q61443123Crabp2 Promotes Metastasis of Lung Cancer Cells via HuR and Integrin β1/FAK/ERK Signaling
Q36545695Cx26 knockout predisposes the mammary gland to primary mammary tumors in a DMBA-induced mouse model of breast cancer
Q37702357Dioscin augments HSV-tk-mediated suicide gene therapy for melanoma by promoting connexin-based intercellular communication
Q33699418Downregulated connexin32 promotes EMT through the Wnt/β-catenin pathway by targeting Snail expression in hepatocellular carcinoma
Q47220416Dysregulated connexin 43 in HER2-positive drug resistant breast cancer cells enhances proliferation and migration
Q89544565Emerging findings into molecular mechanism of brain metastasis
Q61448933Emerging roles of gap junction proteins connexins in cancer metastasis, chemoresistance and clinical application
Q34710990Endogenous Voltage Potentials and the Microenvironment: Bioelectric Signals that Reveal, Induce and Normalize Cancer
Q36444280Eukaryotic Translation Initiation Factor 5A (EIF5A) Regulates Pancreatic Cancer Metastasis by Modulating RhoA and Rho-associated Kinase (ROCK) Protein Expression Levels
Q42396415Evidence Showing That Tumors Can Grow Without Angiogenesis and Can Switch Between Angiogenic and Nonangiogenic Phenotypes
Q64245289Exploring Differential Connexin Expression across Melanocytic Tumor Progression Involving the Tumor Microenvironment
Q64075384Facets of Communication: Gap Junction Ultrastructure and Function in Cancer Stem Cells and Tumor Cells
Q48108646Foe or friend? Janus-faces of the neurovascular unit in the formation of brain metastases
Q37310526Gap Junction Blockers: An Overview of their Effects on Induced Seizures in Animal Models.
Q92642770Gap Junction Intercellular Communication in the Carcinogenesis Hallmarks: Is This a Phenomenon or Epiphenomenon?
Q90628313Gap Junctions and Breast Cancer Dormancy
Q35537353Gap junction coupling is required for tumor cell migration through lymphatic endothelium
Q38722005Gap junction protein connexin43 deregulation contributes to bladder carcinogenesis via targeting MAPK pathway
Q38856036Gap junctional signaling in pattern regulation: Physiological network connectivity instructs growth and form
Q37613777Gap junctions and cancer: communicating for 50 years
Q38874498Gap junctions modulate glioma invasion by direct transfer of microRNA
Q54540610Genetics: Transcribing for the enemy.
Q33779216High mobility group box 1 antagonist limits metastatic seeding in the lungs via reduction of cell-cell adhesion
Q38213988Imaging hallmarks of cancer in living mice
Q36889788In vivo Modeling and Molecular Characterization: A Path Toward Targeted Therapy of Melanoma Brain Metastasis
Q92941476Inhibition of Gap Junctions Sensitizes Primary Glioblastoma Cells for Temozolomide
Q34981782Long-range gap junctional signaling controls oncogene-mediated tumorigenesis in Xenopus laevis embryos
Q34482050Mechanisms of environmental chemicals that enable the cancer hallmark of evasion of growth suppression.
Q28069421Melanoma Brain Metastasis: Mechanisms, Models, and Medicine
Q34448162Metastasis as a therapeutic target in prostate cancer: a conceptual framework.
Q36829245Metastasis prevention by targeting the dormant niche
Q92511346Microenvironmental Regulation of Tumor Progression and Therapeutic Response in Brain Metastasis
Q41619582Mind the Gaps in Tumor Immunity: Impact of Connexin-Mediated Intercellular Connections
Q38764364Molecular insights into melanoma brain metastases
Q91280474Neurologic complications of melanoma
Q37309831Osteocytic connexin hemichannels suppress breast cancer growth and bone metastasis
Q38857603Overexpression of connexin 43 reduces melanoma proliferative and metastatic capacity
Q35417215PLEKHA5 as a Biomarker and Potential Mediator of Melanoma Brain Metastasis
Q91462143PLEKHA5 regulates tumor growth in metastatic melanoma
Q41362182Possible role of hemichannels in cancer
Q54962187Recent advances in the biology and treatment of brain metastases of non-small cell lung cancer: summary of a multidisciplinary roundtable discussion.
Q52627188Roles of astrocytic connexin-43, hemichannels, and gap junctions in oxygen-glucose deprivation/reperfusion injury induced neuroinflammation and the possible regulatory mechanisms of salvianolic acid B and carbenoxolone.
Q64066878Spatial Arrangements of Connexin43 in Cancer Related Cells and Re-Arrangements under Treatment Conditions: Investigations on the Nano-Scale by Super-Resolution Localization Light Microscopy
Q52370671The Complex Subtype-Dependent Role of Connexin 43 (GJA1) in Breast Cancer.
Q52673453The Evolving Landscape of Brain Metastasis.
Q35891990The role of neural connexins in HeLa cell mobility and intercellular communication through tunneling tubes

Search more.