Genetic determinants of macular pigments in women of the Carotenoids in Age-Related Eye Disease Study

scientific article published on 28 March 2013

Genetic determinants of macular pigments in women of the Carotenoids in Age-Related Eye Disease Study is …
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scholarly articleQ13442814

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P356DOI10.1167/IOVS.12-10867
P8608Fatcat IDrelease_23g5dwsebfgnlb2o4k2gtoo7yq
P932PMC publication ID3626525
P698PubMed publication ID23404124
P5875ResearchGate publication ID235604364

P50authorLesley F TinkerQ85643662
Paul S BernsteinQ88167571
Erin S LeBlancQ89239956
Robert P IgoQ92784819
Kristin N MeyerQ96127926
Gloria E SartoQ114375000
Barbara J TruittQ114447141
Chitra K KarkiQ114723333
Karen M GehrsQ58411078
Sudha IyengarQ64008607
P2093author name stringZhe Liu
Michael L Klein
Elizabeth J Johnson
Corinne D Engelman
Robert B Wallace
Barbara A Blodi
D Max Snodderly
Julie A Mares
Jennifer Robinson
Gregory Hageman
P2860cites workFinding the missing heritability of complex diseasesQ22122198
Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degenerationQ24622351
Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC)Q24622766
Identification of StARD3 as a lutein-binding protein in the macula of the primate retinaQ24628314
A dominant mutation in RPE65 identified by whole-exome sequencing causes retinitis pigmentosa with choroidal involvementQ24635141
PLINK: a tool set for whole-genome association and population-based linkage analysesQ24677407
Missing heritability and strategies for finding the underlying causes of complex diseaseQ29614586
Genetic loci associated with plasma phospholipid n-3 fatty acids: a meta-analysis of genome-wide association studies from the CHARGE ConsortiumQ30431111
The prime role of HDL to transport lutein into the retina: evidence from HDL-deficient WHAM chicks having a mutant ABCA1 transporterQ80853945
The influence of supplemental lutein and docosahexaenoic acid on serum, lipoproteins, and macular pigmentationQ81247711
CMO1 deficiency abolishes vitamin A production from beta-carotene and alters lipid metabolism in miceQ81250317
The ABCG5 polymorphism contributes to individual responses to dietary cholesterol and carotenoids in eggsQ83154450
The impact of macular pigment augmentation on visual performance in normal subjects: COMPASSQ83211085
Macular pigment and visual performance in glare: benefits for photostress recovery, disability glare, and visual discomfortQ83377582
Anti-inflammatory effects of lutein in retinal ischemic/hypoxic injury: in vivo and in vitro studiesQ84748765
Analysis of the macular pigment by HPLC: retinal distribution and age studyQ68367274
Dietary omega-3 fatty acids and accumulation of docosahexaenoic acid in rod photoreceptor cells of the retina and at synapsesQ68440774
The macular pigment. I. Absorbance spectra, localization, and discrimination from other yellow pigments in primate retinasQ71356050
In vivo measurement of lipofuscin in Stargardt's disease--Fundus flavimaculatusQ71741579
Dietary modification of human macular pigment densityQ73671816
Predictors of optical density of lutein and zeaxanthin in retinas of older women in the Carotenoids in Age-Related Eye Disease Study, an ancillary study of the Women's Health InitiativeQ79340995
Apolipoprotein e gene and age-related maculopathy in older individuals: the cardiovascular health studyQ79518790
HPLC measurement of ocular carotenoid levels in human donor eyes in the lutein supplementation eraQ79655255
Effect of dietary lutein and zeaxanthin on plasma carotenoids and their transport in lipoproteins in age-related macular degenerationQ79896842
A new instrument for the quantification of macular pigment density: first results in patients with AMD and healthy subjectsQ30844471
Influence of lutein supplementation on macular pigment, assessed with two objective techniques.Q30929610
Relation among serum and tissue concentrations of lutein and zeaxanthin and macular pigment densityQ31389893
Discerning the ancestry of European Americans in genetic association studiesQ33315561
Genome-wide association study of plasma polyunsaturated fatty acids in the InCHIANTI StudyQ33400334
rs5888 variant of SCARB1 gene is a possible susceptibility factor for age-related macular degenerationQ33508828
RPE65: role in the visual cycle, human retinal disease, and gene therapyQ33652414
A CD36-related transmembrane protein is coordinated with an intracellular lipid-binding protein in selective carotenoid transport for cocoon colorationQ33748224
Macular pigment and lutein supplementation in retinitis pigmentosa and Usher syndromeQ33953350
Strong association of the Y402H variant in complement factor H at 1q32 with susceptibility to age-related macular degenerationQ34021032
A class B scavenger receptor mediates the cellular uptake of carotenoids in DrosophilaQ34075196
Augmentation of macular pigment following supplementation with all three macular carotenoids: an exploratory studyQ34108927
Association of macular pigment density with plasma ω-3 fatty acids: the PIMAVOSA studyQ34138412
Esterification does not impair lutein bioavailability in humans.Q34162985
Inhibition of the visual cycle by A2E through direct interaction with RPE65 and implications in Stargardt disease.Q34199909
Macular carotenoid supplementation in subjects with atypical spatial profiles of macular pigment.Q34278325
The impact of macular pigment augmentation on visual performance using different carotenoid formulations.Q34310338
Macular pigment response to a supplement containing meso-zeaxanthin, lutein and zeaxanthinQ34627818
Single nucleotide polymorphisms upstream from the β-carotene 15,15'-monoxygenase gene influence provitamin A conversion efficiency in female volunteersQ34633920
Associations between age-related nuclear cataract and lutein and zeaxanthin in the diet and serum in the Carotenoids in the Age-Related Eye Disease Study, an Ancillary Study of the Women's Health InitiativeQ34760523
Healthy lifestyles related to subsequent prevalence of age-related macular degeneration.Q34785911
Vitamin D status and early age-related macular degeneration in postmenopausal womenQ34786173
Complement activation by photooxidation products of A2E, a lipofuscin constituent of the retinal pigment epitheliumQ35133725
Genetic defects in vitamin A metabolism of the retinal pigment epitheliumQ35183321
Surface plasmon resonance (SPR) studies on the interactions of carotenoids and their binding proteinsQ35789333
The heritability of macular response to supplemental lutein and zeaxanthin: a classic twin studyQ36136223
Heritability of the spatial distribution and peak density of macular pigment: a classical twin studyQ36238357
The putative role of lutein and zeaxanthin as protective agents against age-related macular degeneration: promise of molecular genetics for guiding mechanistic and translational research in the field.Q36317120
Shifting paradigm of association studies: value of rare single-nucleotide polymorphismsQ36477625
Distribution, interconversion, and dose response of n-3 fatty acids in humansQ36536062
Xanthophylls are preferentially taken up compared with beta-carotene by retinal cells via a SRBI-dependent mechanismQ36745022
Delta6-desaturase (FADS2) deficiency unveils the role of omega3- and omega6-polyunsaturated fatty acidsQ36862651
Macular pigment and lutein supplementation in ABCA4-associated retinal degenerationsQ37069102
Lutein and zeaxanthin supplementation reduces photooxidative damage and modulates the expression of inflammation-related genes in retinal pigment epithelial cellsQ37098578
Common variation in the beta-carotene 15,15'-monooxygenase 1 gene affects circulating levels of carotenoids: a genome-wide association studyQ37156081
Variation in lipid-associated genes as they relate to risk of advanced age-related macular degenerationQ37366333
Colors with functions: elucidating the biochemical and molecular basis of carotenoid metabolismQ37736472
Marked HDL deficiency and premature coronary heart disease.Q37771219
Retinoic acid, immunity, and inflammationQ37854959
Genetic variations involved in interindividual variability in carotenoid status.Q37940438
A review of the evidence germane to the putative protective role of the macular carotenoids for age-related macular degenerationQ37961646
Importance of β,β-carotene 15,15'-monooxygenase 1 (BCMO1) and β,β-carotene 9',10'-dioxygenase 2 (BCDO2) in nutrition and healthQ37965458
The ringlike structure of macular pigment in age-related maculopathy: results from the Muenster Aging and Retina Study (MARS).Q38462099
Effect of lutein and zeaxanthin on macular pigment and visual function in patients with early age-related macular degenerationQ39575237
Chemistry and metabolism of lipids in the vertebrate retinaQ40154390
Uptake of cholesterol by the retina occurs primarily via a low density lipoprotein receptor-mediated processQ40207342
Genetics and phenotypes of RPE65 mutations in inherited retinal degeneration.Q40736925
Absorption, metabolism, and transport of carotenoids.Q40981969
Small molecule RPE65 antagonists limit the visual cycle and prevent lipofuscin formationQ42164095
Lutein transport by Caco-2 TC-7 cells occurs partly by a facilitated process involving the scavenger receptor class B type I (SR-BI).Q42470830
The relation between the macular carotenoids, lutein and zeaxanthin, and temporal visionQ43056971
Patients with Sjögren-Larsson syndrome lack macular pigment.Q43158883
Apolipoprotein E genotype is associated with macular pigment optical densityQ43182517
Macular pigment density and age-related maculopathy in the Carotenoids in Age-Related Eye Disease Study. An ancillary study of the women's health initiativeQ43881495
Identification and functional analysis of a naturally occurring E89K mutation in the ABCA1 gene of the WHAM chicken.Q44168282
Changes in macular pigment optical density and serum concentrations of its constituent carotenoids following supplemental lutein and zeaxanthin: the LUNA studyQ44212321
Neuroprotective effect of an antioxidant, lutein, during retinal inflammationQ44386863
Improvement of retinal function in early age-related macular degeneration after lutein and zeaxanthin supplementation: a randomized, double-masked, placebo-controlled trialQ44696848
Macular pigment measurement by heterochromatic flicker photometry in older subjects: the carotenoids and age-related eye disease study.Q44743294
Plasma and macular responses to lutein supplement in subjects with and without age-related maculopathy: a pilot studyQ44925974
Identification and characterization of a Pi isoform of glutathione S-transferase (GSTP1) as a zeaxanthin-binding protein in the macula of the human eye.Q45050501
Morphologic and electroretinographic phenotype of SR-BI knockout mice after a long-term atherogenic diet.Q46023211
Substrate specificity of a recombinant chicken beta-carotene 15,15'-monooxygenase that converts beta-carotene into retinalQ46268458
Assessment of ocular exposure to visible light for population studiesQ46450625
Nutritional manipulation of primate retinas. IV. Effects of n--3 fatty acids, lutein, and zeaxanthin on S-cones and rods in the foveal regionQ46509948
Carotenoid transport is decreased and expression of the lipid transporters SR-BI, NPC1L1, and ABCA1 is downregulated in Caco-2 cells treated with ezetimibeQ46715258
Macular pigment and visual performance under glare conditionsQ46736128
Heritability of macular pigment: a twin studyQ46816863
Randomized, double-blind, placebo-controlled study of zeaxanthin and visual function in patients with atrophic age-related macular degeneration: the Zeaxanthin and Visual Function Study (ZVF) FDA IND #78, 973.Q50268024
Xanthophyll accumulation in the human retina during supplementation with lutein or zeaxanthin - the LUXEA (LUtein Xanthophyll Eye Accumulation) study.Q50474439
Supplementation with the carotenoids lutein or zeaxanthin improves human visual performance.Q50478568
Lutein and zeaxanthin dietary supplements raise macular pigment density and serum concentrations of these carotenoids in humans.Q50495142
Genetic variants in BCMO1 and CD36 are associated with plasma lutein concentrations and macular pigment optical density in humans.Q51386596
The association between macular pigment optical density and CFH, ARMS2, C2/BF, and C3 genotype.Q54355696
Effect of Mediterranean diet on the expression of pro-atherogenic genes in a population at high cardiovascular riskQ59158036
Dose-Ranging Study of Lutein Supplementation in Persons Aged 60 Years or OlderQ59325038
Variability of Serum Carotenoids in Response to Controlled Diets Containing Six Servings of Fruits and Vegetables per DayQ63339774
Associations Between Intermediate Age-Related Macular Degeneration and Lutein and Zeaxanthin in the Carotenoids in Age-Related Eye Disease Study (CAREDS)Q63344335
P433issue3
P407language of work or nameEnglishQ1860
P921main subjecteye diseaseQ3041498
P304page(s)2333-2345
P577publication date2013-03-28
P1433published inInvestigative Ophthalmology Visual ScienceQ6060707
P1476titleGenetic determinants of macular pigments in women of the Carotenoids in Age-Related Eye Disease Study
P478volume54

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cites work (P2860)
Q28512836A genetic dissection of intestinal fat-soluble vitamin and carotenoid absorption
Q64244676Assessment of Macular Pigment Optical Density Using Fundus Reflectometry in Diabetic Patients
Q38884071Association between Dietary Xanthophyll (Lutein and Zeaxanthin) Intake and Early Age-Related Macular Degeneration: The Atherosclerosis Risk in Communities Study
Q36826507Association between vitamin D status and age-related macular degeneration by genetic risk
Q31143690Association of HDL-related loci with age-related macular degeneration and plasma lutein and zeaxanthin: the Alienor study
Q34185581Bioavailability of AREDS1 micronutrients from softgel capsules and tablets: a pilot study
Q37686531Brain xanthophyll content and exploratory gene expression analysis: subspecies differences in rhesus macaque
Q37286511Candidate gene study of macular response to supplemental lutein and zeaxanthin
Q35801527Changes in Macular Pigment Optical Density and Serum Lutein Concentration in Japanese Subjects Taking Two Different Lutein Supplements
Q64928522Dietary Antioxidants, Macular Pigment, and Glaucomatous Neurodegeneration: A Review of the Evidence.
Q47106416Dietary guidance for lutein: consideration for intake recommendations is scientifically supported
Q47253521Effect of Dietary Supplementation With Lutein, Zeaxanthin, and ω-3 on Macular Pigment: A Randomized Clinical Trial
Q57163177Effect of age and other factors on macular pigment optical density measured with resonance Raman spectroscopy
Q38220379Effects of light quality on the accumulation of phytochemicals in vegetables produced in controlled environments: a review
Q37537304Genetic evidence for role of carotenoids in age-related macular degeneration in the Carotenoids in Age-Related Eye Disease Study (CAREDS).
Q90319865Hepatic Vitamin A Concentrations in Vervets (Chlorocebus aethiops) Supplemented with Carotenoids Derived from Oil Palm
Q39094660Host-related factors explaining interindividual variability of carotenoid bioavailability and tissue concentrations in humans
Q33925653Inactivity of human β,β-carotene-9',10'-dioxygenase (BCO2) underlies retinal accumulation of the human macular carotenoid pigment
Q30829406Intakes of Lutein, Zeaxanthin, and Other Carotenoids and Age-Related Macular Degeneration During 2 Decades of Prospective Follow-up
Q57177518Intrinsic and Extrinsic Factors Impacting Absorption, Metabolism, and Health Effects of Dietary Carotenoids
Q36468066Joint Associations of Diet, Lifestyle, and Genes with Age-Related Macular Degeneration
Q34733171Long term effects of lutein, zeaxanthin and omega-3-LCPUFAs supplementation on optical density of macular pigment in AMD patients: the LUTEGA study
Q47141535Lutein accumulates in subcellular membranes of brain regions in adult rhesus macaques: Relationship to DHA oxidation products.
Q38901504Lutein and Zeaxanthin Isomers in Eye Health and Disease
Q52588804Lutein, zeaxanthin and mammalian development: Metabolism, functions and implications for health.
Q30693939Lutein, zeaxanthin, and meso-zeaxanthin: The basic and clinical science underlying carotenoid-based nutritional interventions against ocular disease
Q37636009Macular Pigment Optical Density and Measures of Macular Function: Test-Retest Variability, Cross-Sectional Correlations, and Findings from the Zeaxanthin Pilot Study of Response to Supplementation (ZEASTRESS-Pilot).
Q35542894Macular pigment optical density in a healthy Chinese population
Q47834614Macular pigment optical density is positively associated with academic performance among preadolescent children
Q28240096Macular xanthophylls, lipoprotein-related genes, and age-related macular degeneration
Q38921719Plasma long-chain omega-3 polyunsaturated fatty acids and macular pigment in subjects with family history of age-related macular degeneration: the Limpia Study
Q37715993Potential protective function of the sterol regulatory element binding factor 1-fatty acid desaturase 1/2 axis in early-stage age-related macular degeneration
Q48251018RPE65 takes on another role in the vertebrate retina
Q52782567Retinal accumulation of zeaxanthin, lutein, and β-carotene in mice deficient in carotenoid cleavage enzymes.
Q88615813Supplementation with macular carotenoids improves visual performance of transgenic mice
Q35596762The Effect of BCMO1 Gene Variants on Macular Pigment Optical Density in Young Healthy Caucasians.
Q35106624The relationship between BCMO1 gene variants and macular pigment optical density in persons with and without age-related macular degeneration
Q90240716β-carotene in Obesity Research: Technical Considerations and Current Status of the Field

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