| scholarly article | Q13442814 |
| P819 | ADS bibcode | 2013PNAS..110.6518X |
| P356 | DOI | 10.1073/PNAS.1303976110 |
| P932 | PMC publication ID | 3631619 |
| P698 | PubMed publication ID | 23576758 |
| P5875 | ResearchGate publication ID | 236193316 |
| P50 | author | Jennifer J. Trowbridge | Q87858551 |
| P2093 | author name string | Jian Xu | |
| Gail Mandel | |||
| Stuart H Orkin | |||
| Daniel E Bauer | |||
| Thuy D Vo | |||
| Marc A Kerenyi | |||
| Yu-Jung Hsu | |||
| Serena Hou | |||
| Huilan Yao | |||
| P2860 | cites work | Haploinsufficiency for the erythroid transcription factor KLF1 causes hereditary persistence of fetal hemoglobin | Q24293797 |
| A Novel, Erythroid Cell-Specific Murine Transcription Factor that Binds to the CACCC Element and is Related to the Krüppel Family of Nuclear Proteins† | Q24605651 | ||
| Mi2β is required for γ-globin gene silencing: temporal assembly of a GATA-1-FOG-1-Mi2 repressor complex in β-YAC transgenic mice | Q28484457 | ||
| Developmental and species-divergent globin switching are driven by BCL11A | Q28506497 | ||
| Bcl11a is essential for normal lymphoid development | Q28511014 | ||
| Inducible gene targeting in mice | Q29614544 | ||
| Lysine-specific demethylase 1 restricts hematopoietic progenitor proliferation and is essential for terminal differentiation | Q33401808 | ||
| Chemical genetic strategy identifies histone deacetylase 1 (HDAC1) and HDAC2 as therapeutic targets in sickle cell disease | Q33628389 | ||
| CTIP1 and CTIP2 are differentially expressed during mouse embryogenesis | Q33642286 | ||
| Control of globin gene expression during development and erythroid differentiation | Q33645104 | ||
| Transcriptional silencing of {gamma}-globin by BCL11A involves long-range interactions and cooperation with SOX6. | Q33788501 | ||
| Lysine-specific demethylase 1 is a therapeutic target for fetal hemoglobin induction | Q33907537 | ||
| Histone H3 lysine 4 demethylation is a target of nonselective antidepressive medications | Q33997049 | ||
| Use of yeast artificial chromosomes (YACs) in studies of mammalian development: production of beta-globin locus YAC mice carrying human globin developmental mutants | Q34245881 | ||
| DNA methyltransferase 1 is essential for and uniquely regulates hematopoietic stem and progenitor cells | Q35005985 | ||
| A functional element necessary for fetal hemoglobin silencing | Q35217485 | ||
| 5-Azacytidine stimulates fetal hemoglobin synthesis in anemic baboons | Q36304994 | ||
| Combinatorial assembly of developmental stage-specific enhancers controls gene expression programs during human erythropoiesis | Q36335791 | ||
| Correction of sickle cell disease in adult mice by interference with fetal hemoglobin silencing | Q37102932 | ||
| Control of fetal hemoglobin: new insights emerging from genomics and clinical implications | Q37379477 | ||
| Reawakening fetal hemoglobin: prospects for new therapies for the β-globin disorders | Q38035829 | ||
| Use of in vivo biotinylation to study protein-protein and protein-DNA interactions in mouse embryonic stem cells | Q39867620 | ||
| Human fetal hemoglobin expression is regulated by the developmental stage-specific repressor BCL11A. | Q39908659 | ||
| Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation | Q40834659 | ||
| KLF1 regulates BCL11A expression and γ- to β-globin gene switching | Q42950072 | ||
| Binding patterns of BCL11A in the globin and GATA1 loci and characterization of the BCL11A fetal hemoglobin locus | Q43027912 | ||
| A mouse model for visualization and conditional mutations in the erythroid lineage | Q44848170 | ||
| 5-Azacytidine Selectively Increases γ-Globin Synthesis in a Patient with β+Thalassemia | Q72682311 | ||
| P433 | issue | 16 | |
| P407 | language of work or name | English | Q1860 |
| P1104 | number of pages | 6 | |
| P304 | page(s) | 6518-6523 | |
| P577 | publication date | 2013-04-01 | |
| P1433 | published in | Proceedings of the National Academy of Sciences of the United States of America | Q1146531 |
| P1476 | title | Corepressor-dependent silencing of fetal hemoglobin expression by BCL11A. | |
| P478 | volume | 110 |
| Q91581527 | A new target for fetal hemoglobin reactivation |
| Q37327614 | A signature motif mediating selective interactions of BCL11A with the NR2E/F subfamily of orphan nuclear receptors. |
| Q94474226 | Advances in genome editing: the technology of choice for precise and efficient β-thalassemia treatment |
| Q39081873 | An erythroid enhancer of BCL11A subject to genetic variation determines fetal hemoglobin level. |
| Q33850615 | An international effort to cure a global health problem: A report on the 19th Hemoglobin Switching Conference |
| Q27023172 | Anemia: progress in molecular mechanisms and therapies |
| Q28067142 | Animal models of β-hemoglobinopathies: utility and limitations |
| Q28510940 | Antagonistic actions of Rcor proteins regulate LSD1 activity and cellular differentiation |
| Q93335392 | BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression |
| Q54070526 | BCL11A frameshift mutation associated with dyspraxia and hypotonia affecting the fine, gross, oral, and speech motor systems. |
| Q33837435 | BCL11A gene DNA methylation contributes to the risk of type 2 diabetes in males |
| Q91782499 | CARM1-mediated methylation of protein arginine methyltransferase 5 represses human γ-globin gene expression in erythroleukemia cells |
| Q28551340 | Chemical Inhibition of Histone Deacetylases 1 and 2 Induces Fetal Hemoglobin through Activation of GATA2 |
| Q33751386 | Chemical probes targeting epigenetic proteins: Applications beyond oncology |
| Q34456733 | Compound loss of function of nuclear receptors Tr2 and Tr4 leads to induction of murine embryonic β-type globin genes |
| Q47147613 | Concise Review: Epigenetic Regulation of Hematopoiesis: Biological Insights and Therapeutic Applications |
| Q28509390 | Corepressor Rcor1 is essential for murine erythropoiesis |
| Q52690497 | Direct Promoter Repression by BCL11A Controls the Fetal to Adult Hemoglobin Switch. |
| Q90024659 | Disruption of the MBD2-NuRD complex but not MBD3-NuRD induces high level HbF expression in human adult erythroid cells |
| Q36169265 | EHMT1 and EHMT2 inhibition induces fetal hemoglobin expression. |
| Q48023276 | Efficacy and safety of long-term RN-1 treatment to increase HbF in baboons |
| Q99602776 | Embryonic erythropoiesis and hemoglobin switching require transcriptional repressor ETO2 to modulate chromatin organization |
| Q26864609 | Epigenetic regulation of fetal globin gene expression in adult erythroid cells |
| Q46320647 | Evolution of hemoglobin loci and their regulatory elements |
| Q57753972 | Fetal Hemoglobin Induction by Epigenetic Drugs |
| Q26822810 | Fetal globin gene repressors as drug targets for molecular therapies to treat the β-globinopathies |
| Q30249259 | Fetal haemoglobin in sickle-cell disease: from genetic epidemiology to new therapeutic strategies |
| Q45874514 | Fetal haemoglobin induction in sickle cell disease |
| Q38995849 | Fetal hemoglobin regulation in β-thalassemia: heterogeneity, modifiers and therapeutic approaches |
| Q38729714 | Gamma reactivation using the spongy effect of KLF1-binding site sequence: an approach in gene therapy for beta-thalassemia |
| Q39220089 | Gene Therapy for β-Hemoglobinopathies |
| Q87627618 | Gene therapy's out-of-body experience |
| Q50061134 | Genetic Basis and Genetic Modifiers of β-Thalassemia and Sickle Cell Disease |
| Q35087288 | Genotyping of BCL11A and HBS1L-MYB SNPs associated with fetal haemoglobin levels: a SNaPshot minisequencing approach |
| Q38875745 | Hemoglobin genetics: recent contributions of GWAS and gene editing |
| Q33361527 | Hemoglobin switching's surprise: the versatile transcription factor BCL11A is a master repressor of fetal hemoglobin |
| Q36942303 | Histone demethylase Lsd1 represses hematopoietic stem and progenitor cell signatures during blood cell maturation |
| Q36828138 | Homology-driven genome editing in hematopoietic stem and progenitor cells using ZFN mRNA and AAV6 donors. |
| Q41897344 | Hydroxymethylcytosine and demethylation of the γ-globin gene promoter during erythroid differentiation |
| Q47906054 | In Situ Capture of Chromatin Interactions by Biotinylated dCas9. |
| Q34463668 | Induction of adult levels of β-globin in human erythroid cells that intrinsically express embryonic or fetal globin by transduction with KLF1 and BCL11A-XL |
| Q35913083 | Krüppel-Like Transcription Factor KLF1 Is Required for Optimal γ- and β-Globin Expression in Human Fetal Erythroblasts |
| Q36300224 | LSD1/KDM1A promotes hematopoietic commitment of hemangioblasts through downregulation of Etv2. |
| Q37550182 | Large-scale hypomethylated blocks associated with Epstein-Barr virus-induced B-cell immortalization |
| Q37395719 | Lineage-specific BCL11A knockdown circumvents toxicities and reverses sickle phenotype |
| Q58606848 | MIR-144 Mediated NRF2 Gene Silencing Inhibits Fetal Hemoglobin Expression in Sickle Cell Disease |
| Q37107194 | Minireview: Multiomic candidate biomarkers for clinical manifestations of sickle cell severity: Early steps to precision medicine |
| Q39399184 | Molecular basis of β thalassemia and potential therapeutic targets |
| Q42341702 | NRF2 mediates γ-globin gene regulation and fetal hemoglobin induction in human erythroid progenitors |
| Q42381246 | Normal hematologic parameters and fetal hemoglobin silencing with heterozygous IKZF1 mutations |
| Q41576877 | Oral tetrahydrouridine and decitabine for non-cytotoxic epigenetic gene regulation in sickle cell disease: A randomized phase 1 study. |
| Q37107201 | Original Research: A case-control genome-wide association study identifies genetic modifiers of fetal hemoglobin in sickle cell disease |
| Q36913598 | Original Research: Generation of non-deletional hereditary persistence of fetal hemoglobin β-globin locus yeast artificial chromosome transgenic mouse models: -175 Black HPFH and -195 Brazilian HPFH |
| Q89091509 | POGZ Is Required for Silencing Mouse Embryonic β-like Hemoglobin and Human Fetal Hemoglobin Expression |
| Q45874809 | Pharmacological and molecular approaches for the treatment of β-hemoglobin disorders. |
| Q88984021 | Poly(C)-Binding Protein Pcbp2 Enables Differentiation of Definitive Erythropoiesis by Directing Functional Splicing of the Runx1 Transcript |
| Q36700492 | Pomalidomide reverses γ-globin silencing through the transcriptional reprogramming of adult hematopoietic progenitors |
| Q90685005 | Potential role of LSD1 inhibitors in the treatment of sickle cell disease: a review of preclinical animal model data |
| Q47269581 | Probing the interaction between the histone methyltransferase/deacetylase subunit RBBP4/7 and the transcription factor BCL11A in epigenetic complexes |
| Q61697710 | RN-1, a potent and selective lysine-specific demethylase 1 inhibitor, increases γ-globin expression, F reticulocytes, and F cells in a sickle cell disease mouse model |
| Q93117329 | Rational targeting of a NuRD subcomplex guided by comprehensive in situ mutagenesis |
| Q34052021 | Reactivation of developmentally silenced globin genes by forced chromatin looping. |
| Q45875308 | Recent progress in understanding and manipulating haemoglobin switching for the haemoglobinopathies |
| Q38367473 | Recent trends in the gene therapy of β-thalassemia |
| Q36909390 | Regulation of the fetal hemoglobin silencing factor BCL11A. |
| Q38635450 | Society for Pediatric Research 2015 Young Investigator Award: genetics of human hematopoiesis-what patients can teach us about blood cell production |
| Q48533330 | Targeting histone methyltransferase and demethylase in acute myeloid leukemia therapy. |
| Q92534004 | Targeting sickle cell disease root-cause pathophysiology with small molecules |
| Q64290214 | The E3 ligase adaptor molecule SPOP regulates fetal hemoglobin levels in adult erythroid cells |
| Q35859235 | The LSD1 inhibitor RN-1 induces fetal hemoglobin synthesis and reduces disease pathology in sickle cell mice |
| Q41032514 | The LSD1 inhibitor RN-1 recapitulates the fetal pattern of hemoglobin synthesis in baboons (P. anubis). |
| Q49919974 | The intrinsic genetic and epigenetic regulator factors as therapeutic targets, and the effect on fetal globin gene expression |
| Q37189626 | The malignant brain tumor (MBT) domain protein SFMBT1 is an integral histone reader subunit of the LSD1 demethylase complex for chromatin association and epithelial-to-mesenchymal transition |
| Q36652029 | Transcription factors LRF and BCL11A independently repress expression of fetal hemoglobin |
| Q40384669 | Transcriptional Control of Stem and Progenitor Potential |
| Q46716752 | rs11886868 and rs4671393 of BCL11A associated with HbF level variation and modulate clinical events among sickle cell anemia patients. |
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