Phase II clinical study of BC-3781, a pleuromutilin antibiotic, in treatment of patients with acute bacterial skin and skin structure infections

scientific article published on 19 February 2013

Phase II clinical study of BC-3781, a pleuromutilin antibiotic, in treatment of patients with acute bacterial skin and skin structure infections is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1128/AAC.02106-12
P932PMC publication ID3632892
P698PubMed publication ID23422913
P5875ResearchGate publication ID235669364

P2093author name stringF Obermayr
K J Tack
R Novak
G H Talbot
W T Prince
Z Ivezic-Schoenfeld
C Lell
P2860cites workInfectious Diseases Society of America/American Thoracic Society Consensus Guidelines on the Management of Community-Acquired Pneumonia in AdultsQ22242958
Bad bugs, no drugs: no ESKAPE! An update from the Infectious Diseases Society of AmericaQ29616084
The pleuromutilin antibiotics: a new class for human use.Q34095587
Practice guidelines for the diagnosis and management of skin and soft-tissue infectionsQ34460523
Antimicrobial activity of the investigational pleuromutilin compound BC-3781 tested against Gram-positive organisms commonly associated with acute bacterial skin and skin structure infectionsQ35806254
Staphylococcus aureus with reduced susceptibility to vancomycinQ35882353
Results of a double-blind, randomized trial of ceftobiprole treatment of complicated skin and skin structure infections caused by gram-positive bacteria.Q36422630
Progress on developing endpoints for registrational clinical trials of community-acquired bacterial pneumonia and acute bacterial skin and skin structure infections: update from the Biomarkers Consortium of the Foundation for the National InstitutesQ36486840
Integrated analysis of CANVAS 1 and 2: phase 3, multicenter, randomized, double-blind studies to evaluate the safety and efficacy of ceftaroline versus vancomycin plus aztreonam in complicated skin and skin-structure infectionQ38371341
The role of diabetes mellitus in the treatment of skin and skin structure infections caused by methicillin-resistant Staphylococcus aureus: results from three randomized controlled trialsQ43795846
Telavancin versus vancomycin for the treatment of complicated skin and skin-structure infections caused by gram-positive organismsQ46620675
Managing skin and soft tissue infections: expert panel recommendations on key decision pointsQ79353901
Antimicrobial activity of the novel pleuromutilin antibiotic BC-3781 against organisms responsible for community-acquired respiratory tract infections (CARTIs)Q83353954
P433issue5
P407language of work or nameEnglishQ1860
P304page(s)2087-2094
P577publication date2013-02-19
P1433published inAntimicrobial Agents and ChemotherapyQ578004
P1476titlePhase II clinical study of BC-3781, a pleuromutilin antibiotic, in treatment of patients with acute bacterial skin and skin structure infections
P478volume57

Reverse relations

cites work (P2860)
Q41872353A novel pleuromutilin antibacterial compound, its binding mode and selectivity mechanism
Q30249262Antibiotics in the clinical pipeline at the end of 2015.
Q38133967Antibiotics in the clinical pipeline in 2013.
Q90131070Antimicrobial resistance in methicillin-resistant Staphylococcus aureus to newer antimicrobial agents
Q38772340Antimicrobial-resistant sexually transmitted infections: gonorrhoea and Mycoplasma genitalium
Q47780684Biosynthetic Machinery of Diterpene Pleuromutilin Isolated from Basidiomycete Fungi.
Q64268314Boron-Pleuromutilins as Anti- Wolbachia Agents with Potential for Treatment of Onchocerciasis and Lymphatic Filariasis
Q64066325Current Treatment Options for Acute Skin and Skin-structure Infections
Q38239799Fungal natural products in research and development.
Q34525879In Vitro Activity of Lefamulin Tested against Streptococcus pneumoniae with Defined Serotypes, Including Multidrug-Resistant Isolates Causing Lower Respiratory Tract Infections in the United States
Q52659745In Vitro Activity of Lefamulin against Sexually Transmitted Bacterial Pathogens.
Q40052692In vitro activity of the novel pleuromutilin lefamulin (BC-3781) and effect of efflux pump inactivation on multidrug-resistant and extensively-drug resistant Neisseria gonorrhoeae
Q64072703In vivo pharmacodynamics of lefamulin, the first systemic pleuromutilin for human use, in a neutropenic murine thigh infection model
Q64072714Introduction: lefamulin and pharmacokinetic/pharmacodynamic rationale to support the dose selection of lefamulin
Q90284581Lefamulin. Comment on: "Novel Antibiotics for Multidrug-Resistant Gram-Positive Microorganisms. Microorganisms, 2019, 7, 270"
Q26796722Management of Mycoplasma genitalium infections - can we hit a moving target?
Q39362169Managing community acquired pneumonia in the elderly - the next generation of pharmacotherapy on the horizon
Q42355223Mycoplasma genitalium infections: current treatment options and resistance issues
Q38247457Natural product and natural product derived drugs in clinical trials.
Q38172657New antibacterial agents: patent applications published in 2011.
Q38132217New antibiotics for bad bugs: where are we?
Q64072710Pharmacokinetics and tolerability of lefamulin following intravenous and oral dosing
Q37835585Pleuromutilins: Potent Drugs for Resistant Bugs-Mode of Action and Resistance
Q34508161Simultaneous assessment of the pharmacokinetics of a pleuromutilin, lefamulin, in plasma, soft tissues and pulmonary epithelial lining fluid.
Q34497915Structural insights into species-specific features of the ribosome from the pathogen Staphylococcus aureus
Q37570744The good, the bad and the tasty: The many roles of mushrooms

Search more.