Synergistic Action of a RAF Inhibitor and a Dual PI3K/mTOR Inhibitor in Thyroid Cancer

scientific article published on August 10, 2011

Synergistic Action of a RAF Inhibitor and a Dual PI3K/mTOR Inhibitor in Thyroid Cancer is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1158/1078-0432.CCR-11-0933
P953full work available at URLhttps://aacrjournals.org/clincancerres/article-pdf/17/20/6482/1998890/6482.pdf
https://clincancerres.aacrjournals.org/content/clincanres/17/20/6482.full.pdf
https://doi.org/10.1158/1078-0432.ccr-11-0933
https://europepmc.org/articles/PMC4828042
https://europepmc.org/articles/PMC4828042?pdf=render
P932PMC publication ID4828042
P698PubMed publication ID21831957

P2093author name stringNing Jin
Tianyun Jiang
Barry D. Nelkin
Douglas W. Ball
David M. Rosen
P2860cites workPrognostic significance of somatic RET oncogene mutations in sporadic medullary thyroid cancer: a 10-year follow-up study.Q27851420
NVP-BEZ235, a dual PI3K/mTOR inhibitor, prevents PI3K signaling and inhibits the growth of cancer cells with activating PI3K mutations.Q27851451
Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancersQ27851457
Inhibition of Mutated, Activated BRAF in Metastatic MelanomaQ27860458
Cancer statistics, 2010Q27860525
Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitorsQ29547463
RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAFQ29616828
Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancerQ29618030
Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activityQ29618117
Specific apoptosis induction by the dual PI3K/mTor inhibitor NVP-BEZ235 in HER2 amplified and PIK3CA mutant breast cancer cellsQ33564297
Vandetanib for the treatment of patients with locally advanced or metastatic hereditary medullary thyroid cancerQ33710562
The PI3K-Akt-mTOR pathway in initiation and progression of thyroid tumorsQ33770769
Prognostic utility of BRAF mutation in papillary thyroid cancerQ33771120
BAY 43-9006 inhibition of oncogenic RET mutantsQ34565246
Efficacy of pazopanib in progressive, radioiodine-refractory, metastatic differentiated thyroid cancers: results of a phase 2 consortium study.Q35023367
4E-BP1 is a key effector of the oncogenic activation of the AKT and ERK signaling pathways that integrates their function in tumorsQ35778060
Activity of XL184 (Cabozantinib), an Oral Tyrosine Kinase Inhibitor, in Patients With Medullary Thyroid CancerQ36822111
Vandetanib in patients with locally advanced or metastatic medullary thyroid cancer: a randomized, double-blind phase III trialQ36910409
Dual inhibition of mitogen-activated protein kinase kinase and mammalian target of rapamycin in differentiated and anaplastic thyroid cancerQ37379562
Differential induction of apoptosis in HER2 and EGFR addicted cancers following PI3K inhibition.Q37396608
Role of MAPK pathway oncoproteins in thyroid cancer pathogenesis and as drug targetsQ37397367
Genetic alterations in the phosphatidylinositol-3 kinase/Akt pathway in thyroid cancerQ37767709
Compensatory activation of Akt in response to mTOR and Raf inhibitors - a rationale for dual-targeted therapy approaches in neuroendocrine tumor diseaseQ39720433
Basal and treatment-induced activation of AKT mediates resistance to cell death by AZD6244 (ARRY-142886) in Braf-mutant human cutaneous melanoma cellsQ42478581
Selectively targeting mutant BRAF in thyroid cancerQ42938752
Dependence on phosphoinositide 3-kinase and RAS-RAF pathways drive the activity of RAF265, a novel RAF/VEGFR2 inhibitor, and RAD001 (Everolimus) in combinationQ43177478
Cytostatic activity of adenosine triphosphate-competitive kinase inhibitors in BRAF mutant thyroid carcinoma cells.Q43251079
Kinase inhibitors for refractory thyroid cancersQ45579100
BRAF Mutations in Papillary Thyroid Carcinomas Inhibit Genes Involved in Iodine MetabolismQ61951314
P433issue20
P407language of work or nameEnglishQ1860
P921main subjectphosphoinositide-3 kinase inhibitorQ7187512
P304page(s)6482-6489
P577publication date2011-08-10
P1433published inClinical Cancer ResearchQ332253
P1476titleSynergistic action of a RAF inhibitor and a dual PI3K/mTOR inhibitor in thyroid cancer
Synergistic Action of a RAF Inhibitor and a Dual PI3K/mTOR Inhibitor in Thyroid Cancer
P478volume17

Reverse relations

cites work (P2860)
Q35578255A novel dual AMPK activator/mTOR inhibitor inhibits thyroid cancer cell growth
Q42939358Accelerated disease progression after discontinuation of sorafenib in a patient with metastatic papillary thyroid cancer
Q38305056Advances in thyroid cancer treatment: latest evidence and clinical potential
Q39186912An update on the pathophysiology and management of polycystic liver disease
Q93269603Apoptosis Activation in Thyroid Cancer Cells by Jatrorrhizine-Platinum(II) Complex via Downregulation of PI3K/AKT/Mammalian Target of Rapamycin (mTOR) Pathway
Q28086785Autophagy in thyroid cancer: present knowledge and future perspectives
Q36243554B-Raf activation cooperates with PTEN loss to drive c-Myc expression in advanced prostate cancer
Q21198860B-Raf and the inhibitors: from bench to bedside
Q53077419BRAFwild papillary thyroid carcinoma has two distinct mRNA expression patterns with different clinical behaviors.
Q39374983Cabozantinib (XL184) for the treatment of locally advanced or metastatic progressive medullary thyroid cancer.
Q41251561Cellular signaling pathway alterations and potential targeted therapies for medullary thyroid carcinoma
Q27852136Concomitant BRAF and PI3K/mTOR blockade is required for effective treatment of BRAF(V600E) colorectal cancer
Q37635839Dual Inhibition of PI3K/AKT and MEK/ERK Pathways Induces Synergistic Antitumor Effects in Diffuse Intrinsic Pontine Glioma Cells
Q27332333Dual Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Inhibitor NVP-BEZ235 Has a Therapeutic Potential and Sensitizes Cisplatin in Nasopharyngeal Carcinoma
Q54117927Dual mTOR/PI3K inhibition limits PI3K-dependent pathways activated upon mTOR inhibition in autosomal dominant polycystic kidney disease
Q38704670Efficacy of an HSP90 inhibitor, ganetespib, in preclinical thyroid cancer models
Q36864736Evolving approaches to patients with advanced differentiated thyroid cancer
Q92929300Exogenous Hydrogen Sulfide Regulates the Growth of Human Thyroid Carcinoma Cells
Q36799818FOXM1 is a molecular determinant of the mitogenic and invasive phenotype of anaplastic thyroid carcinoma
Q38128097Genetics and epigenetics of sporadic thyroid cancer
Q28551145HER2+ Cancer Cell Dependence on PI3K vs. MAPK Signaling Axes Is Determined by Expression of EGFR, ERBB3 and CDKN1B
Q83750559In Search of a Real “Targeted” Therapy for Thyroid Cancer
Q28548302Mitogen-Inducible Gene-6 Mediates Feedback Inhibition from Mutated BRAF towards the Epidermal Growth Factor Receptor and Thereby Limits Malignant Transformation
Q90194104Molecular Alterations in Thyroid Cancer: From Bench to Clinical Practice
Q34329018Molecular pathogenesis and mechanisms of thyroid cancer
Q38083427Multidrug Therapy for Polycystic Kidney Disease: A Review and Perspective
Q38239229PI3K/Akt/mTOR signaling in medullary thyroid cancer: a promising molecular target for cancer therapy
Q38103961Phase I/II RAF kinase inhibitors in cancer therapy
Q50876534Possible Roles of the Xenobiotic Transporter P-glycoproteins Encoded by the MDR1 3435 C>T Gene Polymorphism in Differentiated Thyroid Cancers
Q88595370RASSF1A Deficiency Enhances RAS-Driven Lung Tumorigenesis
Q34307356Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascade inhibitors: how mutations can result in therapy resistance and how to overcome resistance
Q37985518Signaling Pathways as Specific Pharmacologic Targets for Neuroendocrine Tumor Therapy: RET, PI3K, MEK, Growth Factors, and Notch
Q34284733Switch in signaling control of mTORC1 activity after oncoprotein expression in thyroid cancer cell lines
Q36057504Synergistic antitumour activity of RAF265 and ZSTK474 on human TT medullary thyroid cancer cells
Q36208936TSLP Signaling Network Revealed by SILAC-Based Phosphoproteomics
Q91814537Targeting mTOR and Metabolism in Cancer: Lessons and Innovations
Q39130053Targeting mTOR in RET mutant medullary and differentiated thyroid cancer cells.
Q94564096The Altered Metabolic Molecular Signatures Contribute to the RAD001 Resistance in Gastric Neuroendocrine Tumor
Q38005913The Role of Cell Lines in the Study of Neuroendocrine Tumors
Q26853261Time to re-consider the meaning of BRAF V600E mutation in papillary thyroid carcinoma
Q26747168Treatment of advanced thyroid cancer with targeted therapies: ten years of experience
Q33570056Update: the status of clinical trials with kinase inhibitors in thyroid cancer
Q34450398Utility of a PI3K/mTOR inhibitor (NVP-BEZ235) for thyroid cancer therapy.
Q35025521Utility of a histone deacetylase inhibitor (PXD101) for thyroid cancer treatment
Q37649634mTOR pathway in colorectal cancer: an update
Q37725293p53 constrains progression to anaplastic thyroid carcinoma in a Braf-mutant mouse model of papillary thyroid cancer

Search more.