Microdissection and analytical PCR for the investigation of mtDNA lesions

scientific article published on January 2007

Microdissection and analytical PCR for the investigation of mtDNA lesions is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/S0091-679X(06)80024-5
P698PubMed publication ID17445710

P2093author name stringCarlos T Moraes
Sion L Williams
P2860cites workPrinciple and applications of digital PCRQ28237698
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High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson diseaseQ29619113
Mitochondrial DNA deletion mutations colocalize with segmental electron transport system abnormalities, muscle fiber atrophy, fiber splitting, and oxidative damage in sarcopeniaQ30649164
Mitochondrial DNA deletion mutations are concomitant with ragged red regions of individual, aged muscle fibers: analysis by laser-capture microdissectionQ30760899
Microdissection of histologic sections: past, present, and futureQ30844836
Frequent mutations in the mitochondrial control region DNA in breast tissueQ31112986
A simple combined microdissection and aspiration device for the rapid procurement of single cells from clinical peripheral blood smearsQ31931772
The laser in the Lowry technique for microdissection of freeze-dried tissue slicesQ32066517
Detection of deleted mitochondrial DNA in Kearns-Sayre syndrome using laser capture microdissection.Q33194853
The increase of mitochondrial DNA content in endometrial adenocarcinoma cells: a quantitative study using laser-captured microdissected tissuesQ33215975
Mitochondrial neurogastrointestinal encephalomyopathy: evidence of mitochondrial DNA depletion in the small intestineQ33236131
Loss of heterozygosity in lobular carcinoma in situ of the breastQ33836982
Double-strand breaks of mouse muscle mtDNA promote large deletions similar to multiple mtDNA deletions in humansQ34062921
Rapid directional shift of mitochondrial DNA heteroplasmy in animal tissues by a mitochondrially targeted restriction endonucleaseQ34063452
Myoclonic epilepsy and ragged-red fiber disease (MERRF) is associated with a mitochondrial DNA tRNA(Lys) mutationQ34152888
Mutant mitochondrial helicase Twinkle causes multiple mtDNA deletions and a late-onset mitochondrial disease in miceQ34201844
Single-sperm typing: determination of genetic distance between the G gamma-globin and parathyroid hormone loci by using the polymerase chain reaction and allele-specific oligomersQ34323318
Somatic mutations of the mitochondrial genome in human colorectal tumoursQ34478926
Somatic mitochondrial DNA mutations in prostate cancer and normal appearing adjacent glands in comparison to age-matched prostate samples without malignant histologyQ35790237
Two direct repeats cause most human mtDNA deletionsQ35864144
Single-molecule PCR: an artifact-free PCR approach for the analysis of somatic mutationsQ36252221
Mitochondrial DNA mutations in human colonic crypt stem cellsQ36524727
Atypical ductal hyperplasia of the breast: clonal proliferation with loss of heterozygosity on chromosomes 16q and 17p.Q37263268
The determination of complete human mitochondrial DNA sequences in single cells: implications for the study of somatic mitochondrial DNA point mutationsQ39096996
Detection and quantification of mitochondrial DNA deletions in individual cells by real-time PCR.Q39681978
Cell-by-cell scanning of whole mitochondrial genomes in aged human heart reveals a significant fraction of myocytes with clonally expanded deletionsQ39730030
Recombination of mitochondrial DNA in skeletal muscle of individuals with multiple mitochondrial DNA heteroplasmyQ41809981
A direct repeat is a hotspot for large-scale deletion of human mitochondrial DNA.Q41951578
Myoclonic epilepsy and ragged red fibers (MERRF) syndrome: selective vulnerability of CNS neurons does not correlate with the level of mitochondrial tRNAlys mutation in individual neuronal isolates.Q46607163
Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neuronsQ48588748
Somatic mitochondrial DNA mutations in single neurons and gliaQ48719653
Deletion mutants are functionally dominant over wild-type mitochondrial genomes in skeletal muscle fiber segments in mitochondrial diseaseQ48933491
Monoclonal Origin of Multicentric Kaposi's Sarcoma LesionsQ58366797
Repeat unit sequence variation in minisatellites: a novel source of DNA polymorphism for studying variation and mutation by single molecule analysisQ68929075
Phenotype-genotype correlations in skeletal muscle of patients with mtDNA deletionsQ71852983
Distribution of wild-type and common deletion forms of mtDNA in normal and respiration-deficient muscle fibers from patients with mitochondrial myopathyQ72372563
Quantification and sequencing of somatic deleted mtDNA in single cells: evidence for partially duplicated mtDNA in aged human tissuesQ73341946
The dangers of extended PCR in the clinicQ78199393
MtDNA point mutations are associated with deletion mutations in aged ratQ81513728
P921main subjectmicrodissectionQ4293202
P304page(s)481-501
P577publication date2007-01-01
P1433published inMethods in Cell BiologyQ2638096
P1476titleMicrodissection and analytical PCR for the investigation of mtDNA lesions
P478volume80

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