A missense mutation in the FUT6 gene results in total absence of alpha3-fucosylation of human alpha1-acid glycoprotein

scientific article published on June 1996

A missense mutation in the FUT6 gene results in total absence of alpha3-fucosylation of human alpha1-acid glycoprotein is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.271.24.14492
P698PubMed publication ID8662894
P5875ResearchGate publication ID237933741

P2093author name stringOriol R
Larson G
Mollicone R
Van den Eijnden DH
Van Dijk W
Brinkman-Van der Linden EC
P2860cites workA cloned human cDNA determines expression of a mouse stage-specific embryonic antigen and the Lewis blood group alpha(1,3/1,4)fucosyltransferaseQ24318318
Expression of human chromosome 19p alpha(1,3)-fucosyltransferase genes in normal tissues. Alternative splicing, polyadenylation, and isoformsQ28295888
Five specificity patterns of (1----3)-alpha-L-fucosyltransferase activity defined by use of synthetic oligosaccharide acceptors. Differential expression of the enzymes during human embryonic development and in adult tissuesQ28316034
Acceptor specificity of different length constructs of human recombinant alpha 1,3/4-fucosyltransferases. Replacement of the stem region and the transmembrane domain of fucosyltransferase V by protein A results in an enzyme with GDP-fucose hydrolyziQ30981873
Elevated levels of abnormally-fucosylated haptoglobins in cancer seraQ36028472
Inflammation-induced expression of sialyl Lewis X-containing glycan structures on alpha 1-acid glycoprotein (orosomucoid) in human seraQ36361464
Purification, properties and possible gene assignment of an alpha 1,3-fucosyltransferase expressed in human liverQ41262375
Cancer-associated elevation of α(1 → 3)-l-fucosyltransferase activity in human serumQ43575585
Alterations in the carbohydrate moiety of alpha-1-acid glycoprotein purified from human cirrhotic ascitic fluidQ43925837
Crossed immuno-affinoelectrophoresis. An analytical method to predict the result of affinity chromatographyQ47932885
Acceptor specificity and tissue distribution of three human alpha-3-fucosyltransferasesQ48932467
Determination of the primary structures of 16 asialo-carbohydrate units derived from human plasma alpha 1-acid glycoprotein by 360-MHZ 1H NMR spectroscopy and permethylation analysisQ67427242
400-MHz 1H-NMR spectroscopy of fucosylated tetrasialyl oligosaccharides isolated from normal and cirrhotic alpha 1-acid glycoproteinQ67929308
Glycosylation of three molecular forms of human alpha1-acid glycoprotein having different interactions with concanavalin A. Variations in the occurrence of di-, tri-, and tetraantennary glycans and the degree of sialylationQ68466013
Studies on the effect of the hepatocyte-stimulating factor on galactose-beta 1----4-N-acetylglucosamine alpha 2----6-sialyltransferase in cultured hepatocytesQ68860460
Tumor-related elevation of serum (alpha 1----3)-L-fucosyltransferase activity in gastric cancerQ69375378
Activity and secretion of sialyltransferase in primary monolayer cultures of rat hepatocytes cultured with and without dexamethasoneQ69539765
Structure determination of the glycans of human-serum alpha 1-antichymotrypsin using 1H-NMR spectroscopy and deglycosylation by N-glycanaseQ70138801
Structural analysis on the sugar chains of human alpha 1-antitrypsin: presence of fucosylated biantennary glycan in hepatocellular carcinomaQ70460313
Increased plasma alpha (1 --> 3)-L-fucosyltransferase activities in patients with hepatocellular carcinomaQ70986859
Glycosylation of alpha 1-acid glycoprotein in septic shock: changes in degree of branching and in expression of sialyl Lewis(x) groupsQ71481078
Stability of blood coagulation factors and inhibitors in blood drawn into half-strength citrate anticoagulantQ71690975
The use of human milk fucosyltransferase in the synthesis of tumor-associated trimeric X determinantsQ72233915
P433issue24
P407language of work or nameEnglishQ1860
P304page(s)14492-14495
P577publication date1996-06-01
P1433published inJournal of Biological ChemistryQ867727
P1476titleA missense mutation in the FUT6 gene results in total absence of alpha3-fucosylation of human alpha1-acid glycoprotein
P478volume271

Reverse relations

cites work (P2860)
Q35648842A fluorescent bisboronic acid compound that selectively labels cells expressing oligosaccharide Lewis X.
Q34346443ABH and Lewis histo-blood group antigens, a model for the meaning of oligosaccharide diversity in the face of a changing world
Q38344428Advances in molecular genetics of alpha-2- and alpha-3/4-fucosyltransferases.
Q35027094Alpha(1)-acid glycoprotein: an acute phase protein with inflammatory and immunomodulating properties
Q38314147Alteration of sugar chains on alpha(1)-acid glycoprotein secreted following cytokine stimulation of HuH-7 cells in vitro
Q30724288Altered glycosylation of alpha1-acid glycoprotein in patients with inflammation and diabetes mellitus
Q40624595Complement Regulatory Protein C1 Inhibitor Binds to Selectins and Interferes with Endothelial-Leukocyte Adhesion
Q44787125Distinct glycoforms of human alpha1-acid glycoprotein have comparable synthesis rates: a [13C]valine-labelling study in healthy humans
Q73568460Do synovial fluid acute phase proteins from patients with rheumatoid arthritis originate from serum?
Q33687866Evolutionary considerations in relating oligosaccharide diversity to biological function
Q36050468Fucosylated Glycans in α1-Acid Glycoprotein for Monitoring Treatment Outcomes and Prognosis of Cancer Patients
Q30821619Fucosylation of N-glycans regulates the secretion of hepatic glycoproteins into bile ducts
Q33784627Genomics meets glycomics-the first GWAS study of human N-Glycome identifies HNF1α as a master regulator of plasma protein fucosylation
Q38333345Human alpha1,3/4-fucosyltransferases. III. A Lys/Arg residue located within the alpha1,3-FucT motif is required for activity but not substrate binding
Q71870443Identification of a new plasma alpha(1,3)fucosyltransferase (FUT6) allele requires an extended genotyping strategy
Q40907008Identification of two functionally deficient plasma alpha 3-fucosyltransferase (FUT6) alleles
Q35876153In vivo clearance of alpha-1 acid glycoprotein is influenced by the extent of its N-linked glycosylation and by its interaction with the vessel wall.
Q43580839Increased alpha3-fucosylation of alpha(1)-acid glycoprotein in patients with congenital disorder of glycosylation type IA (CDG-Ia).
Q43768088Increased alpha3-fucosylation of alpha1-acid glycoprotein in Type I diabetic patients is related to vascular function
Q34575757Interleukin-1beta induces sialyl Lewis X on hepatocellular carcinoma HuH-7 cells via enhanced expression of ST3Gal IV and FUT VI gene
Q22254625Localization of alpha 1,3-fucosyltransferase VI in Weibel-Palade bodies of human endothelial cells
Q77768693Severe rheumatoid arthritis prohibits the pregnancy-induced decrease in alpha3-fucosylation of alpha1-acid glycoprotein
Q42541975Sialyl Lewis(x) epitopes do not occur on acute phase proteins in mice: relationship to the absence of alpha3-fucosyltransferase in the liver
Q41048755Studies on the interaction between hyaluronan and a rat colon cancer cell line
Q47975101The gain-of-function Chinese hamster ovary mutant LEC11B expresses one of two Chinese hamster FUT6 genes due to the loss of a negative regulatory factor
Q92668985Tri-antennary tri-sialylated mono-fucosylated glycan of alpha-1 antitrypsin as a non-invasive biomarker for non-alcoholic steatohepatitis: a novel glycobiomarker for non-alcoholic steatohepatitis
Q77103904Tumor cells as the origin of elevated serum alpha1,3fucosyltransferase in association with malignancy
Q43779024Tumor necrosis factor alpha increases the expression of glycosyltransferases and sulfotransferases responsible for the biosynthesis of sialylated and/or sulfated Lewis x epitopes in the human bronchial mucosa
Q45146173alpha1-acid glycoprotein fucosylation as a marker of carcinoma progression and prognosis

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