scholarly article | Q13442814 |
P50 | author | Wayne L. Hubbell | Q7976400 |
P2093 | author name string | James R Halpert | |
Zhongyu Yang | |||
Dmitri R Davydov | |||
Nadezhda Davydova | |||
P2860 | cites work | Crystal structure of human cytochrome P450 2D6 | Q24298673 |
Crystal structures of human cytochrome P450 3A4 bound to metyrapone and progesterone | Q24299505 | ||
Structural and mechanistic insights into the interaction of cytochrome P4503A4 with bromoergocryptine, a type I ligand | Q24598661 | ||
The challenges of dealing with promiscuous drug-metabolizing enzymes, receptors and transporters | Q25112732 | ||
Mammalian microsomal cytochrome P450 monooxygenase: structural adaptations for membrane binding and functional diversity | Q27621446 | ||
Pivotal role of water in the mechanism of P450BM-3 | Q27635979 | ||
Substrate recognition and molecular mechanism of fatty acid hydroxylation by cytochrome P450 from Bacillus subtilis. Crystallographic, spectroscopic, and mutational studies | Q27640290 | ||
The 1.92-A structure of Streptomyces coelicolor A3(2) CYP154C1. A new monooxygenase that functionalizes macrolide ring systems | Q27640294 | ||
Crystal structure of human cytochrome P450 2C9 with bound warfarin | Q27641685 | ||
An open conformation of mammalian cytochrome P450 2B4 at 1.6-Å resolution | Q27642370 | ||
Structure of human microsomal cytochrome P450 2C8. Evidence for a peripheral fatty acid binding site | Q27642793 | ||
Crystal Structures of Cytochrome P450 2B4 in Complex with the Inhibitor 1-Biphenyl-4-methyl-1 H -imidazole: Ligand-Induced Structural Response through α-Helical Repositioning , | Q27655307 | ||
P450cin Active Site Water: Implications for Substrate Binding and Solvent Accessibility | Q27678939 | ||
Anion-Dependent Stimulation of CYP3A4 Monooxygenase | Q27701001 | ||
Pressure effects on intra- and intermolecular interactions within proteins. | Q30330245 | ||
The ins and outs of cytochrome P450s. | Q30356342 | ||
Structural features of cytochromes P450 and ligands that affect drug metabolism as revealed by X-ray crystallography and NMR. | Q30396630 | ||
High pressure effects on protein structure and function | Q30423793 | ||
Peripheral ligand-binding site in cytochrome P450 3A4 located with fluorescence resonance energy transfer (FRET) | Q30511797 | ||
Adaptations to High Hydrostatic Pressure | Q33427720 | ||
How does the reductase help to regulate the catalytic cycle of cytochrome P450 3A4 using the conserved water channel? | Q33817658 | ||
Identifying conformational changes with site-directed spin labeling | Q34019511 | ||
Effects of high hydrostatic pressures on living cells: a consequence of the properties of macromolecules and macromolecule-associated water | Q34073329 | ||
Role of active site water molecules and substrate hydroxyl groups in oxygen activation by cytochrome P450 158A2: a new mechanism of proton transfer | Q34461465 | ||
High-pressure EPR reveals conformational equilibria and volumetric properties of spin-labeled proteins | Q34534205 | ||
The effects of osmotic and hydrostatic pressures on macromolecular systems | Q34620000 | ||
Revisiting volume changes in pressure-induced protein unfolding. | Q34620061 | ||
High pressure, a tool for exploring heme protein active sites | Q34620097 | ||
Interactions among cytochromes P450 in microsomal membranes: oligomerization of cytochromes P450 3A4, 3A5, and 2E1 and its functional consequences | Q35055663 | ||
A large-scale allosteric transition in cytochrome P450 3A4 revealed by luminescence resonance energy transfer (LRET). | Q35078270 | ||
Activation volumes in enzymic catalysis: their sources and modification by low-molecular-weight solutes | Q35085264 | ||
Model-independent decomposition of two-state data | Q35086625 | ||
Protein hydration changes during catalysis: a new mechanism of enzymic rate-enhancement and ion activation/inhibition of catalysis | Q35087304 | ||
A survey of active site access channels in cytochromes P450. | Q35818833 | ||
Estimating hydration changes upon biomolecular reactions from osmotic stress, high pressure, and preferential hydration experiments. | Q36017150 | ||
Identification of a functional water channel in cytochrome P450 enzymes. | Q36032795 | ||
Energetics of heterotropic cooperativity between alpha-naphthoflavone and testosterone binding to CYP3A4 | Q36113874 | ||
Analysis of human cytochrome P450 3A4 cooperativity: construction and characterization of a site-directed mutant that displays hyperbolic steroid hydroxylation kinetics | Q36481303 | ||
Substrate binding to cytochromes P450. | Q37214645 | ||
Circular dichroism and site-directed spin labeling reveal structural and dynamical features of high-pressure states of myoglobin | Q37377420 | ||
Plasticity of CYP2B enzymes: structural and solution biophysical methods | Q37429225 | ||
Pivotal role of P450-P450 interactions in CYP3A4 allostery: the case of α-naphthoflavone | Q37483394 | ||
Environmental effects in computational spectroscopy: accuracy and interpretation. | Q37722646 | ||
Conformational plasticity and structure/function relationships in cytochromes P450. | Q37743467 | ||
Is there a relationship between the substrate preferences and structural flexibility of cytochromes P450? | Q37972328 | ||
Conformational diversity and ligand tunnels of mammalian cytochrome P450s | Q38099062 | ||
The effect of high pressure upon proteins and other biomolecules | Q40154461 | ||
High pressure effects on proteins and other biomolecules | Q40335414 | ||
Deconvolutions based on singular value decomposition and the pseudoinverse: a guide for beginners | Q40736570 | ||
P450s: structural similarities and functional differences. | Q40993726 | ||
CYP261 enzymes from deep sea bacteria: a clue to conformational heterogeneity in cytochromes P450. | Q41888032 | ||
Role of subunit interactions in P450 oligomers in the loss of homotropic cooperativity in the cytochrome P450 3A4 mutant L211F/D214E/F304W. | Q42094327 | ||
Cytochrome P450 from Photobacterium profundum SS9, a piezophilic bacterium, exhibits a tightened control of water access to the active site | Q42173613 | ||
Allosteric mechanisms in cytochrome P450 3A4 studied by high-pressure spectroscopy: pivotal role of substrate-induced changes in the accessibility and degree of hydration of the heme pocket. | Q42173769 | ||
Mechanism of interactions of alpha-naphthoflavone with cytochrome P450 3A4 explored with an engineered enzyme bearing a fluorescent probe. | Q42173777 | ||
Kinetics of dithionite-dependent reduction of cytochrome P450 3A4: heterogeneity of the enzyme caused by its oligomerization. | Q42173805 | ||
Stochastic ensembles, conformationally adaptive teamwork, and enzymatic detoxification | Q42731458 | ||
Comparative investigation of superoxide trapping by cyclic nitrone spin traps: the use of singular value decomposition and multiple linear regression analysis | Q44627934 | ||
Conformational heterogeneity of cytochrome P450 3A4 revealed by high pressure spectroscopy. | Q44663408 | ||
Kinetics and thermodynamics of ligand binding by cytochrome P450 3A4. | Q46935182 | ||
How large are the volume changes accompanying protein transitions and binding? | Q47740169 | ||
Hydrophobic effects on partial molar volume. | Q51975982 | ||
High-pressure-induced transitions in microsomal cytochrome P450 2B4 in solution: evidence for conformational inhomogeneity in the oligomers. | Q52335945 | ||
Component resolution using multilinear models. | Q52359467 | ||
Dynamics of Water Molecules in the Active-Site Cavity of Human Cytochromes P450 | Q56975735 | ||
Water as biocatalyst in cytochrome P450 | Q57397808 | ||
Protein Dynamics Tightly Connected to the Dynamics of Surrounding and Internal Water Molecules | Q57814723 | ||
Hydrophobic interaction electrophoresis under high hydrostatic pressure: study of the effects of pressure upon the interaction of serum albumin with a long-chain aliphatic ligand | Q68047031 | ||
High affinity of ergopeptides for cytochromes P450 3A. Importance of their peptide moiety for P450 recognition and hydroxylation of bromocriptine | Q72119079 | ||
The Pressure Dependence of the Spin Equilibrium in Camphor-Bound Ferric Cytochrome P-450 | Q72935909 | ||
Partial volumes and compressibilities of extended polypeptide chains in aqueous solution: additivity scheme and implication of protein unfolding at normal and high pressure | Q73581673 | ||
Allosteric behavior in cytochrome p450-dependent in vitro drug-drug interactions: a prospective based on conformational dynamics | Q73755989 | ||
Dynamics of protein-bound water in the heme domain of P450BM3 studied by high-pressure spectroscopy: comparison with P450cam and P450 2B4 | Q77795407 | ||
High pressure: a new tool to study P450 structure and function | Q78496564 | ||
Multiple sequential steps involved in the binding of inhibitors to cytochrome P450 3A4 | Q79475811 | ||
Allosteric P450 mechanisms: multiple binding sites, multiple conformers or both? | Q82758182 | ||
A singular value decomposition approach for kinetic analysis of reactions of HNO with myoglobin | Q85404566 | ||
P433 | issue | 7 | |
P407 | language of work or name | English | Q1860 |
P1104 | number of pages | 14 | |
P304 | page(s) | 1485-1498 | |
P577 | publication date | 2016-04-01 | |
P1433 | published in | Biophysical Journal | Q2032955 |
P1476 | title | Conformational Mobility in Cytochrome P450 3A4 Explored by Pressure-Perturbation EPR Spectroscopy | |
P478 | volume | 110 |
Q58796074 | Effects of polymorphic variation on the thermostability of heterogenous populations of CYP3A4 and CYP2C9 enzymes in solution |
Q46445841 | High-Level Production and Properties of the Cysteine-Depleted Cytochrome P450 3A4. |
Q50050835 | High-pressure EPR spectroscopy studies of the E. coli lipopolysaccharide transport proteins LptA and LptC. |
Q37611698 | Physical Studies of P450-P450 Interactions: Predicting Quaternary Structures of P450 Complexes in Membranes from Their X-ray Crystal Structures |
Q89353053 | Steroid bioconjugation to a CYP3A4 allosteric site and its effect on substrate binding and coupling efficiency |
Q92860132 | Structural and dynamic origins of ESR lineshapes in spin-labeled GB1 domain: the insights from spin dynamics simulations based on long MD trajectories |
Search more.