Mutational analysis of plant cap-binding protein eIF4E reveals key amino acids involved in biochemical functions and potyvirus infection. (scientific article published on 14 May 2008)

The Translation Initiation Factor eIF-4E Binds to a Common Motif Shared by the Translation Factor eIF-4γ and the Translational Repressors 4E-Binding Proteins

Q24336014

Cap-independent translation conferred by the 5' leader of tobacco etch virus is eukaryotic initiation factor 4G dependent

Q24530671

Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E

Q24533512

SWISS-MODEL: An automated protein homology-modeling server

Q24672647

Phylogenetic analysis of eIF4E-family members

Q24813999

Cap-dependent translation initiation in eukaryotes is regulated by a molecular mimic of eIF4G

Q27618954

Biophysical studies of eIF4E cap-binding protein: recognition of mRNA 5' cap structure and synthetic fragments of eIF4G and 4E-BP1 proteins

Q27639133

The Structure of Eukaryotic Translation Initiation Factor-4E from Wheat Reveals a Novel Disulfide Bond

Q27643900

Cocrystal structure of the messenger RNA 5' cap-binding protein (eIF4E) bound to 7-methyl-GDP

Q27739838

SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling

Q27860614

The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling

Q27860637

Cooperative modulation by eIF4G of eIF4E-binding to the mRNA 5' cap in yeast involves a site partially shared by p20.

Q27933394

Yeast vectors for the controlled expression of heterologous proteins in different genetic backgrounds

Q28131643

Calicivirus translation initiation requires an interaction between VPg and eIF 4 E.

Q28507110

Analysis of the mRNA cap-binding ability of human eukaryotic initiation factor-4E by use of recombinant wild-type and mutant forms

Q30424908

Strain-specific interaction of the tobacco etch virus NIa protein with the translation initiation factor eIF4E in the yeast two-hybrid system

Q30890179

Isolation of an Arabidopsis thaliana mutant in which the multiplication of both cucumber mosaic virus and turnip crinkle virus is affected

Q33785249

Complex formation between potyvirus VPg and translation eukaryotic initiation factor 4E correlates with virus infectivity

Q33810236

Controlling gene expression through RNA regulons: the role of the eukaryotic translation initiation factor eIF4E.

Q34605347

Sources of resistance to viruses in the Potyviridae

Q35542440

Visualization of the interaction between the precursors of VPg, the viral protein linked to the genome of turnip mosaic virus, and the translation eukaryotic initiation factor iso 4E in Planta

Q35635019

Chromatographic resolution of in vivo phosphorylated and nonphosphorylated eukaryotic translation initiation factor eIF-4E: increased cap affinity of the phosphorylated form

Q35656281

Isolation and sequence of a cDNA encoding the cap binding protein of wheat eukaryotic protein synthesis initiation factor 4F

Q35924720

Genetics of plant virus resistance.

Q36217904

Translation initiation factors: a weak link in plant RNA virus infection

Q36339166

Highlights and prospects of potyvirus molecular biology

Q36739745

Interaction of the viral protein genome linked of turnip mosaic potyvirus with the translational eukaryotic initiation factor (iso) 4E of Arabidopsis thaliana using the yeast two-hybrid system

Q36872652

An eIF4E allele confers resistance to an uncapped and non-polyadenylated RNA virus in melon

Q38308801

Site-directed mutagenesis of the tryptophan residues in yeast eukaryotic initiation factor 4E. Effects on cap binding activity

Q38346063

Identification and characterization of the functional elements within the tobacco etch virus 5' leader required for cap-independent translation.

Q39596367

Complete inhibition of tobamovirus multiplication by simultaneous mutations in two homologous host genes.

Q39682641

Characteristics of the Microplate Method of Enzyme-Linked Immunosorbent Assay for the Detection of Plant Viruses

Q40766152

Phosphorylation of eukaryotic initiation factor 4E markedly reduces its affinity for capped mRNA.

Q40766564

Poliovirus RNA replication requires genome circularization through a protein-protein bridge

Q40791248

The Arabidopsis cucumovirus multiplication 1 and 2 loci encode translation initiation factors 4E and 4G.

Q40886890

Lettuce mosaic virus pathogenicity determinants in susceptible and tolerant lettuce cultivars map to different regions of the viral genome

Q43626040

Natural variation and functional analyses provide evidence for co-evolution between plant eIF4E and potyviral VPg.

Q43952163

The VPg of tobacco etch virus RNA is the 49-kDa proteinase or the N-terminal 24-kDa part of the proteinase

Q44629495

Introduction of a NIa proteinase cleavage site between the reporter gene and HC-Pro only partially restores the biological properties of GUS- or GFP-tagged LMV.

Q44682583

Interaction of VPg-Pro of turnip mosaic virus with the translation initiation factor 4E and the poly(A)-binding protein in planta

Q44811262

Selective involvement of members of the eukaryotic initiation factor 4E family in the infection of Arabidopsis thaliana by potyviruses

Q45264609

Biological and molecular variability of lettuce mosaic virus isolates

Q45389198

Molecular and Biological Characterization of Lettuce mosaic virus (LMV) Isolates Reveals a Distinct and Widespread Type of Resistance-Breaking Isolate: LMV-Most

Q45389629

Lettuce mosaic virus: from pathogen diversity to host interactors.

Q45392055

Mutations in the eIF(iso)4G translation initiation factor confer high resistance of rice to Rice yellow mottle virus

Q45415681

Simultaneous mutations in translation initiation factors eIF4E and eIF(iso)4E are required to prevent pepper veinal mottle virus infection of pepper

Q45415831

Multiple resistance traits control Plum pox virus infection in Arabidopsis thaliana.

Q45417038

The potyviral virus genome-linked protein VPg forms a ternary complex with the eukaryotic initiation factors eIF4E and eIF4G and reduces eIF4E affinity for a mRNA cap analogue.

Q45419127

The pvr1 locus in Capsicum encodes a translation initiation factor eIF4E that interacts with Tobacco etch virus VPg.

Q45477444

Mutations in potato virus Y genome-linked protein determine virulence toward recessive resistances in Capsicum annuum and Lycopersicon hirsutum

Q45670362

The eukaryotic translation initiation factor 4E controls lettuce susceptibility to the Potyvirus Lettuce mosaic virus.

Q45722641

A natural recessive resistance gene against potato virus Y in pepper corresponds to the eukaryotic initiation factor 4E (eIF4E).

Q45729792

Mutations in pea seedborne mosaic virus genome-linked protein VPg after pathotype-specific virulence in Pisum sativum

Q45737127

The 6K2 protein and the VPg of potato virus A are determinants of systemic infection in Nicandra physaloides

Q45745212

Isolation of an Arabidopsis thaliana mutant in which accumulation of cucumber mosaic virus coat protein is delayed

Q45754590

Functional dissection of naturally occurring amino acid substitutions in eIF4E that confers recessive potyvirus resistance in plants

Q46985613

The Arabidopsis thaliana cDNAs coding for eIF4E and eIF(iso)4E are not functionally equivalent for yeast complementation and are differentially expressed during plant development

Q47779968

The potyvirus recessive resistance gene, sbm1, identifies a novel role for translation initiation factor eIF4E in cell-to-cell trafficking.

Q48169344

Viral genome-linked protein (VPg) controls accumulation and phloem-loading of a potyvirus in inoculated potato leaves

Q48315310

Plant translation initiation factors: it is not easy to be green.

Q50797918

Evidence that the recessive bymovirus resistance locus rym4 in barley corresponds to the eukaryotic translation initiation factor 4E gene.

Q53853311

The eukaryotic translation initiation factor 4E confers multiallelic recessive Bymovirus resistance in Hordeum vulgare (L.).

Q53855305

The Arabidopsis eukaryotic initiation factor (iso)4E is dispensable for plant growth but required for susceptibility to potyviruses

Q56920082

Central domain of a potyvirus VPg is involved in the interaction with the host translation initiation factor eIF4E and the viral protein HcPro

Q56922403

Coordinated and selective recruitment of eIF4E and eIF4G factors for potyvirus infection inArabidopsis thaliana

Q56922418

Loss-of-Susceptibility Mutants of Arabidopsis thaliana Reveal an Essential Role for eIF(iso)4E during Potyvirus Infection

Q60042605

Translational Repression by Human 4E-BP1 in Yeast Specifically Requires Human eIF4E as Target

Q65560729

The 5' untranslated region of PVY RNA, even located in an internal position, enables initiation of translation

Q72279089

Evidence for an internal ribosome entry site within the 5' non-translated region of turnip mosaic potyvirus RNA

Q72815514

Potyvirus genome-linked protein, VPg, directly affects wheat germ in vitro translation: interactions with translation initiation factors eIF4F and eIFiso4F

Q80112317

P433

issue

P407

language of work or name

English

Q1860

P921

main subject

mutational analysis

Q1955810

P304

page(s)

7601-7612

P577

publication date

2008-05-14

P1433

published in

Journal of Virology

Q1251128

P1476

title

Mutational analysis of plant cap-binding protein eIF4E reveals key amino acids involved in biochemical functions and potyvirus infection

P478

volume

Reverse relations

cites work (P2860)

Q92050595	A Novel Interaction Network Used by Potyviruses in Virus-Host Interactions at the Protein Level
Q35916267	A TILLING approach to generate broad-spectrum resistance to potyviruses in tomato is hampered by eIF4E gene redundancy
Q92204858	A complex eIF4E locus impacts the durability of va resistance to Potato virus Y in tobacco
Q56828434	An exceptionally high nucleotide and haplotype diversity and a signature of positive selection for the eIF4E resistance gene in barley are revealed by allele mining and phylogenetic analyses of natural populations
Q39795195	Analysis of the interacting partners eIF4F and 3'-CITE required for Melon necrotic spot virus cap-independent translation.
Q59352150	Chemical shift assignment of the viral protein genome-linked (VPg) from potato virus Y
Q42584267	Crystallization and preliminary X-ray analysis of eukaryotic initiation factor 4E from Pisum sativum
Q37989485	Eukaryotic translation initiation factor 4E-mediated recessive resistance to plant viruses and its utility in crop improvement
Q53369640	Fine mapping and identification of candidate rice genes associated with qSTV11(SG), a major QTL for rice stripe disease resistance.
Q46901178	Fusion proteins of Arabidopsis cap-binding proteins: Cautionary "tails" of woe.
Q35762432	Gibson assembly: an easy way to clone potyviral full-length infectious cDNA clones expressing an ectopic VPg.
Q45037064	Involvement of the cylindrical inclusion (CI) protein in the overcoming of an eIF4E-mediated resistance against Lettuce mosaic potyvirus
Q91735429	Mimicking natural polymorphism in eIF4E by CRISPR-Cas9 base editing is associated with resistance to potyviruses
Q42253195	Multiple copies of eukaryotic translation initiation factors in Brassica rapa facilitate redundancy, enabling diversification through variation in splicing and broad-spectrum virus resistance
Q38538455	Plant Translation Factors and Virus Resistance
Q37683095	Recessive resistance to plant viruses.
Q42156955	Structure of a viral cap-independent translation element that functions via high affinity binding to the eIF4E subunit of eIF4F.
Q38776106	Structure of eIF4E in Complex with an eIF4G Peptide Supports a Universal Bipartite Binding Mode for Protein Translation
Q27666804	Structure-Based Mutational Analysis of eIF4E in Relation to sbm1 Resistance to Pea Seed-Borne Mosaic Virus in Pea
Q50529598	The 20S proteasome α5 subunit of Arabidopsis thaliana carries an RNase activity and interacts in planta with the lettuce mosaic potyvirus HcPro protein.
Q36842143	The oncogene eIF4E: using biochemical insights to target cancer
Q50420889	Trans-species synthetic gene design allows resistance pyramiding and broad-spectrum engineering of virus resistance in plants
Q33655882	Translational control of the activation of transcription factor NF-κB and production of type I interferon by phosphorylation of the translation factor eIF4E.
Q87241364	Two Arabidopsis loci encode novel eukaryotic initiation factor 4E isoforms that are functionally distinct from the conserved plant eukaryotic initiation factor 4E
Q37583114	Virus versus host cell translation love and hate stories