DC-based cancer vaccines

scientific article published on May 2007

DC-based cancer vaccines is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1172/JCI31205
P932PMC publication ID1857263
P698PubMed publication ID17476349

P2093author name stringEli Gilboa
P2860cites workalpha-type-1 polarized dendritic cells: a novel immunization tool with optimized CTL-inducing activityQ80516665
Knocking the SOCS1 off dendritic cellsQ81105362
Modification of professional antigen-presenting cells with small interfering RNA in vivo to enhance cancer vaccine potencyQ81307106
Telomerase mRNA-transfected dendritic cells stimulate antigen-specific CD8+ and CD4+ T cell responses in patients with metastatic prostate cancerQ81482708
GILZ expression in human dendritic cells redirects their maturation and prevents antigen-specific T lymphocyte responseQ81491673
Professional antigen-presentation function by human gammadelta T CellsQ81810232
Synergistic activation of dendritic cells by combined Toll-like receptor ligation induces superior CTL responses in vivoQ82828413
CD40 AND CD154 IN CELL-MEDIATED IMMUNITYQ22255634
Adjuvant-enhanced antibody responses in the absence of toll-like receptor signalingQ24684997
Dendritic cells and the control of immunityQ27860918
Pathogen recognition and innate immunityQ27861084
The CD40/CD154 receptor/ligand dyadQ28202756
Co-stimulatory members of the TNFR family: keys to effective T-cell immunity?Q28207052
TNF/TNFR family members in costimulation of T cell responsesQ28240053
Cancer despite immunosurveillance: immunoselection and immunosubversionQ28263865
Toll-like receptor control of the adaptive immune responsesQ29547305
Immunobiology of dendritic cellsQ29547465
Exosomes: composition, biogenesis and functionQ29547721
Immunosuppressive networks in the tumour environment and their therapeutic relevanceQ29619244
Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factorQ29619247
Eradication of established murine tumors using a novel cell-free vaccine: dendritic cell-derived exosomesQ29619437
Antigen density presented by dendritic cells in vivo differentially affects the number and avidity of primary, memory, and recall CD8+ T cells.Q30310494
Expression library immunization to discover and improve vaccine antigensQ30833383
Mechanisms of exogenous antigen presentation by MHC class I molecules in vitro and in vivo: implications for generating CD8+ T cell responses to infectious agents, tumors, transplants, and vaccinesQ33683185
Engineering an intracellular pathway for major histocompatibility complex class II presentation of antigensQ33714644
The makings of a tumor rejection antigenQ33748013
Dendritic-cell trafficking to lymph nodes through lymphatic vesselsQ33989067
Prostaglandin E2 is a key factor for CCR7 surface expression and migration of monocyte-derived dendritic cellsQ34141893
Enhancement of vaccine-mediated antitumor immunity in cancer patients after depletion of regulatory T cellsQ34147162
Viral vectors for dendritic cell-based immunotherapyQ34207596
The role of MHC class II-restricted tumor antigens and CD4+ T cells in antitumor immunityQ34232543
Dendritic cells as sensors of infection.Q34260225
Killing of dendritic cells: a life cut short or a purposeful death?Q34355697
Autologous dendritic cells transfected with prostate-specific antigen RNA stimulate CTL responses against metastatic prostate tumorsQ34787754
Direct stimulation of T cells by membrane vesicles from antigen-presenting cellsQ34984478
Dendritic cells under the spell of prostaglandinsQ35077130
The use of dendritic cells in cancer immunotherapyQ35084257
Enhancing DNA vaccine potency by coadministration of DNA encoding antiapoptotic proteinsQ35108258
Clinical applications of dendritic cell vaccination in the treatment of cancerQ35597274
Manipulating dendritic cell biology for the active immunotherapy of cancerQ35825249
Targeting plasmid-encoded proteins to the antigen presentation pathwaysQ35826370
Cancer immunotherapy with mRNA-transfected dendritic cellsQ35826417
B lymphocytes as antigen-presenting cell-based genetic vaccinesQ35826422
Dendritic cell-based vaccines in cancer immunotherapy: an update on clinical and immunological results.Q35914669
Transfer of antigen between migrating and lymph node-resident DCs in peripheral T-cell tolerance and immunityQ35941910
Regulation of antigen presentation and cross-presentation in the dendritic cell network: facts, hypothesis, and immunological implications.Q36037772
Dendritic-cell-based therapeutic vaccination against cancerQ36070700
Migration of dendritic cell based cancer vaccines: in vivo veritas?Q36070704
Dendritic cells as therapeutic vaccines against cancerQ36085614
Role of antigen, CD8, and cytotoxic T lymphocyte (CTL) avidity in high dose antigen induction of apoptosis of effector CTLQ36367150
Regulation of dendritic cell migration to the draining lymph node: impact on T lymphocyte traffic and primingQ36371607
Negative selection during the peripheral immune response to antigenQ36376090
Expression of the serpin serine protease inhibitor 6 protects dendritic cells from cytotoxic T lymphocyte-induced apoptosis: differential modulation by T helper type 1 and type 2 cellsQ36376315
Immune regulation in tumor-bearing hostsQ36390008
A type I interferon autocrine-paracrine loop is involved in Toll-like receptor-induced interleukin-12p70 secretion by dendritic cells.Q36403615
An inverse relationship between T cell receptor affinity and antigen dose during CD4(+) T cell responses in vivo and in vitroQ36433369
Checkpoint blockade in cancer immunotherapyQ36490768
On regulation of phagosome maturation and antigen presentationQ36598303
Selected Toll-like receptor agonist combinations synergistically trigger a T helper type 1-polarizing program in dendritic cellsQ37139993
Selective expansion of high- or low-avidity cytotoxic T lymphocytes and efficacy for adoptive immunotherapy.Q37629901
Experimental and clinical studies with active specific immunotherapyQ38628391
Dacarbazine (DTIC) versus vaccination with autologous peptide-pulsed dendritic cells (DC) in first-line treatment of patients with metastatic melanoma: a randomized phase III trial of the DC study group of the DeCOG.Q40357536
Enhancing the immunostimulatory function of dendritic cells by transfection with mRNA encoding OX40 ligand.Q40477269
Silencing of SOCS1 enhances antigen presentation by dendritic cells and antigen-specific anti-tumor immunityQ40488939
Injection of immature dendritic cells into adjuvant-treated skin obviates the need for ex vivo maturationQ40614046
Delivery of tumor-derived RNA for the induction of cytotoxic T-lymphocytesQ40668644
Highly efficient gene delivery by mRNA electroporation in human hematopoietic cells: superiority to lipofection and passive pulsing of mRNA and to electroporation of plasmid cDNA for tumor antigen loading of dendritic cellsQ40701084
Enhancement of antitumor immunity by prolonging antigen presentation on dendritic cellsQ40753335
Induction of cytotoxic T cell responses and tumor immunity against unrelated tumors using telomerase reverse transcriptase RNA transfected dendritic cells.Q40856900
High avidity CTLs for two self-antigens demonstrate superior in vitro and in vivo antitumor efficacy.Q40978441
Induction of primary carcinoembryonic antigen (CEA)-specific cytotoxic T lymphocytes in vitro using human dendritic cells transfected with RNA.Q41049213
Expansion of FOXP3high regulatory T cells by human dendritic cells (DCs) in vitro and after injection of cytokine-matured DCs in myeloma patientsQ42742001
Stimulation history dictates memory CD8 T cell phenotype: implications for prime-boost vaccinationQ43725424
Functionally distinct dendritic cell (DC) populations induced by physiologic stimuli: prostaglandin E(2) regulates the migratory capacity of specific DC subsetsQ44083646
Therapeutic dendritic-cell vaccine for simian AIDS.Q44259259
Mature dendritic cells derived from human monocytes within 48 hours: a novel strategy for dendritic cell differentiation from blood precursorsQ44394548
Rapid high efficiency sensitization of CD8+ T cells to tumor antigens by dendritic cells leads to enhanced functional avidity and direct tumor recognition through an IL-12-dependent mechanismQ44555982
Long-term outcomes in patients with metastatic melanoma vaccinated with melanoma peptide-pulsed CD34(+) progenitor-derived dendritic cellsQ44662354
Immunization with lentiviral vector-transduced dendritic cells induces strong and long-lasting T cell responses and therapeutic immunityQ45027178
Therapeutic dendritic-cell vaccine for chronic HIV-1 infectionQ45165349
Therapeutic vaccination with papillomavirus E6 and E7 long peptides results in the control of both established virus-induced lesions and latently infected sites in a pre-clinical cottontail rabbit papillomavirus modelQ45429014
Optimization of the sequence of antigen loading and CD40-ligand-induced maturation of dendritic cellsQ47783881
Immunological and clinical responses in metastatic renal cancer patients vaccinated with tumor RNA-transfected dendritic cellsQ47938199
Immunology. Licence to killQ47982772
Generation of an optimized polyvalent monocyte-derived dendritic cell vaccine by transfecting defined RNAs after rather than before maturation.Q50777089
Re-engineered CD40 receptor enables potent pharmacological activation of dendritic-cell cancer vaccines in vivo.Q51550263
Long-lived memory CD8+ T cells are programmed by prolonged antigen exposure and low levels of cellular activation.Q51983937
Both dendritic cells and macrophages can stimulate naive CD8 T cells in vivo to proliferate, develop effector function, and differentiate into memory cells.Q51989826
Immunization with HIV-1 Gag protein conjugated to a TLR7/8 agonist results in the generation of HIV-1 Gag-specific Th1 and CD8+ T cell responses.Q51991421
Differing roles of inflammation and antigen in T cell proliferation and memory generation.Q52022095
Final maturation of dendritic cells is associated with impaired responsiveness to IFN-gamma and to bacterial IL-12 inducers: decreased ability of mature dendritic cells to produce IL-12 during the interaction with Th cells.Q54102042
Targeting HER-2/neu in early breast cancer development using dendritic cells with staged interleukin-12 burst secretion.Q55043174
Inflammatory mediators are insufficient for full dendritic cell activation and promote expansion of CD4+ T cell populations lacking helper functionQ56880717
Paralysis of Dendritic Cell IL-12 Production by Microbial Products Prevents Infection-Induced ImmunopathologyQ56880739
Human Dendritic Cells Transfected with RNA Encoding Prostate-Specific Antigen Stimulate Prostate-Specific CTL Responses In VitroQ56967620
Effective migration of antigen-pulsed dendritic cells to lymph nodes in melanoma patients is determined by their maturation stateQ57779701
Rapid Peptide Turnover and Inefficient Presentation of Exogenous Antigen Critically Limit the Activation of Self-Reactive CTL by Dendritic CellsQ58235001
IFN-α-conditioned dendritic cells are highly efficient in inducing cross-priming CD8+ T cells against exogenous viral antigensQ58960918
Kinetics of dendritic cell activation: impact on priming of TH1, TH2 and nonpolarized T cellsQ73035410
Pro-inflammatory cytokines and prostaglandins induce maturation of potent immunostimulatory dendritic cells under fetal calf serum-free conditionsQ74179201
Generation of survivin-specific CD8+ T effector cells by dendritic cells pulsed with protein or selected peptidesQ74314851
Vaccination with a Melan-A peptide selects an oligoclonal T cell population with increased functional avidity and tumor reactivityQ77892680
The DRiP hypothesis decennial: support, controversy, refinement and extensionQ79827462
The promise of cancer vaccinesQ80038678
P433issue5
P407language of work or nameEnglishQ1860
P304page(s)1195-1203
P577publication date2007-05-01
P1433published inJournal of Clinical InvestigationQ3186904
P1476titleDC-based cancer vaccines
P478volume117

Reverse relations

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Q34856875Prostate cancer as a model for tumour immunotherapy
Q39816081Protective anti-tumour immune responses by murine dendritic cells pulsed with recombinant Tat-carcinoembryonic antigen derived from Escherichia coli.
Q33384384Protein disulfide isomerases are antibody targets during immune-mediated tumor destruction
Q34316777Quality assessment of cellular therapies: the emerging role of molecular assays
Q39300036RAFTsomes containing epitope-MHC-II complexes mediated CD4+ T cell activation and antigen-specific immune responses
Q37686532RNA as performance-enhancers for dendritic cells
Q34529895Rabies virus expressing dendritic cell-activating molecules enhances the innate and adaptive immune response to vaccination
Q38248440Recent advances in the use of therapeutic cancer vaccines in genitourinary malignancies
Q23918376Recognition of live phosphatidylserine-labeled tumor cells by dendritic cells: a novel approach to immunotherapy of skin cancer
Q34708479Recombinant mammaglobin A adenovirus-infected dendritic cells induce mammaglobin A-specific CD8+ cytotoxic T lymphocytes against breast cancer cells in vitro
Q49773390Recombinant rabies virus with the glycoprotein fused with a DC-binding peptide is an efficacious rabies vaccine
Q34735086Recombinant rabies viruses expressing GM-CSF or flagellin are effective vaccines for both intramuscular and oral immunizations.
Q33713903Recombinant vesicular stomatitis virus transduction of dendritic cells enhances their ability to prime innate and adaptive antitumor immunity
Q27025996Regulatory dendritic cell therapy: from rodents to clinical application
Q41963849Relationship of vaccine efficacy to the kinetics of DC and T-cell responses induced by PLG-based cancer vaccines
Q36645834Rhamnogalacturonan II is a Toll-like receptor 4 agonist that inhibits tumor growth by activating dendritic cell-mediated CD8+ T cells
Q36067874Safe and Reproducible Preparation of Functional Dendritic Cells for Immunotherapy in Glioblastoma Patients
Q37063739Signaling defects in anti-tumor T cells
Q39663885Significant anti-tumour activity of adoptively transferred T cells elicited by intratumoral dendritic cell vaccine injection through enhancing the ratio of CD8+ T cell/regulatory T cells in tumour
Q39398295Simultaneous targeting of toll- and nod-like receptors induces effective tumor-specific immune responses
Q59335796Single-Cell Transcriptomics in Cancer Immunobiology: The Future of Precision Oncology
Q27334432Size-dependent effects of gold nanoparticles uptake on maturation and antitumor functions of human dendritic cells in vitro
Q35122102Specific microtubule-depolymerizing agents augment efficacy of dendritic cell-based cancer vaccines
Q64992567Stabilization of acute myeloid leukemia with a dendritic cell vaccine.
Q26823515Strategies and Advancements in Harnessing the Immune System for Gastric Cancer Immunotherapy
Q53581193Study on the mesothelin-specific cytotoxicity against epithelial ovarian cancer with full-length mesothelin cDNA-transduced dendritic cells.
Q84086496Survival in rectal cancer is predicted by T cell infiltration of tumour-associated lymphoid nodules
Q39317517Synergistical toll-like receptors activated dendritic cells induce antitumor effects against carcinoembryonic antigen-expressing colon cancer
Q37002795T-cell death and cancer immune tolerance
Q37051003TLR ligand suppression or enhancement of Treg cells? A double-edged sword in immunity to tumours
Q41994790TLR4 engagement during TLR3-induced proinflammatory signaling in dendritic cells promotes IL-10-mediated suppression of antitumor immunity
Q90252257TNP-470 skews DC differentiation to Th1-stimulatory phenotypes and can serve as a novel adjuvant in a cancer vaccine
Q35516545Targeting NKT cells and PD-L1 pathway results in augmented anti-tumor responses in a melanoma model
Q36915898Targeting of antigens to B cells augments antigen-specific T-cell responses and breaks immune tolerance to tumor-associated antigen MUC1
Q36975757The 'kiss of death' by dendritic cells to cancer cells
Q37952783The 2011 Nobel Prize in physiology or medicine
Q51700278The DRAGO gamma camera.
Q55220517The Role of the Insulin-Like Growth Factor 1 Pathway in Immune Tumor Microenvironment and Its Clinical Ramifications in Gynecologic Malignancies.
Q39802340The Tat-conjugated N-terminal region of mucin antigen 1 (MUC1) induces protective immunity against MUC1-expressing tumours
Q39711562The establishment of dendritic cell-tumor fusion vaccines for hormone refractory prostate cancer cell
Q37687418The evolving role of dendritic cells in cancer therapy
Q34010091The immunobiology of mushrooms
Q36866151The natural killer cell response and tumor debulking are associated with prolonged survival in recurrent glioblastoma patients receiving dendritic cells loaded with autologous tumor lysates.
Q38902037The siRNA cocktail targeting interleukin 10 receptor and transforming growth factor-β receptor on dendritic cells potentiates tumour antigen-specific CD8(+) T cell immunity
Q36485047Therapeutic dendritic cell vaccine preparation using tumor RNA transfection: a promising approach for the treatment of prostate cancer.
Q34202646Three-day dendritic cells for vaccine development: Antigen uptake, processing and presentation
Q37826217Tolerogenic dendritic cells and their potential applications
Q38453096Tolerogenic dendritic cells show gene expression profiles that are different from those of immunogenic dendritic cells in DBA/1 mice.
Q38103222Tracking and evaluation of dendritic cell migration by cellular magnetic resonance imaging
Q39791562Treatment of established colon carcinoma-bearing mice by dendritic cells pulsed with lysates of heat-treated tumor cells
Q53109846Trial watch: Dendritic cell-based anticancer immunotherapy.
Q27024047Trial watch: Dendritic cell-based anticancer therapy
Q36388529Trial watch: Dendritic cell-based interventions for cancer therapy
Q42867339Trial watch: Dendritic cell-based interventions for cancer therapy
Q49592937Tumor Immuno-Environment in Cancer Progression and Therapy
Q39814228Tumor cell lysate-pulsed dendritic cells induce a T cell response against colon cancer in vitro and in vivo
Q41977894Tumor-associated antigens for specific immunotherapy of prostate cancer
Q47689335Tumor-derived exosomes educate dendritic cells to promote tumor metastasis via HSP72/HSP105-TLR2/TLR4 pathway
Q33763653Tumor-infiltrating regulatory dendritic cells inhibit CD8+ T cell function via L-arginine metabolism.
Q37729243Tumour escape mechanisms and their therapeutic implications in combination tumour therapy
Q44828889Tumour regression induced by co-administration of MIP-3α and CpG in an experimental model of colon carcinoma.
Q30846001Twelve-year survival and immune correlates in dendritic cell-vaccinated melanoma patients.
Q43196387Type 2 Bias of T cells expanded from the blood of melanoma patients switched to type 1 by IL-12p70 mRNA-transfected dendritic cells
Q41271614Type I IFN signaling on dendritic cells is required for NK cell-mediated anti-tumor immunity
Q37130475Type I interferons as vaccine adjuvants against infectious diseases and cancer
Q37909430Using monoclonal antibodies to stimulate antitumor cellular immunity
Q37729146Vaccines as early therapeutic interventions for cancer therapy: neutralising the immunosuppressive tumour environment and increasing T cell avidity may lead to improved responses
Q26825850Vaccines for pancreatic cancer
Q39768767Vaccines using dendritic cells, differentiated with propofol, enhance antitumor immunity in mice
Q38206582Various ways to improve whole cancer cell vaccines
Q27491330Viral Vaccines and CTL Response
Q35572421Virus-induced tumor inflammation facilitates effective DC cancer immunotherapy in a Treg-dependent manner in mice
Q39781975Well-defined block copolymers for gene delivery to dendritic cells: probing the effect of polycation chain-length
Q57159608What's New in Gastric Cancer: The Therapeutic Implications of Molecular Classifications and Future Perspectives
Q52716742Whole protein and defined CD8(+) and CD4(+) peptides linked to penetratin targets both MHC class I and II antigen presentation pathways.
Q36691357Whole tumor antigen vaccination using dendritic cells: comparison of RNA electroporation and pulsing with UV-irradiated tumor cells.
Q35058235Whole tumor antigen vaccines
Q38208388Wilms' tumor gene 1 immunotherapy in pelvic gynecological malignancies
Q53092559mRNA Electroporation of Dendritic Cells with WT1, Survivin, and TriMix (a Mixture of caTLR4, CD40L, and CD70).

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