ATM mediates spermidine-induced mitophagy via PINK1 and Parkin regulation in human fibroblasts

scientific article published on 19 April 2016

ATM mediates spermidine-induced mitophagy via PINK1 and Parkin regulation in human fibroblasts is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/SREP24700
P8608Fatcat IDrelease_pi4cy3cysndmfpsqmugyu4x3ba
P932PMC publication ID4835770
P698PubMed publication ID27089984

P2093author name stringQian Qiu
Yingmei Zhang
Xueyan Gu
Yihong Tian
Yongmei Qi
P2860cites workPINK1 is selectively stabilized on impaired mitochondria to activate ParkinQ21145802
Guidelines for the use and interpretation of assays for monitoring autophagyQ21996341
PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1Q24297155
PINK1 is recruited to mitochondria with parkin and associates with LC3 in mitophagyQ24299149
Parkin is recruited selectively to impaired mitochondria and promotes their autophagyQ24317471
TIGAR regulates DNA damage and repair through pentosephosphate pathway and Cdk5-ATM pathwayQ24337162
Mitochondrial dysfunction in ataxia-telangiectasiaQ24630465
Regulation of autophagy by cytoplasmic p53Q24651258
ATM binds to beta-adaptin in cytoplasmic vesiclesQ24671480
PINK1-phosphorylated mitofusin 2 is a Parkin receptor for culling damaged mitochondriaQ28592217
Methods in mammalian autophagy researchQ29547276
Autophagy as a regulated pathway of cellular degradationQ29547914
Induction of autophagy by spermidine promotes longevityQ29614498
The PINK1/Parkin pathway regulates mitochondrial morphologyQ29615641
PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagyQ29616005
PINK1-dependent recruitment of Parkin to mitochondria in mitophagyQ29620567
Mitochondrial degradation by autophagy (mitophagy) in GFP-LC3 transgenic hepatocytes during nutrient deprivationQ30498226
Tracker dyes to probe mitochondrial autophagy (mitophagy) in rat hepatocytesQ33556360
ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROSQ33733064
Ataxia telangiectasia derived iPS cells show preserved x-ray sensitivity and decreased chromosomal instabilityQ33813801
ATM Activation by Oxidative StressQ34145092
Spermidine may decrease ER stress in pancreatic beta cells and may reduce apoptosis via activating AMPK dependent autophagy pathway.Q34207201
Selenium compounds activate ATM-dependent DNA damage response via the mismatch repair protein hMLH1 in colorectal cancer cellsQ34236531
mTORC1 signaling under hypoxic conditions is controlled by ATM-dependent phosphorylation of HIF-1αQ34418791
Selective mitochondrial autophagy, or mitophagy, as a targeted defense against oxidative stress, mitochondrial dysfunction, and agingQ34556311
Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteomeQ34600785
ATM activation in the presence of oxidative stressQ34619774
ATM is a cytoplasmic protein in mouse brain required to prevent lysosomal accumulation.Q34980532
Anthracycline-containing chemotherapy causes long-term impairment of mitochondrial respiration and increased reactive oxygen species release in skeletal muscle.Q35138773
Late-responding normal tissue cells benefit from high-precision radiotherapy with prolonged fraction delivery times via enhanced autophagyQ35171994
Role of PINK1 binding to the TOM complex and alternate intracellular membranes in recruitment and activation of the E3 ligase ParkinQ35783335
Ataxia-telangiectasia mutated kinase regulates ribonucleotide reductase and mitochondrial homeostasisQ35951468
Polyamines: metabolism and implications in human diseasesQ36077521
ATM regulates cell fate choice upon p53 activation by modulating mitochondrial turnover and ROS levelsQ36188841
PINK1-mediated phosphorylation of the Parkin ubiquitin-like domain primes mitochondrial translocation of Parkin and regulates mitophagyQ36476931
Mitochondria--a nexus for aging, calorie restriction, and sirtuins?Q37074956
Spermidine: a novel autophagy inducer and longevity elixirQ37683313
Mitochondrial dysfunction in some oxidative stress-related genetic diseases: Ataxia-Telangiectasia, Down Syndrome, Fanconi Anaemia and Werner SyndromeQ37711146
The ATM protein kinase: regulating the cellular response to genotoxic stress, and moreQ38088935
Tools and techniques to measure mitophagy using fluorescence microscopyQ38152233
PINK1/Parkin-mediated mitophagy in mammalian cellsQ38362214
Molecular interaction between parkin and PINK1 in mammalian neuronal cellsQ39891186
PINK1 controls mitochondrial localization of Parkin through direct phosphorylationQ39924212
Intrinsic mitochondrial dysfunction in ATM-deficient lymphoblastoid cellsQ40112631
Control of macroautophagy by calcium, calmodulin-dependent kinase kinase-beta, and Bcl-2.Q40179972
The dynamics of autophagy visualized in live cells: from autophagosome formation to fusion with endo/lysosomesQ40250494
Molecular linkage between the kinase ATM and NF-kappaB signaling in response to genotoxic stimuliQ40312088
ATM engages the TSC2/mTORC1 signaling node to regulate autophagy.Q40450307
Simultaneous impairment of mitochondrial fission and fusion reduces mitophagy and shortens replicative lifespanQ41560727
A new role for ATM: regulating mitochondrial function and mitophagyQ42149812
Differential localization of ATM is correlated with activation of distinct downstream signaling pathwaysQ42584836
ROS act as an upstream signal to mediate cadmium-induced mitophagy in mouse brainQ42703305
Unconventional PINK1 localization to the outer membrane of depolarized mitochondria drives Parkin recruitmentQ43165330
Nuclear retention of ATM at sites of DNA double strand breaksQ43675407
The mitochondrial permeability transition initiates autophagy in rat hepatocytes.Q43711895
The polyamines spermine and spermidine protect proteins from structural and functional damage by AGE precursors: a new role for old molecules?Q44388360
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P304page(s)24700
P577publication date2016-04-19
P1433published inScientific ReportsQ2261792
P1476titleATM mediates spermidine-induced mitophagy via PINK1 and Parkin regulation in human fibroblasts
P478volume6

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cites work (P2860)
Q64949698ATM Induces Cell Death with Autophagy in Response to H2O2 Specifically in Caenorhabditis elegans Nondividing Cells.
Q89581525Ataxia telangiectasia mutated interacts with Parkin and induces mitophagy independent of kinase activity. Evidence from mantle cell lymphoma
Q52332679Ataxia-Telangiectasia Mutated Kinase in the Control of Oxidative Stress, Mitochondria, and Autophagy in Cancer: A Maestro With a Large Orchestra.
Q57116638B355252, A Novel Small Molecule, Confers Neuroprotection Against Cobalt Chloride Toxicity In Mouse Hippocampal Cells Through Altering Mitochondrial Dynamics And Limiting Autophagy Induction
Q94464358Distinct Contributions of the Peroxisome-Mitochondria Fission Machinery During Sexual Development of the Fungus Podospora anserina
Q92479828Mitochondrial dysfunction in neurodegenerative diseases and the potential countermeasure
Q94564493MitophAging: Mitophagy in Aging and Disease
Q92839769Mitophagy and Oxidative Stress in Cancer and Aging: Focus on Sirtuins and Nanomaterials
Q39329727Neurodegeneration in ataxia-telangiectasia: Multiple roles of ATM kinase in cellular homeostasis.
Q39155198Target acquired: Selective autophagy in cardiometabolic disease
Q92661220The Molecular and Physiological Effects of Protein-Derived Polyamines in the Intestine
Q37510423p53 and p73 Regulate Apoptosis but Not Cell-Cycle Progression in Mouse Embryonic Stem Cells upon DNA Damage and Differentiation

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