Methanolic leaf extract of Gymnema sylvestre augments glucose uptake and ameliorates insulin resistance by upregulating glucose transporter-4, peroxisome proliferator-activated receptor-gamma, adiponectin, and leptin levels in vitro

scientific article published on March 2016

Methanolic leaf extract of Gymnema sylvestre augments glucose uptake and ameliorates insulin resistance by upregulating glucose transporter-4, peroxisome proliferator-activated receptor-gamma, adiponectin, and leptin levels in vitro is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.5455/JICE.20160224051727
P932PMC publication ID4835989
P698PubMed publication ID27104035
P5875ResearchGate publication ID297656422

P2093author name stringMarikunte V Venkataranganna
Gollapalle L Viswanatha
Godavarthi Ashok
Kirangadur Manjunath
Puttanarasaiah Mahesh Kumar
P2860cites workPositional cloning of the mouse obese gene and its human homologueQ22251285
Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinaseQ24309462
Cloning and characterization of the major insulin-responsive glucose transporter expressed in human skeletal muscle and other insulin-responsive tissuesQ28115108
Obesity wars: molecular progress confronts an expanding epidemicQ28240764
Peroxisome proliferator-activated receptors: nuclear control of metabolismQ28374684
The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesityQ28506782
Critical nodes in signalling pathways: insights into insulin actionQ29614735
Insulin signal transduction: possible mechanisms for insulin resistanceQ33631074
An essential role for interleukin-5 and eosinophils in helminth-induced airway hyperresponsivenessQ33762876
Adipocyte differentiation and gene expressionQ34101102
Expression of adiponectin receptors in pancreatic beta cellsQ34280547
Medicinal plants of India with anti-diabetic potentialQ34646801
Enzyme changes and glucose utilisation in diabetic rabbits: the effect of Gymnema sylvestre, R.BrQ34713728
Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency.Q34785785
Thematic review series: adipocyte biology. Adipose tissue function and plasticity orchestrate nutritional adaptation.Q36765385
Acute regulation by insulin of phosphatidylinositol-3-kinase, Rad, Glut 4, and lipoprotein lipase mRNA levels in human muscleQ37356920
PPARγ signaling and metabolism: the good, the bad and the futureQ37407887
Globular adiponectin protected ob/ob mice from diabetes and ApoE-deficient mice from atherosclerosisQ38361016
Troglitazone induces GLUT4 translocation in L6 myotubes.Q40808543
Regulation of glucose transport in cultured muscle cells by novel hypoglycemic agentsQ41318046
Glucose transport is rate limiting for skeletal muscle glucose metabolism in normal and STZ-induced diabetic ratsQ41429121
Differential regulation of the GLUT-1 and GLUT-4 glucose transport systems by glucose and insulin in L6 muscle cells in cultureQ41695790
Multiple defects in the adipocyte glucose transport system cause cellular insulin resistance in gestational diabetes. Heterogeneity in the number and a novel abnormality in subcellular localization of GLUT4 glucose transportersQ42502926
Multiple regulatory roles of a novel Saccharomyces cerevisiae protein, encoded by YOL002c, in lipid and phosphate metabolismQ42673088
Induction of adipocyte complement-related protein of 30 kilodaltons by PPARgamma agonists: a potential mechanism of insulin sensitizationQ42818292
PPARgamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived proteinQ42826174
Isoproterenol inhibits resistin gene expression through a G(S)-protein-coupled pathway in 3T3-L1 adipocytesQ42827465
Association of adiponectin mutation with type 2 diabetes: a candidate gene for the insulin resistance syndromeQ44043277
Impaired activation of phosphatidylinositol 3-kinase by leptin is a novel mechanism of hepatic leptin resistance in diet-induced obesityQ44782012
Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients.Q51555890
Possible regeneration of the islets of Langerhans in streptozotocin-diabetic rats given Gymnema sylvestre leaf extracts.Q51613980
Antidiabetic effect of a leaf extract from Gymnema sylvestre in non-insulin-dependent diabetes mellitus patientsQ68633062
Effect of feeding Gymnema sylvestre leaves on blood glucose in beryllium nitrate treated ratsQ68969487
Leptin induces insulin-like signaling that antagonizes cAMP elevation by glucagon in hepatocytesQ73643341
1,2,3,4,6 Penta-O-galloyl-β-d-glucose, a bioactivity guided isolated compound from Mangifera indica inhibits 11β-HSD-1 and ameliorates high fat diet-induced diabetes in C57BL/6 miceQ85962039
Methanolic extract of Momordica cymbalaria enhances glucose uptake in L6 myotubes in vitro by up-regulating PPAR-γ and GLUT-4Q86446411
P433issue2
P921main subjectinsulin resistanceQ1053470
Gymnema sylvestreQ2725835
leaf extractQ129177468
P304page(s)146-152
P577publication date2016-03-01
P1433published inJournal of intercultural ethnopharmacologyQ27726465
P1476titleMethanolic leaf extract of Gymnema sylvestre augments glucose uptake and ameliorates insulin resistance by upregulating glucose transporter-4, peroxisome proliferator-activated receptor-gamma, adiponectin, and leptin levels in vitro
P478volume5

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cites work (P2860)
Q58795255Antidiabetic Effects of Isolated Triterpene Glycoside Fraction from
Q54996310MD-1, a poly herbal formulation indicated in diabetes mellitus ameliorates glucose uptake and inhibits adipogenesis - an in vitro study.

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