Genetics of iron regulation and the possible role of iron in Parkinson's disease

scientific article published on 11 July 2008

Genetics of iron regulation and the possible role of iron in Parkinson's disease is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/J.NBD.2008.07.001
P932PMC publication ID3643980
P698PubMed publication ID18675357
P5875ResearchGate publication ID23144687
P4011Semantic Scholar paper ID6ee34e683d39f79add962b6f404b889b028275f5

P50authorBeate RitzQ62506980
Shannon L RhodesQ67212276
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Modulation of metal-induced genotoxicity by Maillard reaction products isolated from coffeeQ74830250
Expression of iron transport proteins and excessive iron accumulation in the brain in neurodegenerative disordersQ77208531
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Iron and paraquat as synergistic environmental risk factors in sporadic Parkinson's disease accelerate age-related neurodegeneration.Q40114497
Screening for mutations of the HFE gene in Parkinson's disease patients with hyperechogenicity of the substantia nigraQ40293900
Altered brain metabolism of iron as a cause of neurodegenerative diseases?Q40391355
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Diferric transferrin regulates transferrin receptor 2 protein stabilityQ40524098
Iron acquisition and expression of iron regulatory proteins in the developing brain: manipulation by ethanol exposure, iron deprivation and cellular dysfunctionQ40537938
Multiple risk factors for Parkinson's diseaseQ40539898
Alpha-synuclein up-regulation and aggregation during MPP+-induced apoptosis in neuroblastoma cells: intermediacy of transferrin receptor iron and hydrogen peroxideQ40595894
The enigma of neuromelanin in Parkinson's disease substantia nigraQ40608849
Receptor-mediated transcytosis of lactoferrin through the blood-brain barrier.Q40969107
Alpha-synuclein in Lewy bodiesQ27860680
A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overloadQ28139987
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Transferrin receptor 2-alpha supports cell growth both in iron-chelated cultured cells and in vivoQ28140681
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Oxidative stress in neurodegeneration: cause or consequence?Q28275946
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Disruption of ceruloplasmin and hephaestin in mice causes retinal iron overload and retinal degeneration with features of age-related macular degenerationQ28281967
Identification of the iron-responsive element for the translational regulation of human ferritin mRNAQ28302958
Receptor-mediated transcytosis of transferrin across the blood-brain barrierQ28303216
Expression of the iron transporter ferroportin in synaptic vesicles and the blood-brain barrierQ28507937
Slc11a2 is required for intestinal iron absorption and erythropoiesis but dispensable in placenta and liverQ28509001
Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in miceQ28510424
Identification of an intestinal heme transporterQ28513323
Identification of differentially expressed genes in response to dietary iron deprivation in rat duodenumQ28575734
Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout miceQ28586797
A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expressionQ28590840
Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cellsQ28594532
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Balancing acts: molecular control of mammalian iron metabolismQ29620380
The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammationQ29620394
Are men at greater risk for Parkinson's disease than women?Q30433122
Dopaminergic cell death induced by MPP(+), oxidant and specific neurotoxicants shares the common molecular mechanismQ31961819
Echogenicity of the substantia nigra in Parkinson's disease and its relation to clinical findingsQ33182444
Association of HFE common mutations with Parkinson's disease, Alzheimer's disease and mild cognitive impairment in a Portuguese cohortQ33249091
Seleno-L-methionine protects against beta-amyloid and iron/hydrogen peroxide-mediated neuron deathQ33272194
Disturbance of iron metabolism as a contributing factor to SN hyperechogenicity in Parkinson's disease: implications for idiopathic and monogenetic formsQ33283198
Heme oxygenase: recent advances in understanding its regulation and role.Q33750898
Cloning of the cDNA encoding an RNA regulatory protein--the human iron-responsive element-binding proteinQ33842468
Immunohistochemical and subcellular localization of Parkin protein: absence of protein in autosomal recessive juvenile parkinsonism patientsQ33861614
Neuromelanin biosynthesis is driven by excess cytosolic catecholamines not accumulated by synaptic vesicles.Q33922930
Effect of tea and other dietary factors on iron absorptionQ34058571
Receptor-mediated endocytosis of transferrin at the blood-brain barrierQ34062024
Mutation in the gene encoding ferritin light polypeptide causes dominant adult-onset basal ganglia diseaseQ34083035
Impaired iron homeostasis in Parkinson's disease.Q34155212
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Inhibition of food iron absorption by coffeeQ34259075
Coincident expression and distribution of melanotransferrin and transferrin receptor in human brain capillary endotheliumQ34388931
Hysterectomy, menopause, and estrogen use preceding Parkinson's disease: an exploratory case-control study.Q34464847
A meta-analysis of coffee drinking, cigarette smoking, and the risk of Parkinson's diseaseQ34526685
Ferritin: a novel mechanism for delivery of iron to the brain and other organs.Q34622902
A novel transferrin/TfR2-mediated mitochondrial iron transport system is disrupted in Parkinson's diseaseQ34658144
Influence of neuromelanin on oxidative pathways within the human substantia nigraQ34802086
Long-lasting neural and behavioral effects of iron deficiency in infancyQ34977210
Iron misregulation in the brain: a primary cause of neurodegenerative disordersQ35172307
A protein-chameleon: conformational plasticity of alpha-synuclein, a disordered protein involved in neurodegenerative disordersQ35212177
Neuroferritinopathy in a French family with late onset dominant dystoniaQ35442453
An iron-sulfur cluster plays a novel regulatory role in the iron-responsive element binding proteinQ35468837
The crucial role of metal ions in neurodegeneration: the basis for a promising therapeutic strategyQ35545150
Iron metabolism and the IRE/IRP regulatory system: an updateQ35754458
The relevance of iron in the pathogenesis of Parkinson's disease.Q35754511
Occupational and environmental risk factors for Parkinson's diseaseQ35791905
Ubiquitin-proteasome system and Parkinson's diseasesQ35998400
Hepcidin--a regulator of intestinal iron absorption and iron recycling by macrophagesQ36057889
Gene-environment interactions in parkinsonism and Parkinson's disease: the Geoparkinson studyQ36144981
Prevalence of haemochromatosis gene mutations in Parkinson's diseaseQ36226909
Metal ions and oxidative protein modification in neurological disease.Q36294760
Iron, neuroinflammation, and Alzheimer's diseaseQ36322650
TIM-2 is expressed on B cells and in liver and kidney and is a receptor for H-ferritin endocytosisQ36403570
Mitochondrial dysfunction, free radical generation and cellular stress response in neurodegenerative disordersQ36664537
Implications for estrogens in Parkinson's disease: an epidemiological approach.Q36721786
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Relationship of iron to oligodendrocytes and myelinationQ41087116
Neuropathology of Parkinson's diseaseQ41095404
Prevention of neuroleptic-induced dopamine D2 receptor supersensitivity by chronic iron salt treatmentQ41994164
Ceruloplasmin gene variations and substantia nigra hyperechogenicity in Parkinson disease.Q42470896
Cellular distribution of transferrin, ferritin, and iron in normal and aged human brainsQ42477389
Microglial cells prevent nitric oxide-induced neuronal apoptosis in vitroQ42540242
Domain homologues of dopamine beta-hydroxylase and ferric reductase: roles for iron metabolism in neurodegenerative disorders?Q42658403
The specific vulnerability of the substantia nigra to MPTP is related to the presence of transition metalsQ43466545
Glial cells contribute more to iron and aluminum accumulation but are more resistant to oxidative stress than neuronal cellsQ43509406
Metal-triggered structural transformations, aggregation, and fibrillation of human alpha-synuclein. A possible molecular NK between Parkinson's disease and heavy metal exposureQ43735123
The herbicide paraquat causes up-regulation and aggregation of alpha-synuclein in mice: paraquat and alpha-synucleinQ43798526
Distribution of divalent metal transporter 1 and metal transport protein 1 in the normal and Belgrade rat.Q43825415
Normal deposition of brain iron in childhood and adolescence: MR imaging at 1.5 T.Q44034310
The relationship between intracellular free iron and cell injury in cultured neurons, astrocytes, and oligodendrocytes.Q44066996
Ferritin induction protects cortical astrocytes from heme-mediated oxidative injuryQ44105509
Coffee drinking influences plasma antioxidant capacity in humans.Q44162829
Risk tables for parkinsonism and Parkinson's disease.Q44309519
Effects of L-dopa and other amino acids against paraquat-induced nigrostriatal degenerationQ44365099
Genetic or pharmacological iron chelation prevents MPTP-induced neurotoxicity in vivo: a novel therapy for Parkinson's diseaseQ44386905
Adult nutrient intake as a risk factor for Parkinson's diseaseQ44487546
Iron-binding characteristics of neuromelanin of the human substantia nigra.Q44542032
Antioxidant and prooxidant properties of caffeine, theobromine and xanthine.Q44576868
Antioxidative activities of fractions obtained from brewed coffeeQ44753377
Iron accumulation, iron-mediated toxicity and altered levels of ferritin and transferrin receptor in cultured astrocytes during incubation with ferric ammonium citrate.Q44792347
In vitro and ex vivo antihydroxyl radical activity of green and roasted coffeeQ44804830
Intranigral iron injection induces behavioral and biochemical "parkinsonism" in ratsQ44848373
Ironing iron out in Parkinson's disease and other neurodegenerative diseases with iron chelators: a lesson from 6-hydroxydopamine and iron chelators, desferal and VK-28.Q44856789
Characterization and modulation of the transferrin receptor on brain capillary endothelial cellsQ44923706
Antioxidant behaviour of caffeine: efficient scavenging of hydroxyl radicalsQ44938311
Electrochemical investigation into the redox activity of Fe(II)/Fe(III) in the presence of nicotine and possible relations to neurodegenerative diseases.Q45036424
Role of dietary iron restriction in a mouse model of Parkinson's diseaseQ45142327
Effect of reproductive factors and postmenopausal hormone use on the risk of Parkinson disease.Q45933973
Polymorphisms in iron-responsive binding protein 2 and lack of association with sporadic Parkinson's diseaseQ46372187
Neuroprotection by iron chelator against proteasome inhibitor-induced nigral degenerationQ46541429
Hepcidin is decreased in TFR2 hemochromatosisQ46624831
Pooled analysis of tobacco use and risk of Parkinson diseaseQ46785257
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Identification of a novel route of iron transcytosis across the mammalian blood-brain barrierQ47239973
Mutations in the hemochromatosis gene (HFE), Parkinson's disease and parkinsonismQ47710928
Screening for mutations of the IRP2 gene in Parkinson's disease patients with hyperechogenicity of the substantia nigra.Q47839890
Parkinson's disease risks associated with dietary iron, manganese, and other nutrient intakesQ47848377
The significance of the mutated divalent metal transporter (DMT1) on iron transport into the Belgrade rat brain.Q48116475
Neonatal iron exposure induces neurobehavioural dysfunctions in adult miceQ48135971
Screening for mutations of the ferritin light and heavy genes in Parkinson's disease patients with hyperechogenicity of the substantia nigraQ48146389
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Increased nigral iron content in postmortem parkinsonian brainQ48182830
Infusion of iron into the rat substantia nigra: Nigral pathology and dose‐dependent loss of striatal dopaminergic markersQ48299583
Assessment of brain iron and neuronal integrity in patients with Parkinson's disease using novel MRI contrasts.Q48346436
Residual substantia nigra neuromelanin in Parkinson's disease is cross-linked to alpha-synucleinQ48386115
Expression of the neuronal transferrin receptor is age dependent and susceptible to iron deficiencyQ48404946
Manganese: a transition metal protects nigrostriatal neurons from oxidative stress in the iron-induced animal model of parkinsonismQ48422450
???Q64789964
Brain capillary endothelial cells mediate iron transport into the brain by segregating iron from transferrin without the involvement of divalent metal transporter 1.Q48458370
Trace element concentration in human brain. Activation analysis of cobalt, iron, rubidium, selenium, zinc, chromium, silver, cesium, antimony and scandiumQ48472892
Iron induces degeneration of nigrostriatal neuronsQ48494836
Increased murine neonatal iron intake results in Parkinson-like neurodegeneration with age.Q48502457
Substantia nigra echogenicity is normal in non-extrapyramidal cerebral disorders but increased in Parkinson's diseaseQ48573193
Transferrin receptor on endothelium of brain capillariesQ48602638
Altered systemic iron metabolism in Parkinson's diseaseQ48625403
EPR investigations of the iron domain in neuromelanin.Q48659091
In vivo detection of iron and neuromelanin by transcranial sonography: a new approach for early detection of substantia nigra damageQ48829730
Neonatal iron potentiates adult MPTP-induced neurodegenerative and functional deficitsQ48952359
Receptor-mediated transcytosis of transferrin through blood-brain barrier endothelial cellsQ49016593
Crosslinking of alpha-synuclein by advanced glycation endproducts--an early pathophysiological step in Lewy body formation?Q49019886
The effect of age on the non-haemin iron in the human brain.Q51318963
Risk of Parkinson disease in women: effect of reproductive characteristics.Q51940269
Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis.Q52549517
Environmental risk factors and Parkinson's disease: a metaanalysis.Q52932783
Immunocytochemical co-localization of the proteasome in ubiquitinated structures in neurodegenerative diseases and the elderly.Q53216133
Deregulation of proteins involved in iron metabolism in hepcidin-deficient mice.Q53926764
The effect of a synthetic neuromelanin on yield of free hydroxyl radicals generated in model systemsQ54170347
Distribution of divalent metal transporter 1 and metal transport protein 1 in the normal and Belgrade ratQ54975411
Inhibition of non-haem iron absorption in man by polyphenolic-containing beverages.Q55034248
NeuroferritinopathyQ57316219
Binding of a cytosolic protein to the iron-responsive element of human ferritin messenger RNAQ57397581
Gender differences in Parkinson's diseaseQ57779630
The Cys282Tyr polymorphism in the HFE gene in Australian Parkinson's disease patientsQ60687066
Increased iron (III) and total iron content in post mortem substantia nigra of parkinsonian brainQ61714016
In Vitro Antioxidant and ex Vivo Protective Activities of Green and Roasted CoffeeQ62111342
Analysis of ferritin genes in Parkinson diseaseQ62391452
TorsinA accumulation in Lewy bodies in sporadic Parkinson's diseaseQ64769140
Extensive axonal Lewy neurites in Parkinson's disease: a novel pathological feature revealed by alpha-synuclein immunocytochemistryQ64861825
Excessive iron accumulation in the brain: a possible potential risk of neurodegeneration in Parkinson's disease.Q67218564
Dopamine, 6-hydroxydopamine, iron, and dioxygen--their mutual interactions and possible implication in the development of Parkinson's diseaseQ67228588
Detection and isolation of a hepatic membrane receptor for ferritinQ67277091
Epidemiology of Parkinson's disease.Q67401761
Basal ganglia iron content in Parkinson's disease measured with magnetic resonance.Q67405918
[Environmental factors in the etiology of Parkinson's disease]Q68546394
Nature of inhibition of mitochondrial respiratory complex I by 6-HydroxydopamineQ71464560
Transferrin and iron in normal, Alzheimer's disease, and Parkinson's disease brain regionsQ71894700
Intranigral injected iron progressively reduces striatal dopamine metabolismQ72232437
Magnetic resonance imaging evidence of decreased putamenal iron content in idiopathic Parkinson's diseaseQ72269342
Increased iron-related MRI contrast in the substantia nigra in Parkinson's diseaseQ72319648
Role of flavonoids and iron chelation in antioxidant actionQ72377049
Binding of iron to neuromelanin of human substantia nigra and synthetic melanin: an electron paramagnetic resonance spectroscopy studyQ73370745
Association study between iron-related genes polymorphisms and Parkinson's diseaseQ74519525
P433issue2
P921main subjectParkinson's diseaseQ11085
P304page(s)183-195
P577publication date2008-07-11
P1433published inNeurobiology of DiseaseQ15716606
P1476titleGenetics of iron regulation and the possible role of iron in Parkinson's disease
P478volume32

Reverse relations

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