The pivotal role of RhoA GTPase in the molecular signaling of axon growth inhibition after CNS injury and targeted therapeutic strategies

scientific article published on January 2007

The pivotal role of RhoA GTPase in the molecular signaling of axon growth inhibition after CNS injury and targeted therapeutic strategies is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.3727/000000007783464740
P698PubMed publication ID17503736

P2093author name stringQi Mei
Robert E Gross
Claire-Anne Gutekunst
Enrique Torre
P2860cites workVersican V2 and the central inhibitory domain of Nogo-A inhibit neurite growth via p75NTR/NgR-independent pathways that converge at RhoA.Q51822782
Chimaerins act downstream from neurotrophins in overcoming the inhibition of neurite outgrowth produced by myelin-associated glycoprotein.Q52087295
Getting RIP'd Stunts Your Growth.Q53671116
Myelin-associated inhibitors regulate cofilin phosphorylation and neuronal inhibition through LIM kinase and Slingshot phosphatase.Q54476575
CRMP-2 induces axons in cultured hippocampal neuronsQ57936437
Chronic Enhancement of the Intrinsic Growth Capacity of Sensory Neurons Combined with the Degradation of Inhibitory Proteoglycans Allows Functional Regeneration of Sensory Axons through the Dorsal Root Entry Zone in the Mammalian Spinal CordQ58429249
Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinaseQ22010473
Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loopQ22011174
Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cellsQ24301058
Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase)Q24319737
Rho activation patterns after spinal cord injury and the role of activated Rho in apoptosis in the central nervous systemQ24675542
Structural bases for CRMP function in plexin-dependent semaphorin3A signalingQ27642826
Cellular motility driven by assembly and disassembly of actin filamentsQ27860676
A p75(NTR) and Nogo receptor complex mediates repulsive signaling by myelin-associated glycoproteinQ27919630
The p75 receptor acts as a displacement factor that releases Rho from Rho-GDI.Q27919637
LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complexQ27919650
Regulation and functions of Rho-associated kinaseQ28138022
Inhibitor of neurite outgrowth in humansQ28144415
Nogo-A is a myelin-associated neurite outgrowth inhibitor and an antigen for monoclonal antibody IN-1Q28144424
Nogo-66 receptor antagonist peptide promotes axonal regenerationQ28201650
Oligodendrocyte-myelin glycoprotein is a Nogo receptor ligand that inhibits neurite outgrowthQ28204972
P75 interacts with the Nogo receptor as a co-receptor for Nogo, MAG and OMgpQ28214328
Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA and growth cone morphologyQ28215013
Neuroscience. It takes more than two to NogoQ28218397
Regeneration beyond the glial scarQ28239915
Regeneration of adult axons in white matter tracts of the central nervous systemQ28257832
Modulation of Rho GTPase activity alleviates chondroitin sulfate proteoglycan-dependent inhibition of neurite extensionQ28268155
A TNF receptor family member, TROY, is a coreceptor with Nogo receptor in mediating the inhibitory activity of myelin inhibitorsQ28305967
RGMa inhibition promotes axonal growth and recovery after spinal cord injury.Q28571215
Axonal regeneration and lack of astrocytic gliosis in EphA4-deficient miceQ28592877
Ephrin-A5 induces collapse of growth cones by activating Rho and Rho kinaseQ28647593
Inhibition of myosin light chain kinase by p21-activated kinaseQ28678502
Chondroitinase ABC promotes functional recovery after spinal cord injuryQ29615017
The role of the Rho GTPases in neuronal developmentQ29616295
Rho GTPases in neuronal morphogenesisQ29620432
The glial scar and central nervous system repairQ33731601
The Nogo-Nogo receptor pathway limits a spectrum of adult CNS axonal growthQ33767284
The role of local actin instability in axon formationQ33855372
Phosphorylation by Rho kinase regulates CRMP-2 activity in growth conesQ34124216
Repulsive factors and axon regeneration in the CNS.Q34141473
The Rho/ROCK pathway mediates neurite growth-inhibitory activity associated with the chondroitin sulfate proteoglycans of the CNS glial scarQ34190151
Meningeal cell-derived semaphorin 3A inhibits neurite outgrowthQ34286587
Myelin-, reactive glia-, and scar-derived CNS axon growth inhibitors: expression, receptor signaling, and correlation with axon regenerationQ34309248
The Nogo signaling pathway for regeneration blockQ34329058
Cocaine-induced expression changes of axon guidance molecules in the adult rat brainQ34390929
TAJ/TROY, an orphan TNF receptor family member, binds Nogo-66 receptor 1 and regulates axonal regenerationQ34391328
A selective Sema3A inhibitor enhances regenerative responses and functional recovery of the injured spinal cordQ34572480
Signaling the pathway to regenerationQ34747085
Nogo on the go.Q34984937
Signaling at the growth cone: ligand-receptor complexes and the control of axon growth and guidanceQ35099606
Myelin-associated inhibitors of axonal regeneration in the adult mammalian CNS.Q35209949
Regulation of growth cone actin filaments by guidance cuesQ35575896
Signalling mechanisms mediating neuronal responses to guidance cuesQ35610287
Axon regeneration: it's getting crowded at the gates of TROY.Q36108126
Lentivirus-mediated gene transfer to the central nervous system: therapeutic and research applicationsQ36366788
Targeting Rho to stimulate repair after spinal cord injuryQ36455786
Rho family GTPases and neuronal growth cone remodelling: relationship between increased complexity induced by Cdc42Hs, Rac1, and acetylcholine and collapse induced by RhoA and lysophosphatidic acidQ36565713
Myelin-associated glycoprotein inhibits microtubule assembly by a Rho-kinase-dependent mechanismQ38314500
Myelin-associated glycoprotein inhibits axonal regeneration from a variety of neurons via interaction with a sialoglycoproteinQ38362117
Injury-induced class 3 semaphorin expression in the rat spinal cordQ40640541
Contact inhibition in the failure of mammalian CNS axonal regenerationQ40732280
Degeneration and regeneration of axons in the lesioned spinal cordQ40980911
cAMP-induced morphological changes are counteracted by the activated RhoA small GTPase and the Rho kinase ROKalphaQ41014721
Elevation of intracellular cAMP inhibits RhoA activation and integrin-dependent leukocyte adhesion induced by chemoattractants.Q41090098
Identification of myelin-associated glycoprotein as a major myelin-derived inhibitor of neurite growthQ41440802
Inhibition of lysophosphatidate- and thrombin-induced neurite retraction and neuronal cell rounding by ADP ribosylation of the small GTP-binding protein Rho.Q41450596
Axon guidance: GTPases help axons reach their targetsQ41690542
The p75 receptor transduces the signal from myelin-associated glycoprotein to Rho.Q42112958
Chondroitinase ABC promotes sprouting of intact and injured spinal systems after spinal cord injury.Q42140143
Peripheral nerve explants grafted into the vitreous body of the eye promote the regeneration of retinal ganglion cell axons severed in the optic nerveQ42519727
Nogo receptor mRNA expression in intact and regenerating CNS neuronsQ42525632
Characterization of new cell permeable C3-like proteins that inactivate Rho and stimulate neurite outgrowth on inhibitory substratesQ42813288
Lack of evidence that myelin-associated glycoprotein is a major inhibitor of axonal regeneration in the CNS.Q42819573
Neuronal responses to myelin are mediated by rho kinaseQ43465628
Regulation of rho GTPases by crosstalk and neuronal activity in vivo.Q43906183
Regeneration of sensory axons within the injured spinal cord induced by intraganglionic cAMP elevationQ44042967
Spinal axon regeneration induced by elevation of cyclic AMP.Q44042969
A possible role of RhoA/Rho-kinase in experimental spinal cord injury in rat.Q44247647
Axon regeneration in young adult mice lacking Nogo-A/B.Q44420135
Suppression of p75NTR does not promote regeneration of injured spinal cord in mice.Q44728744
Counteracting the Nogo receptor enhances optic nerve regeneration if retinal ganglion cells are in an active growth state.Q44770108
cAMP and Schwann cells promote axonal growth and functional recovery after spinal cord injuryQ44905187
Combinatorial therapy with neurotrophins and cAMP promotes axonal regeneration beyond sites of spinal cord injury.Q44978640
Alpha2-chimaerin, cyclin-dependent Kinase 5/p35, and its target collapsin response mediator protein-2 are essential components in semaphorin 3A-induced growth-cone collapse.Q45106002
Long distance directed axonal growth from human dopaminergic mesencephalic neuroblasts implanted along the nigrostriatal pathway in 6-hydroxydopamine lesioned adult ratsQ45125547
Application of Rho antagonist to neuronal cell bodies promotes neurite growth in compartmented cultures and regeneration of retinal ganglion cell axons in the optic nerve of adult rats.Q45249968
Phosphorylation of cofilin by LIM-kinase is necessary for semaphorin 3A-induced growth cone collapse.Q45345107
EphA receptors regulate growth cone dynamics through the novel guanine nucleotide exchange factor ephexinQ45345123
Conversion of neuronal growth cone responses from repulsion to attraction by cyclic nucleotides.Q46084871
Secreted semaphorins modulate synaptic transmission in the adult hippocampus.Q46425957
MAG induces regulated intramembrane proteolysis of the p75 neurotrophin receptor to inhibit neurite outgrowthQ46543783
In situ gelling hydrogels for conformal repair of spinal cord defects, and local delivery of BDNF after spinal cord injuryQ46649232
Suppression of Rho-kinase activity promotes axonal growth on inhibitory CNS substratesQ47978419
The astrocyte/meningeal cell interface is a barrier to neurite outgrowth which can be overcome by manipulation of inhibitory molecules or axonal signalling pathways.Q48105647
Effect of focal cerebral infarctions on lesional RhoA and RhoB expressionQ48197997
Expression of the gene encoding the chemorepellent semaphorin III is induced in the fibroblast component of neural scar tissue formed following injuries of adult but not neonatal CNS.Q48245393
Systemic deletion of the myelin-associated outgrowth inhibitor Nogo-A improves regenerative and plastic responses after spinal cord injury.Q48323682
Activated macrophages and the blood-brain barrier: inflammation after CNS injury leads to increases in putative inhibitory moleculesQ48558550
Demonstration of the potential for chronically injured neurons to regenerate axons into intraspinal peripheral nerve graftsQ48692872
Prolonged lesional expression of RhoA and RhoB following spinal cord injuryQ48895631
Axonal Elongation into Peripheral Nervous System "Bridges" After Central Nervous System Injury in Adult RatsQ49156758
Extension and regeneration of corticospinal axons after early spinal injury and the maintenance of corticospinal topography.Q50779856
Regeneration of dorsal column fibers into and beyond the lesion site following adult spinal cord injury.Q51451500
P433issue3
P304page(s)245-262
P577publication date2007-01-01
P1433published inCell TransplantationQ15761863
P1476titleThe pivotal role of RhoA GTPase in the molecular signaling of axon growth inhibition after CNS injury and targeted therapeutic strategies
P478volume16