Benefit of chondroitinase ABC on sensory axon regeneration in a laceration model of spinal cord injury in the rat

scientific article published on June 2008

Benefit of chondroitinase ABC on sensory axon regeneration in a laceration model of spinal cord injury in the rat is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.SURNEU.2008.02.009
P932PMC publication ID2504084
P698PubMed publication ID18486695
P5875ResearchGate publication ID5363214

P2093author name stringChristopher B Shields
Darlene A Burke
Lisa B E Shields
Rebecca Gray
Yi Ping Zhang
P2860cites workRegrowth of axons into the distal spinal cord through a Schwann-cell-seeded mini-channel implanted into hemisected adult rat spinal cord.Q48228432
Degradation of chondroitin sulfate proteoglycan enhances the neurite-promoting potential of spinal cord tissueQ48313494
Localization of Nogo-A and Nogo-66 receptor proteins at sites of axon-myelin and synaptic contact.Q48561046
Oligodendrocytes arrest neurite growth by contact inhibition.Q48843200
Regenerative Nerve Fiber Growth in the Adult Central Nervous SystemQ48857473
Neurotrophins BDNF and NT-3 promote axonal re-entry into the distal host spinal cord through Schwann cell-seeded mini-channelsQ49044172
A novel DNA enzyme reduces glycosaminoglycan chains in the glial scar and allows microtransplanted dorsal root ganglia axons to regenerate beyond lesions in the spinal cord.Q51039622
Regeneration of dorsal column fibers into and beyond the lesion site following adult spinal cord injury.Q51451500
Dural closure, cord approximation, and clot removal: enhancement of tissue sparing in a novel laceration spinal cord injury model.Q51692148
Neuropilin-2 is required in vivo for selective axon guidance responses to secreted semaphorins.Q52170285
Chronic Enhancement of the Intrinsic Growth Capacity of Sensory Neurons Combined with the Degradation of Inhibitory Proteoglycans Allows Functional Regeneration of Sensory Axons through the Dorsal Root Entry Zone in the Mammalian Spinal CordQ58429249
Improving axonal growth and functional recovery after experimental spinal cord injury by neutralizing myelin associated inhibitorsQ60223546
Reduction of neurite outgrowth in a model of glial scarring following CNS injury is correlated with the expression of inhibitory molecules on reactive astrocytesQ67703308
Axonal growth on astrocytes is not inhibited by oligodendrocytesQ67982457
Injury-induced proteoglycans inhibit the potential for laminin-mediated axon growth on astrocytic scarsQ71815667
Chondroitin sulfate proteoglycan immunoreactivity increases following spinal cord injury and transplantationQ73343119
Brain derived versican V2 is a potent inhibitor of axonal growthQ73441516
Intact aggrecan and chondroitin sulfate-depleted aggrecan core glycoprotein inhibit axon growth in the adult rat spinal cordQ75445653
PKC mediates inhibitory effects of myelin and chondroitin sulfate proteoglycans on axonal regenerationQ75447896
Robust regeneration of adult sensory axons in degenerating white matter of the adult rat spinal cordQ78003481
Increased expression of the putative axon growth-repulsive extracellular matrix molecule, keratan sulphate proteoglycan, following traumatic injury of the adult rat spinal cordQ78457828
Combining an autologous peripheral nervous system "bridge" and matrix modification by chondroitinase allows robust, functional regeneration beyond a hemisection lesion of the adult rat spinal cordQ79892954
Chondroitinase ABC promotes axonal re-growth and behavior recovery in spinal cord injuryQ80242034
Identification of the Nogo inhibitor of axon regeneration as a Reticulon proteinQ22253157
Identification of a receptor mediating Nogo-66 inhibition of axonal regenerationQ24290847
The chondroitin sulfate proteoglycans neurocan, brevican, phosphacan, and versican are differentially regulated following spinal cord injuryQ28191612
Oligodendrocyte-myelin glycoprotein is a Nogo receptor ligand that inhibits neurite outgrowthQ28204972
Myelin-associated glycoprotein as a functional ligand for the Nogo-66 receptorQ28207833
Myelin-associated glycoprotein interacts with the Nogo66 receptor to inhibit neurite outgrowthQ28216797
Regeneration beyond the glial scarQ28239915
Regeneration of adult axons in white matter tracts of the central nervous systemQ28257832
Changes in distribution, cell associations, and protein expression levels of NG2, neurocan, phosphacan, brevican, versican V2, and tenascin-C during acute to chronic maturation of spinal cord scar tissueQ28566378
Chondroitinase ABC promotes functional recovery after spinal cord injuryQ29615017
Functional axonal regeneration through astrocytic scar genetically modified to digest chondroitin sulfate proteoglycansQ33767291
Progress in spinal cord research - a refined strategy for the International Spinal Research TrustQ34016624
Neurotrophic factors, cellular bridges and gene therapy for spinal cord injuryQ34249936
Myelin-, reactive glia-, and scar-derived CNS axon growth inhibitors: expression, receptor signaling, and correlation with axon regenerationQ34309248
Ephrin signaling in axon guidanceQ34347809
Oligodendrocyte-myelin glycoprotein (OMgp) is an inhibitor of neurite outgrowthQ34527751
Extracellular matrix in spinal cord regeneration: getting beyond attraction and inhibitionQ34585719
Nogo and the Nogo-66 receptorQ35002832
New roles for old proteins in adult CNS axonal regenerationQ35069019
Chondroitin sulphate proteoglycans in the central nervous system: changes and synthesis after injuryQ35090882
Production and characterization of monoclonal antibodies directed against connective tissue proteoglycansQ38352913
Regeneration of CNS axons back to their target following treatment of adult rat brain with chondroitinase ABC.Q38524950
Observations on the pathology of human spinal cord injury. A review and classification of 22 new cases with details from a case of chronic cord compression with extensive focal demyelination.Q40868923
NT-3 promotes growth of lesioned adult rat sensory axons ascending in the dorsal columns of the spinal cord.Q40914375
Comparing astrocytic cell lines that are inhibitory or permissive for axon growth: the major axon-inhibitory proteoglycan is NG2.Q40923776
Cell adhesion molecules and neuronal regenerationQ40924693
Identification of myelin-associated glycoprotein as a major myelin-derived inhibitor of neurite growthQ41440802
Glial cell extracellular matrix: boundaries for axon growth in development and regenerationQ41606080
Elimination of basal lamina and the collagen "scar" after spinal cord injury fails to augment corticospinal tract regenerationQ41713434
Chondroitinase ABC promotes sprouting of intact and injured spinal systems after spinal cord injury.Q42140143
Laminin overrides the inhibitory effects of peripheral nervous system and central nervous system myelin-derived inhibitors of neurite growthQ42514334
Inhibitory proteoglycan immunoreactivity is higher at the caudal than the rostral Schwann cell graft-transected spinal cord interfaceQ43556178
Myelin-associated glycoprotein interacts with ganglioside GT1b. A mechanism for neurite outgrowth inhibitionQ43560231
Excitotoxic model of post-traumatic syringomyelia in the rat.Q43745752
Spinal cord injury elicits expression of keratan sulfate proteoglycans by macrophages, reactive microglia, and oligodendrocyte progenitors.Q43974980
Ascending sensory, but not other long-tract axons, regenerate into the connective tissue matrix that forms at the site of a spinal cord injury in miceQ44481450
Synergistic effects of brain-derived neurotrophic factor and chondroitinase ABC on retinal fiber sprouting after denervation of the superior colliculus in adult rats.Q44540533
NG2 is a major chondroitin sulfate proteoglycan produced after spinal cord injury and is expressed by macrophages and oligodendrocyte progenitors.Q46345563
Axonal Regeneration through Regions of Chondroitin Sulfate Proteoglycan Deposition after Spinal Cord Injury: A Balance of Permissiveness and InhibitionQ46479010
P433issue6
P304page(s)568-77; discussion 577
P577publication date2008-06-01
P1433published inWorld NeurosurgeryQ15765829
P1476titleBenefit of chondroitinase ABC on sensory axon regeneration in a laceration model of spinal cord injury in the rat
P478volume69

Reverse relations

cites work (P2860)
Q35127473A systematic review of directly applied biologic therapies for acute spinal cord injury
Q37718952Astrocytic and vascular remodeling in the injured adult rat spinal cord after chondroitinase ABC treatment
Q49050144Basic techniques for long distance axon tracing in the spinal cord
Q28555030Chondroitinase C Selectively Degrades Chondroitin Sulfate Glycosaminoglycans that Inhibit Axonal Growth within the Endoneurium of Peripheral Nerve
Q40419695Combined chondroitinase and KLF7 expression reduce net retraction of sensory and CST axons from sites of spinal injury
Q37247610Dorsal column sensory axons degenerate due to impaired microvascular perfusion after spinal cord injury in rats
Q42840267Effects of dantrolene on apoptosis and immunohistochemical expression of NeuN in the spinal cord after traumatic injury in rats
Q96128596Evaluating Chondroitin Sulfate and Dermatan Sulfate Expression in Glial Scar to Determine Appropriate Intervention Time in Rats
Q37928624Extracellular matrix and perineuronal nets in CNS repair
Q38716618In vitro models of axon regeneration
Q35783366Local Delivery of High-Dose Chondroitinase ABC in the Sub-Acute Stage Promotes Axonal Outgrowth and Functional Recovery after Complete Spinal Cord Transection
Q38179520Manipulating the extracellular matrix and its role in brain and spinal cord plasticity and repair
Q37061055Migration of Adipose-derived Mesenchymal Stem Cells Stably Expressing Chondroitinase ABC In vitro
Q36125734Phenotypic Screening of Small-Molecule Inhibitors: Implications for Therapeutic Discovery and Drug Target Development in Traumatic Brain Injury
Q57460363Regenerative Strategies for the Central Nervous System
Q37677472Spinal Cord Injury and Related Clinical Trials
Q37346515The 'sweet' and 'bitter' involvement of glycosaminoglycans in lung diseases: pharmacotherapeutic relevance

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